Detailed information for compound 1306230

Basic information

Technical information
  • TDR Targets ID: 1306230
  • Name: (3-chloro-5-ethoxy-4-prop-2-enoxyphenyl)-pyrr olidin-1-ylmethanethione
  • MW: 325.854 | Formula: C16H20ClNO2S
  • H donors: 0 H acceptors: 0 LogP: 4.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1c(Cl)cc(cc1OCC)C(=S)N1CCCC1
  • InChi: 1S/C16H20ClNO2S/c1-3-9-20-15-13(17)10-12(11-14(15)19-4-2)16(21)18-7-5-6-8-18/h3,10-11H,1,4-9H2,2H3
  • InChiKey: WRKUVZCQTPVKTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-allyloxy-3-chloro-5-ethoxy-phenyl)-pyrrolidin-1-yl-methanethione
  • (4-allyloxy-3-chloro-5-ethoxyphenyl)-1-pyrrolidinylmethanethione
  • (3-chloro-5-ethoxy-4-prop-2-enoxy-phenyl)-pyrrolidin-1-yl-methanethione
  • SMR000498091
  • ZINC02866353
  • 1-{[4-(allyloxy)-3-chloro-5-ethoxyphenyl]carbonothioyl}pyrrolidine
  • MLS001000769

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0374 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0636 0.0901
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0032 0.0054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0168 0.1925 0.4227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0374 0.4542 1
Brugia malayi fibroinase precursor 0.0066 0.0636 0.1399
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.0636 0.2067
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Brugia malayi Cathepsin L-like precursor 0.0317 0.3816 0.84
Plasmodium falciparum serine repeat antigen 7 0.0066 0.0636 0.1413
Brugia malayi MH2 domain containing protein 0.0118 0.1298 0.2857
Loa Loa (eye worm) hypothetical protein 0.0215 0.2526 0.5526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Brugia malayi Cathepsin L-like precursor 0.0317 0.3816 0.84
Toxoplasma gondii cathepsin CPC1 0.0066 0.0636 0.1413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Onchocerca volvulus 0.0317 0.3816 0.8536
Brugia malayi cathepsin L-like precursor 0.0215 0.2526 0.5562
Giardia lamblia Cathepsin B precursor 0.0066 0.0636 0.2067
Schistosoma mansoni hypothetical protein 0.0041 0.0318 0.0683
Loa Loa (eye worm) cysteine protease 0.0317 0.3816 0.8387
Giardia lamblia Cathepsin L precursor 0.0066 0.0636 0.2067
Brugia malayi Cathepsin L-like precursor 0.0317 0.3816 0.84
Loa Loa (eye worm) hypothetical protein 0.0102 0.1084 0.2325
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0066 0.0636 0.1413
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0636 0.1107
Onchocerca volvulus Cathepsin F homolog 0.0317 0.3816 0.8536
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0066 0.0636 0.1413
Entamoeba histolytica cysteine protease, putative 0.0066 0.0636 0.0901
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2986 0.6546
Echinococcus granulosus cathepsin L 0.0066 0.0636 0.1338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1925 0.5034
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0066 0.0636 0.1413
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0321 0.0706
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Entamoeba histolytica cysteine proteinase 2 0.0168 0.1925 0.459
Echinococcus granulosus cysteine protease 0.0168 0.1925 0.4196
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1298 0.2798
Brugia malayi Cathepsin L-like precursor 0.0102 0.1084 0.2387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Echinococcus granulosus cathepsin l1 0.0317 0.3816 0.8389
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0317 0.3816 0.3796
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.0636 0.1399
Loa Loa (eye worm) hypothetical protein 0.0055 0.049 0.1006
Toxoplasma gondii preprocathepsin c precursor, putative 0.0066 0.0636 0.1413
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0626 0.1315
Schistosoma mansoni cathepsin F (C01 family) 0.0215 0.2526 0.5554
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0168 0.1925 0.4227
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Trypanosoma cruzi cysteine peptidase, putative 0.0317 0.3816 0.8398
Mycobacterium leprae Probable lipase LipE 0.0035 0.024 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.1925 0.4712
Echinococcus multilocularis geminin 0.0205 0.2393 0.2369
Loa Loa (eye worm) hypothetical protein 0.0066 0.0636 0.1329
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0167
Toxoplasma gondii exonuclease III APE 0.0041 0.0321 0.0563
Giardia lamblia Cysteine protease 0.0066 0.0636 0.2067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0317 0.3816 0.8387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0215 0.2526 0.6395
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0236 0.0452
