Detailed information for compound 1292446

Basic information

Technical information
  • TDR Targets ID: 1292446
  • Name: 5-phenyl-3-[3,4,5-trihydroxy-6-(hydroxymethyl )oxan-2-yl]oxypentanoic acid
  • MW: 356.368 | Formula: C17H24O8
  • H donors: 5 H acceptors: 6 LogP: -0.18 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(OC(CC(=O)O)CCc2ccccc2)C(C(C1O)O)O
  • InChi: 1S/C17H24O8/c18-9-12-14(21)15(22)16(23)17(25-12)24-11(8-13(19)20)7-6-10-4-2-1-3-5-10/h1-5,11-12,14-18,21-23H,6-9H2,(H,19,20)
  • InChiKey: HRYIDVZLDQBLFF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-phenyl-3-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-pentanoic acid
  • 5-phenyl-3-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]pentanoic acid
  • 5-phenyl-3-(3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl)oxy-valeric acid
  • 5-phenyl-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-pentanoic acid
  • ACon0_001487
  • ACon1_001072
  • MLS000877001
  • SMR000440688
  • MEGxp0_001073

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens caspase 6, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Brugia malayi Cell death protein 3 precursor caspase 6, apoptosis-related cysteine peptidase 293 aa 270 aa 34.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0322 0.9051
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0126
Giardia lamblia Sgs1 DNA helicase, putative 0.0047 0.0037 0.0867
Echinococcus granulosus snurportin 1 0.0372 0.0674 0.2216
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.0131 0.1902
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0041 0.0114
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0008 0.0236
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.0134 0.2251
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0014 0.0024
Loa Loa (eye worm) glutaminase 2 0.033 0.0593 0.0739
Echinococcus granulosus chromobox protein 1 0.0084 0.011 0.0343
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0047 0.0037 0.003
Onchocerca volvulus Alhambra homolog 0.0035 0.0014 0.0021
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0014 0.0022
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0141 0.0446
Plasmodium falciparum metacaspase-like protein 0.0032 0.0008 0.0035
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0071 0.0064
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.011 0.013
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0014 0.0392
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0134 0.1943
Loa Loa (eye worm) RecQ helicase 0.0079 0.01 0.0117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0045 0.0122
Echinococcus multilocularis caspase 8 0.0032 0.0008 0.0004
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0007 0.0202
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.0087 0.1302
Loa Loa (eye worm) hypothetical protein 0.01 0.0141 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0047 0.0617
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.0661 1
Brugia malayi Bromodomain containing protein 0.0035 0.0014 0.0007
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.0348 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0007 0.0095
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.0348 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Echinococcus multilocularis snurportin 1 0.0372 0.0674 0.2216
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0348 0.0438
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0011 0.0171
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.0131 0.0124
Schistosoma mansoni hypothetical protein 0.01 0.0141 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0038 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0134 0.202
Echinococcus granulosus chromobox protein 1 0.0084 0.011 0.0343
Brugia malayi PHD-finger family protein 0.0035 0.0014 0.0007
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0093 0.132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.0008
Brugia malayi glutaminase DH11.1 0.033 0.0593 0.0586
Schistosoma mansoni hypothetical protein 0.01 0.0141 0.0177
Toxoplasma gondii hypothetical protein 0.0059 0.0061 0.1743
Trypanosoma brucei Metacaspase-4 0.0032 0.0008 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0048 0.0622
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0071 0.0213
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0141 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0038 0.0627
Plasmodium falciparum phd finger protein, putative 0.0035 0.0014 0.0216
Echinococcus granulosus Cyclin dependent kinase 2 associated protein 0.1567 0.3018 1
Trypanosoma brucei unspecified product 0.0088 0.0118 0.1704
Onchocerca volvulus Diphthamide biosynthesis protein 7 homolog 0.1567 0.3018 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0071 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0046 0.0685
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0008 0.0001
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0032 0.0008 0.0004
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0141 0.0446
Plasmodium falciparum metacaspase 1 0.0032 0.0008 0.0035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.004 0.1152
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0047 0.0037 0.0098
Echinococcus granulosus peregrin 0.0035 0.0014 0.0024
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0047 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0372 0.0674 0.0849
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0141 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0011 0.0171
Loa Loa (eye worm) hypothetical protein 0.006 0.0064 0.0072
Trypanosoma cruzi metacaspase, putative 0.0032 0.0008 0.0113
Brugia malayi chromobox protein homolog 3 0.0047 0.0038 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0014
Trichomonas vaginalis glutaminase, putative 0.033 0.0593 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0134 0.202
Echinococcus granulosus caspase 8 0.0032 0.0008 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Mycobacterium ulcerans hypothetical protein 0.0192 0.0322 0.41
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0045 0.1283
Brugia malayi Phosphoglycerate kinase 0.0206 0.0348 0.0342
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.005 0.0742
Echinococcus granulosus dna polymerase eta 0.0095 0.0131 0.0413
Schistosoma mansoni importin beta-1 0.0035 0.0014 0.0016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0171 0.0546
Schistosoma mansoni chromobox protein 0.0084 0.011 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Echinococcus multilocularis Cyclin dependent kinase 2 associated protein 0.1567 0.3018 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0007 0.0095
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0008 0.0113
