Detailed information for compound 1263801

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.301 | Formula: C18H14O4
  • H donors: 0 H acceptors: 2 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)cc(c(c2)C(=O)C)OCc1ccccc1
  • InChi: 1S/C18H14O4/c1-12(19)15-9-14-7-8-18(20)22-16(14)10-17(15)21-11-13-5-3-2-4-6-13/h2-10H,11H2,1H3
  • InChiKey: KGCGFZVCFSWNLQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Echinococcus granulosus roundabout 2 0.0201 0.0405 0.0984
Schistosoma mansoni protein kinase 0.0227 0.0477 0.1164
Schistosoma mansoni titin 0.0061 0.0022 0.0025
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.006 0.002 0.0018
Echinococcus multilocularis suppressor of cytokine signaling 7 0.006 0.002 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0066 0.0037 0.0284
Entamoeba histolytica cell division protein kinase 2, putative 0.011 0.0158 0.1198
Echinococcus granulosus fibroblast growth factor receptor 4 0.0241 0.0514 0.1259
Brugia malayi Protein kinase domain containing protein 0.1169 0.305 0.3041
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0066 0.0037 0.005
Entamoeba histolytica protein kinase, putative 0.0179 0.0345 0.2811
Loa Loa (eye worm) AGC/PKN protein kinase 0.0107 0.0149 0.0137
Loa Loa (eye worm) TK protein kinase 0.0166 0.0309 0.0297
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.007 0.0047 0.0035
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.011 0.0158 0.0366
Echinococcus multilocularis cyclin dependent kinase 5 0.011 0.0158 0.0366
Echinococcus granulosus epidermal growth factor receptor 0.0886 0.2278 0.5684
Loa Loa (eye worm) AUR protein kinase 0.0484 0.1178 0.1167
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0066 0.0038 0.0064
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.006 0.002 0.0018
Onchocerca volvulus 0.006 0.002 0.0053
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0886 0.2278 0.5684
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0067 0.0041 0.0028
Schistosoma mansoni tyrosine kinase 0.0109 0.0154 0.0355
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0416 0.0992 0.0981
Echinococcus granulosus cyclin dependent kinase 0.011 0.0158 0.0366
Loa Loa (eye worm) hypothetical protein 0.0071 0.0051 0.0039
Brugia malayi tRNA modification GTPase TrmE family protein 0.006 0.002 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0149 0.0343
Entamoeba histolytica protein kinase, putative 0.0484 0.1178 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0061 0.0022 0.001
Echinococcus granulosus tensin C1 domain containing phosphatase 0.006 0.002 0.0018
Echinococcus multilocularis c src tyrosine kinase 0.0132 0.0217 0.0513
Brugia malayi serine/threonine-protein kinase 6 0.0484 0.1178 0.1167
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0188 0.0371 0.0359
Trichomonas vaginalis STE family protein kinase 0.0176 0.0336 0.2779
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.0047 0.0035
Echinococcus multilocularis serine:threonine protein kinase 3 0.0244 0.0523 0.128
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0066 0.0037 0.0025
Echinococcus granulosus serine:threonine protein kinase 0.0067 0.0039 0.0066
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0077 0.0068 0.0319
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0149 0.1174
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0128 0.0933
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0074 0.006 0.0119
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0114 0.0167 0.1184
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0093 0.011 0.0245
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0179 0.0417
Brugia malayi cell division control protein 2 homolog 0.011 0.0158 0.0146
Schistosoma mansoni protein kinase 0.0155 0.0279 0.0669
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.008 0.0075 0.0158
Loa Loa (eye worm) TK/EGFR protein kinase 0.1516 0.3999 0.3991
Brugia malayi Variant SH3 domain containing protein 0.0083 0.0083 0.007
Echinococcus multilocularis SHC transforming protein 3 0.006 0.002 0.0018
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0028
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0127 0.0204 0.1704
Echinococcus granulosus mitogen activated protein kinase 11 0.0149 0.0265 0.0633
Echinococcus granulosus tyrosine protein kinase Lyn 0.0216 0.0447 0.109
Brugia malayi Protein kinase domain containing protein 0.0109 0.0154 0.0142
Giardia lamblia Kinase, NEK 0.0127 0.0204 0.1505
Loa Loa (eye worm) AGC/NDR protein kinase 0.0107 0.0149 0.0137
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1169 0.305 0.3041
Echinococcus granulosus c-Jun N-terminal kinases 0.0251 0.0542 0.133
Echinococcus granulosus tyrosine protein kinase Fyn 0.0189 0.0372 0.0902
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0142 0.0246 0.0234
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0731 0.1854 0.462
Echinococcus multilocularis peroxidasin 0.0068 0.0041 0.0073
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0241 0.0514 0.1259
Schistosoma mansoni tyrosine kinase 0.0176 0.0338 0.0817
Echinococcus granulosus rho-associated protein kinase 1 0.1212 0.3168 0.7916
Echinococcus granulosus tensin 0.006 0.002 0.0018
Onchocerca volvulus 0.0062 0.0025 0.0069
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0067 0.0041 0.0028
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0109 0.0154 0.0355
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1169 0.305 0.762
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0022 0.0025
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.0265 0.0633
Plasmodium vivax glycogen synthase kinase 3, putative 0.0416 0.0992 0.8414
Loa Loa (eye worm) hypothetical protein 0.0109 0.0154 0.0142
Echinococcus granulosus titin 0.0061 0.0022 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0074 0.006 0.0407
Echinococcus granulosus casein kinase I alpha 0.0064 0.0032 0.0048
Echinococcus multilocularis tyrosine protein kinase HCK 0.0106 0.0146 0.0334
Loa Loa (eye worm) hypothetical protein 0.0131 0.0214 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0082 0.0594
Echinococcus multilocularis death associated protein kinase 1 0.0816 0.2085 0.5199
Echinococcus granulosus protein kinase C gamma type 0.0147 0.0257 0.0614
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0189 0.0372 0.0902
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0109 0.0772
Onchocerca volvulus 0.0109 0.0154 0.0416
Loa Loa (eye worm) CAMK protein kinase 0.0061 0.0022 0.001
Echinococcus multilocularis tyrosine protein kinase Abl 0.0209 0.0426 0.1038
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0149 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0484 0.1178 1
Loa Loa (eye worm) SRC-1 0.0189 0.0372 0.036
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0127 0.0204 0.048
Echinococcus granulosus serine threonine protein kinase nrc 0.0094 0.0113 0.0253
Schistosoma mansoni cell adhesion molecule 0.007 0.0047 0.0087
