TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 558.898 | Formula: C30H27Cl3FNO2
H donors: 1 H acceptors: 0 LogP: 8.6 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: NCC(c1ccc(cc1F)c1ccccc1Cl)Cc1ccc(cc1)OCCOc1c(Cl)cc(cc1Cl)C
InChi: 1S/C30H27Cl3FNO2/c1-19-14-27(32)30(28(33)15-19)37-13-12-36-23-9-6-20(7-10-23)16-22(18-35)25-11-8-21(17-29(25)34)24-4-2-3-5-26(24)31/h2-11,14-15,17,22H,12-13,16,18,35H2,1H3
InChiKey: ZUNPKGJBZFDEPB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	renin	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin I	Get druggable targets OG5_126885	All targets in OG5_126885
Babesia bovis	eukaryotic aspartyl protease family protein	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	plasmepsin	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Pepsinogen A1, related	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium hominis	aspartyl protease precursor	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	Cathepsin D precursor, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium parvum	membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl protease ASP1	Get druggable targets OG5_126885	All targets in OG5_126885
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	pepsinogen, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	cathepsin E, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin II	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K01379 cathepsin D [EC3.4.23.5], putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	aspartic protease BmAsp-2	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	aspartyl protease, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Renin, related	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	aspartyl proteinase, putative	Get druggable targets OG5_126885	All targets in OG5_126885

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin X	renin	406 aa	352 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cpg binding protein	0.0026	0.0189	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0137	0.0225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.013	0.0187
Trypanosoma cruzi	cysteine proteinase, putative	0.0013	0.005	0.021
Schistosoma mansoni	hypothetical protein	0.0056	0.0526	0.0872
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0075	0.074	0.1226
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0191	0.0316
Trichomonas vaginalis	set domain proteins, putative	0.0625	0.6956	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0062	0.0089
Plasmodium vivax	aspartyl proteinase, putative	0.0059	0.0565	0.7118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0095	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Leishmania major	cathepsin L-like protease	0.0098	0.1009	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0816	0.1338
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0026	0.019	0.0311
Echinococcus granulosus	cysteine protease	0.0013	0.005	0.0082
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0075	0.074	0.1226
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0191	0.0316
Leishmania major	cathepsin L-like protease	0.0026	0.0191	0.1651
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0034	0.0285	0.2617
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0023	0.0156	0.0259
Toxoplasma gondii	cathepsin CPL	0.0026	0.0191	0.0191
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0079	0.0794	0.1316
Entamoeba histolytica	cysteine proteinase 2	0.0013	0.005	0.1738
Echinococcus granulosus	cathepsin l1	0.0017	0.0095	0.0157
Toxoplasma gondii	PHD-finger domain-containing protein	0.0023	0.0156	0.0156
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0526	0.0863
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.1009	1
Echinococcus multilocularis	cathepsin L	0.0013	0.005	0.0082
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0059	0.0565	0.0937
Loa Loa (eye worm)	jmjC domain-containing protein	0.0047	0.043	0.0704
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Echinococcus multilocularis	lamin	0.0021	0.0137	0.0227
Toxoplasma gondii	aspartyl protease	0.0014	0.0057	0.0057
Schistosoma mansoni	cpg binding protein	0.0026	0.0189	0.0313
Trypanosoma cruzi	cruzipain precursor, putative	0.0098	0.1009	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.027	0.0388
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0034	0.0285	0.0473
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0054	0.0512	0.0849
Onchocerca volvulus		0.0026	0.0191	0.0274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Leishmania major	cathepsin L-like protease	0.0098	0.1009	1
Echinococcus granulosus	chromobox protein 1	0.0054	0.0513	0.085
Toxoplasma gondii	aspartyl protease ASP1	0.0059	0.0565	0.0565
Echinococcus granulosus	dnaJ subfamily B	0.0345	0.3795	0.6285
Loa Loa (eye worm)	hypothetical protein	0.0026	0.019	0.0311
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1437	0.2381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0191	0.0274
Plasmodium falciparum	plasmepsin VIII, putative	0.0014	0.0057	0.1008
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0191	0.6684
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0191	0.0316
Onchocerca volvulus		0.0026	0.0191	0.0274
Loa Loa (eye worm)	hypothetical protein	0.001	0.0014	0.0023
Onchocerca volvulus	Alhambra homolog	0.0023	0.0156	0.0225
Echinococcus multilocularis	chromobox protein 1	0.0054	0.0513	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0034	0.0285	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0029	0.0042
