Detailed information for compound 1259691

Basic information

Technical information
  • TDR Targets ID: 1259691
  • Name: N-[[2-(2,5-difluorophenyl)-5-methyl-1,3-oxazo l-4-yl]methyl]-N-[(1,3,5-trimethylpyrazol-4-y l)methyl]cyclopropanamine
  • MW: 386.438 | Formula: C21H24F2N4O
  • H donors: 0 H acceptors: 2 LogP: 3.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)c1nc(c(o1)C)CN(C1CC1)Cc1c(C)nn(c1C)C)F
  • InChi: 1S/C21H24F2N4O/c1-12-18(13(2)26(4)25-12)10-27(16-6-7-16)11-20-14(3)28-21(24-20)17-9-15(22)5-8-19(17)23/h5,8-9,16H,6-7,10-11H2,1-4H3
  • InChiKey: FJNLHZWCZQSEMQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[2-(2,5-difluorophenyl)-5-methyl-oxazol-4-yl]methyl]-N-[(1,3,5-trimethylpyrazol-4-yl)methyl]cyclopropanamine
  • N-[[2-(2,5-difluorophenyl)-5-methyl-4-oxazolyl]methyl]-N-[(1,3,5-trimethyl-4-pyrazolyl)methyl]cyclopropanamine
  • cyclopropyl-[[2-(2,5-difluorophenyl)-5-methyl-oxazol-4-yl]methyl]-[(1,3,5-trimethylpyrazol-4-yl)methyl]amine
  • MLS000731716
  • N-{[2-(2,5-difluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]cyclopropanamine
  • SMR000318576

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax SET domain protein, putative 0.0032 0.007 0.0085
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Brugia malayi Matrixin family protein 0.0019 0.0016 0.0022
Trypanosoma brucei aminopeptidase, putative 0.009 0.0312 0.1394
Plasmodium falciparum glutathione reductase 0.0103 0.0364 0.0438
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0248
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0073 0.0248
Brugia malayi Matrixin family protein 0.0019 0.0016 0.0022
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0605 0.2455 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0032 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0063 0.0203
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Echinococcus multilocularis leucyl aminopeptidase 0.009 0.0312 0.0312
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0094 0.0106
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0032 0.0115
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.007 0.0227 0.0805
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0021 0.0021
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0032 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.007 0.0235
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0002 0.0001
Leishmania major trypanothione reductase 0.0103 0.0364 0.1642
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0203 0.0871
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Echinococcus multilocularis inhibitor of apoptosis protein 0.0081 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.007 0.0227 0.0227
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Onchocerca volvulus 0.0027 0.0049 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0032 0.0054
Toxoplasma gondii leucyl aminopeptidase LAP 0.0605 0.2455 0.3021
Plasmodium falciparum thioredoxin reductase 0.0103 0.0364 0.0438
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0084 0.0305
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0352 0.1401 0.6612
Loa Loa (eye worm) phosphofructokinase 0.0119 0.043 0.043
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0032 0.0046
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0203 0.0203
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.009 0.0312 0.0312
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0379
Echinococcus multilocularis lamin dm0 0.0055 0.0166 0.0166
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.026 0.102 0.4077
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0008 0.0016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0084 0.0261
Schistosoma mansoni ap endonuclease 0.002 0.0021 0.0021
Echinococcus granulosus expressed conserved protein 0.0046 0.0127 0.0127
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0513 0.2062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0084 0.0305
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0352 0.1401 0.1401
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.017 0.017
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0045 0.0064
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.007 0.0085
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0271 0.0271
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.043 0.043
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.007 0.0227 0.0227
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.007 0.0448
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Loa Loa (eye worm) hypothetical protein 0.017 0.0644 0.0644
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0521 0.0521
Toxoplasma gondii hypothetical protein 0.0016 0.0001 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0505 0.0505
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0021 0.003
Onchocerca volvulus 0.0062 0.0193 0.0441
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0069 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0081 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) acetyltransferase 0.014 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.0062 0.0193 0.0193
Onchocerca volvulus Phospholipase A2 homolog 0.0268 0.1054 0.2423
Plasmodium falciparum thioredoxin reductase 0.0036 0.0084 0.0094
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0055 0.0055
Brugia malayi Peptidase family M1 containing protein 0.1058 0.4344 0.6187
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0452 0.182 0.8618
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.043 0.1962
