TDR Targets

Basic information

Technical information

TDR Targets ID: 1292839
Name: 1-[4-[[2-[(4-chlorophenyl)methyl]-5-methyl-[1 ,2,4]triazolo[5,1-b]pyrimidin-7-yl]amino]phen yl]ethanone
MW: 391.854 | Formula: C21H18ClN5O
H donors: 1 H acceptors: 4 LogP: 4.64 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Cc1nc2n(n1)c(Nc1ccc(cc1)C(=O)C)cc(n2)C
InChi: 1S/C21H18ClN5O/c1-13-11-20(24-18-9-5-16(6-10-18)14(2)28)27-21(23-13)25-19(26-27)12-15-3-7-17(22)8-4-15/h3-11,24H,12H2,1-2H3
InChiKey: KJMWNRGVQGBVLK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-[[2-(4-chlorobenzyl)-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-yl]amino]phenyl]ethanone
D245-0609
NCGC00117633-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed), beta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma congolense	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Trypanosoma brucei	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania mexicana	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania donovani	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei gambiense	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	polymerase (DNA directed), beta	335 aa	303 aa	32.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0156	0.1391
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0038	0.0355
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.0998	1
Echinococcus granulosus	dynactin 5 p25	0.0072	0.0142	0.1262
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0054	0.0476
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0069	0.0637
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0118	0.0278	0.247
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0156	0.1448
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0038	0.0341
Onchocerca volvulus		0.0069	0.0134	0.1527
Treponema pallidum	replicative DNA helicase (dnaB)	0.0393	0.1081	1
Echinococcus granulosus	phd:f box containing protein	0.0025	0.0005	0.0047
Plasmodium falciparum	SUMO-conjugating enzyme UBC9	0.0025	0.0007	0.0122
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0051	0.0083	0.078
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0156	0.2043
Toxoplasma gondii	hexokinase	0.0081	0.017	0.6029
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0278	0.152
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0069	0.0613
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0053	0.0089	0.0791
Trypanosoma brucei	hexokinase	0.0081	0.017	0.1655
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0034	0.0306
Echinococcus granulosus	JmjC domain containing protein 4	0.0025	0.0005	0.0047
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0038	0.1211
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0032	0.0027	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0047	0.0563
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.0256	0.3388
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0154	0.0383	0.3404
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0156	0.1448
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0998	1
Leishmania major	hexokinase, putative	0.0081	0.017	0.1655
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0494	0.3804
Trypanosoma brucei	hexokinase	0.0081	0.017	0.1655
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0054	0.0476
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0032	0.0027	0.0242
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.0998	1
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.0256	0.2368
Brugia malayi	ube2i2 protein	0.0025	0.0007	0.0027
Loa Loa (eye worm)	phosphofructokinase	0.0111	0.0256	0.3388
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0045	0.0063	0.0583
Brugia malayi	Hexokinase family protein	0.0025	0.0006	0.0012
Mycobacterium leprae	RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN].	0.011	0.0254	0.0376
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.0256	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0156	0.1391
Loa Loa (eye worm)	hexokinase	0.0081	0.017	0.2221
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0032	0.0027	0.0242
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0437	0.4349
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0069	0.0859
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0049	0.0076	0.0705
Echinococcus multilocularis	JmjC domain containing protein 4	0.0025	0.0005	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0043	0.006	0.0735
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.011	0.0981
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.002	0.0909
Schistosoma mansoni	protein phosphatase 2C	0.0025	0.0005	0.0049
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0095	0.021	0.1941
