Detailed information for compound 1273887

Basic information

Technical information
  • TDR Targets ID: 1273887
  • Name: (7-methyl-2-oxochromen-4-yl)methyl 2-chlorobe nzoate
  • MW: 328.746 | Formula: C18H13ClO4
  • H donors: 0 H acceptors: 2 LogP: 3.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)oc(=O)cc2COC(=O)c1ccccc1Cl
  • InChi: 1S/C18H13ClO4/c1-11-6-7-13-12(9-17(20)23-16(13)8-11)10-22-18(21)14-4-2-3-5-15(14)19/h2-9H,10H2,1H3
  • InChiKey: QFTLQOYSUMAYNS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (7-methyl-2-oxo-chromen-4-yl)methyl 2-chlorobenzoate
  • 2-chlorobenzoic acid (7-methyl-2-oxo-4-chromenyl)methyl ester
  • 2-chlorobenzoic acid (2-keto-7-methyl-chromen-4-yl)methyl ester
  • ZINC03507163
  • T5401689

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0025 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.031
Onchocerca volvulus 0.0007 0.0001 0.0288
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0002 0.0428
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0005 0.049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0003 0.031
Mycobacterium tuberculosis Conserved protein 0.0035 0.0025 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0003 0.0072
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0038 0.3968
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0033 0.0786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0003 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0001
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Mycobacterium ulcerans AcrR family transcriptional regulator 1.1713 1 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0005 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0025 0.2598
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0003 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0019 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0025 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0025 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0025 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.2559
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0004 0.0045
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.014 0.3354
Schistosoma mansoni patched 1 0.0051 0.0038 0.0916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0033 0.0786
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0002 0.0021
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0002 0.0844
Brugia malayi Patched related family protein 4 0.0007 0.0001 0.0074
Brugia malayi Patched protein homolog 1 0.0007 0.0001 0.0074
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Mycobacterium ulcerans beta-lactamase 0.0035 0.0025 0.0023
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0005 0.1674
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.242
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0002 0.0127
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0003 0.0072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.2559
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.2559
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0005 0.0934
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0005 0.1301
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0033 0.0786
Mycobacterium ulcerans TetR family transcriptional regulator 1.1713 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0416 0.5012
Onchocerca volvulus 0.0007 0.0001 0.0288
Onchocerca volvulus 0.0008 0.0002 0.0704
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0003 0.0036
Onchocerca volvulus 0.0035 0.0025 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0023
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0005 0.0315
Onchocerca volvulus 0.0007 0.0001 0.0288
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0003 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0005 0.0934
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0003 0.0072
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0003 0.0036
Echinococcus multilocularis geminin 0.0166 0.0136 0.1636
Onchocerca volvulus 0.0035 0.0025 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0096 1
Brugia malayi beta-lactamase 0.0035 0.0025 0.2559
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0003 0.0072
Echinococcus multilocularis cpg binding protein 0.0037 0.0026 0.0311
Loa Loa (eye worm) glutamate receptor 0.0039 0.0028 0.2926
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.049
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0002 0.0205
Echinococcus granulosus geminin 0.0166 0.0136 0.3264
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0019 0.7556
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0033 0.0394
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0025 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0019 0.7556
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.2559
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0025 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0003 0.031
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0002 0.018
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0011 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0025 0.6328
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Brugia malayi Patched related family protein 10 0.0007 0.0001 0.0074
Loa Loa (eye worm) patched family protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.049
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0011 0.1136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi Receptor family ligand binding region containing protein 0.001 0.0003 0.0328
Mycobacterium tuberculosis Conserved protein 0.0035 0.0025 0.0024
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0005 0.0934
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0025 0.059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0003 0.031
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0025 0.6328
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0019 0.0018
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0048 0.0036 0.0432
Schistosoma mansoni hypothetical protein 0.0035 0.0025 0.059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.049
Brugia malayi hypothetical protein 0.0007 0.0001 0.0074
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0096 1
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0005 0.0113
Brugia malayi hypothetical protein 0.0012 0.0005 0.049
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Brugia malayi DKFZp564C0469 protein 0.0012 0.0005 0.049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.031
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0002 0.018
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0.0003 0.0328
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0013 0.5072
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0002 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0025 0.0024