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0021 0.0069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0084 0.0305
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.007 0.0235
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0032 0.0054
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0032 0.0054
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0081 0.0273 0.0389
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1116 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.007 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0032 0.0054
Onchocerca volvulus 0.0352 0.1401 0.3224
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.007 0.0085
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.01 0.01
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0084 0.0313
Loa Loa (eye worm) hypothetical protein 0.007 0.0227 0.0227
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0032 0.0046
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0001 0.0001
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0023 0.0033 0.0047
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Brugia malayi Flap endonuclease-1 0.0028 0.0055 0.0078
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0469 0.1889 0.8949
Loa Loa (eye worm) aminopeptidase N 0.0522 0.2109 0.2109
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2416 1 1
Onchocerca volvulus 0.0081 0.0273 0.0626
Schistosoma mansoni lamin 0.0055 0.0166 0.0166
Loa Loa (eye worm) POT family protein 0.0045 0.0122 0.0122
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.007 0.0227 0.091
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0522 0.2109 0.2109
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0522 0.2109 1
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0166 0.0237
Brugia malayi Protein kinase domain containing protein 0.0056 0.017 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Brugia malayi hypothetical protein 0.0133 0.049 0.0697
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0021 0.0053
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0108 0.0132
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Trypanosoma brucei Aminopeptidase M1, putative 0.0522 0.2109 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0522 0.2109 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.0911 0.3701
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0021 0.0016
Echinococcus multilocularis Ankyrin 0.0016 0.0002 0.0002
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0469 0.1889 0.8949
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0364 0.1642
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0055 0.031
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0081 0.0273 0.0273
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Mycobacterium ulcerans aminopeptidase N PepN 0.0352 0.1401 0.5694
Brugia malayi Matrixin family protein 0.0019 0.0016 0.0022
Echinococcus granulosus lamin dm0 0.0055 0.0166 0.0166
Onchocerca volvulus 0.0055 0.0166 0.038
Brugia malayi Thioredoxin reductase 0.0103 0.0364 0.0518
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0063 0.0203
Echinococcus granulosus death domain containing protein 0.0016 0.0002 0.0002
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1116 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.007 0.0227 0.0278
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0094 0.0669
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0084 0.0103
Toxoplasma gondii aminopeptidase N protein 0.1966 0.8125 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.007 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.043 0.1962
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0108 0.0108
Onchocerca volvulus 0.0522 0.2109 0.4853
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0032 0.0099
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0056 0.017 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.043 0.1962
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.017 0.0714
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0271 0.0271
Loa Loa (eye worm) TATA binding protein associated factor 0.0352 0.1401 0.1401
Treponema pallidum NADH oxidase 0.0036 0.0084 0.0581
Echinococcus multilocularis caspase 2 0.0062 0.0193 0.0193
Brugia malayi hypothetical protein 0.0062 0.0193 0.0274
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.043 0.043
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0019 0.0016 0.0016
Brugia malayi hypothetical protein 0.0352 0.1401 0.1996
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0032 0.0099
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0452 0.182 0.8618
Schistosoma mansoni flap endonuclease-1 0.0026 0.0043 0.0043
Schistosoma mansoni netrin receptor unc5 0.0016 0.0002 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.043 0.043
Echinococcus multilocularis tissue type plasminogen activator 0.0056 0.017 0.017
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0203 0.0203
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0605 0.2455 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.026 0.102 0.4145
Schistosoma mansoni hypothetical protein 0.0081 0.0273 0.0273
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0016 0.0001 0.0001
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.043 0.1644
Onchocerca volvulus 0.0023 0.0032 0.0071
Onchocerca volvulus Deterin homolog 0.0081 0.0273 0.0626
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.067 0.2726 0.2726
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0084 0.0261