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0127 0.0204 0.1505
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Schistosoma mansoni cell adhesion molecule 0.0067 0.0041 0.0071
Plasmodium falciparum glycogen synthase kinase 3 0.0416 0.0992 0.8375
Echinococcus multilocularis casein kinase I delta 0.0064 0.0032 0.0048
Echinococcus granulosus tyrosine protein kinase Src64B 0.0189 0.0372 0.0902
Echinococcus multilocularis raf serine:threonine protein kinase 0.0082 0.0081 0.0173
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0158 0.1252
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0119 0.0269
Brugia malayi SH2 domain containing protein 0.0109 0.0154 0.0142
Brugia malayi Protein kinase domain containing protein 0.0109 0.0154 0.0142
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0251 0.0542 0.0531
Entamoeba histolytica protein kinase domain containing protein 0.0416 0.0992 0.8392
Entamoeba histolytica casein kinase, putative 0.0064 0.0032 0.0104
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.006 0.002 0.0053
Plasmodium vivax casein kinase 1, putative 0.0064 0.0032 0.0235
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1226 0.3205 0.8009
Onchocerca volvulus 0.0117 0.0177 0.0478
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0244 0.0523 0.0511
Schistosoma mansoni hypothetical protein 0.006 0.002 0.0018
Entamoeba histolytica protein kinase, putative 0.0064 0.0032 0.0105
Brugia malayi C1-like domain containing protein 0.0139 0.0237 0.0225
Brugia malayi SRC-1 0.0189 0.0372 0.036
Schistosoma mansoni serine/threonine-protein kinase 0.0099 0.0128 0.0289
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.007 0.0047 0.0087
Trichomonas vaginalis CK1 family protein kinase 0.0064 0.0032 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Echinococcus multilocularis nervana 2 0.0066 0.0038 0.0064
Echinococcus multilocularis lachesin 0.0067 0.0041 0.0071
Echinococcus multilocularis cyclin dependent kinase 1 0.011 0.0158 0.0366
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0077 0.0068 0.0319
Schistosoma mansoni GTPase activating protein 0.006 0.002 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Onchocerca volvulus 0.0109 0.0154 0.0416
Schistosoma mansoni nck2/grb4 0.0083 0.0083 0.0176
Toxoplasma gondii AGC kinase 0.0066 0.0037 0.005
Trypanosoma brucei protein kinase, putative 0.0416 0.0992 0.8375
Loa Loa (eye worm) STAT protein 0.006 0.002 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0484 0.1178 0.2924
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0077 0.0068 0.0319
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0066 0.0037 0.0025
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1169 0.305 0.3041
Echinococcus multilocularis ephrin type A receptor 4 A 0.0111 0.016 0.037
Plasmodium falciparum protein kinase 5 0.011 0.0158 0.1105
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0109 0.0154 0.0355
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Brugia malayi P38 map kinase family protein 2 0.0149 0.0265 0.0253
Entamoeba histolytica hypothetical protein 0.0114 0.0167 0.1276
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Schistosoma mansoni septate junction protein 0.0067 0.0041 0.0071
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.011 0.0158 0.1105
Schistosoma mansoni tyrosine kinase 0.0132 0.0217 0.0513
Brugia malayi Protein kinase domain containing protein 0.011 0.0158 0.0146
Echinococcus multilocularis dual specificity 0.0114 0.0167 0.0389
Echinococcus granulosus roundabout 2 0.007 0.0047 0.0087
Schistosoma mansoni hypothetical protein 0.0127 0.0204 0.048
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0092 0.0109 0.0894
Entamoeba histolytica casein kinase 1, putative 0.0064 0.0032 0.0104
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0114 0.0168 0.1192
Trichomonas vaginalis CK1 family protein kinase 0.0064 0.0032 0.0165
Echinococcus granulosus epidermal growth factor receptor 0.1516 0.3999 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.007 0.0047 0.0087
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0377 0.0885 0.219
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0158 0.0366
Echinococcus multilocularis casein kinase I delta 0.0064 0.0032 0.0048
Plasmodium vivax unspecified product 0.0092 0.0109 0.0894
Trichomonas vaginalis STE family protein kinase 0.0155 0.0279 0.2288
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Brugia malayi P21-Rho-binding domain containing protein 0.0127 0.0204 0.0192
Trypanosoma cruzi cdc2-related kinase 3 0.011 0.0158 0.1105
Echinococcus multilocularis signal transduction protein lnk realted 0.006 0.002 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0074 0.006 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0348 0.0841
Trypanosoma cruzi casein kinase II, putative 0.0092 0.0109 0.0675
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.002 0.0007
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.011 0.0245
Onchocerca volvulus Serine\/threonine kinase homolog 0.0211 0.0432 0.1167
Echinococcus granulosus contactin 0.007 0.0047 0.0087
Brugia malayi Protein kinase domain containing protein 0.0729 0.1848 0.1838
Plasmodium falciparum NIMA related kinase 1 0.0127 0.0204 0.1505
Schistosoma mansoni tensin-related 0.006 0.002 0.0018
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0279 0.0618 0.0606
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0131 0.0214 0.0506
Giardia lamblia Kinase, CMGC CDK 0.011 0.0158 0.1105
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0484 0.1178 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0041 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Echinococcus multilocularis Protein kinase C, brain isozyme 0.018 0.0348 0.0841
Loa Loa (eye worm) TK protein kinase 0.0106 0.0146 0.0133
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0141 0.0243 0.0231
Brugia malayi Sex muscle abnormal protein 5 0.0083 0.0083 0.007
Echinococcus multilocularis Immunoglobulin 0.0131 0.0214 0.0506
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0066 0.0037 0.0025
Brugia malayi Prion-like- 0.0067 0.0041 0.0028
Loa Loa (eye worm) hypothetical protein 0.0067 0.0039 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0484 0.1178 1
Echinococcus granulosus protein kinase c epsilon type 0.0141 0.0243 0.0578
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Echinococcus multilocularis casein kinase i 0.0064 0.0032 0.0048
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0416 0.0992 0.2457
Entamoeba histolytica protein kinase, putative 0.0179 0.0345 0.2811
Brugia malayi serine/threonine protein kinase 6 0.0484 0.1178 0.1167
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0077 0.0066 0.0298
Schistosoma mansoni tyrosine kinase 0.0729 0.1848 0.4604
Loa Loa (eye worm) hypothetical protein 0.0083 0.0083 0.0071
Entamoeba histolytica protein kinase, putative 0.016 0.0294 0.2366
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0067 0.0041 0.011
