TDR Targets

Basic information

Technical information

TDR Targets ID: 1282128
Name: 3,5-dichloro-4-methoxy-N-(2-phenylphenyl)benz amide
MW: 372.245 | Formula: C20H15Cl2NO2
H donors: 1 H acceptors: 1 LogP: 5.61 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(Cl)cc(cc1Cl)C(=O)Nc1ccccc1c1ccccc1
InChi: 1S/C20H15Cl2NO2/c1-25-19-16(21)11-14(12-17(19)22)20(24)23-18-10-6-5-9-15(18)13-7-3-2-4-8-13/h2-12H,1H3,(H,23,24)
InChiKey: UAXQFTDEMALETR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-2-biphenylyl-3,5-dichloro-4-methoxybenzamide
SMR000201381
ZINC02880707
MLS000582680

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Echinococcus granulosus	cathepsin l1	0.0013	0.0007	0.0071
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0004	0.022
Leishmania major	ATP-dependent phosphofructokinase	0.0123	0.0132	1
Schistosoma mansoni	lamin	0.0031	0.0027	0.1225
Brugia malayi	beta-lactamase family protein	0.004	0.0038	0.1973
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0004	0.022
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0076	0.338
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.1054
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0027	0.144
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0022	0.0017	0.0779
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0017	0.0779
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0022	0.0017	0.0289
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.8866	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0027	0.144
Brugia malayi	Cathepsin L-like precursor	0.0013	0.0007	0.0381
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0076	0.338
Echinococcus multilocularis	6 phosphofructokinase	0.0123	0.0132	0.1287
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.0132	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0051	0.655
Onchocerca volvulus		0.004	0.0038	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0014	0.0753
Onchocerca volvulus		0.0019	0.0014	0.2336
Loa Loa (eye worm)	beta-lactamase	0.004	0.0038	0.1973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Onchocerca volvulus		0.0019	0.0014	0.2336
Mycobacterium ulcerans	6-phosphofructokinase	0.0123	0.0132	0.0095
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0076	0.0038
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0017	0.0779
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.003	0.5977
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0051	1
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0011	0.223
Onchocerca volvulus		0.004	0.0038	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0039	0.1758
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0038	0.2847
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0014	0.0549
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0017	0.0779
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0017	0.0136
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0014	0.0753
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0027	0.144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0004	0.0177
Trichomonas vaginalis	esterase, putative	0.004	0.0038	0.2626
Leishmania major	cathepsin L-like protease	0.0019	0.0014	0.0549
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0017	0.0779
Toxoplasma gondii	cathepsin CPL	0.0019	0.0014	0.142
Loa Loa (eye worm)	hypothetical protein	0.003	0.0027	0.1407
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0017	0.0289
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0067	0.5111
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.019	1
Brugia malayi	hypothetical protein	0.0022	0.0017	0.0916
Loa Loa (eye worm)	fibroinase	0.0019	0.0014	0.0753
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0017	0.0916
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0061	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0916
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.0132	1
Entamoeba histolytica	hypothetical protein	0.0022	0.0017	0.1054
Entamoeba histolytica	phosphofructokinase, putative	0.0123	0.0132	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0017	0.3067
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0038	0.1678
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0051	0.3675
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0038	0.2626
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Schistosoma mansoni	6-phosphofructokinase	0.0123	0.0132	0.5896
Plasmodium vivax	unspecified product	0.001	0.0004	0.0775
Onchocerca volvulus		0.0019	0.0014	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0381
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0017	0.0779
Echinococcus multilocularis	cysteine protease	0.0019	0.0014	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0014	0.0811
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.1054
Brugia malayi	Cathepsin L-like precursor	0.0013	0.0007	0.0381
Toxoplasma gondii	phosphofructokinase PFKII	0.0033	0.003	0.3679
Leishmania major	cathepsin L-like protease	0.0019	0.0014	0.0549
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0017	0.0289
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0017	0.0779
Trypanosoma cruzi	cysteine protease, putative	0.001	0.0004	0.03
Brugia malayi	intermediate filament protein	0.0031	0.0027	0.144
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0008	0.0277
Toxoplasma gondii	6-phosphofructokinase	0.0033	0.003	0.3679
Leishmania major	cathepsin L-like protease	0.0019	0.0014	0.0549
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0017	0.0779
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0011	0.0599
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.001	0.0004	0.03
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0014	0.246
Brugia malayi	regulator of G-protein signaling rgs-7	0.0022	0.0017	0.0916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0644
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0004	0.0005
Schistosoma mansoni	6-phosphofructokinase	0.0123	0.0132	0.5896
Onchocerca volvulus		0.0019	0.0014	0.2336
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0038	0.2847
Loa Loa (eye worm)	acetyltransferase	0.0175	0.019	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.0185	0.3879
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0022	0.0017	0.0916
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0051	0.655
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0017	0.0779
Schistosoma mansoni	z-protein (S1r protein)	0.0022	0.0017	0.0779
Echinococcus granulosus	GPCR family 2	0.0019	0.0014	0.0224
Echinococcus multilocularis	cysteine protease	0.0019	0.0014	0.0104
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0014	0.0811
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0046	1
Leishmania major	cathepsin L-like protease	0.0019	0.0014	0.0549
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0075	0.5647
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0916
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0038	0.2626
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0017	0.0289
Leishmania major	cathepsin L-like protease	0.0019	0.0014	0.0549
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0004	0.0002
Echinococcus granulosus	cathepsin l1	0.0019	0.0014	0.0223
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0033	0.003	0.3679
Onchocerca volvulus		0.0019	0.0014	0.2336