Brugia malayi hypothetical protein 0.0522 0.2109 0.3004
Onchocerca volvulus Matrilysin homolog 0.0042 0.0112 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus granulosus caspase 2 0.0062 0.0193 0.0193
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0084 0.0103
Brugia malayi 6-phosphofructokinase 0.0119 0.043 0.0613
Echinococcus granulosus leucyl aminopeptidase 0.009 0.0312 0.0312
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.007 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0108 0.0419
Loa Loa (eye worm) matrixin family protein 0.0046 0.0128 0.0128
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0074 0.0105
Plasmodium falciparum M18 aspartyl aminopeptidase 0.007 0.0227 0.027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0055 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.007 0.0086
Echinococcus granulosus Ankyrin 0.0016 0.0002 0.0002
Onchocerca volvulus 0.1058 0.4344 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0084 0.0305
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0084 0.0103
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0513 0.1983
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0047 0.0047
Mycobacterium ulcerans hydrolase 0.0023 0.0033 0.0102
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.043 0.1962
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0166 0.0166
Toxoplasma gondii hypothetical protein 0.0016 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0063 0.0068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.007 0.007
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0084 0.0328
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0379
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.007 0.0235
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.007 0.0253
Onchocerca volvulus 0.0055 0.0166 0.038
Brugia malayi Hemopexin family protein 0.0027 0.0049 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi 6-phosphofructokinase 0.0119 0.043 0.0613
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0364 0.0446
Loa Loa (eye worm) hypothetical protein 0.0537 0.2172 0.2172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.009 0.0312 0.0444
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Echinococcus granulosus flap endonuclease 1 0.0028 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0164 0.062 0.062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0065 0.0065
Echinococcus granulosus leucyl aminopeptidase 0.009 0.0312 0.0312
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.007 0.0085
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.0911 0.3701
Loa Loa (eye worm) hypothetical protein 0.0056 0.017 0.017
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0084 0.0103
Toxoplasma gondii microneme protein MIC17C 0.0016 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.0103 0.0364 0.0364
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Trypanosoma brucei Aminopeptidase M1, putative 0.0522 0.2109 1
Leishmania major hypothetical protein, conserved 0.003 0.0063 0.0203
Trypanosoma brucei trypanothione reductase 0.0103 0.0364 0.1642
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.043 0.1962
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Loa Loa (eye worm) matrixin family protein 0.0042 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0081 0.0273 0.0273
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0091 0.0091
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0203 0.0289
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0084 0.0094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0138 0.0196
Onchocerca volvulus Matrilysin homolog 0.0019 0.0016 0.0033
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0032 0.0099
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0094 0.0351
Plasmodium falciparum flap endonuclease 1 0.0028 0.0055 0.0058
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.043 0.043
Echinococcus multilocularis leucyl aminopeptidase 0.009 0.0312 0.0312
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0203 0.0871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.007 0.007
Loa Loa (eye worm) RecQ helicase 0.0023 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0027 0.0049 0.0049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0084 0.0313
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0203 0.0871
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0055 0.0162
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0063 0.0077
Loa Loa (eye worm) hypothetical protein 0.0062 0.0193 0.0193
Echinococcus granulosus geminin 0.0164 0.062 0.062
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.007 0.0227 0.0988
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.0911 0.3628
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Trypanosoma cruzi aminopeptidase, putative 0.0522 0.2109 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Trypanosoma brucei aminopeptidase, putative 0.0352 0.1401 0.6612
Brugia malayi Peptidase family M1 containing protein 0.0522 0.2109 0.3004
Trypanosoma cruzi Aminopeptidase M1, putative 0.0522 0.2109 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.007 0.007
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.017 0.0644 0.0644
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0032 0.0054
Schistosoma mansoni hypothetical protein 0.0056 0.0169 0.0169
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0203 0.0871
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0032 0.0054