Giardia lamblia Kinase, CMGC CK2 0.0092 0.0109 0.0675
Schistosoma mansoni vesicular amine transporter 0.0131 0.0214 0.0506
Echinococcus granulosus expressed conserved protein 0.006 0.002 0.0018
Echinococcus granulosus tyrosine protein kinase Fyn 0.0189 0.0372 0.0902
Echinococcus multilocularis epidermal growth factor receptor 0.0886 0.2278 0.5684
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0149 0.1174
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0176 0.0336 0.0813
Entamoeba histolytica protein kinase domain containing protein 0.0114 0.0167 0.1276
Echinococcus granulosus casein kinase i 0.0064 0.0032 0.0048
Brugia malayi STE20-like kinase MST 0.0244 0.0523 0.0511
Loa Loa (eye worm) hypothetical protein 0.0079 0.0072 0.006
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Brugia malayi hypothetical protein 0.0133 0.022 0.0208
Onchocerca volvulus 0.0109 0.0154 0.0416
Echinococcus granulosus protein kinase shaggy 0.0416 0.0992 0.2457
Loa Loa (eye worm) hypothetical protein 0.0167 0.0313 0.0301
Entamoeba histolytica protein kinase, putative 0.0114 0.0167 0.1276
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0377 0.0885 0.0874
Echinococcus multilocularis tyrosine protein kinase Srms 0.0166 0.0309 0.0743
Toxoplasma gondii aurora kinase 0.0484 0.1178 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0107 0.0149 0.0343
Onchocerca volvulus 0.006 0.002 0.0053
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0066 0.0401
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0484 0.1178 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0067 0.004 0.0027
Brugia malayi Variant SH3 domain containing protein 0.0093 0.011 0.0098
Loa Loa (eye worm) hypothetical protein 0.0134 0.0223 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0093 0.011 0.0245
Schistosoma mansoni tyrosine kinase 0.0189 0.0372 0.0902
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0037 0.0063
Echinococcus multilocularis insulin receptor 0.0729 0.1848 0.4604
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0542 0.133
Trypanosoma brucei cdc2-related kinase 3 0.011 0.0158 0.1105
Brugia malayi Protein kinase domain containing protein 0.0179 0.0345 0.0333
Plasmodium falciparum protein kinase, putative 0.0077 0.0066 0.03
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0107 0.0149 0.0343
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0066 0.0038 0.0064
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0189 0.0372 0.0902
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0119 0.0269
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0204 0.1645
Brugia malayi cytokine inducible SH2-containing protein 5 0.006 0.002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0114 0.0167 0.0155
Brugia malayi RhoGAP domain containing protein 0.0093 0.011 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0149 0.0343
Schistosoma mansoni tensin 0.006 0.002 0.0018
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.019 0.0375 0.0363
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0064 0.0032 0.0048
Schistosoma mansoni serine/threonine-protein kinase 0.0099 0.0128 0.0289
Trypanosoma cruzi cdc2-related kinase 3 0.011 0.0158 0.1105
Brugia malayi protein kinase C3,putative 0.0141 0.0241 0.0229
Brugia malayi SH2 domain containing protein 0.0109 0.0154 0.0142
Onchocerca volvulus 0.0079 0.0072 0.0194
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0139 0.0237 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Echinococcus multilocularis casein kinase I alpha 0.0064 0.0032 0.0048
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0227 0.0477 0.1164
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0189 0.0372 0.0902
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0067 0.0041 0.0071
Echinococcus granulosus SH2 domain containing adapter protein F 0.006 0.002 0.0018
Onchocerca volvulus 0.006 0.002 0.0053
Echinococcus multilocularis SH2 domain containing adapter protein F 0.006 0.002 0.0018
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0106 0.0147 0.0135
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.002 0.0007
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.011 0.0158 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0066 0.0458
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.006 0.002 0.0018
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0074 0.006 0.0119
Echinococcus multilocularis 0.0454 0.1098 0.2724
Trypanosoma brucei protein kinase, putative 0.0077 0.0066 0.03
Leishmania major protein kinase, putative 0.0077 0.0068 0.0319
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0416 0.0992 0.2457
Echinococcus multilocularis tensin 0.006 0.002 0.0018
Onchocerca volvulus 0.006 0.002 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0158 0.1252
Echinococcus granulosus NCK adaptor protein 0.0083 0.0083 0.0176
Entamoeba histolytica casein kinase, putative 0.0092 0.0109 0.0772
Brugia malayi serine/threonine kinase 12 0.0484 0.1178 0.1167
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0416 0.0992 0.2457
Trypanosoma brucei rac serine-threonine kinase, putative 0.0179 0.0345 0.2735
Loa Loa (eye worm) hypothetical protein 0.0131 0.0215 0.0202
Entamoeba histolytica protein kinase, putative 0.0107 0.0149 0.112
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0077 0.0066 0.0298
Entamoeba histolytica p21-activated kinase 0.0181 0.0351 0.286
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0041 0.0028
Echinococcus granulosus tyrosine protein kinase Blk 0.0166 0.0309 0.0743
Echinococcus granulosus c src tyrosine kinase 0.0132 0.0217 0.0513
Echinococcus granulosus casein kinase I alpha 0.0064 0.0032 0.0048
Echinococcus granulosus roundabout 2 0.007 0.0047 0.0087
Schistosoma mansoni hypothetical protein 0.0127 0.0204 0.048
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0176 0.0336 0.0813
Leishmania major protein kinase, putative 0.0484 0.1178 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.006 0.002 0.0018
Echinococcus multilocularis aurora kinase A 0.0484 0.1178 0.2924
Entamoeba histolytica protein kinase, putative 0.0064 0.0032 0.0105
Echinococcus granulosus activin receptor type 0.0077 0.0066 0.0135
Echinococcus granulosus suppressor of cytokine signaling 7 0.006 0.002 0.0018
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Echinococcus granulosus N chimaerin 0.0093 0.011 0.0245
Echinococcus granulosus protein kinase c iota type 0.022 0.0458 0.1119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0041 0.0028
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.011 0.0158 0.0146
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0066 0.0037 0.005
Brugia malayi Protein kinase domain containing protein 0.0107 0.0149 0.0137
Schistosoma mansoni tensin 0.006 0.002 0.0018
Trypanosoma cruzi aurora B kinase, putative 0.0484 0.1178 1
Trichomonas vaginalis CK1 family protein kinase 0.0064 0.0032 0.0165
Schistosoma mansoni protein kinase 0.0092 0.0109 0.0242