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0033	0.003	0.2073
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0014	0.0753
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.022
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0123	0.0132	0.0095
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0011	0.0975
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0046	0.3297
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Onchocerca volvulus		0.0031	0.0027	0.6651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.003	0.6286
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.003	0.2073
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0076	0.0038
Loa Loa (eye worm)	cysteine protease	0.0019	0.0014	0.0753
Entamoeba histolytica	phosphofructokinase, putative	0.0123	0.0132	1
Schistosoma mansoni	DNA helicase recq5	0.001	0.0004	0.0187
Brugia malayi	hypothetical protein	0.0022	0.0017	0.0916
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0038	0.1973
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.003	0.2073
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0008	0.0277
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.003	0.2073
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0004	0.022
Brugia malayi	phosphofructokinase	0.0123	0.0132	0.693
Echinococcus multilocularis	expressed protein	0.0423	0.0471	0.469
Plasmodium vivax	vivapain-3	0.001	0.0004	0.0775
Onchocerca volvulus		0.0019	0.0014	0.2336
Echinococcus granulosus	lamin	0.0031	0.0027	0.0503
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0891	0.0999	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0014	0.0105
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0061	0.3195
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0033	0.003	0.5
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0123	0.0132	1
Leishmania major	cathepsin L-like protease	0.0072	0.0075	0.5385
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0017	0.0916
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0014	0.0105
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0017	0.0289
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0017	0.0779
Entamoeba histolytica	phosphofructokinase, putative	0.0123	0.0132	1
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0038	0.7366
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0004	0.0002
Echinococcus multilocularis	lamin	0.0031	0.0027	0.0236
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0014	0.0641
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0039	0.2067
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0009	0.0469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0007	0.0258
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0076	0.1537
Leishmania major	cathepsin L-like protease	0.0072	0.0075	0.5385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0022	0.0017	0.0289
Loa Loa (eye worm)	RGS-3 protein	0.0022	0.0017	0.0916
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0014	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.002	0.127
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0004	0.0208
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0017	0.0289
Echinococcus granulosus	intermediate filament protein	0.0031	0.0027	0.0503
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.0132	1
Entamoeba histolytica	hypothetical protein	0.0022	0.0017	0.1054
Loa Loa (eye worm)	hypothetical protein	0.006	0.0061	0.3195
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.1054
Echinococcus granulosus	6 phosphofructokinase	0.0123	0.0132	0.2744
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0027	0.1225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.002	0.0164
Loa Loa (eye worm)	6-phosphofructokinase	0.0123	0.0132	0.693
Loa Loa (eye worm)	hypothetical protein	0.0015	0.001	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0916
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0011	0.0599
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.019	0.8508
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0038	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0009	0.0469
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0076	0.0721
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0017	0.0136
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0008	0.0277
Loa Loa (eye worm)	hypothetical protein	0.004	0.0038	0.1973
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0014	0.0753
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0022	0.0017	0.0136
Echinococcus multilocularis	geminin	0.0205	0.0224	0.2211
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.002	0.127
Schistosoma mansoni	hypothetical protein	0.0205	0.0224	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0014	0.0757
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0014	0.0753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Leishmania major	hypothetical protein, conserved	0.004	0.0038	0.2416
Toxoplasma gondii	ABC1 family protein	0.004	0.0038	0.467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0075	0.5647
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0017	0.0779
Brugia malayi	cathepsin L-like precursor	0.0013	0.0007	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0916
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.003	0.6286
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.8866	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0057	0.4324
Brugia malayi	PXA domain containing protein	0.0022	0.0017	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0916
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0014	0.0811
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.003	0.5977
Plasmodium vivax	vivapain-1	0.001	0.0004	0.0775
Trypanosoma cruzi	cysteine proteinase, putative	0.001	0.0004	0.03
Echinococcus granulosus	Regulator of G protein signaling 20	0.0022	0.0017	0.0289
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0017	0.0136
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0017	0.0136
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0014	0.2336
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0017	0.0779
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0022	0.0017	0.0136
Loa Loa (eye worm)	phosphofructokinase	0.0123	0.0132	0.693
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0014	0.2336
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0004	0.0177
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0014	0.0753
Loa Loa (eye worm)	RecQ helicase	0.0024	0.002	0.1062
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.003	0.2073
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0014	0.0753
Brugia malayi	beta-lactamase family protein	0.004	0.0038	0.1973
Echinococcus multilocularis	musashi	0.0031	0.0027	0.0236
Loa Loa (eye worm)	hypothetical protein	0.004	0.0038	0.1973
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0123	0.0132	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0017	0.0136
Echinococcus granulosus	lamin dm0	0.0031	0.0027	0.0503
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0033	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0038	0.1973
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0017	0.0136
Echinococcus multilocularis	regulator of G protein signaling	0.0022	0.0017	0.0136
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0004	0.0208
