Detailed information for compound 1248300

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 535.48 | Formula: C25H30NO10P
  • H donors: 2 H acceptors: 4 LogP: 1.83 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(/C=C/2\CN(C/C(=C\c3cc(OC)c(c(c3)OC)OC)/C2=O)P(=O)(O)O)cc(c1OC)OC
  • InChi: 1S/C25H30NO10P/c1-31-19-9-15(10-20(32-2)24(19)35-5)7-17-13-26(37(28,29)30)14-18(23(17)27)8-16-11-21(33-3)25(36-6)22(12-16)34-4/h7-12H,13-14H2,1-6H3,(H2,28,29,30)/b17-7+,18-8+
  • InChiKey: HXBAJCJVGASJTO-ZEELXFFVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0071 0.0237
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.011 0.0158
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0087 0.0292
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.002 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0373 0.0994
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0355 0.0488
Leishmania major pteridine reductase 1 0.0064 0.0355 0.1695
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0064 0.0355 0.1695
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1139 0.3033
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0498
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0137 0.023
Loa Loa (eye worm) retinol dehydrogenase 12 0.0064 0.0355 0.0947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1139 0.3033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0355 0.1194
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0211 0.0975
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0952 0.5952 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0137 0.0113
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0107 0.0107
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.011 0.0469
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0107 0.0285
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.011 0.0158
Mycobacterium ulcerans oxidoreductase 0.0064 0.0355 0.0488
Schistosoma mansoni hypothetical protein 0.0011 0.0021 0.0056
Mycobacterium tuberculosis Probable oxidoreductase 0.0218 0.1325 0.2144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0373 0.0994
Echinococcus multilocularis survival motor neuron protein 1 0.048 0.2978 0.2978
Brugia malayi glutathione reductase 0.0086 0.0491 0.165
Loa Loa (eye worm) hypothetical protein 0.0213 0.129 0.3436
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0216 0.0337
Schistosoma mansoni smad 0.0025 0.0107 0.0285
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0016 0.0043
Schistosoma mansoni hypothetical protein 0.0067 0.0373 0.0994
Trichomonas vaginalis ran, putative 0.0042 0.0211 0.0355
Brugia malayi MH2 domain containing protein 0.0025 0.0107 0.0359
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0603 0.3754 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0064 0.0355 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0216 0.0748
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0216 0.1
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.2017 1
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Loa Loa (eye worm) hypothetical protein 0.0042 0.0216 0.0576
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0952 0.5952 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0064 0.0355 0.1463
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0127 0.0338
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1139 0.3824
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0355 0.1194
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0305 0.1445
Echinococcus granulosus importin 5 0.0011 0.0016 0.0043
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0064 0.0355 0.0498
Onchocerca volvulus 0.0064 0.0355 0.6273
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.011 0.0158
Schistosoma mansoni ran 0.0042 0.0211 0.0563
Echinococcus granulosus RUN 0.0043 0.0217 0.0578
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0052
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0218 0.1325 0.2081
Brugia malayi Importin beta-1 subunit 0.0057 0.0305 0.1026
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0071 0.0015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0603 0.3754 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0216 0.0576
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0107 0.0285
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0211 0.071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0373 0.0994
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.0092
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0107 0.0285
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0217 0.0338
Brugia malayi beta-lactamase family protein 0.0042 0.0216 0.0726
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0021 0.0056
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0004 0.001
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0109 0.3065
Trypanosoma brucei pteridine reductase 1 0.0064 0.0355 0.1695
Echinococcus multilocularis cpg binding protein 0.003 0.0137 0.0137
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0109 0.008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0238 0.04
Echinococcus granulosus dnaJ subfamily B 0.0402 0.2483 0.6612
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0211 0.0328
Mycobacterium ulcerans lipase LipD 0.0042 0.0216 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.034
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.002 0.0345
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0016 0.0043
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0137 0.4711
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0355 0.0947
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Echinococcus granulosus cpg binding protein 0.003 0.0137 0.0365
Echinococcus multilocularis translational activator gcn1 0.0011 0.0016 0.0016
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0068 0.0088
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0333 0.0888
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0064 0.0355 0.0488
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0071 0.0188
Schistosoma mansoni importin-beta 2 0.0011 0.0016 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0333 0.0888