Echinococcus multilocularis protein kinase shaggy 0.0416 0.0992 0.2457
Trichomonas vaginalis STE family protein kinase 0.0176 0.0336 0.2779
Onchocerca volvulus 0.1326 0.3481 0.9409
Trichomonas vaginalis CMGC family protein kinase 0.0416 0.0992 0.8402
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.0047 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Trypanosoma brucei Casein kinase II 0.0092 0.0109 0.0675
Brugia malayi Protein kinase domain containing protein 0.0109 0.0154 0.0142
Onchocerca volvulus Tyrosine kinase homolog 0.1406 0.3699 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0223 0.0211
Schistosoma mansoni tyrosine kinase 0.0837 0.2144 0.5347
Brugia malayi map kinase activated protein kinase protein 2 0.0377 0.0885 0.0874
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0094 0.0113 0.0253
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Trichomonas vaginalis AGC family protein kinase 0.0484 0.1178 1
Brugia malayi hypothetical protein 0.0109 0.0154 0.0142
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0149 0.0265 0.2034
Giardia lamblia Kinase, CMGC GSK 0.0416 0.0992 0.8375
Echinococcus granulosus twitchin 0.0189 0.0374 0.0906
Entamoeba histolytica protein kinase , putative 0.0484 0.1178 1
Brugia malayi intracellular kinase 0.0416 0.0992 0.0981
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Brugia malayi Tyrosine-protein kinase abl-1 0.0209 0.0426 0.0414
Echinococcus granulosus casein kinase ii subunit alpha 0.0092 0.0109 0.0242
Echinococcus granulosus titin 0.0061 0.0022 0.0025
Echinococcus multilocularis SH2 domain containing protein 7 0.006 0.002 0.0018
Brugia malayi Protein kinase domain containing protein 0.0176 0.0336 0.0324
Schistosoma mansoni tyrosine kinase 0.0238 0.0506 0.1239
Trichomonas vaginalis AGC family protein kinase 0.0484 0.1178 1
Trypanosoma cruzi cdc2-related kinase 1 0.011 0.0158 0.1105
Schistosoma mansoni serine/threonine protein kinase 0.1212 0.3168 0.7916
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Echinococcus granulosus casein kinase I alpha 0.0064 0.0032 0.0048
Echinococcus granulosus SHC transforming protein 3 0.006 0.002 0.0018
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0139 0.0237 0.0225
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0377 0.0885 0.219
Echinococcus multilocularis protein kinase c iota type 0.022 0.0458 0.1119
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0131 0.0214 0.0506
Echinococcus granulosus tyrosine kinase 0.0166 0.0309 0.0743
Echinococcus granulosus ephrin type A receptor 4 A 0.0111 0.016 0.037
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.0095 0.0649
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0094 0.0113 0.0253
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1353 0.3553 0.3545
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0083 0.0083 0.007
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0484 0.1178 1
Echinococcus granulosus SH2 motif 0.006 0.002 0.0018
Loa Loa (eye worm) CDC7 protein kinase 0.0082 0.0082 0.0069
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Leishmania major casein kinase II, putative 0.0092 0.0109 0.0675
Schistosoma mansoni serine/threonine protein kinase 0.1169 0.305 0.762
Entamoeba histolytica protein kinase, putative 0.016 0.0294 0.2366
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0066 0.0458
Echinococcus granulosus Glutaredoxin protein 5 0.0066 0.0038 0.0064
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0174 0.0331 0.0319
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0037 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Brugia malayi MAP kinase sur-1 0.0077 0.0066 0.0053
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0189 0.0372 0.0902
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0052 0.0279
Brugia malayi serine/threonine-protein kinase plk-2 0.0211 0.0432 0.042
Echinococcus granulosus casein kinase I delta 0.0064 0.0032 0.0048
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0484 0.1178 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0118 0.0179 0.0417
Entamoeba histolytica protein kinase domain containing protein 0.0416 0.0992 0.8392
Schistosoma mansoni protein kinase 0.0176 0.0336 0.0813
Loa Loa (eye worm) TK/ROR protein kinase 0.008 0.0075 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0082 0.0594
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0149 0.1174
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0107 0.0149 0.0137
Echinococcus granulosus tyrosine protein kinase ABL1 0.0309 0.0701 0.1729
Echinococcus multilocularis serine:threonine protein kinase N2 0.0107 0.0149 0.0343
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0484 0.1178 0.2924
Entamoeba histolytica hypothetical protein 0.0127 0.0204 0.1591
Trypanosoma brucei protein kinase, putative 0.0077 0.0066 0.0298
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0064 0.0032 0.0048
Echinococcus granulosus tyrosine protein kinase shark 0.0109 0.0154 0.0355
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0189 0.0372 0.0902
Toxoplasma gondii AGC kinase 0.0174 0.0331 0.2609
Loa Loa (eye worm) AGC/AKT protein kinase 0.0179 0.0345 0.0333
Echinococcus multilocularis rho associated protein kinase 0.1212 0.3168 0.7916
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.007 0.0047 0.0087
Echinococcus granulosus defective proboscis extension response 0.0131 0.0214 0.0506
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0211 0.0432 0.042
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0066 0.0037 0.005
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0083 0.0083 0.0176
Onchocerca volvulus 0.0082 0.0082 0.0221
Echinococcus multilocularis neuroglian 0.007 0.0047 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0375 0.0909
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Loa Loa (eye worm) AUR protein kinase 0.0484 0.1178 0.1167
Brugia malayi protein unc-22 0.0061 0.0022 0.001
Onchocerca volvulus 0.0416 0.0992 0.2681
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0114 0.0167 0.0155
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0416 0.0992 0.8375
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0082 0.0594
Echinococcus granulosus NDR protein kinase 0.0107 0.0149 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0032 0.0048
Schistosoma mansoni cell adhesion molecule 0.007 0.0047 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0179 0.0417
Echinococcus multilocularis Immunoglobulin 0.0131 0.0214 0.0506
Echinococcus multilocularis tyrosine protein kinase shark 0.0109 0.0154 0.0355
Echinococcus multilocularis tyrosine kinase 0.0109 0.0154 0.0355
Trypanosoma cruzi Protein kinase B 0.0099 0.0128 0.0837
Echinococcus granulosus signal transduction protein lnk realted 0.006 0.002 0.0018
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0094 0.0113 0.0711
Brugia malayi casein kinase I 0.0064 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0028
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.006 0.002 0.0018
