Detailed information for compound 1293690

Basic information

Technical information
  • TDR Targets ID: 1293690
  • Name: (E)-3-(3,4-dimethoxyphenyl)-N-(11-oxo-6,7,8,9 -tetrahydropyrido[2,1-b]quinazolin-2-yl)prop- 2-enamide
  • MW: 405.446 | Formula: C23H23N3O4
  • H donors: 1 H acceptors: 2 LogP: 2.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/C(=O)Nc2ccc3c(c2)c(=O)n2c(n3)CCCC2)ccc1OC
  • InChi: 1S/C23H23N3O4/c1-29-19-10-6-15(13-20(19)30-2)7-11-22(27)24-16-8-9-18-17(14-16)23(28)26-12-4-3-5-21(26)25-18/h6-11,13-14H,3-5,12H2,1-2H3,(H,24,27)/b11-7+
  • InChiKey: OEKHNMVQPIAKLS-YRNVUSSQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(3,4-dimethoxyphenyl)-N-(11-keto-6,7,8,9-tetrahydropyrido[2,1-b]quinazolin-2-yl)acrylamide
  • SMR000310017
  • (2E)-3-(3,4-dimethoxyphenyl)-N-(11-oxo-6,8,9,11-tetrahydro-7H-pyrido[2,1-b]quinazolin-2-yl)acrylamide
  • MLS000660498

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0074 0.0252 0.0252
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Loa Loa (eye worm) hypothetical protein 0.0028 0.0045 0.0196
Schistosoma mansoni protein kinase 0.0161 0.0646 0.1751
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0132 0.0514 0.224
Brugia malayi beta-lactamase family protein 0.0043 0.0115 0.0501
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0074 0.0252 0.0684
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.008 0.1522
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0117 0.0448 0.7421
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3687 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0631 0.275
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0184 0.0749 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0773 0.2097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.02
Echinococcus granulosus glycyl tRNA synthetase 0.003 0.0052 0.0141
Echinococcus multilocularis transient receptor potential ion channel A 0.0294 0.1246 0.3379
Loa Loa (eye worm) hypothetical protein 0.0103 0.0383 0.1671
Trypanosoma cruzi sugar transporter, putative 0.0074 0.0252 0.3367
Echinococcus granulosus Sugar transporter ERD6 protein 0.0074 0.0252 0.0684
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0001 0.0001
Schistosoma mansoni pyruvate kinase 0.0036 0.008 0.0216
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0115 0.0978
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0134
Echinococcus multilocularis lysine specific demethylase 5A 0.0106 0.0397 0.1078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0132 0.0514 0.1393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0416 0.1801 0.785
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0117 0.0448 0.6932
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0035 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0115 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Brugia malayi major facilitator superfamily protein 0.0074 0.0252 0.11
Schistosoma mansoni transient receptor potential channel 0.0304 0.1292 0.3503
Schistosoma mansoni sugar transporter 0.0074 0.0252 0.0684
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0525 0.2294 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0001 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.001 0.0086
Schistosoma mansoni hypothetical protein 0.0132 0.0514 0.1393
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0276 0.3686
Schistosoma mansoni glycyl-tRNA synthetase 0.003 0.0052 0.0141
Brugia malayi major facilitator superfamily protein 0.0074 0.0252 0.11
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0036 0.0484
Mycobacterium ulcerans hypothetical protein 0.0043 0.0115 0.1774
Trichomonas vaginalis sugar transporter, putative 0.0163 0.0655 0.2824
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0115 0.0459
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.003 0.0052 0.0692
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0026 0.0036 0.0484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Echinococcus granulosus transient receptor potential ion channel A 0.0294 0.1246 0.3379
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Toxoplasma gondii hypothetical protein 0.0033 0.0065 0.0099
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0035 0.0096
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0598 0.5091
Trypanosoma brucei glucose transporter 2A 0.0163 0.0655 0.8744
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0026 0.0036 0.0484
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0115 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Brugia malayi Sugar transporter family protein 0.0074 0.0252 0.11
Brugia malayi hypothetical protein 0.0074 0.0252 0.11
Giardia lamblia Sugar-proton symporter 0.0074 0.0252 0.1597
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0184 0.0749 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0135
Leishmania major glucose transporter, lmgt1 0.0163 0.0655 0.8744
Chlamydia trachomatis proline--tRNA ligase 0.0056 0.017 0.2151
Echinococcus multilocularis lamin 0.0058 0.0181 0.049
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Loa Loa (eye worm) pyruvate kinase 0.0036 0.008 0.0347
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0188 0.0818
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0065 0.0065
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0598 0.9954
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0046 0.02