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0216 0.0262
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.002 0.0066
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0211 0.0722
Echinococcus multilocularis transportin 1 0.0011 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0043 0.0217 0.0578
Brugia malayi Muscleblind-like protein 0.0304 0.1866 0.6269
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0064 0.0355 0.0422
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.002 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0216 0.0576
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.029
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.024 0.1116
Leishmania major hypothetical protein, conserved 0.0042 0.0216 0.1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0021 0.0021
Mycobacterium ulcerans beta-lactamase 0.0042 0.0216 0.0251
Brugia malayi CXXC zinc finger family protein 0.0028 0.0127 0.0426
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0137 0.0116
Onchocerca volvulus 0.0064 0.0355 0.6273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1139 0.1139
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0064 0.0355 0.0571
Echinococcus multilocularis importin 5 0.0011 0.0016 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0109 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1139 0.1139
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0305 0.0305
Schistosoma mansoni tar DNA-binding protein 0.0187 0.1127 0.3002
Loa Loa (eye worm) nuclear factor I 0.0014 0.0036 0.0097
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0212 0.0355
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0137 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1139 0.3033
Mycobacterium tuberculosis Probable oxidoreductase 0.0064 0.0355 0.0498
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0137 0.034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0137 0.0603
Echinococcus granulosus geminin 0.0505 0.3132 0.8341
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0109 0.0463
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0212 0.0329
Brugia malayi Doublecortin family protein 0.0043 0.0217 0.0729
Trypanosoma brucei trypanothione reductase 0.0086 0.0491 0.2375
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0064 0.0355 0.0355
Schistosoma mansoni polycystin 1-related 0.0043 0.0217 0.0578
Onchocerca volvulus 0.0028 0.0127 0.2238
Loa Loa (eye worm) transcription factor SMAD2 0.0368 0.2269 0.6042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0137 0.0137
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.002 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.2017 1
Brugia malayi MH2 domain containing protein 0.0025 0.0107 0.0359
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.1127 0.3785
Plasmodium falciparum glutathione reductase 0.0086 0.0491 0.08
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0064 0.0355 0.0498
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.034
Schistosoma mansoni hypothetical protein 0.0402 0.2483 0.6612
Echinococcus multilocularis snurportin 1 0.0603 0.3754 0.3754
Schistosoma mansoni smad 0.0011 0.002 0.0052
Schistosoma mansoni lipoxygenase 0.0181 0.1088 0.2897
Schistosoma mansoni cpg binding protein 0.003 0.0137 0.0365
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0137 0.046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0326 0.0869
Treponema pallidum NADH oxidase 0.003 0.0137 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.0495 0.0495
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0109 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0216 0.0726
Loa Loa (eye worm) hypothetical protein 0.048 0.2978 0.7931
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0071 0.0188
Plasmodium falciparum thioredoxin reductase 0.003 0.0137 0.0203
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0137 0.0113
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0216 0.0262
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.2017 1
Echinococcus granulosus importin subunit beta 1 0.0057 0.0305 0.0813
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0373 0.1253
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0218 0.1325 0.2144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0109 0.3065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.129 0.4332
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0137 0.0116
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0373 0.0373
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0064 0.0355 0.0488
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0212 0.0355
Plasmodium falciparum glutathione reductase 0.003 0.0137 0.0203
Brugia malayi RNA, U transporter 1 0.0161 0.0963 0.3233
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0842 0.2828
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0211 0.0328
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0109 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0216 0.0262
Schistosoma mansoni rab6-interacting 0.0043 0.0217 0.0578
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0137 0.023
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0216 0.0184
Loa Loa (eye worm) hypothetical protein 0.0067 0.0373 0.0994
Loa Loa (eye worm) oxidoreductase 0.0064 0.0355 0.0947
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0137 0.034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0196 0.1186 0.1909
Schistosoma mansoni Smad4 0.0011 0.002 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.024 0.0868
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0491 0.0729
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0064 0.0355 0.1695
Loa Loa (eye worm) hypothetical protein 0.0304 0.1866 0.4971
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1139 0.3033
Echinococcus granulosus Smad4 0.0025 0.0107 0.0285
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.0603
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0109 0.0366
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.0272
Brugia malayi beta-lactamase 0.0042 0.0216 0.0726