Brugia malayi	aspartic protease BmAsp-1, identical	0.0014	0.0057	0.0093
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0191	0.3376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0207	0.0297
Plasmodium vivax	plasmepsin IV, putative	0.0059	0.0565	0.7118
Loa Loa (eye worm)	TAR-binding protein	0.0136	0.1437	0.2356
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.005	0.1738
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0079	0.0794	0.1316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.005	0.0071
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0017	0.0028
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1437	0.2381
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.1009	1
Schistosoma mansoni	chromobox protein	0.0054	0.0513	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0029	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0095	0.0155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0285	0.041
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0243	0.035
Onchocerca volvulus		0.0088	0.0894	0.1286
Brugia malayi	chromobox protein homolog 3	0.003	0.0243	0.0399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0013	0.005	0.021
Brugia malayi	Pre-SET motif family protein	0.055	0.61	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0027	0.0207	0.1814
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0026	0.019	0.0314
Schistosoma mansoni	hypothetical protein	0.0026	0.019	0.0314
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0062	0.0089
Onchocerca volvulus		0.0026	0.0191	0.0274
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.1862	0.3086
Plasmodium vivax	vivapain-3	0.0013	0.005	0.0625
Echinococcus multilocularis	jumonji domain containing protein	0.0032	0.0257	0.0425
Schistosoma mansoni	intermediate filament proteins	0.0021	0.0137	0.0227
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0011	0.0029	0.0048
Plasmodium vivax	plasmepsin V, putative	0.0014	0.0057	0.0717
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Trypanosoma cruzi	cysteine peptidase, putative	0.0013	0.005	0.021
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0013	0.005	0.0878
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0011	0.0029	0.0048
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Schistosoma mansoni	lamin	0.0021	0.0137	0.0227
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0079	0.0794	0.1315
Echinococcus granulosus	lamin	0.0021	0.0137	0.0227
Brugia malayi	latrophilin 2 splice variant baaae	0.0056	0.0526	0.0863
Echinococcus granulosus	chromobox protein 1	0.0054	0.0513	0.085
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0079	0.0794	0.0794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Loa Loa (eye worm)	phosphatidylinositol 3	0.0034	0.0285	0.0468
Onchocerca volvulus		0.0021	0.0137	0.0197
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0191	0.0274
Echinococcus granulosus	cathepsin L	0.0013	0.005	0.0082
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.1009	1
Plasmodium vivax	SET domain protein, putative	0.0079	0.0794	1
Onchocerca volvulus		0.0021	0.0137	0.0197
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Plasmodium falciparum	plasmepsin IX	0.0014	0.0057	0.1008
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0191	0.0313
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0143	0.0206
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0128	0.0184
Echinococcus granulosus	cathepsin L cysteine protease	0.0013	0.005	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Plasmodium falciparum	plasmepsin V	0.0014	0.0057	0.1008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0029	0.0042
Brugia malayi	SET domain containing protein	0.0012	0.0039	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0084	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Loa Loa (eye worm)	heterochromatin protein 1	0.0054	0.0513	0.0841
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.005	0.0071
Plasmodium falciparum	plasmepsin III	0.0014	0.0057	0.1008
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.003	0.0243	0.035
Echinococcus granulosus	microtubule associated protein 2	0.0544	0.6034	0.9993
Echinococcus multilocularis	musashi	0.0021	0.0137	0.0227
Plasmodium vivax	vivapain-2	0.0026	0.0191	0.2403
Loa Loa (eye worm)	hypothetical protein	0.008	0.0798	0.1308
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0017	0.0028
Echinococcus granulosus	jumonji domain containing protein	0.0032	0.0257	0.0425
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0158	0.0228
Trypanosoma cruzi	target of rapamycin kinase 3	0.0027	0.0207	0.1814
Echinococcus granulosus	intermediate filament protein	0.0021	0.0137	0.0227
Mycobacterium ulcerans	pantoate--beta-alanine ligase	0.0895	1	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0169	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0207	0.0297
Onchocerca volvulus		0.008	0.0798	0.1147
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Brugia malayi	Intermediate filament tail domain containing protein	0.0021	0.0137	0.0225
Echinococcus multilocularis	tumor protein p63	0.0544	0.6038	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0062	0.0089
Plasmodium vivax	aspartyl protease, putative	0.0014	0.0057	0.0717
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.015	0.0216
Plasmodium vivax	vivapain-1	0.0013	0.005	0.0625
Trichomonas vaginalis	chromobox protein, putative	0.0054	0.0513	0.0738