Entamoeba histolytica hypothetical protein 0.0041 0.0104 0.0604
Mycobacterium ulcerans hypothetical protein 0.0026 0.0036 0.0444
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0046 0.0125
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0773 0.2097
Echinococcus multilocularis peregrin 0.0029 0.0049 0.0132
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.001 0.0044
Echinococcus granulosus solute carrier family 22 0.0074 0.0252 0.0684
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0115 0.0501
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.0773 0.3371
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.0389 0.2425
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0049 0.0049
Echinococcus granulosus General substrate transporter 0.0451 0.196 0.5315
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Plasmodium vivax proline--tRNA ligase, putative 0.0184 0.0749 0.0749
Chlamydia trachomatis thioredoxin reductase 0.0151 0.0601 1
Echinococcus multilocularis General substrate transporter 0.0451 0.196 0.5315
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0161 0.0646 0.0974
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.01 0.0368 0.5587
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.001 0.0027
Treponema pallidum prolyl-tRNA synthetase 0.0056 0.017 0.0939
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0151 0.0601 0.9494
Schistosoma mansoni pyruvate kinase 0.0018 0.0001 0.0003
Onchocerca volvulus 0.0043 0.0115 0.3252
Echinococcus granulosus Threonyl tRNA synthetase C 0.003 0.0052 0.0141
Leishmania major pyruvate kinase 0.0036 0.008 0.1063
Echinococcus granulosus tumor protein p63 0.0337 0.1442 0.391
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0849 0.3757 0.5666
Leishmania major DNA polymerase eta, putative 0.002 0.001 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0252 0.106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.008 0.0347
Entamoeba histolytica hypothetical protein 0.0041 0.0104 0.0604
Leishmania major DNA polymerase kappa, putative 0.002 0.001 0.0135
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0046 0.0125
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0035 0.0162
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0046 0.0046
Leishmania major threonyl-tRNA synthetase, putative 0.003 0.0052 0.0692
Mycobacterium tuberculosis Conserved protein 0.0043 0.0115 0.0978
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0026 0.0036 0.0484
Giardia lamblia Prolyl-tRNA synthetase 0.0158 0.0631 0.4005
Loa Loa (eye worm) hypothetical protein 0.0079 0.0276 0.1204
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0175
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.003 0.0052 0.0226
Trypanosoma cruzi hexose transporter, putative 0.0163 0.0655 0.8744
Onchocerca volvulus 0.0058 0.0181 0.6487
Mycobacterium ulcerans lipase LipD 0.0043 0.0115 0.1774
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0026 0.0036 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0646 0.1751
Schistosoma mansoni sugar transporter 0.0074 0.0252 0.0684
Leishmania major lysyl-tRNA synthetase, putative 0.0117 0.0448 0.5987
Entamoeba histolytica protein kinase, putative 0.0161 0.0646 0.4065
Loa Loa (eye worm) sugar transporter 0.0525 0.2294 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0276 0.0276
Brugia malayi Calcitonin receptor-like protein seb-1 0.0416 0.1801 0.785
Brugia malayi follicle stimulating hormone receptor 0.0224 0.0933 0.4069
Leishmania major hypothetical protein, conserved 0.0026 0.0036 0.0484
Entamoeba histolytica thioredoxin reductase, putative 0.0151 0.0601 0.3778
Echinococcus multilocularis glycyl tRNA synthetase 0.003 0.0052 0.0141
Loa Loa (eye worm) pyruvate kinase 0.0036 0.008 0.0347
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0074 0.0252 0.4099
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0049 0.0132
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0161 0.0646 0.0646
Plasmodium falciparum pyruvate kinase 0.0036 0.008 0.008
Onchocerca volvulus 0.0074 0.0252 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0161 0.0646 0.0646
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0115 0.0978
Echinococcus granulosus geminin 0.0345 0.1479 0.4012
Loa Loa (eye worm) pyruvate kinase 0.0036 0.008 0.0347
Loa Loa (eye worm) hypothetical protein 0.0128 0.0497 0.2168
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.008 0.1063
Onchocerca volvulus 0.0074 0.0252 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0184 0.0749 1
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0046 0.0125
Brugia malayi hypothetical protein 0.0074 0.0252 0.11
Brugia malayi jmjC domain containing protein 0.0028 0.0046 0.02
Giardia lamblia Threonyl-tRNA synthetase 0.003 0.0052 0.0323
Echinococcus multilocularis tumor protein p63 0.0337 0.1442 0.391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0773 0.2097
Trichomonas vaginalis glucose transporter, putative 0.0074 0.0252 0.106
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.02
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0046 0.0125
Schistosoma mansoni lysyl-tRNA synthetase 0.0117 0.0448 0.1216
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0035 0.0111
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0115 0.0501
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0115 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0252 0.106