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Brugia malayi MH1 domain containing protein 0.0014 0.0036 0.0122
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0064 0.0355 0.0422
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0064 0.0355 0.0498
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Trypanosoma brucei oxidoreductase-like protein 0.0064 0.0355 0.1695
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.024 0.0868
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.024 0.0868
Schistosoma mansoni hypothetical protein 0.0067 0.0373 0.0994
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0068 0.0011
Loa Loa (eye worm) Smad1 0.0025 0.0107 0.0285
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0107 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0217 0.0578
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0216 0.0363
Mycobacterium tuberculosis Probable reductase 0.0196 0.1186 0.1909
Mycobacterium ulcerans hypothetical protein 0.0173 0.1038 0.1648
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0218 0.1325 0.2144
Trichomonas vaginalis hypothetical protein 0.0952 0.5952 1
Brugia malayi Thioredoxin reductase 0.0086 0.0491 0.165
Loa Loa (eye worm) TAR-binding protein 0.0187 0.1127 0.3002
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0064 0.0355 0.1695
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0216 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.029
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0216 0.0363
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0137 0.0127
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0211 0.0211
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0491 0.2162
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0927 0.4555
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0567 0.1903
Plasmodium falciparum enoyl-acyl carrier reductase 0.0952 0.5952 1
Loa Loa (eye worm) glutathione reductase 0.0086 0.0491 0.1309
Schistosoma mansoni lipoxygenase 0.0104 0.0605 0.1611
Entamoeba histolytica Ran family GTPase 0.0042 0.0211 0.5944
Schistosoma mansoni hypothetical protein 0.0067 0.0373 0.0994
Trichomonas vaginalis hypothetical protein 0.0011 0.0016 0.0027
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0952 0.5952 1
Onchocerca volvulus 0.0043 0.0217 0.3832
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0137 0.0203
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Onchocerca volvulus 0.0042 0.0216 0.3817
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0238 0.086
Echinococcus multilocularis tar DNA binding protein 0.0187 0.1127 0.1127
Leishmania major trypanothione reductase 0.0086 0.0491 0.2375
Plasmodium vivax glutathione reductase, putative 0.0086 0.0491 0.08
Chlamydia trachomatis oxoacy-ACP reductase 0.0064 0.0355 0.0488
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0217 0.0578
Mycobacterium ulcerans hypothetical protein 0.0042 0.0216 0.0251
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0087 0.0292
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.1038 0.1657
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0491 0.1309
Onchocerca volvulus 0.0042 0.0216 0.3817
Loa Loa (eye worm) hypothetical protein 0.0145 0.0866 0.2305
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0216 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1139 0.3033
Plasmodium falciparum thioredoxin reductase 0.0086 0.0491 0.08
Schistosoma mansoni Smad4 0.0025 0.0107 0.0285
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0216 0.0576
Echinococcus multilocularis RUN 0.0043 0.0217 0.0217
Echinococcus multilocularis Smad4 0.0025 0.0107 0.0107
Onchocerca volvulus 0.0042 0.0216 0.3817
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.019 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0182
Schistosoma mansoni rab6-interacting 0.0043 0.0217 0.0578
Schistosoma mansoni tar DNA-binding protein 0.0187 0.1127 0.3002
Schistosoma mansoni Smad4 0.0011 0.002 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.011 0.0203
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0109 0.0069
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0137 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0187 0.1127 0.3002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0211 0.0328
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0181 0.1088 0.1088
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0109 0.0069
Brugia malayi hypothetical protein 0.0043 0.0217 0.0729
Schistosoma mansoni hypothetical protein 0.0505 0.3132 0.8341
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.011 0.0158
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0137 0.034
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0293
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.019 0.8465
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0016 0.0459
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0109 0.0366
Schistosoma mansoni hypothetical protein 0.0067 0.0373 0.0994
Brugia malayi Smad1 0.0025 0.0107 0.0359
Toxoplasma gondii ABC1 family protein 0.0042 0.0216 0.0337
Echinococcus granulosus GPCR family 2 0.0067 0.0373 0.0994
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0217 0.0578
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0064 0.0355 0.1695
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0064 0.0355 0.0571
Schistosoma mansoni importin beta-1 0.0057 0.0305 0.0813
Loa Loa (eye worm) hypothetical protein 0.0043 0.0217 0.0578
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0952 0.5952 1
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.2483 0.2483
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0211 0.0563
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0216 0.0251
Mycobacterium leprae Probable lipase LipE 0.0042 0.0216 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1139 0.3033
Schistosoma mansoni survival motor neuron protein 0.0098 0.0567 0.1509
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0308 0.0491
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0137 0.0603
Schistosoma mansoni hypothetical protein 0.0098 0.0567 0.1509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0182