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0038 0.0098
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.0348 0.4674
Echinococcus multilocularis peregrin 0.0035 0.0014 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0126
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0141 0.0446
Trypanosoma brucei metacaspase MCA2 0.0032 0.0008 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0014 0.0414
Echinococcus granulosus caspase 0.0032 0.0008 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.0118 0.1704
Brugia malayi Importin beta-1 subunit 0.0035 0.0014 0.0007
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0093 0.1403
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0093 0.1403
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0007 0.0181
Trichomonas vaginalis chromobox protein, putative 0.0084 0.011 0.1852
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Trypanosoma cruzi metacaspase, putative 0.0032 0.0008 0.0113
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0141 0.0135
Giardia lamblia PHD finger protein 15 0.0035 0.0014 0.0216
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0134 0.1943
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0125 0.0156
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0348 0.0438
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0284 0.4291
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0348 0.5873
Trypanosoma brucei unspecified product 0.0044 0.0032 0.0383
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0348 0.5223
Echinococcus multilocularis dna polymerase eta 0.0095 0.0131 0.0413
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0037
Plasmodium vivax importin-beta 2, putative 0.0035 0.0014 0.0194
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0014 0.0009
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0008 0.0009
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0049 0.0042 0.1021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0046 0.0685
Schistosoma mansoni DNA polymerase eta 0.0095 0.0131 0.0164
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.0348 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0661 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0284 0.4291
Schistosoma mansoni hypothetical protein 0.01 0.0141 0.0177
Echinococcus multilocularis chromobox protein 1 0.0084 0.011 0.0343
Trichomonas vaginalis DNA helicase recq, putative 0.0079 0.01 0.1671
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.0348 1
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0029 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Schistosoma mansoni caspase-3 (C14 family) 0.0032 0.0008 0.0009
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0072 0.0087 0.2332
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0093 0.1403
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0047 0.0037 0.0098
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0014 0.0024
Trypanosoma cruzi metacaspase, putative 0.0032 0.0008 0.0113
Loa Loa (eye worm) hypothetical protein 0.0047 0.0038 0.0039
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0047 0.0037 0.1051
Echinococcus multilocularis dna polymerase kappa 0.0096 0.0134 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.4073 0.7932 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.0134 0.2251
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0017
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0007 0.0106
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.4073 0.7932 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0071 0.2022
Brugia malayi Cell death protein 3 precursor 0.0032 0.0008 0.0001
Trichomonas vaginalis DNA helicase recq, putative 0.0053 0.005 0.0827
Giardia lamblia DINP protein human, muc B family 0.0072 0.0087 0.2333
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.005 0.0652
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0046 0.0685
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0032 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0087 0.1218
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0029 0.0028
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0053 0.005 0.0742
Entamoeba histolytica recQ family helicase, putative 0.0053 0.005 0.1407
Schistosoma mansoni glutaminase 0.033 0.0593 0.0746
Brugia malayi jmjC domain containing protein 0.0115 0.0171 0.0165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0134 0.202
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0014 0.0414
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0348 0.5269
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0048 0.0622
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0008 0.0236
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0093 0.132
Leishmania major DNA polymerase eta, putative 0.0051 0.0045 0.0666
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0047 0.0037 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0126
Schistosoma mansoni DNA helicase recq1 0.0047 0.0037 0.0045
Brugia malayi jmjC domain containing protein 0.0043 0.0029 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0047 0.0037 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0661 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0071 0.0088
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.0087 0.0563
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0014 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0134 0.202
Trichomonas vaginalis DNA helicase recq1, putative 0.0079 0.01 0.1671
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0088 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0126
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.0348 0.5269
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0674 0.0842
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Echinococcus multilocularis bloom syndrome protein 0.0079 0.01 0.0308
Loa Loa (eye worm) hypothetical protein 0.0179 0.0296 0.0364
Giardia lamblia Phosphoglycerate kinase 0.0206 0.0348 1
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.0348 0.5269
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.0009
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0047 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0047 0.0617
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0068 0.1018
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0141 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0206 0.0348 0.0431
Trypanosoma brucei metacaspase MCA3 0.0032 0.0008 0.0018
Schistosoma mansoni deleted in oral cancer 1/cdk2-associated protein-like 0.1567 0.3018 0.3804
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0048 0.0622
Trichomonas vaginalis chromobox protein, putative 0.0084 0.011 0.1852
Schistosoma mansoni chromobox protein 0.0084 0.011 0.0138