Brugia malayi hypothetical protein 0.0039 0.01 0.0142
Onchocerca volvulus 0.0032 0.007 0.016
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.007 0.0235
Schistosoma mansoni lamin 0.0055 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0138
Trypanosoma brucei aspartyl aminopeptidase, putative 0.007 0.0227 0.0988
Loa Loa (eye worm) hypothetical protein 0.0352 0.1401 0.1401
Echinococcus multilocularis expressed conserved protein 0.0046 0.0127 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0032 0.0099
Brugia malayi TATA binding protein associated factor 0.0352 0.1401 0.1996
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0364 0.0364
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0032 0.0032
Onchocerca volvulus Phospholipase A2 homolog 0.067 0.2726 0.6275
Brugia malayi hypothetical protein 0.1701 0.7021 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0352 0.1401 0.6612
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0513 0.2075
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.007 0.0235
Mycobacterium tuberculosis Probable oxidoreductase 0.026 0.102 0.4145
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0522 0.2109 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.017 0.0644 0.0644
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0021 0.0016
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.009 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0054 0.0162 0.0162
Loa Loa (eye worm) aspartyl aminopeptidase 0.007 0.0227 0.0227
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Schistosoma mansoni inhibitor of apoptosis protein 0.0081 0.0273 0.0273
Schistosoma mansoni leucine aminopeptidase 0.009 0.0312 0.0312
Brugia malayi Uncoordinated protein 44 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.0911 0.3701
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0203 0.0871
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0364 0.0364
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0032 0.0046
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0084 0.0313
Onchocerca volvulus Matrix metalloproteinase homolog 0.0042 0.0112 0.0256
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.043 0.1962
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0203 0.0203
Echinococcus granulosus inhibitor of apoptosis protein 0.0081 0.0273 0.0273
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0452 0.182 0.8618
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0352 0.1401 0.6612
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0069 0.0224 0.0224
Toxoplasma gondii kringle domain-containing protein 0.0056 0.017 0.0209
Brugia malayi cytosol aminopeptidase 0.009 0.0312 0.0444
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0021 0.0021
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0521 0.0743
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Toxoplasma gondii microneme protein MIC4 0.0016 0.0001 0.0001
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.007 0.0227 0.0988
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0379
Chlamydia trachomatis cytosol aminopeptidase 0.0605 0.2455 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0013
Echinococcus granulosus aspartyl aminopeptidase 0.007 0.0227 0.0227
Toxoplasma gondii aminopeptidase n, putative 0.1966 0.8125 1
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0001 0.0001
Echinococcus granulosus tissue type plasminogen activator 0.0056 0.017 0.017
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0522 0.2109 0.2109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0084 0.0305
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0002 0.0002
Toxoplasma gondii PAN/Apple domain-containing protein 0.0016 0.0001 0.0001
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2416 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.007 0.0235
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.009 0.0312 0.0444
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.007 0.0235
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0352 0.1401 0.6612
Echinococcus granulosus bloom syndrome protein 0.0023 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0033 0.0074 0.0074
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.007 0.0227 0.0988
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0073 0.0248
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.043 0.374
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0108 0.0419
Echinococcus multilocularis musashi 0.0055 0.0166 0.0166
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.0911 0.3701
Loa Loa (eye worm) hypothetical protein 0.0062 0.0193 0.0193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0021 0.0024
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0605 0.2455 0.3021
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0091 0.0091
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Toxoplasma gondii microneme protein, putative 0.0016 0.0001 0.0001
Mycobacterium ulcerans aminopeptidase N PepN 0.0522 0.2109 0.8585
Brugia malayi hypothetical protein 0.003 0.0063 0.009
Schistosoma mansoni ap endonuclease 0.002 0.0021 0.0021
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.007 0.0227 0.0227
Brugia malayi hypothetical protein 0.002 0.0018 0.0026
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.017 0.0644 0.2984
Loa Loa (eye worm) hypothetical protein 0.0346 0.1378 0.1378
Trichomonas vaginalis set domain proteins, putative 0.0255 0.1 0.4691
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0352 0.1401 0.6612
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.007 0.0235