Loa Loa (eye worm) hypothetical protein 0.0042 0.0216 0.0576
Echinococcus multilocularis smad 0.0025 0.0107 0.0107
Echinococcus multilocularis geminin 0.0505 0.3132 0.3132
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0196 0.1186 0.1909
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0305 0.1445
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.034
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0952 0.5952 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0137 0.0116
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0064 0.0355 0.0488
Mycobacterium tuberculosis Probable dehydrogenase 0.0196 0.1186 0.1909
Onchocerca volvulus 0.0098 0.0567 1
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0217 0.0578
Trichomonas vaginalis esterase, putative 0.0042 0.0216 0.0363
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.0866 0.2907
Brugia malayi hypothetical protein 0.048 0.2978 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0137 0.0365
Toxoplasma gondii thioredoxin reductase 0.0086 0.0491 0.08
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0217 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0109 0.0069
Brugia malayi MH2 domain containing protein 0.0368 0.2269 0.7619
Loa Loa (eye worm) acetyltransferase 0.0142 0.0842 0.2243
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0333 0.0461
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0216 0.0363
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0355 0.0488
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0064 0.0355 0.0484
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0211 0.0563
Schistosoma mansoni ran 0.0042 0.0211 0.0563
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0137 0.0603
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0137 0.0203
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0064 0.0355 0.0571
Brugia malayi TAR-binding protein 0.0187 0.1127 0.3785
Plasmodium falciparum importin beta, putative 0.0057 0.0305 0.0487
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Schistosoma mansoni cpg binding protein 0.003 0.0137 0.0365
Brugia malayi RNA binding protein 0.0187 0.1127 0.3785
Mycobacterium tuberculosis Conserved protein 0.0042 0.0216 0.0262
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0217 0.0338
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0271 0.1657 0.2709
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0238 0.04
Mycobacterium ulcerans hypothetical protein 0.0025 0.0109 0.0069
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0491 0.08
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.129 0.3436
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0216 0.0576
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0109 0.008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0333 0.1585
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0137 0.0365
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0817 0.2176
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0355 0.0488
Schistosoma mansoni smad1 5 8 and 0.0025 0.0107 0.0285
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0216 0.0748
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0952 0.5952 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.002 0.0052
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0137 0.0203
Leishmania major oxidoreductase-like protein 0.0064 0.0355 0.1695
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0071 0.1988
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0842 0.0842
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0216 0.0363
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0182
Echinococcus granulosus smad 0.0025 0.0107 0.0285
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0109 0.0069
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0137 0.0116
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0064 0.0355 0.1463
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0181 0.1088 0.2897
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0097
Brugia malayi MH1 domain containing protein 0.0025 0.0107 0.0359
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.034
Schistosoma mansoni smad1 5 8 and 0.0025 0.0107 0.0285
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.0603
Brugia malayi hypothetical protein 0.0026 0.011 0.037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.129 0.4332
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0333 0.0888
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0355 0.0498
Plasmodium vivax importin-beta 2, putative 0.0057 0.0305 0.0487
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.029
Schistosoma mansoni hypothetical protein 0.0505 0.3132 0.8341
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0216 0.0251
Echinococcus granulosus translational activator gcn1 0.0011 0.0016 0.0043
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0355 0.0488
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0211 1
Leishmania major GTP-binding protein, putative 0.0042 0.0211 0.0975
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0216 0.0363
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0188
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0333 0.0534
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0216 0.0262
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0333 0.045
Echinococcus granulosus survival motor neuron protein 1 0.048 0.2978 0.7931
Brugia malayi MH1 domain containing protein 0.0025 0.0107 0.0359
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0952 0.5952 1
Brugia malayi kap beta 3 protein 0.0011 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.0216 0.0576
Echinococcus granulosus muscleblind protein 0.0304 0.1866 0.4971
Leishmania major importin beta-1 subunit, putative 0.0046 0.0238 0.1108
Echinococcus granulosus transportin 1 0.0011 0.0016 0.0043
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0188
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.011 0.0203
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0217 0.0217
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0137 0.0603
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0238 0.04