Echinococcus granulosus serine/threonine protein kinase 0.0099 0.0128 0.0289
Giardia lamblia Kinase, AGC PKA 0.0094 0.0113 0.0711
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0077 0.0066 0.0298
Echinococcus granulosus Immunoglobulin 0.0131 0.0214 0.0506
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0114 0.0167 0.1184
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0077 0.0066 0.03
Leishmania major protein kinase, putative 0.0077 0.0066 0.03
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.011 0.0158 0.1105
Loa Loa (eye worm) hypothetical protein 0.0139 0.0235 0.0223
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0165
Echinococcus multilocularis mitogen activated protein kinase 0.0077 0.0066 0.0134
Brugia malayi protein-tyrosine kinase 0.0166 0.0309 0.0297
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0077 0.0066 0.0298
Trichomonas vaginalis STE family protein kinase 0.0127 0.0204 0.1645
Echinococcus multilocularis titin 0.0061 0.0022 0.0025
Schistosoma mansoni adapter molecule crk 0.0083 0.0083 0.0176
Brugia malayi Protein kinase c protein 2 0.01 0.013 0.0118
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.0265 0.2034
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0077 0.0066 0.0298
Echinococcus multilocularis PAK box P21 Rho binding 0.0127 0.0204 0.048
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0064 0.0032 0.0048
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0066 0.0037 0.005
Echinococcus multilocularis twitchin 0.0058 0.0016 0.0009
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0116 0.0174 0.0406
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0067 0.0039 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0082 0.0174
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0041 0.0028
Loa Loa (eye worm) hypothetical protein 0.0065 0.0034 0.0022
Schistosoma mansoni cell adhesion molecule 0.017 0.032 0.0772
Brugia malayi Protein kinase domain containing protein 0.0067 0.0039 0.0026
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0189 0.0372 0.0902
Brugia malayi Variant SH3 domain containing protein 0.0083 0.0083 0.007
Onchocerca volvulus 0.1212 0.3168 0.8563
Loa Loa (eye worm) TK/EPH protein kinase 0.0128 0.0206 0.0194
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0028
Echinococcus granulosus mitogen activated protein kinase 0.0077 0.0066 0.0134
Echinococcus multilocularis roundabout 2 0.007 0.0047 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0348 0.0841
Schistosoma mansoni tensin-related 0.006 0.002 0.0018
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0077 0.0066 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.0371 0.0901
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.0401 0.0976
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0066 0.0458
Echinococcus multilocularis CDC7 cell division cycle 7 0.0082 0.0082 0.0174
Echinococcus multilocularis casein kinase I alpha 0.0064 0.0032 0.0048
Brugia malayi STAT protein, DNA binding domain containing protein 0.006 0.002 0.0007
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Leishmania major protein kinase A catalytic subunit isoform 1 0.0066 0.0037 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Brugia malayi Immunoglobulin I-set domain containing protein 0.1543 0.4072 0.4065
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.006 0.002 0.0007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.006 0.002 0.0007
Echinococcus granulosus tyrosine protein kinase Srms 0.0109 0.0154 0.0355
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Brugia malayi hypothetical protein 0.006 0.002 0.0007
Echinococcus granulosus peroxidasin 0.0068 0.0041 0.0073
Loa Loa (eye worm) TK/ABL protein kinase 0.0309 0.0701 0.069
Entamoeba histolytica cell division protein kinase 2, putative 0.011 0.0158 0.1198
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0132 0.0217 0.0513
Brugia malayi ephrin receptor 1 precursor 0.0078 0.007 0.0058
Entamoeba histolytica protein kinase, putative 0.0416 0.0992 0.8392
Echinococcus granulosus insulin receptor 0.0729 0.1848 0.4604
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1169 0.305 0.8244
Echinococcus multilocularis serine:threonine protein kinase 0.0067 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0025 0.0013
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0107 0.0149 0.0343
Echinococcus granulosus tyrosine protein kinase Src42A 0.0116 0.0174 0.0406
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0052 0.0279
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.006 0.0119
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0083 0.0083 0.007
Echinococcus multilocularis protein kinase c epsilon type 0.0141 0.0243 0.0578
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0188 0.0371 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Brugia malayi Protein kinase domain containing protein 0.0074 0.006 0.0047
Entamoeba histolytica protein kinase, putative 0.0174 0.0331 0.2685
Schistosoma mansoni serine/threonine kinase 0.0107 0.0149 0.0343
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0094 0.0113 0.0928
Loa Loa (eye worm) hypothetical protein 0.0133 0.022 0.0208
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0067 0.0041 0.0071
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0261 0.0569 0.1397
Echinococcus multilocularis Glutaredoxin protein 5 0.0066 0.0038 0.0064
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0097 0.0122 0.011
Schistosoma mansoni ste20-related kinase 0.0194 0.0386 0.0938
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0064 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0115 0.0171 0.0158
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0077 0.0068 0.042
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0066 0.0134
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0064 0.0032 0.0019
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0128 0.0933
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0189 0.0372 0.0902
Echinococcus multilocularis casein kinase I alpha 0.0064 0.0032 0.0048
Echinococcus multilocularis N chimaerin 0.0093 0.011 0.0245
Giardia lamblia Aurora kinase 0.0484 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0092 0.008
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0094 0.0113 0.0711
Entamoeba histolytica hypothetical protein 0.0127 0.0204 0.1591
Trichomonas vaginalis CMGC family protein kinase 0.0416 0.0992 0.8402
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0142 0.0246 0.0586
Echinococcus multilocularis tyrosine protein kinase otk 0.0067 0.0041 0.0071
Echinococcus granulosus serine:threonine protein kinase 3 0.0244 0.0523 0.128
Giardia lamblia Kinase, PLK 0.0211 0.0432 0.3489
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0107 0.0149 0.0343
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0127 0.0204 0.048
Echinococcus multilocularis serine:threonine protein kinase 38 0.0107 0.0149 0.0343