Loa Loa (eye worm) hypothetical protein 0.0304 0.1292 0.5631
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0345 0.0937
Loa Loa (eye worm) threonyl-tRNA synthetase 0.003 0.0052 0.0226
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.008 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0115 0.0459
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0629 0.1707
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0276 0.3686
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0036 0.0115
Leishmania major hypothetical protein, conserved 0.0079 0.0276 0.3686
Echinococcus granulosus dna polymerase eta 0.002 0.001 0.0027
Entamoeba histolytica hypothetical protein 0.0041 0.0104 0.0604
Echinococcus multilocularis transient receptor potential gamma protein 0.0304 0.1292 0.3503
Echinococcus granulosus TRP transient receptor potential channel 0.0113 0.0429 0.1163
Toxoplasma gondii ABC1 family protein 0.0043 0.0115 0.0173
Echinococcus multilocularis muscleblind protein 0.0157 0.0629 0.1707
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.131 0.8314
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trichomonas vaginalis chaperonin, putative 0.0026 0.0035 0.0111
Plasmodium falciparum hexose transporter 0.0525 0.2294 0.2294
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0158 0.0631 0.275
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0158 0.0631 0.1711
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0345 0.0937
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.0773 0.3371
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0117 0.0448 0.1919
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0115 0.1774
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.0933 0.4069
Leishmania major glucose transporter, lmgt2 0.0163 0.0655 0.8744
Schistosoma mansoni jumonji/arid domain-containing protein 0.0106 0.0397 0.1078
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.01 0.0368 0.3137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0151 0.0601 1
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0046 0.0125
Schistosoma mansoni hypothetical protein 0.0345 0.1479 0.4012
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0135
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Onchocerca volvulus 0.0074 0.0252 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0115 0.0501
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.008 0.0678
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Trichomonas vaginalis sugar transporter, putative 0.0163 0.0655 0.2824
Trypanosoma cruzi hexose transporter, putative 0.0089 0.0321 0.4285
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0046 0.0125
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.008 0.0347
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.008 0.0305
Schistosoma mansoni lysyl-tRNA synthetase 0.0117 0.0448 0.1216
Schistosoma mansoni jumonji domain containing protein 0.0146 0.0579 0.157
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.5675
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0158 0.0631 0.3971
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.5347
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.1071 0.4668
Loa Loa (eye worm) sugar transporter 0.0074 0.0252 0.11
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Onchocerca volvulus 0.0074 0.0252 1
Toxoplasma gondii transporter, major facilitator family protein 0.0074 0.0252 0.038
Echinococcus multilocularis calcium activated potassium channel 0.002 0.0009 0.0025
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0049 0.0073
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0158 0.0631 0.1711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0773 0.2097
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0525 0.2294 0.6221
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0115 0.0459
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0115 0.0978
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0132 0.0514 0.1393
Brugia malayi hypothetical protein 0.0041 0.0104 0.0456
Echinococcus multilocularis solute carrier family 22 0.0074 0.0252 0.0684
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0501
Loa Loa (eye worm) hypothetical protein 0.0157 0.0629 0.2744
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.008 0.1522
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0198 0.1687
Schistosoma mansoni hypothetical protein 0.0041 0.0104 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0036 0.0115
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.0345
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0001 0.0002
Brugia malayi lysyl-tRNA synthetase 0.0117 0.0448 0.1955
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0046 0.02
Onchocerca volvulus 0.0074 0.0252 1
Brugia malayi jmjC domain containing protein 0.0028 0.0046 0.02
Onchocerca volvulus 0.0074 0.0252 1
Schistosoma mansoni lamin 0.0058 0.0181 0.049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0045 0.0122
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0213
Toxoplasma gondii sugar transporter ST1 0.0074 0.0252 0.038
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0035 0.0472
Schistosoma mansoni protein kinase 0.0161 0.0646 0.1751
Echinococcus granulosus lysine specific demethylase 5A 0.0106 0.0397 0.1078
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.001 0.0135