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0858
Brugia malayi Bloom's syndrome protein homolog 0.0079 0.01 0.0093
Echinococcus granulosus dna polymerase kappa 0.0096 0.0134 0.0422
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0071 0.0088
Treponema pallidum phosphoglycerate kinase 0.0206 0.0348 0.5
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0008 0.0113
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.0348 1
Leishmania major metacaspase, putative 0.0032 0.0008 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0029 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0008 0.0035
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Brugia malayi hypothetical protein 0.0043 0.0031 0.0024
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0008 0.0009
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0858
Echinococcus multilocularis caspase 2 0.0032 0.0008 0.0004
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0858
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0093 0.1403
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.0348 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.0008 0.0113
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0348 0.5269
Trypanosoma brucei metacaspase 0.0032 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0001
Leishmania major DNA polymerase kappa, putative 0.0072 0.0087 0.1302
Entamoeba histolytica hypothetical protein 0.0043 0.0031 0.0858
Loa Loa (eye worm) hypothetical protein 0.0095 0.0131 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0045 0.0746
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0284 0.4236
Mycobacterium ulcerans glutaminase 0.033 0.0593 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0029 0.0035
Plasmodium falciparum importin beta, putative 0.0035 0.0014 0.0194
Brugia malayi Phosphoglycerate kinase 0.0075 0.0093 0.0086
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0045 0.0666
Echinococcus multilocularis caspase 0.0032 0.0008 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0031 0.0078
Trypanosoma brucei unspecified product 0.0044 0.0032 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Plasmodium vivax metacaspase 1, putative 0.0032 0.0008 0.0035
Brugia malayi RNA, U transporter 1 0.0099 0.014 0.0133
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.0348 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0171 0.0546
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0014 0.0101
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0047 0.0037 0.1051
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.0661 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0014 0.0101
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0093 0.1403
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0126
Schistosoma mansoni blooms syndrome DNA helicase 0.0055 0.0053 0.0066
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0029 0.0073
Echinococcus granulosus importin subunit beta 1 0.0035 0.0014 0.0022
Onchocerca volvulus 0.0037 0.0018 0.0032
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.0348 0.5
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0071 0.0213
Echinococcus granulosus caspase 2 0.0032 0.0008 0.0004
Brugia malayi Protein kinase domain containing protein 0.4073 0.7932 0.793
Loa Loa (eye worm) hypothetical protein 0.1567 0.3018 0.38
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0047 0.0037 0.0098
Echinococcus granulosus bloom syndrome protein 0.0079 0.01 0.0308
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0008 0.0126
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.0348 0.1134
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0131 0.198
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.0348 0.1134
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0348 0.5873
Loa Loa (eye worm) glutaminase 0.033 0.0593 0.0739
Echinococcus multilocularis chromobox protein 1 0.0084 0.011 0.0343
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0348 0.5223
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0008 0.0236
Leishmania major DNA polymerase eta, putative 0.0095 0.0131 0.198
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0047 0.0037 0.0098
Schistosoma mansoni apoptosis regulator bax 0.01 0.0141 0.0177
Schistosoma mansoni DNA helicase recq5 0.0047 0.0037 0.0045
Brugia malayi polk-prov protein 0.0052 0.0047 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0093 0.1403
Brugia malayi Heterochromatin protein 1 0.0084 0.011 0.0103
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0008 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0134 0.1943
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0041 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0045 0.0746
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0046 0.0595
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.0348 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0126

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 0.283 uM PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 30.93 uM PubChem BioAssay. Caspase 7 Counterscreen for Selectivity Fluorescent Measured in Cell-Based System Using Plate Reader - 7052-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 33.7 uM PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2805, AID2817] ChEMBL. No reference
EC50 (functional) = 57.6 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2805, AID2817] ChEMBL. No reference
EC50 (functional) = 59.2 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2805, AID2817] ChEMBL. No reference
EC50 (functional) = 73 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2805, AID2817] ChEMBL. No reference
IC50 (functional) = 1.606105247 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
IC50 (binding) = 23.645 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2014, AID2028, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
IC50 (functional) = 50.23 uM PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 57.57 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (binding) = 69.43 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2012, AID2030, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
IC50 (functional) > 94.115 uM PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3548 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 1.0312 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5237 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7096 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 26.8545 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 53.0367 um PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Human Galactosidase (GALK). (Class of assay: confirmatory) [Related pubchem assays: 1868, 1379 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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