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0066 0.0636 0.1384
Loa Loa (eye worm) hypothetical protein 0.0066 0.0636 0.1329
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.0636 0.1107
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0109 0.0169
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0321 0.0226
Echinococcus granulosus GPCR family 2 0.0019 0.0037 0.001
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0066 0.0636 0.1413
Brugia malayi beta-lactamase family protein 0.0035 0.024 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0066 0.0636 0.1107
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0321 0.0338
Loa Loa (eye worm) hypothetical protein 0.0317 0.3816 0.8387
Echinococcus multilocularis cathepsin L cysteine protease 0.0317 0.3816 0.3796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Onchocerca volvulus 0.0317 0.3816 0.8536
Schistosoma mansoni cathepsin C 0.0066 0.0636 0.1384
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.049 0.1015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0321 0.064
Schistosoma mansoni zinc finger protein 0.0021 0.0068 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0066 0.0636 0.0901
Giardia lamblia Cathepsin B precursor 0.0161 0.1844 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0636 0.1107
Plasmodium vivax vivapain-2 0.0317 0.3816 1
Plasmodium vivax unspecified product 0.0102 0.1084 0.2625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0636 0.1107
Entamoeba histolytica cysteine proteinase, putative 0.0215 0.2526 0.6311
Plasmodium vivax unspecified product 0.0066 0.0636 0.1413
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0102 0.1084 0.2325
Loa Loa (eye worm) hypothetical protein 0.0102 0.1084 0.2325
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.024 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.1925 0.4712
Giardia lamblia Cathepsin L-like protease 0.0066 0.0636 0.2067
Schistosoma mansoni ap endonuclease 0.0041 0.0321 0.069
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.024 0.0609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0321 0.0822
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0321 0.0822
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0037 0.0082
Plasmodium vivax SET domain protein, putative 0.0036 0.0253 0.0379
Loa Loa (eye worm) hypothetical protein 0.0374 0.4542 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0318 0.0699
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0648
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0082 0.01
Trypanosoma cruzi cysteine proteinase, putative 0.0168 0.1925 0.4227
Loa Loa (eye worm) ctsf protein 0.0317 0.3816 0.8387
Giardia lamblia Cathepsin B precursor 0.0066 0.0636 0.2067
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0626 0.0595
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.024 0.045
Schistosoma mansoni cathepsin B (C01 family) 0.0066 0.0636 0.1384
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0636 0.1384
Trypanosoma cruzi cruzipain precursor, putative 0.0102 0.1084 0.2374
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0066 0.0636 0.1413
Loa Loa (eye worm) beta-lactamase 0.0035 0.024 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0636 0.1107
Echinococcus multilocularis cathepsin L 0.0066 0.0636 0.0605
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Plasmodium vivax vivapain-3 0.0168 0.1925 0.4894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.049 0.1063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.024 0.0511
Entamoeba histolytica cysteine protease, putative 0.0066 0.0636 0.0901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0037 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0064
Brugia malayi Pre-SET motif family protein 0.0251 0.2986 0.6575
Schistosoma mansoni bromodomain containing protein 0.0069 0.0675 0.1472
Loa Loa (eye worm) hypothetical protein 0.0077 0.0779 0.1647
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0066 0.0636 0.1413
Echinococcus granulosus cathepsin L cysteine proteinase 0.0317 0.3816 0.8389
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0066 0.0636 0.0901
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0636 0.1399
Entamoeba histolytica cysteine protease, putative 0.0066 0.0636 0.0901
Echinococcus granulosus zinc finger protein 0.0021 0.0068 0.0078
Brugia malayi cathepsin L-like cysteine proteinase 0.0066 0.0636 0.1399
Giardia lamblia Hypothetical protein 0.0066 0.0636 0.2067
Toxoplasma gondii cathepsin B 0.0161 0.1844 0.4676
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0636 0.1107
Plasmodium vivax vivapain-1 0.0168 0.1925 0.4894
Onchocerca volvulus 0.0317 0.3816 0.8536