Echinococcus granulosus short transient receptor potential channel 6 0.0201 0.0827 0.2242
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.008 0.1522
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0117 0.0448 0.5987
Echinococcus multilocularis pyruvate kinase 0.0036 0.008 0.0216
Brugia malayi beta-lactamase 0.0043 0.0115 0.0501
Echinococcus granulosus lamin 0.0058 0.0181 0.049
Giardia lamblia Glycyl-tRNA synthetase 0.003 0.0052 0.0323
Schistosoma mansoni transient receptor potential channel 0.0201 0.0827 0.2242
Plasmodium falciparum calcium-dependent protein kinase 4 0.0161 0.0646 0.0646
Echinococcus granulosus intermediate filament protein 0.0058 0.0181 0.049
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0161 0.0646 0.0974
Entamoeba histolytica hypothetical protein 0.0041 0.0104 0.0604
Giardia lamblia Thioredoxin reductase 0.0151 0.0601 0.3814
Loa Loa (eye worm) hypothetical protein 0.0117 0.0448 0.1955
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0984 0.267
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0001 0.0001
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.003 0.0052 0.0692
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.008 0.1063
Schistosoma mansoni lamin 0.0058 0.0181 0.049
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0115 0.0311
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0161 0.0646 0.0646
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0035 0.0053
Mycobacterium tuberculosis Conserved protein 0.0043 0.0115 0.0978
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0065 0.0065
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0074 0.0252 0.4099
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.1071 0.4668
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0115 0.0978
Trypanosoma brucei THT1 - hexose transporter, putative 0.0163 0.0655 0.8744
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0135
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0046 0.0614
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0031 0.0132
Plasmodium falciparum protein kinase 7 0.1484 0.663 0.663
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3687 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Schistosoma mansoni transient receptor potential channel 4 0.0304 0.1292 0.3503
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0501
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Loa Loa (eye worm) latrophilin receptor protein 2 0.0132 0.0514 0.224
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0345 0.0345
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0601 0.2587
Echinococcus multilocularis geminin 0.0345 0.1479 0.4012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.5347
Echinococcus multilocularis pyruvate kinase 0.0018 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Onchocerca volvulus 0.0048 0.0136 0.4276
Loa Loa (eye worm) major facilitator superfamily transporter 0.0074 0.0252 0.11
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0212
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1175 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0416 0.1801 0.785
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.003 0.0052 0.0267
Trichomonas vaginalis glucose transporter, putative 0.0163 0.0655 0.2824
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0035 0.0035
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.001 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0036 0.0309
Echinococcus multilocularis pyruvate kinase 0.0018 0.0001 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0165 0.0667 0.1808
Schistosoma mansoni sugar transporter 0.0074 0.0252 0.0684
Echinococcus granulosus peregrin 0.0029 0.0049 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0773 0.2097
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Mycobacterium ulcerans sugar transporter 0.0074 0.0252 0.4099
Brugia malayi hypothetical protein 0.0236 0.0984 0.4292
Toxoplasma gondii facilitative glucose transporter GT1 0.0525 0.2294 0.346
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0161 0.0646 0.1751
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0136 0.0592
Schistosoma mansoni jumonji/arid domain-containing protein 0.0106 0.0397 0.1078
Loa Loa (eye worm) hypothetical protein 0.0416 0.1801 0.785
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0276 0.3686
Trypanosoma brucei unspecified product 0.002 0.001 0.0135
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0601 0.2587
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.0397 0.1732
Echinococcus multilocularis lamin dm0 0.0058 0.0181 0.049
Onchocerca volvulus 0.0074 0.0252 1
Schistosoma mansoni protein kinase 0.0161 0.0646 0.1751
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.131 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0163 0.0655 0.8744
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Giardia lamblia Hexose transporter 0.0074 0.0252 0.1597
Trypanosoma brucei sugar transporter, putative 0.0074 0.0252 0.3367
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0045 0.0122
Brugia malayi glycyl-tRNA synthetase 0.003 0.0052 0.0226
Echinococcus granulosus pyruvate kinase 0.0018 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0347
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3687 1
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0035 0.0472