Loa Loa (eye worm)	hexokinase type II	0.0081	0.017	0.2221
Treponema pallidum	recombinase A	0.011	0.0254	0.22
Trypanosoma cruzi	DNA repair protein, putative	0.0034	0.0032	0.0266
Toxoplasma gondii	hypothetical protein	0.0059	0.0105	0.3652
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0049	0.0076	0.0678
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.003	0.002	1
Echinococcus multilocularis	hexokinase	0.0081	0.017	0.1508
Echinococcus multilocularis	hexokinase	0.0081	0.017	0.1508
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0089	0.0823
Loa Loa (eye worm)	hexokinase	0.0051	0.0081	0.1029
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.002	0.0909
Toxoplasma gondii	6-phosphofructokinase	0.003	0.002	0.0548
Echinococcus granulosus	hexokinase	0.0081	0.017	0.1508
Brugia malayi	Bromodomain containing protein	0.0032	0.0027	0.0288
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.0256	0.3388
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0032	0.0027	0.0221
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0116	0.111
Entamoeba histolytica	acetyltransferase, putative	0.0072	0.0142	0.5414
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0083	0.078
Brugia malayi	Bromodomain containing protein	0.0039	0.0047	0.0561
Mycobacterium ulcerans	6-phosphofructokinase	0.0111	0.0256	0.1288
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.002	0.0909
Plasmodium vivax	hypothetical protein, conserved	0.003	0.002	0.087
Echinococcus granulosus	6 phosphofructokinase	0.0111	0.0256	0.2275
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0256	0.3265
Schistosoma mansoni	glutaminase	0.0278	0.0745	0.6893
Loa Loa (eye worm)	ube2i2 protein	0.0025	0.0007	0.0027
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0049	0.0076	0.4315
Mycobacterium tuberculosis	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].	0.3163	0.9173	0.9161
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.002	0.017
Plasmodium vivax	SUMO-conjugating enzyme UBC9, putative	0.0025	0.0007	0.0122
Loa Loa (eye worm)	glutaminase 2	0.0278	0.0745	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0156	0.1448
Brugia malayi	PHD-finger family protein	0.003	0.002	0.0193
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0156	0.2043
Echinococcus granulosus	hexokinase	0.0081	0.017	0.1508
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0118	0.0278	0.2744
Loa Loa (eye worm)	jmjC domain-containing protein	0.0095	0.021	0.2765
Leishmania major	ubiquitin-activating enzyme-like protein	0.0032	0.0027	0.0221
Brugia malayi	jmjC domain containing protein	0.0095	0.021	0.2765
Plasmodium falciparum	phd finger protein, putative	0.003	0.002	0.087
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0111	0.0256	0.0116
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0027	0.0011	0.0098
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0156	0.1448
Brugia malayi	ThiF family protein	0.0049	0.0076	0.0958
Plasmodium falciparum	SUMO-activating enzyme subunit 2	0.0032	0.0027	0.1334
Loa Loa (eye worm)	hypothetical protein	0.003	0.002	0.0193
Trichomonas vaginalis	maltose O-acetyltransferase, putative	0.0069	0.0134	0.1663
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0156	0.2043
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.003	0.002	0.052
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0069	0.0859
Onchocerca volvulus		0.0051	0.0081	0.0826
Brugia malayi	TAR-binding protein	0.0076	0.0156	0.2043
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0156	0.1448
Toxoplasma gondii	phosphofructokinase PFKII	0.003	0.002	0.0548
Onchocerca volvulus		0.0036	0.0038	0.025
Onchocerca volvulus		0.0081	0.017	0.2003
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.0256	0.2523
Leishmania major	ATP-dependent phosphofructokinase	0.0111	0.0256	0.2523
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0069	0.0637
Schistosoma mansoni	hexokinase	0.0081	0.017	0.1569
Plasmodium vivax	hexokinase, putative	0.0081	0.017	1
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0025	0.0005	0.0049
Trichomonas vaginalis	glutaminase, putative	0.0278	0.0745	0.9691
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0256	0.3265
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0126	0.1629
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.011	0.0981
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0032	0.0027	0.0221
Chlamydia trachomatis	replicative DNA helicase	0.0393	0.1081	1
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0028	0.0014	0.0088
Brugia malayi	glutaminase DH11.1	0.0278	0.0745	1
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.0256	0.2368
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.002	0.0182
