Detailed information for compound 1288788

Basic information

Technical information
  • TDR Targets ID: 1288788
  • Name: [2-(ethyl-phenylamino)-2-oxoethyl] 3-phenylpr opanoate
  • MW: 311.375 | Formula: C19H21NO3
  • H donors: 0 H acceptors: 2 LogP: 3.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccccc1)C(=O)COC(=O)CCc1ccccc1
  • InChi: 1S/C19H21NO3/c1-2-20(17-11-7-4-8-12-17)18(21)15-23-19(22)14-13-16-9-5-3-6-10-16/h3-12H,2,13-15H2,1H3
  • InChiKey: FUQTZPBGOIUYMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(ethyl-phenyl-amino)-2-oxo-ethyl] 3-phenylpropanoate
  • 3-phenylpropanoic acid [2-(ethyl-phenylamino)-2-oxoethyl] ester
  • 3-phenylpropionic acid [2-(ethyl-phenyl-amino)-2-keto-ethyl] ester
  • T0506-4982
  • ZINC03276145

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0147 0.0628
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0011 0.0011
Giardia lamblia Hypothetical protein 0.0101 0.0718 0.0616
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2787 0.2787
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0718 0.0616
Toxoplasma gondii exonuclease III APE 0.0021 0.0109 0.0108
Toxoplasma gondii hypothetical protein 0.0101 0.0718 0.0717
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0718 0.0616
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0217 0.0215
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0101 0.0718 1
Echinococcus granulosus protein phosphatase methylesterase 1 0.1216 0.9233 0.9233
Mycobacterium ulcerans hydrolase 0.0101 0.0718 0.2846
Onchocerca volvulus 0.004 0.0253 0.021
Echinococcus granulosus Smad4 0.0008 0.0011 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0253 0.0675
Schistosoma mansoni importin beta-1 0.0035 0.0217 0.0217
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0253 0.0253
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0001 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0253 0.0253
Brugia malayi MH1 domain containing protein 0.0008 0.0011 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0253 0.0252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0044 0.0044
Plasmodium falciparum importin beta, putative 0.0035 0.0217 1
Treponema pallidum carboxylesterase (est) 0.0101 0.0718 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0101 0.0718 0.2846
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0146 0.0038
Schistosoma mansoni coup transcription factor 0.0012 0.0044 0.0044
Mycobacterium leprae Probable lipase LipE 0.004 0.0253 0.1859
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0253 0.0252
Mycobacterium ulcerans hydrolase 0.0101 0.0718 0.2846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0044 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0253 0.0253
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0101 0.0718 0.0717
Onchocerca volvulus 0.004 0.0253 0.021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0044 0.0044
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0101 0.0718 0.343
Brugia malayi nuclear receptor NHR-88 0.0012 0.0044 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0109 0.0108
Toxoplasma gondii hypothetical protein 0.0101 0.0718 0.0717
Schistosoma mansoni ran 0.0026 0.0146 0.0146
Mycobacterium ulcerans oxidoreductase 0.0101 0.0718 0.2846
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Schistosoma mansoni ap endonuclease 0.0021 0.0109 0.0109
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0146 0.0145
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.0146
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0109 0.0108
Brugia malayi MH1 domain containing protein 0.0008 0.0011 0.0011
Giardia lamblia Hypothetical protein 0.0101 0.0718 0.0616
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.0217
Brugia malayi glutaminase DH11.1 0.0301 0.2249 0.2249
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0109 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0044 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0101 0.0718 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0011 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0147 0.0146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0044 0.0044
Brugia malayi hydrolase, alpha/beta fold family protein 0.0101 0.0718 0.0718
Mycobacterium tuberculosis Possible lipase LipV 0.0101 0.0718 0.343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0044 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0044 0.0044
Echinococcus multilocularis Smad4 0.0008 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0253 0.0813
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0109 0.0109
Mycobacterium ulcerans hypothetical protein 0.0101 0.0718 0.2846
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0044 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0044 0.0044
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0146 0.0146
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0217 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0044 0.0044
Schistosoma mansoni smad1 5 8 and 0.0008 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0044 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0044 0.0044
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0146 0.5756
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0616
Brugia malayi Importin beta-1 subunit 0.0035 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0092 0.065 0.065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.0253
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0166 0.0058
Mycobacterium tuberculosis Conserved protein 0.0101 0.0718 0.343
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0253 0.0252
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0166 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0028 0.0166 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.0253
Mycobacterium tuberculosis Probable epoxide hydrolase EphC (epoxide hydratase) 0.0101 0.0718 0.343
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0147 0.0179
Mycobacterium leprae Possible membrane protein 0.0101 0.0718 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0217 0.0217
Toxoplasma gondii hypothetical protein 0.0101 0.0718 0.0717