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0104 0.0283
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0035 0.0096
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0031 0.0134
Brugia malayi jmjC domain containing protein 0.0028 0.0046 0.02
Giardia lamblia DINP protein human, muc B family 0.002 0.001 0.0057
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.01 0.0368 0.3137
Toxoplasma gondii lysine-tRNA ligase 0.0117 0.0448 0.0676
Echinococcus multilocularis lysyl tRNA synthetase 0.0117 0.0448 0.1216
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Onchocerca volvulus 0.0074 0.0252 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Loa Loa (eye worm) hypothetical protein 0.0049 0.0141 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0115 0.1533
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0135
Trichomonas vaginalis esterase, putative 0.0043 0.0115 0.0459
Plasmodium falciparum calcium-dependent protein kinase 2 0.0161 0.0646 0.0646
Echinococcus granulosus pyruvate kinase 0.0018 0.0001 0.0003
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0035 0.0154
Echinococcus granulosus short transient receptor potential channel 6 0.0201 0.0827 0.2242
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Treponema pallidum thioredoxin reductase (trxB) 0.0151 0.0601 0.4363
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0046 0.0125
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Giardia lamblia Pyruvate kinase 0.0036 0.008 0.05
Echinococcus granulosus pyruvate kinase 0.0036 0.008 0.0216
Brugia malayi jmjC domain containing protein 0.0106 0.0397 0.1732
Loa Loa (eye worm) major facilitator superfamily transporter 0.0074 0.0252 0.11
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0113 0.0429 0.1163
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0181 0.0788
Schistosoma mansoni hypothetical protein 0.0525 0.2294 0.6221
Toxoplasma gondii sugar transporter ST3 0.0074 0.0252 0.038
Loa Loa (eye worm) hypothetical protein 0.0157 0.0629 0.2744
Toxoplasma gondii protein kinase, putative 0.1484 0.663 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0115 0.0978
Echinococcus multilocularis GPCR, family 2 0.0132 0.0514 0.1393
Plasmodium falciparum phd finger protein, putative 0.0029 0.0049 0.0049
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Entamoeba histolytica hypothetical protein 0.0104 0.0389 0.2425
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0046 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0501
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.5347
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0103 0.0383 0.1633
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0046 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0115 0.1533
Plasmodium vivax calcium-dependent protein kinase, putative 0.0161 0.0646 0.0646
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0158 0.0631 0.2718
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0175
Schistosoma mansoni glucose transporter 0.0074 0.0252 0.0684
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0046 0.0125
Echinococcus granulosus calcium dependent protein kinase 0.0151 0.0601 0.1629
Plasmodium falciparum calcium-dependent protein kinase 3 0.0161 0.0646 0.0646
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0598 0.9448
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Brugia malayi Transient-receptor-potential like protein 0.0113 0.0429 0.187
Brugia malayi beta-lactamase family protein 0.0043 0.0115 0.0501
Onchocerca volvulus 0.0074 0.0252 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.001 0.0135
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0035 0.0154
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0046 0.0614
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0984 0.267
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0501
Giardia lamblia Lysyl-tRNA synthetase 0.0117 0.0448 0.2845
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0158 0.0631 0.1711
Echinococcus multilocularis pyruvate kinase 0.0018 0.0001 0.0003
Plasmodium falciparum lysine--tRNA ligase 0.0117 0.0448 0.0448
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0184 0.0749 0.113
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0036 0.0484
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0184 0.0749 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0049 0.0212
Brugia malayi Muscleblind-like protein 0.0157 0.0629 0.2744
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.003 0.0052 0.0226
Echinococcus multilocularis solute carrier family 22 0.0074 0.0252 0.0684
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0158 0.0631 0.1711
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0151 0.0601 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0046 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0036 0.0115
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0276 0.0416
Schistosoma mansoni DNA polymerase eta 0.002 0.001 0.0027
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0117 0.0448 0.7421
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0035 0.0218
Echinococcus multilocularis solute carrier family 22 0.0074 0.0252 0.0684
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0181 0.0788
Brugia malayi hypothetical protein 0.0051 0.0149 0.0651
Brugia malayi PHD-finger family protein 0.0029 0.0049 0.0212