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0305 0.0487
Onchocerca volvulus 0.0025 0.0109 0.1922
Echinococcus granulosus tar DNA binding protein 0.0187 0.1127 0.3002
Schistosoma mansoni tar DNA-binding protein 0.0187 0.1127 0.3002
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0373 0.1253
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0068 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0109 0.0463
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.002 0.0052
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0064 0.0355 0.0947
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Loa Loa (eye worm) hypothetical protein 0.0304 0.1866 0.4971
Loa Loa (eye worm) hypothetical protein 0.0042 0.0216 0.0576
Schistosoma mansoni cpg binding protein 0.0028 0.0127 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0109 0.0366
Onchocerca volvulus 0.0043 0.0217 0.3832
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0137 0.0203
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.1127 0.3002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0196 0.1186 0.1909
Loa Loa (eye worm) hypothetical protein 0.0057 0.0305 0.0813
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0373 0.0373
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0927 0.4403
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0212 0.0329
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Toxoplasma gondii exonuclease III APE 0.0019 0.0071 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0109 0.0463
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0216 0.0216
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0107 0.0107
Leishmania major hypothetical protein, conserved 0.0026 0.011 0.0469
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0196 0.1186 0.1909
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0498
Entamoeba histolytica hypothetical protein 0.0046 0.0238 0.6695
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0355 0.0498
Mycobacterium tuberculosis Conserved protein 0.0042 0.0216 0.0262
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0927 0.4555
Loa Loa (eye worm) MH2 domain-containing protein 0.0368 0.2269 0.6042
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.002 0.0052
Mycobacterium tuberculosis Conserved protein 0.0042 0.0216 0.0262
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0216 0.0576
Brugia malayi MH1 domain containing protein 0.0014 0.0036 0.0122
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0212 0.0564
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0355 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0137 0.0203
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0064 0.0355 0.0488
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0107 0.0285
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0333 0.0333
Echinococcus multilocularis GPCR, family 2 0.0067 0.0373 0.0373
Brugia malayi hypothetical protein 0.0043 0.0217 0.0729
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0071 0.0004
Echinococcus multilocularis muscleblind protein 0.0304 0.1866 0.1866
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0064 0.0355 0.0571
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0216 0.0262
Loa Loa (eye worm) hypothetical protein 0.0064 0.0355 0.0947
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0182
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0196 0.1186 0.1844
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0842 0.2243
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0109 0.3065
Schistosoma mansoni loxhd1 0.0043 0.0217 0.0578
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0064 0.0355 0.1463
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.0495 0.1317
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0333 0.045
Schistosoma mansoni tar DNA-binding protein 0.0187 0.1127 0.3002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0182
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0071 0.0272
Schistosoma mansoni dihydropteridine reductase 0.0064 0.0355 0.0947
Toxoplasma gondii hypothetical protein 0.0053 0.0282 0.0448
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0303 0.1195
Schistosoma mansoni hypothetical protein 0.0145 0.0866 0.2305
Brugia malayi hypothetical protein 0.0016 0.0053 0.0178
Echinococcus granulosus snurportin 1 0.0603 0.3754 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0211 0.0722
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0064 0.0355 0.0947
Mycobacterium ulcerans short chain dehydrogenase 0.0064 0.0355 0.0488
Brugia malayi MH2 domain containing protein 0.0011 0.002 0.0066
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0212 0.0329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0333 0.045
Echinococcus multilocularis muscleblind protein 1 0.0304 0.1866 0.1866
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0355 0.0488
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.2017 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0137 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.0119
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.0119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0216 0.0576
Loa Loa (eye worm) beta-lactamase 0.0042 0.0216 0.0576
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.019 0.5337
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0137 0.0603
Schistosoma mansoni smad1 5 8 and 0.0025 0.0107 0.0285
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0064 0.0355 0.0571
Brugia malayi beta-lactamase family protein 0.0042 0.0216 0.0726
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0217 0.0578
Loa Loa (eye worm) RNA binding protein 0.0187 0.1127 0.3002

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 0.06 uM Cytotoxicity against human HL60 cells ChEMBL. 20889340
CC50 (functional) = 0.12 uM Cytotoxicity against human HSC4 cells ChEMBL. 20889340
CC50 (functional) = 0.13 uM Cytotoxicity against human HSC2 cells ChEMBL. 20889340
CC50 (functional) = 0.27 uM Cytotoxicity against human HSC3 cells ChEMBL. 20889340

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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