Brugia malayi ecdysteroid receptor 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0253 0.0813
Mycobacterium leprae conserved hypothetical protein 0.004 0.0253 0.1859
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0253 0.0146
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0011 0.0011
Echinococcus granulosus abhydrolase domain containing protein 8 0.0101 0.0718 0.0718
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0109 0.5017
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0835 0.0835
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0044 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Possible hydrolase 0.0101 0.0718 0.343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0044 0.0044
Mycobacterium leprae POSSIBLE HYDROLASE 0.0101 0.0718 1
Mycobacterium tuberculosis Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap) 0.0101 0.0718 0.343
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.0718 0.343
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0044 0.0044
Onchocerca volvulus 0.0092 0.065 0.0609
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0044 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0044 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Onchocerca volvulus Alpha\/beta hydrolase2 homolog 0.0101 0.0718 0.0677
Brugia malayi RNA, U transporter 1 0.0099 0.0706 0.0706
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0835 0.0835
Mycobacterium tuberculosis Possible lysophospholipase 0.0101 0.0718 0.343
Trichomonas vaginalis ran, putative 0.0026 0.0146 0.0145
Onchocerca volvulus 0.0101 0.0718 0.0677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0101 0.0718 0.0717
Echinococcus multilocularis snurportin 1 0.0372 0.2787 0.2787
Leishmania major hypothetical protein, conserved 0.0101 0.0718 0.0717
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0253 0.0253
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0044 0.0044
Schistosoma mansoni Smad4 0.0008 0.0011 0.0011
Echinococcus granulosus translational activator gcn1 0.0007 0.0001 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0253 0.0813
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.0146
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0011 0.0011
Giardia lamblia Hypothetical protein 0.0101 0.0718 0.0616
Entamoeba histolytica Ran family GTPase 0.0026 0.0146 0.8795
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0146 0.0038
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0217 0.0215
Mycobacterium tuberculosis Conserved protein 0.004 0.0253 0.0813
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0253 0.0813
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0147 0.0146
Echinococcus multilocularis protein phosphatase methylesterase 1 0.1216 0.9233 0.9233
Mycobacterium leprae Possible hydrolase 0.0101 0.0718 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0217 0.0217
Brugia malayi nuclear hormone receptor 0.0012 0.0044 0.0044
Echinococcus granulosus maspardin 0.0101 0.0718 0.0718
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Probable lipase/esterase LipG 0.0101 0.0718 0.343
Schistosoma mansoni ap endonuclease 0.0021 0.0109 0.0109
Mycobacterium ulcerans lipase LipD 0.004 0.0253 0.0675
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0146 0.0146
Mycobacterium tuberculosis Probable lignin peroxidase LipJ 0.0101 0.0718 0.343
Brugia malayi beta-lactamase family protein 0.004 0.0253 0.0253
Toxoplasma gondii ABC1 family protein 0.004 0.0253 0.0252
Mycobacterium ulcerans hypothetical protein 0.0101 0.0718 0.2846
Brugia malayi CCG1-interacting factor B 0.0101 0.0718 0.0718
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0147 0.0146
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0616
Trypanosoma brucei Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0717
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0101 0.0718 0.343
Onchocerca volvulus Valacyclovir hydrolase homolog 0.0101 0.0718 0.0677
Mycobacterium tuberculosis Probable epoxide hydrolase EphB (epoxide hydratase) 0.0101 0.0718 0.343
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0044 0.0044
Mycobacterium ulcerans hydrolase 0.0101 0.0718 0.2846
Leishmania major importin beta-1 subunit, putative 0.0028 0.0166 0.0165
Schistosoma mansoni hypothetical protein 0.0372 0.2787 0.2787
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0147 0.5
Mycobacterium ulcerans hypothetical protein 0.0101 0.0718 0.2846
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0253 0.0675
Loa Loa (eye worm) glutaminase 2 0.0301 0.2249 0.2249
Mycobacterium ulcerans epoxide hydrolase EphC 0.0101 0.0718 0.2846
Brugia malayi MH2 domain containing protein 0.0008 0.0011 0.0011
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.065 0.065
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0253 0.0813
Echinococcus granulosus snurportin 1 0.0372 0.2787 0.2787
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0166 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0044 0.0044
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0044 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0026 0.0147 0.8858
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0253 0.0252
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0717
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0044 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0253 0.0253
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0253 0.0813
Echinococcus multilocularis transportin 1 0.0007 0.0001 0.0001
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0044 0.0044
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0253 0.0253
Mycobacterium ulcerans hypothetical protein 0.004 0.0253 0.0675
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.0253
Echinococcus multilocularis maspardin 0.0101 0.0718 0.0718
Brugia malayi Smad1 0.0008 0.0011 0.0011
Echinococcus multilocularis abhydrolase domain containing protein 8 0.0101 0.0718 0.0718
Brugia malayi MH2 domain containing protein 0.0116 0.0835 0.0835
Mycobacterium tuberculosis Conserved protein 0.004 0.0253 0.0813
Leishmania major GTP-binding protein, putative 0.0026 0.0146 0.0145