Echinococcus granulosus cathepsin l1 0.0215 0.2526 0.553
Loa Loa (eye worm) hypothetical protein 0.0365 0.4429 0.9749
Schistosoma mansoni ap endonuclease 0.0041 0.0321 0.069
Brugia malayi Papain family cysteine protease containing protein 0.0168 0.1925 0.4238
Echinococcus granulosus cathepsin L 0.0168 0.1925 0.4196
Loa Loa (eye worm) hypothetical protein 0.0215 0.2526 0.5526
Loa Loa (eye worm) hypothetical protein 0.006 0.056 0.116
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0636 0.1399
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.1925 0.459
Brugia malayi Papain family cysteine protease containing protein 0.0168 0.1925 0.4238
Brugia malayi Bromodomain containing protein 0.0082 0.0838 0.1846
Brugia malayi cathepsin F-like cysteine proteinase 0.0102 0.1084 0.2387
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0636 0.1384
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1298 0.2798
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.024 0.0208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0037 0.001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.024 0.0528
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.1925 0.459
Plasmodium vivax hypothetical protein, conserved 0.0035 0.024 0.0344
Toxoplasma gondii ABC1 family protein 0.0035 0.024 0.0344
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0037 0.0005
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Onchocerca volvulus Cathepsin L homolog 0.0066 0.0636 0.0945
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0321 0.069
Onchocerca volvulus 0.0036 0.0253 0.0031
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0253 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2636 1
Schistosoma mansoni cathepsin F (C01 family) 0.0317 0.3816 0.8398
Brugia malayi Cathepsin L-like precursor 0.0317 0.3816 0.84
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0066 0.0636 0.1107
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0066 0.0636 0.1413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0215 0.2526 0.6395
Echinococcus multilocularis zinc finger protein 0.0021 0.0068 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.045
Echinococcus multilocularis cathepsin b 0.0374 0.4542 0.4525
Onchocerca volvulus Cathepsin L homolog 0.0317 0.3816 0.8536
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.0636 0.2067
Trypanosoma cruzi cysteine protease, putative 0.0168 0.1925 0.4227
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0066 0.0636 0.1384
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0295 0.0263
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.0164
Leishmania major hypothetical protein, conserved 0.0025 0.0112 0.0274
Giardia lamblia Cathepsin L precursor 0.0066 0.0636 0.2067
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0253 0.0379
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0321 0.0563
Plasmodium vivax vivapain-2 0.0317 0.3816 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.056 0.1232
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0636 0.1399
Echinococcus multilocularis cathepsin L 0.0168 0.1925 0.1899
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0623
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1925 0.5034
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.1925 0.459
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0066 0.0636 0.1107
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0066 0.0636 0.1413
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0066 0.0636 0.1413
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.023
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0041 0.0009
Schistosoma mansoni hypothetical protein 0.0205 0.2393 0.5261
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Trypanosoma brucei cysteine peptidase C (CPC) 0.0161 0.1844 0.4822
Giardia lamblia Cathepsin B precursor 0.0161 0.1844 1
Giardia lamblia Encystation-specific protease 0.0066 0.0636 0.2067
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0321 0.0289
Brugia malayi PHD-finger family protein 0.0027 0.0142 0.0312
Brugia malayi cathepsin B-like cysteine proteinase 0.0374 0.4542 1
Plasmodium falciparum serine repeat antigen 4 0.0066 0.0636 0.1413
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0374 0.4542 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0636 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0636 0.1107
Brugia malayi beta-lactamase 0.0035 0.024 0.0528
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Leishmania major cysteine peptidase A (CPA) 0.0317 0.3816 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0321 0.069