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0452 0.182 0.8618
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0248
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.007 0.0076
Echinococcus multilocularis lamin 0.0055 0.0166 0.0166
Echinococcus multilocularis aspartyl aminopeptidase 0.007 0.0227 0.0227
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0002 0.0002
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0081 0.0273 0.0273
Toxoplasma gondii microneme protein MIC17A 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Death domain containing protein 0.0016 0.0002 0.0002
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.007 0.007
Echinococcus granulosus intermediate filament protein 0.0055 0.0166 0.0166
Onchocerca volvulus 0.0056 0.017 0.0389
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0084 0.0305
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0084 0.0305
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.007 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0248
Entamoeba histolytica aminopeptidase, putative 0.0522 0.2109 1
Brugia malayi Cell death protein 3 precursor 0.0062 0.0193 0.0274
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) peptidase family M1 containing protein 0.0888 0.3637 0.3637
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0023 0.0033 0.0118
Brugia malayi Kringle domain containing protein 0.0056 0.017 0.0242
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.026 0.102 0.4145
Brugia malayi Phospholipase A2 family protein 0.067 0.2726 0.3883
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0084 0.0581
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0084 0.0084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.01 0.01
Brugia malayi intermediate filament protein 0.0055 0.0166 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Toxoplasma gondii subtilisin SUB12 0.0016 0.0001 0.0001
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.017 0.0644 0.0644
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2416 1 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0522 0.2109 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0352 0.1401 0.6612
Schistosoma mansoni hypothetical protein 0.0056 0.017 0.017
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.0193 0.0441
Echinococcus granulosus Solute carrier family 22 5 0.1003 0.4114 0.4114
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.007 0.0227 0.0988
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0084 0.0313
Entamoeba histolytica aspartyl aminopeptidase, putative 0.007 0.0227 0.0988
Echinococcus multilocularis leucyl aminopeptidase 0.009 0.0312 0.0312
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0138 0.0138
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0063 0.0203
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0063 0.0068
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0002 0.0002
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0055 0.0067
Mycobacterium leprae PROBABLE HYDROLASE 0.0023 0.0033 0.0003
Toxoplasma gondii microneme protein MIC17B 0.0016 0.0001 0.0001
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0529 0.2141 0.2141
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.0193 0.0193
Trichomonas vaginalis hypothetical protein 0.0033 0.0073 0.0248
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0522 0.2109 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0352 0.1401 0.6612
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0032 0.0115
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0063 0.0076
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0081 0.0273 0.0389
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.043 0.1962
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0073 0.0248
Toxoplasma gondii exonuclease III APE 0.002 0.0021 0.0025
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.009 0.0312 0.1394
Plasmodium falciparum glutathione reductase 0.0036 0.0084 0.0094
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.043 0.1962
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.007 0.0227 0.0988
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0081 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0706 0.2879 0.2879
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.007 0.0448
Onchocerca volvulus 0.0019 0.0016 0.0033
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.043 0.043
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Echinococcus granulosus leucine aminopeptidase protein 0.0605 0.2455 0.2455
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0352 0.1401 0.1401
Echinococcus granulosus lamin 0.0055 0.0166 0.0166
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0166 0.0166
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0605 0.2455 1
Onchocerca volvulus 0.0256 0.1001 0.2302
Schistosoma mansoni intermediate filament proteins 0.0055 0.0166 0.0166
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0352 0.1401 0.1401
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0364 0.1468
Mycobacterium ulcerans leucyl aminopeptidase 0.0605 0.2455 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0084 0.0305
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0469 0.1889 0.8949
Loa Loa (eye worm) matrix metalloproteinase 0.0019 0.0016 0.0016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.007 0.007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1116 0.5245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0138 0.0196