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0049	0.0076	0.0678
Toxoplasma gondii	hypothetical protein	0.0049	0.0076	0.2601
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.0667	0.8947
Trypanosoma cruzi	DNA repair protein, putative	0.0034	0.0032	0.0266
Trypanosoma cruzi	hexokinase, putative	0.0081	0.017	0.1655
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.002	0.0175
Brugia malayi	ThiF family protein	0.0032	0.0027	0.0296
Plasmodium vivax	SET domain protein, putative	0.0036	0.0038	0.2008
Treponema pallidum	hexokinase (hxk)	0.0081	0.017	0.1408
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.002	0.017
Echinococcus multilocularis	hexokinase	0.0081	0.017	0.1508
Loa Loa (eye worm)	ThiF family protein	0.0032	0.0027	0.0296
Trypanosoma brucei	hexokinase, putative	0.0081	0.017	0.1655
Brugia malayi	Bromodomain containing protein	0.0076	0.0156	0.2034
Onchocerca volvulus	Hexokinase homolog	0.0051	0.0081	0.0826
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0089	0.0823
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.0256	1
Entamoeba histolytica	hexokinase 2	0.0081	0.017	0.6529
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.003	0.002	0.0548
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0095	0.021	0.1941
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0494	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0089	0.1131
Toxoplasma gondii	ThiF family protein	0.0032	0.0027	0.0804
Echinococcus multilocularis	phd:f box containing protein	0.0025	0.0005	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.004
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.004	0.0354
Mycobacterium ulcerans	recombinase A	0.011	0.0254	0.1263
Brugia malayi	Hexokinase family protein	0.0051	0.0081	0.1029
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.002	0.017
Entamoeba histolytica	ankyrin, putative	0.0072	0.0142	0.5414
Entamoeba histolytica	hexokinase 1	0.0081	0.017	0.6529
Echinococcus multilocularis	jumonji domain containing 1A	0.0025	0.0005	0.0047
Echinococcus granulosus	hexokinase	0.0081	0.017	0.1508
Trypanosoma cruzi	hexokinase, putative	0.0081	0.017	0.1655
Echinococcus granulosus	histone lysine methyltransferase setb	0.0053	0.0089	0.0791
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0112	0.144
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0998	1
Trypanosoma brucei	recA bacterial DNA recombination protein, putative	0.0034	0.0032	0.0266
Brugia malayi	hexokinase	0.0081	0.017	0.2221
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.0278	0.2571
Wolbachia endosymbiont of Brugia malayi	recombinase A	0.011	0.0254	0.1189
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0134	0.1663
Schistosoma mansoni	ubiquitin-conjugating enzyme E2 I	0.0025	0.0007	0.0068
Loa Loa (eye worm)	hypothetical protein	0.006	0.0107	0.1381
Brugia malayi	Pre-SET motif family protein	0.0036	0.0038	0.0446
Echinococcus multilocularis	ubiquitin conjugating enzyme e2 i	0.0025	0.0007	0.0065
Toxoplasma gondii	aldehyde dehydrogenase	0.0118	0.0278	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0093	0.0204	0.1815
Loa Loa (eye worm)	hexokinase	0.0081	0.017	0.2221
Echinococcus multilocularis	hexokinase type 2	0.0081	0.017	0.1508
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0083	0.078
Onchocerca volvulus		0.0286	0.0769	1
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0032	0.0027	0.0252
Schistosoma mansoni	hypothetical protein	0.003	0.002	0.0182
Schistosoma mansoni	Replicative DNA helicase	0.0393	0.1081	1
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.002	0.017
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.004	0.0354
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0111	0.0256	0.0383
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.002	0.0525
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0025	0.0007	0.002
Brugia malayi	jmjC domain containing protein	0.0154	0.0383	0.5105
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0107	0.0994
Echinococcus granulosus	ubiquitin conjugating enzyme e2 i	0.0025	0.0007	0.0065
Onchocerca volvulus		0.0081	0.017	0.2003
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.0256	1
Chlamydia trachomatis	recombinase RecA	0.011	0.0254	0.22
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.004
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0027	0.0011	0.0098
Mycobacterium ulcerans	replicative DNA helicase DnaB	0.0393	0.1081	1
Schistosoma mansoni	phd/f-box containing protein	0.0025	0.0005	0.0049
Onchocerca volvulus		0.006	0.0107	0.1173
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0156	0.2043
Echinococcus multilocularis	6 phosphofructokinase	0.0111	0.0256	0.2275