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Brugia malayi Protein kinase domain containing protein 0.0107 0.0149 0.0137
Brugia malayi Protein kinase domain 0.0176 0.0336 0.0324
Schistosoma mansoni protein kinase 0.0227 0.0477 0.1164
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0066 0.0037 0.005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0211 0.0432 0.1052
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0066 0.0037 0.005
Schistosoma mansoni growth factor receptor-bound protein 0.0083 0.0083 0.0176
Echinococcus multilocularis tensin 0.006 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0198 0.0398 0.0386
Giardia lamblia Kinase, NEK 0.0127 0.0204 0.1505
Echinococcus granulosus tyrosine protein kinase Fyn 0.0189 0.0372 0.0902
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0211 0.0432 0.1052
Loa Loa (eye worm) hypothetical protein 0.0148 0.0261 0.0249
Echinococcus granulosus Protein kinase C brain isozyme 0.018 0.0348 0.0841
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Schistosoma mansoni tyrosine kinase 0.0189 0.0372 0.0902
Brugia malayi Casein kinase II, alpha chain 0.0092 0.0109 0.0097
Schistosoma mansoni ephrin receptor 0.0111 0.016 0.037
Plasmodium vivax protein kinase Crk2 0.011 0.0158 0.1314
Onchocerca volvulus 0.0064 0.0032 0.0085
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0096 0.0119 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0158 0.1252
Loa Loa (eye worm) hypothetical protein 0.0086 0.0092 0.008
Trypanosoma cruzi polo-like protein kinase, putative 0.0211 0.0432 0.3489
Loa Loa (eye worm) AGC/PKA protein kinase 0.0066 0.0037 0.0025
Echinococcus multilocularis cyclin dependent kinase 0.011 0.0158 0.0366
Schistosoma mansoni protein kinase 0.0484 0.1178 0.2924
Loa Loa (eye worm) hypothetical protein 0.0079 0.0072 0.006
Schistosoma mansoni suppressor of cytokine signaling 0.006 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0028
Echinococcus granulosus SH2 domain containing protein 7 0.006 0.002 0.0018
Entamoeba histolytica protein kinase, putative 0.0114 0.0167 0.1276
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0127 0.0204 0.048
Loa Loa (eye worm) hypothetical protein 0.0083 0.0083 0.007
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0077 0.0068 0.042
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0167 0.0389
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0251 0.0542 0.133
Loa Loa (eye worm) TK/INSR protein kinase 0.0729 0.1848 0.1838
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0077 0.0066 0.0053
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0074 0.006 0.0047
Echinococcus multilocularis nervana 2 0.0066 0.0038 0.0064
Echinococcus multilocularis SH2 motif 0.006 0.002 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0246 0.0586
Loa Loa (eye worm) hypothetical protein 0.0241 0.0516 0.0504
Echinococcus multilocularis neuroglian 0.0162 0.0298 0.0718
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0416 0.0992 0.8375
Brugia malayi serine/threonine-protein kinase PAK 7 0.1353 0.3553 0.3545
Giardia lamblia Kinase, AGC AKT 0.0109 0.0154 0.1065
Trichomonas vaginalis STE family protein kinase 0.0176 0.0336 0.2779
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1169 0.305 0.3041
Brugia malayi P21-Rho-binding domain containing protein 0.0127 0.0204 0.0192
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0118 0.0179 0.0417
Schistosoma mansoni SH2A 0.006 0.002 0.0018
Schistosoma mansoni shc transforming protein 0.006 0.002 0.0018
Brugia malayi Protein kinase domain containing protein 0.0109 0.0154 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0178 0.1424
Schistosoma mansoni protein kinase 0.0077 0.0066 0.0135
Entamoeba histolytica protein kinase, putative 0.0087 0.0095 0.0649
Echinococcus granulosus raf serine:threonine protein kinase 0.0082 0.0081 0.0173
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.0195 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0016 0.0009
Giardia lamblia Kinase, NEK 0.0127 0.0204 0.1505
Loa Loa (eye worm) hypothetical protein 0.007 0.0047 0.0035
Trypanosoma cruzi polo-like protein kinase, putative 0.0211 0.0432 0.3489
Schistosoma mansoni tyrosine-protein kinase zap-70 0.006 0.002 0.0018
Onchocerca volvulus 0.0109 0.0154 0.0416
Onchocerca volvulus 0.0061 0.0022 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Schistosoma mansoni tyrosine kinase 0.0837 0.2144 0.5347
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0074 0.006 0.0047
Giardia lamblia Kinase, STE STE20 0.0077 0.0068 0.0319
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0092 0.0109 0.0097
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.011 0.0245
Leishmania major protein kinase A catalytic subunit isoform 2 0.0066 0.0037 0.005
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0131 0.0214 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0261 0.2134
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.0265 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0032 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0039 0.0227
Echinococcus multilocularis PAK box P21 Rho binding 0.0155 0.0279 0.0669
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0114 0.0167 0.1184
Brugia malayi Hr1 repeat family protein 0.0107 0.0149 0.0137
Echinococcus multilocularis serine:threonine protein kinase 0.0067 0.0039 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0037 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0345 0.2855
Brugia malayi Immunoglobulin I-set domain containing protein 0.0061 0.0022 0.001
Onchocerca volvulus 0.0109 0.0154 0.0416
Echinococcus multilocularis SH2 motif 0.006 0.002 0.0018
Loa Loa (eye worm) AGC/PKA protein kinase 0.0066 0.0037 0.0025
Schistosoma mansoni suppressor of cytokine signaling 0.006 0.002 0.0018
Echinococcus granulosus CDC7 cell division cycle 7 0.0082 0.0082 0.0174
Giardia lamblia Kinase, AGC PKA 0.0066 0.0037 0.005
Echinococcus multilocularis roundabout 2 0.007 0.0047 0.0087
Loa Loa (eye worm) protein-tyrosine phosphatase 0.006 0.002 0.0007
Echinococcus granulosus SH2 motif 0.006 0.002 0.0018
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0261 0.0569 0.1397
Entamoeba histolytica protein kinase, putative 0.0106 0.0146 0.1088
Loa Loa (eye worm) hypothetical protein 0.0133 0.022 0.0208
Echinococcus granulosus cyclin dependent kinase 5 0.011 0.0158 0.0366
Brugia malayi protein kinase C II. 0.0141 0.0243 0.0231
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.0047 0.0035
Plasmodium falciparum serine/threonine protein kinase, putative 0.0484 0.1178 1
Brugia malayi casein kinase 1, delta 0.0064 0.0032 0.0019
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.0265 0.0633
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0416 0.0992 0.8375
Schistosoma mansoni tyrosine kinase 0.0729 0.1848 0.4604
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0041 0.0028
Entamoeba histolytica protein kinase, putative 0.0484 0.1178 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0074 0.006 0.0047