Echinococcus granulosus lamin dm0 0.0058 0.0181 0.049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0115 0.0311
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.003 0.0052 0.0078
Leishmania major pyruvate kinase 0.0036 0.008 0.1063
Schistosoma mansoni hypothetical protein 0.0048 0.0136 0.0368
Echinococcus granulosus calcium activated potassium channel 0.002 0.0009 0.0025
Leishmania major hypothetical protein, conserved 0.0043 0.0115 0.1533
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0035 0.0096
Echinococcus multilocularis synaptic vesicle 2 protein 0.0074 0.0252 0.0684
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.001 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0773 0.2097
Trichomonas vaginalis myo-inositol transporter, putative 0.0074 0.0252 0.106
Echinococcus multilocularis dna polymerase eta 0.002 0.001 0.0027
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.008 0.1063
Giardia lamblia PHD finger protein 15 0.0029 0.0049 0.0303
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0115 0.1774
Schistosoma mansoni transient receptor potential channel 0.0201 0.0827 0.2242
Mycobacterium ulcerans integral membrane transport protein 0.0074 0.0252 0.4099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0046 0.0125
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.001 0.0044
Toxoplasma gondii sugar transporter ST2 0.0074 0.0252 0.038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Echinococcus granulosus GPCR family 2 0.0132 0.0514 0.1393
Brugia malayi hypothetical protein 0.0074 0.0252 0.11
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0161 0.0646 0.0974
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0079 0.0213
Echinococcus granulosus solute carrier family 22 0.0074 0.0252 0.0684
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Plasmodium vivax pyruvate kinase, putative 0.0036 0.008 0.008
Leishmania major myo-inositol/proton symporter (MIT) 0.0074 0.0252 0.3367
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.003 0.0052 0.0183
Plasmodium vivax sugar transporter, putative 0.0074 0.0252 0.0252
Brugia malayi Latrophilin receptor protein 2 0.0132 0.0514 0.224
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0151 0.0601 0.2587
Plasmodium falciparum mitogen-activated protein kinase 2 0.0849 0.3757 0.3757
Onchocerca volvulus 0.0074 0.0252 1
Plasmodium falciparum proline--tRNA ligase 0.0184 0.0749 0.0749
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0049 0.0132
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0158 0.0631 1
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0104 0.0283
Schistosoma mansoni intermediate filament proteins 0.0058 0.0181 0.049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0163 0.0655 0.8744
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0132
Schistosoma mansoni hypothetical protein 0.0345 0.1479 0.4012
Loa Loa (eye worm) hypothetical protein 0.0285 0.1205 0.5254
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Leishmania major protein kinase, putative 0.0161 0.0646 0.862
Loa Loa (eye worm) hypothetical protein 0.0158 0.0631 0.275
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0074 0.0252 0.3367
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0767
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0276 0.0276
Giardia lamblia DNA repair protein RAD52 0.0366 0.1573 1
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0046 0.0125
Trichomonas vaginalis sugar transport protein, putative 0.0074 0.0252 0.106
Loa Loa (eye worm) hypothetical protein 0.003 0.0052 0.0226
Echinococcus granulosus solute carrier family 22 0.0074 0.0252 0.0684
Echinococcus multilocularis short transient receptor potential channel 6 0.0201 0.0827 0.2242
Echinococcus granulosus jumonji domain containing protein 0.004 0.01 0.0271
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0158 0.0631 0.275
Echinococcus multilocularis pyruvate kinase 0.0028 0.0046 0.0124
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0161 0.0646 0.2815
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.003 0.0052 0.0141
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0345 0.0937
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.131 0.8323
Schistosoma mansoni hypothetical protein 0.0132 0.0514 0.1393
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0079 0.0213
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0849 0.3757 0.3757
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.001 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0252 0.106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.001 0.0027
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.003 0.0052 0.0441
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0035 0.0035
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0046 0.0614
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.001 0.0086
Echinococcus multilocularis short transient receptor potential channel 6 0.0201 0.0827 0.2242
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0115 0.0459
Onchocerca volvulus 0.0074 0.0252 1
Onchocerca volvulus 0.0049 0.0141 0.4547
Brugia malayi hypothetical protein 0.0079 0.0276 0.1204
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.5675
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0345 0.0521
Loa Loa (eye worm) hypothetical protein 0.0161 0.0646 0.2815