Echinococcus multilocularis	Chromobox protein 3	0.0009	0.000000037215	0.000000061633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Brugia malayi	Pre-SET motif family protein	0.0079	0.0794	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.005	0.0082
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0191	0.0313
Plasmodium falciparum	plasmepsin IV	0.0059	0.0565	1
Brugia malayi	Latrophilin receptor protein 2	0.0026	0.019	0.0311
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0017	0.0095	0.0155
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0191	0.0313
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0207	0.0297
Echinococcus multilocularis	lamin dm0	0.0021	0.0137	0.0227
Brugia malayi	CHD4 protein	0.001	0.0016	0.0026
Brugia malayi	hypothetical protein	0.0014	0.0057	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0133	0.0218
Trypanosoma cruzi	cysteine protease, putative	0.0013	0.005	0.021
Entamoeba histolytica	cysteine proteinase 1, putative	0.0013	0.005	0.1738
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0014	0.0057	0.0093
Leishmania major	cathepsin L-like protease	0.0026	0.0191	0.1651
Echinococcus multilocularis	chromobox protein 1	0.0054	0.0513	0.085
Echinococcus multilocularis	GPCR, family 2	0.0026	0.019	0.0314
Schistosoma mansoni	hypothetical protein	0.0026	0.019	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0029	0.0042
Echinococcus multilocularis	cpg binding protein	0.0026	0.0189	0.0313
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0152	0.1619	0.2327
Schistosoma mansoni	cpg binding protein	0.0026	0.0189	0.0313
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.001	0.0014	0.0024
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0059	0.0565	0.0565
Brugia malayi	cytoplasmic intermediate filament protein	0.0011	0.0027	0.0044
Echinococcus granulosus	PHD finger protein rhinoceros	0.0023	0.0156	0.0259
Echinococcus multilocularis	peregrin	0.0023	0.0156	0.0259
Brugia malayi	Pepsin A precursor	0.0014	0.0057	0.0093
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1437	0.2381
Loa Loa (eye worm)	phosphatidylinositol 3	0.0011	0.0029	0.0048
Brugia malayi	Papain family cysteine protease containing protein	0.0013	0.005	0.0081
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0062	0.0089
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0191	0.3376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0285	0.041
Brugia malayi	aspartic protease BmAsp-2, identical	0.0014	0.0057	0.0093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0034	0.0285	0.2617
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0026	0.019	0.0314
Brugia malayi	CXXC zinc finger family protein	0.0024	0.0173	0.0284
Echinococcus multilocularis	dnaJ subfamily B	0.0345	0.3795	0.6285
Schistosoma mansoni	lamin	0.0021	0.0137	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0095	0.0155
Schistosoma mansoni	microtubule-associated protein tau	0.0544	0.6034	1
Plasmodium vivax	aspartyl proteinase, putative	0.0014	0.0057	0.0717
Echinococcus multilocularis	cysteine protease	0.0026	0.0191	0.0316
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.005	0.1738
Onchocerca volvulus		0.0017	0.0095	0.0136
Leishmania major	cathepsin L-like protease	0.0026	0.0191	0.1651
Schistosoma mansoni	hypothetical protein	0.0026	0.019	0.0314
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0095	0.3311
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.005	0.0082
Brugia malayi	N-terminal motif family protein	0.0152	0.1619	0.2654
Plasmodium vivax	aspartyl protease, putative	0.0014	0.0057	0.0717
Trypanosoma cruzi	major cysteine proteinase, putative	0.0077	0.0772	0.7577
Schistosoma mansoni	chromobox protein	0.0054	0.0513	0.085
Plasmodium falciparum	plasmepsin X	0.0014	0.0057	0.1008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0011	0.0029	0.0048
Brugia malayi	cathepsin L-like precursor	0.0017	0.0095	0.0155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0243	0.0399
Plasmodium falciparum	plasmepsin II	0.0059	0.0565	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0095	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	hypothetical protein	0.0345	0.3795	0.629
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0243	0.035
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0191	0.0274
Loa Loa (eye worm)	MH2 domain-containing protein	0.0101	0.1034	0.1695
Onchocerca volvulus		0.0014	0.0057	0.0082
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0026	0.019	0.0314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0034	0.0285	1
Onchocerca volvulus		0.0024	0.0169	0.0243
Brugia malayi	jmjC domain containing protein	0.0029	0.0226	0.037
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0156	0.0256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.005	0.0082
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0136	0.1437	0.2356
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	cellular tumor antigen P53	0.008	0.0798	0.1323
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0062	0.0089
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.009	0.0913	0.9018
Leishmania major	cathepsin L-like protease	0.0098	0.1009	1
Leishmania major	cathepsin L-like protease	0.0026	0.0191	0.1651
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.027	0.0388
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.1862	0.3086
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0011	0.0029	0.0048
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.005	0.1738