Mycobacterium ulcerans hypothetical protein 0.0035 0.0025 0.0023
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0025 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0186 0.0186
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0096 0.1156
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0005 0.0934
Leishmania major hypothetical protein, conserved 0.0035 0.0025 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0005 0.1301
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0005 0.0934
Trichomonas vaginalis esterase, putative 0.0035 0.0025 0.6328
Loa Loa (eye worm) patched family protein 0.0007 0.0001 0.0074
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0072
Schistosoma mansoni hypothetical protein 0.0049 0.0037 0.0878
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0005 0.0113
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0002 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0005 0.0934
Onchocerca volvulus 0.001 0.0003 0.1213
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0023 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0005 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0005 0.0934
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.0037 0.0878
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0096 0.2308
Brugia malayi CXXC zinc finger family protein 0.0035 0.0024 0.2515
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.1978
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.242
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.1978
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Entamoeba histolytica hypothetical protein 0.0012 0.0005 0.0315
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.049
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0023 0.0544
Brugia malayi Myosin head containing protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0033 0.3404
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.1713 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0013 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0004 0.0387
Echinococcus granulosus nibrin 0.0012 0.0005 0.0113
Brugia malayi Patched related family protein 12 0.0007 0.0001 0.0074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0033 0.3404
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0025 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0019 0.0017
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0003 0.1213
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0057 0.1378
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.031
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0003 0.0036
Brugia malayi beta-lactamase family protein 0.0035 0.0025 0.2559
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0002 0.018
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0005 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0003 0.031
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0004 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0019 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0003 0.031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0025 0.0296
Schistosoma mansoni topbp1 0.0012 0.0005 0.0113
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0003 0.1213
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.018
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0.0003 0.0328
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0005 0.1301
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0072
Echinococcus granulosus metabotropic glutamate receptor 5 0.0048 0.0036 0.0862
Schistosoma mansoni hypothetical protein 0.0494 0.0416 1
Brugia malayi beta-lactamase family protein 0.0035 0.0025 0.2559
Onchocerca volvulus 0.0007 0.0001 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0019 0.1978
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0038 0.0459
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0002 0.018
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0328
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0011
Loa Loa (eye worm) patched family protein 0.0007 0.0001 0.0074
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0038 0.0916
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0831 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0025 0.0591
Onchocerca volvulus 0.0008 0.0002 0.0704
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.049
Schistosoma mansoni coup transcription factor 0.001 0.0003 0.0072
Onchocerca volvulus 0.0035 0.0025 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0003 0.0072
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0005 0.08
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.031
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0001
Schistosoma mansoni DNA ligase IV 0.0012 0.0005 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0019 0.0017
Schistosoma mansoni hypothetical protein 0.0166 0.0136 0.3264
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0002 0.0001
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0002 0.0205
Loa Loa (eye worm) patched family protein 0.0007 0.0001 0.0074
Onchocerca volvulus Protein patched homolog 0.0007 0.0001 0.0288
Loa Loa (eye worm) glutamate receptor 0.0015 0.0008 0.0807
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0025 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0025 0.0591
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0019 0.0017
Schistosoma mansoni cpg binding protein 0.0037 0.0026 0.0621
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0019 0.1978
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0013 1
Onchocerca volvulus 0.0008 0.0002 0.0704
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0025 0.0023
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0005 0.1301
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus multilocularis protein patched 0.0051 0.0038 0.0459
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0005 0.0003
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0005 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0003 0.0072
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.1334
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0023 0.0544
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0003 0.0072
Schistosoma mansoni hypothetical protein 0.0166 0.0136 0.3264
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0038 0.0916
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0033 0.0786
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0025 0.6328
Onchocerca volvulus 0.0007 0.0001 0.0288
Schistosoma mansoni cpg binding protein 0.0035 0.0024 0.058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0025 0.0591
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.242
Schistosoma mansoni hypothetical protein 0.0049 0.0037 0.0878
Onchocerca volvulus 0.0035 0.0024 0.983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0003 0.031