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0115 0.0311
Mycobacterium ulcerans beta-lactamase 0.0043 0.0115 0.1774
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0198 0.1687
Onchocerca volvulus 0.0074 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0514 0.224
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Schistosoma mansoni pyruvate kinase 0.0036 0.008 0.0216
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0046 0.0125
Leishmania major hypothetical protein, conserved 0.0026 0.0036 0.0484
Plasmodium vivax JmjC domain containing protein 0.0028 0.0046 0.0046
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0151 0.0601 0.5115
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Leishmania major glucose transporter, lmgt3 0.0163 0.0655 0.8744
Echinococcus granulosus transient receptor potential gamma protein 0.0304 0.1292 0.3503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Loa Loa (eye worm) glycyl-tRNA synthetase 0.003 0.0052 0.0226
Onchocerca volvulus 0.0043 0.0115 0.3252
Brugia malayi Cam kinase protein 1 0.0161 0.0646 0.2815
Plasmodium falciparum calcium-dependent protein kinase 5 0.0161 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0132 0.0514 0.1393
Schistosoma mansoni hypothetical protein 0.0285 0.1205 0.3268
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0132 0.0514 0.1393
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0115 0.0978
Onchocerca volvulus 0.0074 0.0252 1
Brugia malayi Major Facilitator Superfamily protein 0.0074 0.0252 0.11
Schistosoma mansoni survival motor neuron protein 0.0048 0.0136 0.0368
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0049 0.0073
Plasmodium falciparum threonine--tRNA ligase 0.003 0.0052 0.0052
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Schistosoma mansoni hypothetical protein 0.0132 0.0514 0.1393
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0345 0.0521
Plasmodium vivax lysine--tRNA ligase, putative 0.0117 0.0448 0.0448
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0115 0.0459
Plasmodium vivax threonine--tRNA ligase, putative 0.003 0.0052 0.0052
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0276 0.0276
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0035 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0252 0.106
Schistosoma mansoni sugar transporter 0.0074 0.0252 0.0684
Brugia malayi intermediate filament protein 0.0058 0.0181 0.0788
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0104 0.0283
Echinococcus multilocularis pyruvate kinase 0.0036 0.008 0.0216
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0056 0.017 0.2706
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.001 0.0135
Leishmania major hypothetical protein, conserved 0.0028 0.0046 0.0614
Brugia malayi Bromodomain containing protein 0.0029 0.0049 0.0212
Echinococcus multilocularis jumonji domain containing protein 0.004 0.01 0.0271
Brugia malayi Sugar transporter family protein 0.0074 0.0252 0.11
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.131 0.5692
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0198 0.0537
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.003 0.0052 0.0692
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0059 0.0256
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.003 0.0052 0.0262
Loa Loa (eye worm) hypothetical protein 0.0113 0.0429 0.187
Trypanosoma brucei pyruvate kinase 1 0.0036 0.008 0.1063
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0773 0.2097
Onchocerca volvulus 0.0043 0.0115 0.3252
Loa Loa (eye worm) hypothetical protein 0.0058 0.0181 0.0788
Echinococcus multilocularis calcium dependent protein kinase 0.0151 0.0601 0.1629
Entamoeba histolytica protein kinase, putative 0.0161 0.0646 0.4065
Entamoeba histolytica hypothetical protein 0.0117 0.0448 0.2804
Plasmodium falciparum calcium-dependent protein kinase 1 0.0161 0.0646 0.0646
Onchocerca volvulus 0.0074 0.0252 1
Trichomonas vaginalis sugar transporter, putative 0.0163 0.0655 0.2824
Brugia malayi Major Facilitator Superfamily protein 0.0074 0.0252 0.11
Mycobacterium ulcerans glycyl-tRNA synthetase 0.003 0.0052 0.0707
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0165 0.0667 0.1808
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0046 0.0069
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0992
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.001 0.0135
Echinococcus granulosus pyruvate kinase 0.0036 0.008 0.0216
Trichomonas vaginalis glucose transporter, putative 0.0163 0.0655 0.2824
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0646 0.2783
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0655 0.2824
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0161 0.0646 0.2815
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0161 0.0646 0.2815
Trypanosoma brucei glucose transporter 1E 0.0163 0.0655 0.8744
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0181 0.0788
Trypanosoma cruzi glucose transporter, putative 0.0074 0.0252 0.3367
Plasmodium vivax glycine--tRNA ligase, putative 0.003 0.0052 0.0052
Echinococcus multilocularis musashi 0.0058 0.0181 0.049
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0049 0.0132
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0117 0.0448 0.5987
Trypanosoma cruzi hexose transporter, putative 0.0163 0.0655 0.8744
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Echinococcus granulosus dna polymerase kappa 0.002 0.001 0.0027