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0108 0.0133
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0055 0.0162
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0084 0.0084
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0084 0.0305
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0002 0.0002
Toxoplasma gondii aminopeptidase N, putative 0.1966 0.8125 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0032 0.0046
Plasmodium falciparum M1-family alanyl aminopeptidase 0.1966 0.8125 1
Entamoeba histolytica aminopeptidase, putative 0.007 0.0227 0.0988
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0164 0.062 0.062
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.0911 0.3701
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0084 0.0305
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0084 0.0094
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0469 0.1889 0.8949
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0055 0.0162
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0021 0.0021
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0522 0.2109 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0055 0.0055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.006 0.006
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.043 0.1727
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109
Plasmodium falciparum M17 leucyl aminopeptidase 0.0452 0.182 0.2233
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0045 0.0064
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Plasmodium vivax glutathione reductase, putative 0.0103 0.0364 0.0446
Brugia malayi Pre-SET motif family protein 0.0032 0.007 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Toxoplasma gondii thioredoxin reductase 0.0103 0.0364 0.0447
Brugia malayi PAN domain containing protein 0.0016 0.0001 0.0002
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.007 0.0085
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0084 0.0084
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0379
Brugia malayi phosphofructokinase 0.0119 0.043 0.0613
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0032 0.0054
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0002 0.0002
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0193 0.0193
Schistosoma mansoni aminopeptidase A (M01 family) 0.0352 0.1401 0.1401
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0055 0.0162
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.1966 0.8125 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0074 0.0074
Trypanosoma brucei aspartyl aminopeptidase, putative 0.007 0.0227 0.0988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.007 0.007
Echinococcus granulosus aminopeptidase N 0.1058 0.4344 0.4344
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.043 0.1962
Brugia malayi Matrixin family protein 0.0019 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0016 0.0002 0.0002
Brugia malayi Aspartyl aminopeptidase 0.007 0.0227 0.0323
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.007 0.0227 0.0988
Brugia malayi Matrixin family protein 0.0046 0.0128 0.0182
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.009 0.0312 0.0444
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) aminopeptidase in chromosome V 0.009 0.0312 0.0312
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.043 0.174
Loa Loa (eye worm) hypothetical protein 0.0268 0.1054 0.1054
Leishmania major hypothetical protein, conserved 0.0056 0.017 0.0714
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0352 0.1401 0.1401
Brugia malayi glutathione reductase 0.0103 0.0364 0.0518
Echinococcus multilocularis geminin 0.0164 0.062 0.062
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0108 0.0133
Schistosoma mansoni hypothetical protein 0.0039 0.01 0.01
Mycobacterium tuberculosis Probable reductase 0.0234 0.0911 0.3701
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0002 0.0002
Brugia malayi Peptidase family M1 containing protein 0.0352 0.1401 0.1996
Echinococcus multilocularis leucine aminopeptidase protein 0.0605 0.2455 0.2455
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0045 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0352 0.1401 0.1401
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0352 0.1401 0.1717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0084 0.0305
Echinococcus multilocularis aminopeptidase N 0.1058 0.4344 0.4344
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0084 0.012
Plasmodium falciparum cysteine repeat modular protein 1 0.0056 0.017 0.02
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0055 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0364 0.0364
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.043 0.1962
Trypanosoma cruzi aminopeptidase, putative 0.0352 0.1401 0.6612
Brugia malayi POT family protein 0.0045 0.0122 0.0173
Brugia malayi Pre-SET motif family protein 0.0224 0.0871 0.1241
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0193 0.0193
Loa Loa (eye worm) aminopeptidase in chromosome III 0.009 0.0312 0.0312
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0084 0.0305
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.01 0.01
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.0871 0.0871
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0352 0.1401 0.1724
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0522 0.2109 0.2109

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1337 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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