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Giardia lamblia	GTOR	0.0034	0.0285	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.013	0.0187
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0034	0.0285	0.2617
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.013	0.0187
Onchocerca volvulus		0.0026	0.0191	0.0274
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0895	1	0.5
Loa Loa (eye worm)	ctsf protein	0.0026	0.0191	0.0313
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0011	0.0027	0.0044
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0016
Plasmodium falciparum	phd finger protein, putative	0.0023	0.0156	0.2766
Toxoplasma gondii	PHD-finger domain-containing protein	0.0023	0.0156	0.0156
Echinococcus multilocularis	lysine specific demethylase 5A	0.0028	0.021	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1619	0.2654
Plasmodium falciparum	plasmepsin VII	0.0014	0.0057	0.1008
Loa Loa (eye worm)	aspartyl protease 6	0.0014	0.0057	0.0093
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0191	0.0316
Leishmania major	cathepsin L-like protease	0.0026	0.0191	0.1651
Schistosoma mansoni	hypothetical protein	0.0023	0.0156	0.0259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.001	0.0016	0.0026
Echinococcus multilocularis	cysteine protease	0.0026	0.0191	0.0316
Echinococcus granulosus	peregrin	0.0023	0.0156	0.0259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0285	0.041
Schistosoma mansoni	hypothetical protein	0.0026	0.019	0.0314
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0029	0.0226	0.0374
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0059	0.0565	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Brugia malayi	TAR-binding protein	0.0136	0.1437	0.2356
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0568	0.0941
Brugia malayi	intermediate filament protein	0.0021	0.0137	0.0225
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0191	0.0316
Plasmodium falciparum	plasmepsin I	0.0059	0.0565	1
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0156	0.1969
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0081	0.0816	0.1338
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0033	0.027	0.0388
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0076	0.0755	0.1251
Echinococcus granulosus	GPCR family 2	0.0026	0.019	0.0314
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0191	0.6684
Onchocerca volvulus		0.0625	0.6956	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0034	0.0285	0.0473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0229	0.0329
Toxoplasma gondii	aspartyl protease ASP3	0.0014	0.0057	0.0057
Loa Loa (eye worm)	CHromoDomain protein family member	0.001	0.0016	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1437	0.2381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0029	0.0226	0.0374
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0034	0.0285	0.0473
Schistosoma mansoni	cpg binding protein	0.0024	0.0173	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0057	0.0093
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.001	0.0016	0.0026
Brugia malayi	PHD-finger family protein	0.0023	0.0156	0.0256
Onchocerca volvulus		0.0024	0.0173	0.0249
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0033	0.0048
Plasmodium vivax	aspartyl protease, putative	0.0014	0.0057	0.0717
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0013	0.005	0.021
Toxoplasma gondii	pantoate-beta-alanine ligase	0.0895	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0013	0.005	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0029	0.0042
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0009	0	0.0003
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0191	0.0313
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0034	0.0285	0.2617
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0088	0.0894	0.1482
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0156	0.0256
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.055	0.61	1
Onchocerca volvulus		0.0009	0.000000037215	0.000000053503
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0128	0.0184
Brugia malayi	MH2 domain containing protein	0.0101	0.1034	0.1695
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0191	0.1651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0207	0.0297
Loa Loa (eye worm)	fibroinase	0.0026	0.0191	0.0313
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0023	0.0156	0.0259
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0081	0.0816	0.1338
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0191	0.0313
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0027	0.0207	0.1814
Trypanosoma cruzi	cysteine proteinase, putative	0.0013	0.005	0.021
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0191	0.0316
Loa Loa (eye worm)	intermediate filament protein	0.0021	0.0137	0.0225
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0143	0.0206
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.001	0.0016	0.0026
Onchocerca volvulus		0.0014	0.0057	0.0082
Echinococcus granulosus	cathepsin l1	0.0026	0.0191	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.01	0.0163
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0191	0.0316
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0025	0.0187	0.0187
Plasmodium vivax	hypothetical protein, conserved	0.0009	0	0.0002
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0034	0.0285	0.2617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0062	0.0089