Leishmania major protein kinase A catalytic subunit 0.0066 0.0037 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0377 0.0885 0.219
Loa Loa (eye worm) AUR protein kinase 0.0484 0.1178 0.1167
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0037 0.0063
Schistosoma mansoni hypothetical protein 0.006 0.002 0.0018
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0188 0.0371 0.0901
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0731 0.1854 0.462
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0149 0.0265 0.2034
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Toxoplasma gondii CMGC kinase, CK2 family 0.0092 0.0109 0.0675
Echinococcus granulosus aurora kinase A 0.0484 0.1178 0.2924
Schistosoma mansoni tyrosine kinase 0.0132 0.0217 0.0513
Schistosoma mansoni tyrosine kinase 0.0117 0.0175 0.0408
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0142 0.0246 0.0586
Echinococcus multilocularis serine threonine protein kinase 0.0147 0.0257 0.0614
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0176 0.0336 0.0813
Echinococcus granulosus dual specificity 0.0114 0.0167 0.0389
Echinococcus multilocularis growth factor receptor bound protein 2 0.0083 0.0083 0.0176
Echinococcus granulosus casein kinase I delta 0.0064 0.0032 0.0048
Giardia lamblia Kinase, CDC7 0.0082 0.0082 0.0437
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.008 0.0075 0.0158
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Schistosoma mansoni tyrosine kinase 0.0241 0.0514 0.1259
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.006 0.002 0.0053
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.011 0.0158 0.1105
Echinococcus granulosus tyrosine protein kinase HCK 0.0106 0.0146 0.0334
Echinococcus multilocularis activin receptor type 0.0077 0.0066 0.0135
Loa Loa (eye worm) hypothetical protein 0.006 0.002 0.0007
Plasmodium falciparum casein kinase 2, alpha subunit 0.0092 0.0109 0.0675
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0154 0.0142
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0309 0.0701 0.1729
Schistosoma mansoni tyrosine kinase 0.0886 0.2278 0.5684
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1226 0.3205 0.8009
Echinococcus multilocularis rac serine:threonine kinase 0.0099 0.0128 0.0289
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0241 0.0514 0.1259
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0227 0.0477 0.1164
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0028
Echinococcus multilocularis hemicentin 1 0.0067 0.0041 0.0071
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0109 0.0154 0.0142
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0176 0.0336 0.0813
Loa Loa (eye worm) hypothetical protein 0.0067 0.0041 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0164 0.1299
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.0265 0.0633
Echinococcus granulosus mitogen activated protein kinase 3 0.0077 0.0066 0.0134
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0147 0.0257 0.0245
Echinococcus multilocularis hemicentin 1 0.0067 0.0041 0.0071
Schistosoma mansoni protein kinase 0.0176 0.0336 0.0813
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0176 0.0336 0.0813
Loa Loa (eye worm) hypothetical protein 0.0198 0.0398 0.0386
Giardia lamblia Kinase, CMGC GSK 0.0416 0.0992 0.8375
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.0265 0.2034
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0066 0.0037 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.0432 0.1052
Echinococcus multilocularis 0.006 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0126 0.02 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Echinococcus granulosus neuroglian 0.0162 0.0298 0.0718
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0096 0.0119 0.0269
Echinococcus multilocularis cyclin dependent kinase 1 0.011 0.0158 0.0366
Echinococcus granulosus hemicentin 1 0.0067 0.0041 0.0071
Echinococcus granulosus suppressor of cytokine signaling 6 0.006 0.002 0.0018
Schistosoma mansoni septate junction protein 0.0067 0.0041 0.0071
Brugia malayi Protein kinase domain containing protein 0.0109 0.0154 0.0142
Schistosoma mansoni titin 0.0067 0.0041 0.0071
Echinococcus granulosus tyrosine protein kinase Src42A 0.0189 0.0372 0.0902
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0081 0.0173
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.007 0.0047 0.0087
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0166 0.0309 0.0743
Brugia malayi Fibronectin type III domain containing protein 0.0133 0.022 0.0208
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0077 0.0066 0.0298
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1543 0.4072 0.4065
Brugia malayi WH1 domain containing protein 0.0127 0.0204 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.3713 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0066 0.0458
Giardia lamblia Kinase, STE STE20 0.0176 0.0336 0.2658
Trichomonas vaginalis STE family protein kinase 0.0176 0.0336 0.2779
Onchocerca volvulus 0.006 0.002 0.0053
Schistosoma mansoni tensin 0.006 0.002 0.0018
Brugia malayi Temporarily assigned gene name protein 59 0.0125 0.0197 0.0185
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0096 0.0119 0.0269
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.006 0.002 0.0018
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0988 0.2556 0.6381
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0093 0.011 0.0098
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0241 0.0514 0.1259
Echinococcus granulosus serine:threonine protein kinase 0.0067 0.0039 0.0066
Brugia malayi Tensin 0.006 0.002 0.0007
Echinococcus granulosus tyrosine protein kinase otk 0.0067 0.0041 0.0071
Trichomonas vaginalis STE family protein kinase 0.0077 0.0068 0.0479
Echinococcus granulosus lachesin 0.0067 0.0041 0.0071
Schistosoma mansoni neuroglian 0.007 0.0047 0.0087
Onchocerca volvulus 0.1184 0.3093 0.836
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0077 0.0066 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.0432 0.3597
Echinococcus multilocularis suppressor of cytokine signaling 6 0.006 0.002 0.0018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0272 0.0599 0.0587
Giardia lamblia Kinase, CMGC CDK 0.011 0.0158 0.1105
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0189 0.0372 0.0902
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.002 0.0007
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0167 0.0314 0.0756
Loa Loa (eye worm) hypothetical protein 0.0133 0.022 0.0208
Echinococcus multilocularis casein kinase ii subunit alpha 0.0092 0.0109 0.0242
Entamoeba histolytica protein kinase, putative 0.0176 0.0336 0.2735
Onchocerca volvulus 0.0109 0.0154 0.0416
Onchocerca volvulus 0.0112 0.0162 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0243 0.0578
Loa Loa (eye worm) TK protein kinase 0.0272 0.0599 0.0587
Schistosoma mansoni protein kinase 0.0064 0.0032 0.0048