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0014	0.1086
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0014	0.0104
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0022	0.0017	0.0136
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0014	0.246
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0033	0.003	0.6265
Echinococcus granulosus	expressed protein	0.0423	0.0471	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0753
Onchocerca volvulus		0.0031	0.0027	0.6651
Mycobacterium ulcerans	TetR family transcriptional regulator	0.8866	1	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0051	0.1009
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0038	0.2626
Echinococcus granulosus	geminin	0.0205	0.0224	0.4714
Loa Loa (eye worm)	PXA domain-containing protein	0.0022	0.0017	0.0916
Schistosoma mansoni	hypothetical protein	0.0205	0.0224	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0046	1
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.1054
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0038	0.2626
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0022	0.0017	0.0916
Brugia malayi	beta-lactamase	0.004	0.0038	0.1973
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0644
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0017	0.0779
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0051	0.3675
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0014	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0027	0.144
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0014	0.246
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0014	0.0224
Echinococcus granulosus	bloom syndrome protein	0.0024	0.002	0.0349
Plasmodium vivax	vivapain-2	0.0019	0.0014	0.2811
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.0004	0.0055
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0014	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0038	0.1973
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0076	0.0038
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0014	0.2336
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.1054
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0038	0.2626
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Loa Loa (eye worm)	6-phosphofructokinase	0.0123	0.0132	0.693
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0381
Onchocerca volvulus		0.0019	0.0014	0.2336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0004	0.0005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Trypanosoma cruzi	cruzipain precursor, putative	0.0072	0.0075	0.5647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.1054
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.0007	0.0258
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0644
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.001	0.0056
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0038	0.0721
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0017	0.0289
Leishmania major	cathepsin L-like protease	0.0072	0.0075	0.5385
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0022	0.0017	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0916
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0004	0.00000000071796
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.003	0.2073
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0014	0.0753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0007	0.0258
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0004	0.03
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0076	0.5476
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0038	0.1678
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.002	0.1062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0014	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0039	0.2067
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0038	0.2626
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0014	0.0104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Brugia malayi	regulator of G-protein signaling egl-10	0.0022	0.0017	0.0916
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0014	0.0104
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0014	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0014	0.0811
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0008	0.0568
Schistosoma mansoni	lamin	0.0031	0.0027	0.1225
Brugia malayi	PXA domain containing protein	0.0022	0.0017	0.0916
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.0132	1
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0022	0.0017	0.1054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0014	0.0223
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0014	0.0223
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.001	0.012
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0004	0.0177
Loa Loa (eye worm)	ctsf protein	0.0019	0.0014	0.0753
Brugia malayi	A-kinase anchor protein 10, precursor	0.0022	0.0017	0.0916
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0061	0.3195
Plasmodium vivax	vivapain-2	0.0019	0.0014	0.2811
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0014	0.0811
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0033	0.003	0.2073
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0014	0.0105
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.003	0.2073
Loa Loa (eye worm)	hypothetical protein	0.004	0.0038	0.1973
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0014	0.0753
Schistosoma mansoni	DNA helicase recq1	0.001	0.0004	0.0187
Brugia malayi	6-phosphofructokinase	0.0123	0.0132	0.693
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0076	0.0038
Trypanosoma cruzi	cysteine proteinase, putative	0.001	0.0004	0.03
Onchocerca volvulus		0.004	0.0038	1
Mycobacterium ulcerans	transcriptional regulator	0.8866	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0038	0.1973
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0644
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0075	0.5647
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0013	0.0007	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0015	0.0771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.0075	0.5513
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0014	0.0104
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0014	0.0757
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.0007	0.0324
Entamoeba histolytica	hypothetical protein	0.0022	0.0017	0.1054
Brugia malayi	6-phosphofructokinase	0.0123	0.0132	0.693
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0253	0.0278	0.0242
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0123	0.0132	0.0095
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0123	0.0132	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0014	0.0811
Echinococcus multilocularis	lamin dm0	0.0031	0.0027	0.0236
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0022	0.0017	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0757
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0076	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0038	0.1973
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.019	0.1875

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 50 um	PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1389841

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1282128