Schistosoma mansoni	memapsin-2 (A01 family)	0.0014	0.0057	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0033	0.0048
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0565	0.0927
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.005	0.1738
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0079	0.0794	0.1316
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0191	0.6684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0191	0.1651
Echinococcus granulosus	tar DNA binding protein	0.0136	0.1437	0.238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0108	0.0155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.1009	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0191	0.0313
Onchocerca volvulus		0.0026	0.0191	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0095	0.0155
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0081	0.0816	0.1338
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0095	0.0157
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0059	0.0565	0.0813
Brugia malayi	RNA binding protein	0.0136	0.1437	0.2356
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0059	0.0565	0.0927
Echinococcus granulosus	lysine specific demethylase 5A	0.0029	0.0226	0.0374
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0016	0.0082	0.0542
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0057	0.0094
Trichomonas vaginalis	chromobox protein, putative	0.0054	0.0513	0.0738
Brugia malayi	jmjC domain containing protein	0.0075	0.074	0.1214
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0029	0.0042
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0191	0.0313
Echinococcus granulosus	Chromobox protein 3	0.0009	0.000000037215	0.000000061633
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0034	0.0285	0.2617
Loa Loa (eye worm)	cysteine protease	0.0026	0.0191	0.0313
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0034	0.0285	0.0468
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Plasmodium falciparum	plasmepsin VI	0.0059	0.0565	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.006	0.0315
Onchocerca volvulus		0.0026	0.0191	0.0274
Loa Loa (eye worm)	transcription factor SMAD2	0.0101	0.1034	0.1695
Brugia malayi	RNA recognition motif domain containing protein	0.0136	0.1437	0.2356
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0191	0.3376
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0017	0.0028
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0191	0.0313
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0062	0.0089
Plasmodium vivax	vivapain-2	0.0026	0.0191	0.2403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0003	0.0004
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0014	0.0057	0.0057
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0014	0.0057	0.0093
Echinococcus granulosus	tumor protein p63	0.0544	0.6038	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0059	0.0565	0.0936
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0191	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0794	0.1302
Echinococcus granulosus	lamin dm0	0.0021	0.0137	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0095	0.0136
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0079	0.0794	0.1315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0049	0.045	0.045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0191	0.0274
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0191	0.0316
Plasmodium vivax	unspecified product	0.0013	0.005	0.0625
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0013	0.005	0.021
Echinococcus granulosus	histone lysine methyltransferase setb	0.0079	0.0794	0.1315
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0062	0.0089
Echinococcus multilocularis	microtubule associated protein 2	0.0544	0.6034	0.9993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0187	0.0268
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.001	0.0014	0.0024
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0024	0.0173	0.0284
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0026	0.019	0.0311
Brugia malayi	Heterochromatin protein 1	0.0054	0.0513	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0095	0.0155
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0026	0.019	0.0314
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0191	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0039	0.034	0.0557
Entamoeba histolytica	cysteine protease, putative	0.0013	0.005	0.1738
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0021	0.0137	0.0225
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0191	0.0313
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0207	0.0297
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0226	0.037
Brugia malayi	hypothetical protein	0.0014	0.0057	0.0093
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1437	0.2381
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274
Onchocerca volvulus		0.0026	0.0191	0.0274
Brugia malayi	Bromodomain containing protein	0.0023	0.0156	0.0256
Echinococcus multilocularis	tar DNA binding protein	0.0136	0.1437	0.238
Loa Loa (eye worm)	RNA binding protein	0.0136	0.1437	0.2356
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0191	0.0274

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7 nM	Inhibition of human recombinant renin in phosphate buffer	ChEMBL.	20728350
IC50 (binding)	= 1151 nM	Inhibition of human recombinant renin in plasma	ChEMBL.	20728350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1257349

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1257726