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0002 0.018
Echinococcus granulosus expressed conserved protein 0.0112 0.009 0.216
Onchocerca volvulus 0.0029 0.0019 0.7728
Loa Loa (eye worm) beta-lactamase 0.0035 0.0025 0.2559
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0025 0.059
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.3734
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0002 0.018
Entamoeba histolytica hypothetical protein 0.0035 0.0025 0.242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0003 0.031
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0003 0.031
Brugia malayi ecdysteroid receptor 0.001 0.0003 0.031
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0002 0.018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi topoisomerase 0.0012 0.0005 0.049
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0002 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0003 0.031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0024 0.2515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0033 0.0786
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0002 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0019 0.183
Mycobacterium leprae Probable lipase LipE 0.0035 0.0025 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.1334
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0005 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0005 0.0934
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0046
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0002 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0003 0.031
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0072
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0002 0.0001
Mycobacterium ulcerans lipase LipD 0.0035 0.0025 0.0023
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0002 0.0205
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0019 0.0017
Onchocerca volvulus 0.0012 0.0005 0.1914
Toxoplasma gondii ABC1 family protein 0.0035 0.0025 0.478
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi protein C24B5.3 0.0007 0.0001 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0003 0.1213
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0005 0.1301
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0003 0.031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0025 0.0296
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0005 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0025 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.1334
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0098 0.2345
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0005 0.3299
Loa Loa (eye worm) hypothetical protein 0.0062 0.0048 0.4988
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0003 0.0036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0025 0.2559
Echinococcus multilocularis protein dispatched 1 0.0058 0.0044 0.0533
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Echinococcus granulosus FTZ F1 alpha 0.001 0.0003 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0019 0.1978
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0013 0.0012
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0025 0.6328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0033 0.0786
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0003 0.0072
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0013 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0039 0.0028 0.2926
Brugia malayi protein C24B5.3 0.0007 0.0001 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0033 0.0394
Loa Loa (eye worm) oxidoreductase 0.0008 0.0002 0.018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0003 0.0072
Brugia malayi CHE-14 protein 0.0051 0.0038 0.3968
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi steroid hormone receptor 0.001 0.0003 0.031
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0019 0.183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.031
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0025 0.6328
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0004 0.0374
Schistosoma mansoni topbp1 0.0012 0.0005 0.0113
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0005 0.049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.1978
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.2559
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0019 0.183
Onchocerca volvulus 0.0007 0.0001 0.0288
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0019 0.7556
Onchocerca volvulus Protein patched homolog 0.0007 0.0001 0.0288
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.014 0.1681
Brugia malayi hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.031
Mycobacterium ulcerans transcriptional regulator 1.1713 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0036
Onchocerca volvulus 0.0007 0.0001 0.0288
Onchocerca volvulus 0.0008 0.0002 0.0704
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.3968
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.1334
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0036
Schistosoma mansoni cpg binding protein 0.0037 0.0026 0.0621
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0002 0.0127
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0025 0.2559
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0119 0.0096 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0025 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0003 0.031
Brugia malayi hypothetical protein 0.0007 0.0001 0.0074
Echinococcus granulosus cpg binding protein 0.0037 0.0026 0.0621
Loa Loa (eye worm) patched family protein 0.0007 0.0001 0.0074
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0005 0.08
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0051 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0019 0.0017
Treponema pallidum DNA ligase (lig) 0.0012 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.2559
Brugia malayi hypothetical protein 0.0012 0.0005 0.049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0003 0.031
Brugia malayi hypothetical protein 0.0035 0.0025 0.2557
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0025 0.0024
Echinococcus multilocularis expressed conserved protein 0.0112 0.009 0.1082
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0002 0.018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Echinococcus multilocularis nibrin 0.0012 0.0005 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.1334
Brugia malayi Patched family protein 0.0007 0.0001 0.0074
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.0037 0.0878
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0074
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0002 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8492 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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