Echinococcus granulosus mitogen activated protein kinase 14 0.0149 0.0265 0.0633
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0189 0.0372 0.0902
Schistosoma mansoni protein kinase C mu 0.0139 0.0237 0.0565
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0107 0.0149 0.0343
Echinococcus multilocularis NCK adaptor protein 0.0083 0.0083 0.0176
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1169 0.305 0.762
Echinococcus multilocularis SH2 motif 0.006 0.002 0.0018
Brugia malayi Protein kinase domain containing protein 0.019 0.0375 0.0363
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0142 0.0246 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0109 0.0829
Schistosoma mansoni tyrosine kinase 0.0837 0.2144 0.5347
Echinococcus granulosus nervana 2 0.0066 0.0038 0.0064
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0099 0.0128 0.0837
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0064 0.0032 0.0048
Onchocerca volvulus 0.006 0.002 0.0053
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.008 0.0074 0.0529
Loa Loa (eye worm) hypothetical protein 0.0167 0.0314 0.0302
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0178 0.1424
Entamoeba histolytica protein kinase, putative 0.0155 0.0279 0.224
Onchocerca volvulus 0.0134 0.0223 0.0602
Brugia malayi Stress-activated protein kinase jnk-1 0.0251 0.0542 0.0531
Schistosoma mansoni vav2 0.0098 0.0124 0.0281
Echinococcus granulosus nervana 2 0.0066 0.0038 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0041 0.0028
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0096 0.0119 0.0269
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0211 0.0432 0.3489
Echinococcus granulosus growth factor receptor bound protein 2 0.0083 0.0083 0.0176
Loa Loa (eye worm) hypothetical protein 0.0131 0.0214 0.0202
Schistosoma mansoni protein kinase 0.0127 0.0204 0.048
Echinococcus multilocularis roundabout 2 0.0201 0.0405 0.0984
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0077 0.0066 0.03
Schistosoma mansoni growth factor receptor-bound protein 0.0083 0.0083 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0158 0.0366
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0064 0.0032 0.0019
Brugia malayi Furin-like cysteine rich region family protein 0.1516 0.3999 0.3991
Echinococcus multilocularis mitogen activated protein kinase 3 0.0077 0.0066 0.0134
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.007 0.0047 0.0087
Toxoplasma gondii AGC kinase 0.0066 0.0037 0.005
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0189 0.0372 0.0902
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0127 0.0204 0.0192
Brugia malayi Protein kinase domain containing protein 0.0188 0.037 0.0358
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0066 0.0037 0.005
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0176 0.0336 0.0813
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0189 0.0372 0.0902
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0166 0.0309 0.0743
Entamoeba histolytica protein kinase, putative 0.0074 0.006 0.0347
Schistosoma mansoni kinase 0.012 0.0185 0.0433
Brugia malayi SH2 domain containing protein 0.006 0.002 0.0007
Brugia malayi Peroxidasin 0.0068 0.0041 0.0029
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0484 0.1178 0.2924
Trypanosoma brucei cdc2-related kinase 1 0.011 0.0158 0.1105
Trypanosoma brucei polo-like protein kinase 0.0211 0.0432 0.3489
Echinococcus granulosus PAK box P21 Rho binding 0.0127 0.0204 0.048
Echinococcus granulosus neuroglian 0.007 0.0047 0.0087
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.022 0.0208
Schistosoma mansoni tyrosine kinase 0.025 0.0538 0.132
Echinococcus multilocularis suppressor of cytokine signaling 7 0.006 0.002 0.0018
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0077 0.0066 0.03
Brugia malayi p70 ribosomal S6 kinase beta 0.0174 0.0331 0.0319
Schistosoma mansoni tyrosine kinase 0.1516 0.3999 1
Schistosoma mansoni signal transduction protein lnk-related 0.006 0.002 0.0018
Schistosoma mansoni atypical protein kinase C 0.0226 0.0475 0.116
Echinococcus granulosus tyrosine kinase 0.0109 0.0154 0.0355
Schistosoma mansoni hypothetical protein 0.0127 0.0204 0.048
Brugia malayi Protein kinase domain containing protein 0.0082 0.0082 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0074 0.006 0.0407
Onchocerca volvulus 0.0082 0.0082 0.0221
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0109 0.0154 0.116
Brugia malayi Variant SH3 domain containing protein 0.0066 0.0037 0.0025
Schistosoma mansoni tyrosine kinase 0.0886 0.2278 0.5684
Entamoeba histolytica serine/threonine protein kinase, putative 0.0211 0.0432 0.3557
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.007 0.0047 0.0087
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0127 0.0204 0.048
Schistosoma mansoni nephrin 0.007 0.0047 0.0087
Echinococcus multilocularis myosin iiia 0.0077 0.0068 0.014
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0416 0.0992 0.0981
Trypanosoma cruzi cdc2-related kinase 1 0.011 0.0158 0.1105
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0114 0.0167 0.1184
Loa Loa (eye worm) hypothetical protein 0.0134 0.0223 0.0211
Echinococcus multilocularis epidermal growth factor receptor 0.1516 0.3999 1
Giardia lamblia Kinase, CMGC MAPK 0.0077 0.0066 0.0298
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0077 0.0066 0.0298
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.006 0.002 0.0018
Trypanosoma brucei aurora B kinase 0.0484 0.1178 1
Entamoeba histolytica protein kinase 2, putative 0.0094 0.0113 0.0807
Echinococcus multilocularis tyrosine protein kinase Blk 0.0166 0.0309 0.0743
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0149 0.0265 0.0253
Loa Loa (eye worm) hypothetical protein 0.0112 0.0162 0.015
Entamoeba histolytica protein kinase domain containing protein 0.0484 0.1178 1
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0066 0.0037 0.005
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.011 0.0158 0.0146
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0107 0.0149 0.0343
Schistosoma mansoni roundabout 0.0067 0.0041 0.0071
Echinococcus granulosus hypothetical protein 0.006 0.002 0.0018
Schistosoma mansoni nephrin 0.0164 0.0305 0.0734
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0037 0.0214
Echinococcus granulosus cyclin dependent kinase 1 0.011 0.0158 0.0366

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 100000 nM Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method ChEMBL. 21067924
Ki (binding) > 100000 nM Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method ChEMBL. 21067924
Ki (binding) > 100 uM Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration method ChEMBL. 21067924
Ki (binding) > 100 uM Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration method ChEMBL. 21067924

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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