Giardia lamblia ENC6 protein 0.0101 0.0718 0.0616
Mycobacterium tuberculosis Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) 0.0101 0.0718 0.343
Mycobacterium ulcerans lipase LipV 0.0101 0.0718 0.2846
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0101 0.0718 0.343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0044 0.0044
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0718 0.343
Echinococcus granulosus smad 0.0008 0.0011 0.0011
Trichomonas vaginalis glutaminase, putative 0.0301 0.2249 0.2248
Brugia malayi beta-lactamase 0.004 0.0253 0.0253
Mycobacterium ulcerans hypothetical protein 0.0101 0.0718 0.2846
Mycobacterium tuberculosis Conserved protein 0.0101 0.0718 0.343
Loa Loa (eye worm) beta-lactamase 0.004 0.0253 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0044 0.0044
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0147 0.0179
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0717
Plasmodium vivax importin-beta 2, putative 0.0035 0.0217 0.8535
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0253 0.0813
Schistosoma mansoni glutaminase 0.0301 0.2249 0.2249
Schistosoma mansoni smad1 5 8 and 0.0008 0.0011 0.0011
Mycobacterium ulcerans thioesterase 0.0101 0.0718 0.2846
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0044 0.0044
Mycobacterium ulcerans lysophospholipase 0.0101 0.0718 0.2846
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0044 0.0044
Echinococcus multilocularis translational activator gcn1 0.0007 0.0001 0.0001
Echinococcus multilocularis smad 0.0008 0.0011 0.0011
Onchocerca volvulus 0.004 0.0253 0.021
Leishmania major hypothetical protein, conserved 0.0101 0.0718 0.0717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.065 0.065
Brugia malayi beta-lactamase family protein 0.004 0.0253 0.0253
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0166 0.0165
Trichomonas vaginalis esterase, putative 0.004 0.0253 0.0252
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0616
Mycobacterium tuberculosis Possible hydrolase 0.0101 0.0718 0.343
Mycobacterium ulcerans glutaminase 0.0301 0.2249 1
Leishmania major hypothetical protein, conserved 0.004 0.0253 0.0252
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0147 0.0146
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0718 0.343
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0011 0.0011
Mycobacterium tuberculosis Unknown protein 0.0101 0.0718 0.343
Onchocerca volvulus 0.0101 0.0718 0.0677
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0044 0.0044
Schistosoma mansoni smad1 5 8 and 0.0008 0.0011 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0101 0.0718 0.343
Loa Loa (eye worm) glutaminase 0.0301 0.2249 0.2249
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0147 1
Echinococcus granulosus importin 5 0.0007 0.0001 0.0001
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.6744
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0101 0.0718 0.0717
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0044 0.0044
Brugia malayi MH2 domain containing protein 0.0008 0.0011 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0109 0.0109
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0146 0.0038
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0616
Loa Loa (eye worm) Smad1 0.0008 0.0011 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0109 0.6543
Mycobacterium ulcerans hydrolase 0.0101 0.0718 0.2846
Mycobacterium tuberculosis Unknown protein 0.0101 0.0718 0.343
Mycobacterium tuberculosis Unknown protein 0.0101 0.0718 0.343
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0253 0.0252
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.0253
Mycobacterium ulcerans hydrolase 0.0101 0.0718 0.2846
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0044 0.0044
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0101 0.0718 0.0717
Echinococcus multilocularis importin 5 0.0007 0.0001 0.0001
Echinococcus granulosus transportin 1 0.0007 0.0001 0.0001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0146 0.0145
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0253 0.0252
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1885 1
Brugia malayi kap beta 3 protein 0.0007 0.0001 0.0001
Schistosoma mansoni importin-beta 2 0.0007 0.0001 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0718 0.343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus multilocularis abhydrolase domain containing protein 13 0.0101 0.0718 0.0718
Mycobacterium leprae PROBABLE LIPASE/ESTERASE LIPG 0.0101 0.0718 1
Mycobacterium tuberculosis Possible hydrolase 0.0101 0.0718 0.343
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0044 0.0044
Brugia malayi steroid hormone receptor 0.0012 0.0044 0.0044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0109 0.0109
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.065 0.065
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0253 0.0146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0044 0.0044
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0109 0.4282
Plasmodium vivax hypothetical protein, conserved 0.004 0.0253 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0109 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0044 0.0044
Schistosoma mansoni smad 0.0008 0.0011 0.0011
Mycobacterium ulcerans beta-lactamase 0.004 0.0253 0.0675
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0147 0.6792
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0109 0.0108
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0011 0.0011
Schistosoma mansoni ran 0.0026 0.0146 0.0146
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0147 0.5797
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.0253
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0147 0.0215
Mycobacterium tuberculosis Conserved protein 0.004 0.0253 0.0813
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.0253
Loa Loa (eye worm) CCG1-interacting factor B 0.0101 0.0718 0.0718
Mycobacterium ulcerans hydrolase 0.0101 0.0718 0.2846

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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