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0111	0.0256	0.2222
Brugia malayi	6-phosphofructokinase	0.0111	0.0256	0.3388
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0256	0.3265
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.0256	0.3265
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0069	0.0613
Mycobacterium ulcerans	glutaminase	0.0278	0.0745	0.6453
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.002	0.0909
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0083	0.078
Brugia malayi	6-phosphofructokinase	0.0111	0.0256	0.3388
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.0278	0.2571
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.0256	0.2523
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0118	0.0278	0.247
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0094	0.1204
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.002	0.0525
Loa Loa (eye worm)	glutaminase	0.0278	0.0745	1
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.002	0.017
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0437	0.4349
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0658
Leishmania major	hexokinase, putative	0.0081	0.017	0.1655
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0038	0.0355
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.002	0.017
Echinococcus granulosus	lysine specific demethylase 6a	0.0025	0.0005	0.0047
Brugia malayi	Hexokinase family protein	0.0081	0.017	0.2221
Schistosoma mansoni	jumonji domain containing protein	0.0134	0.0325	0.3004
Trypanosoma brucei	ubiquitin-conjugating enzyme E2, putative	0.0025	0.0007	0.002
Wolbachia endosymbiont of Brugia malayi	replicative DNA helicase	0.0393	0.1081	1
Schistosoma mansoni	phosphatidylserine receptor	0.0025	0.0005	0.0049
Mycobacterium leprae	Conserved hypothetical protein	0.1159	0.3318	1
Echinococcus granulosus	tumor protein p63	0.0408	0.1125	1
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0025	0.0007	0.002
Brugia malayi	phosphofructokinase	0.0111	0.0256	0.3388
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.002	0.0175
Schistosoma mansoni	bromodomain containing protein	0.0064	0.0121	0.1119
Echinococcus multilocularis	lysine specific demethylase 6a	0.0025	0.0005	0.0047
Onchocerca volvulus		0.0081	0.017	0.2003
Mycobacterium leprae	PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase	0.0393	0.1081	0.2975
Echinococcus granulosus	jumonji domain containing 1A	0.0025	0.0005	0.0047
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.0769	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0069	0.0613
Echinococcus multilocularis	tumor protein p63	0.0408	0.1125	1
Loa Loa (eye worm)	twinkle helicase	0.0112	0.0261	0.3456
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0278	0.152
Echinococcus granulosus	hexokinase type 2	0.0081	0.017	0.1508
Giardia lamblia	PHD finger protein 15	0.003	0.002	0.9513
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0049	0.0076	0.4315
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0154	0.0383	0.3404
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0885	0.2519	0.2411
Brugia malayi	Pre-SET motif family protein	0.0251	0.0667	0.8947
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0278	0.152
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0118	0.0278	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0076	0.0958
Plasmodium falciparum	hexokinase	0.0081	0.017	1
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0025	0.0007	0.0073
Echinococcus granulosus	lysine specific demethylase 5A	0.0095	0.021	0.1865
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0025	0.0007	0.002
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0437	0.4349
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0069	0.0613
Brugia malayi	hexokinase type II	0.0026	0.0008	0.004
Schistosoma mansoni	jumonji domain containing protein	0.0025	0.0005	0.0049
Echinococcus multilocularis	peregrin	0.0032	0.0027	0.0237
Echinococcus granulosus	peregrin	0.0032	0.0027	0.0237
Loa Loa (eye worm)	hexokinase	0.0025	0.0006	0.0012
Trichomonas vaginalis	6-phosphofructokinase, putative	0.003	0.002	0.017
Brugia malayi	PHD-finger family protein	0.0025	0.0007	0.0023
Brugia malayi	RNA binding protein	0.0076	0.0156	0.2043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0069	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0143	0.1863
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.002	0.0193

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2512 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference
Potency (binding)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1406424

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1292839