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0646 0.1751
Toxoplasma gondii glycyl-tRNA synthetase 0.003 0.0052 0.0078
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0065 0.0211 0.0919
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0059 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.001 0.0135
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Loa Loa (eye worm) hypothetical protein 0.0236 0.0984 0.4292
Plasmodium vivax hexose transporter 0.0525 0.2294 0.2294
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0074 0.0252 0.365
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0345 0.5198
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0074 0.0252 0.2147
Echinococcus granulosus synaptic vesicle 2 protein 0.0074 0.0252 0.0684
Brugia malayi latrophilin 2 splice variant baaae 0.0285 0.1205 0.5254
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0065 0.0107
Brugia malayi jmjC domain containing protein 0.0165 0.0667 0.2907
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.008 0.0729
Brugia malayi Major Facilitator Superfamily protein 0.0074 0.0252 0.11
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0161 0.0646 0.862
Mycobacterium leprae Probable lipase LipE 0.0043 0.0115 0.1321
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.003 0.0052 0.0267
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0366 0.1573 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.001 0.0027
Chlamydia trachomatis lysine--tRNA ligase 0.0117 0.0448 0.7225
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0115 0.1533
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0035 0.0472
Loa Loa (eye worm) hypothetical protein 0.0094 0.0345 0.1506
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0601 0.2587
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0141 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0252 0.106
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.003 0.0052 0.0692
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2294 0.6221
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0074 0.0252 0.2147
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0345 0.2333
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0115 0.1321
Onchocerca volvulus 0.0058 0.0181 0.6487
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0132 0.0514 0.1393
Brugia malayi MH2 domain containing protein 0.0255 0.1071 0.4668
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.131 0.8314
Onchocerca volvulus Putative transporter 0.0074 0.0252 1
Schistosoma mansoni glucose transport protein 0.0525 0.2294 0.6221
Brugia malayi Sugar transporter family protein 0.0525 0.2294 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0501
Onchocerca volvulus 0.0074 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Loa Loa (eye worm) hypothetical protein 0.0191 0.0781 0.3404
Trypanosoma brucei THT1 - hexose transporter, putative 0.0163 0.0655 0.8744
Mycobacterium ulcerans pyruvate kinase 0.0036 0.008 0.1177
Echinococcus granulosus phd:f box containing protein 0.0028 0.0046 0.0125
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0035 0.0154
Trypanosoma cruzi hexose transporter, putative 0.0163 0.0655 0.8744
Chlamydia trachomatis pyruvate kinase 0.0036 0.008 0.0506
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.008 0.012
Trypanosoma cruzi hexose transporter, putative 0.0074 0.0252 0.3367
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0198 0.2723
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0184 0.0749 1
Echinococcus multilocularis solute carrier family 22 0.0074 0.0252 0.0684
Brugia malayi jmjC domain containing protein 0.0028 0.0046 0.02
Echinococcus granulosus solute carrier family 22 0.0074 0.0252 0.0684
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0115 0.0978
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0601 0.2587
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Loa Loa (eye worm) hypothetical protein 0.0074 0.0252 0.11
Echinococcus granulosus lysyl tRNA synthetase 0.0117 0.0448 0.1216
Leishmania major hypothetical protein, conserved 0.0074 0.0252 0.3367
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0046 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0074 0.0252 0.0684
Trypanosoma brucei glucose transporter, putative 0.0163 0.0655 0.8744
Mycobacterium ulcerans threonyl-tRNA synthetase 0.003 0.0052 0.0707
Trypanosoma cruzi hexose transporter 0.0163 0.0655 0.8744
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.001 0.0027
Schistosoma mansoni glucose transport protein 0.0525 0.2294 0.6221
Schistosoma mansoni glucose transport protein 0.0525 0.2294 0.6221
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0252 0.106
Brugia malayi Probable ClpP-like protease 0.0094 0.0345 0.1506
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0065 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0655 0.2824
Onchocerca volvulus 0.0074 0.0252 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0046 0.0125
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0198 0.0537
Echinococcus granulosus muscleblind protein 0.0157 0.0629 0.1707

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.4467 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 0.8275 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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