Giardia lamblia Cathepsin B precursor 0.0066 0.0636 0.2067
Brugia malayi Cathepsin L-like precursor 0.0317 0.3816 0.84
Plasmodium falciparum serine repeat antigen 9 0.0066 0.0636 0.1413
Echinococcus multilocularis GPCR, family 2 0.0019 0.0037 0.0005
Schistosoma mansoni hypothetical protein 0.0205 0.2393 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Schistosoma mansoni cathepsin s 0.0102 0.1084 0.2374
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Trypanosoma cruzi cysteine peptidase, putative 0.0317 0.3816 0.8398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Giardia lamblia Cathepsin B precursor 0.0066 0.0636 0.2067
Toxoplasma gondii cathepsin CPC2 0.0066 0.0636 0.1413
Trypanosoma cruzi cysteine peptidase, putative 0.0317 0.3816 0.8398
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0066 0.0636 0.2067
Echinococcus multilocularis cysteine protease 0.0317 0.3816 0.3796
Trypanosoma cruzi cysteine peptidase, putative 0.0102 0.1084 0.2374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0066 0.0636 0.1384
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0317 0.3816 1
Entamoeba histolytica cysteine proteinase, putative 0.0317 0.3816 1
Entamoeba histolytica hypothetical protein 0.0066 0.0636 0.0901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.0636 0.1107
Onchocerca volvulus Cathepsin L homolog 0.0317 0.3816 0.8536
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0321 0.5
Giardia lamblia Cathepsin B precursor 0.0161 0.1844 1
Brugia malayi Papain family cysteine protease containing protein 0.0317 0.3816 0.84
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0066 0.0636 0.1399
Schistosoma mansoni cathepsin S (C01 family) 0.0066 0.0636 0.1384
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0321 0.0226
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0636 0.1384
Loa Loa (eye worm) hypothetical protein 0.0066 0.0636 0.1329
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0253 0.0221
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0636 0.1329
Plasmodium falciparum serine repeat antigen 3 0.0066 0.0636 0.1413
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0215 0.2526 0.5554
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0109 0.0222
Brugia malayi Cathepsin L-like precursor 0.0215 0.2526 0.5562
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0636 0.1107
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0295 0.0582
Loa Loa (eye worm) hypothetical protein 0.0066 0.0636 0.1329
Trypanosoma cruzi cruzipain precursor, putative 0.0317 0.3816 0.8398
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0317 0.3816 0.3796
Onchocerca volvulus 0.0317 0.3816 0.8536
Onchocerca volvulus 0.0365 0.4429 1
Loa Loa (eye worm) fibroinase 0.0317 0.3816 0.8387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Brugia malayi Cathepsin L-like precursor 0.0215 0.2526 0.5562
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0168 0.1925 0.4227
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0066 0.0636 0.1413
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0064
Giardia lamblia Cathepsin L precursor 0.0066 0.0636 0.2067
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0161 0.1844 0.4822
Mycobacterium leprae conserved hypothetical protein 0.0035 0.024 0.5
Brugia malayi Cathepsin L-like cysteine proteinase 0.0215 0.2526 0.5562
Schistosoma mansoni cathepsin F (C01 family) 0.0317 0.3816 0.8398
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0636 0.1384
Giardia lamblia Cysteine protease 0.0066 0.0636 0.2067
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0109 0.0077
Plasmodium vivax serine-repeat antigen (SERA) 0.0066 0.0636 0.1413
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0636 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0636 0.1107
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0321 0.0563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0253 0.0557
Loa Loa (eye worm) hypothetical protein 0.0047 0.0388 0.078
Entamoeba histolytica cysteine protease, putative 0.0066 0.0636 0.0901
Plasmodium vivax serine-repeat antigen (SERA) 0.0066 0.0636 0.1413
Plasmodium falciparum cysteine proteinase falcipain 1 0.0168 0.1925 0.4894
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0168 0.1925 0.4227
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0374 0.4542 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0037 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0317 0.3816 0.8398
Giardia lamblia Cathepsin L precursor 0.0066 0.0636 0.2067
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.024 0.0511
Giardia lamblia Cysteine protease 0.0066 0.0636 0.2067
Loa Loa (eye worm) hypothetical protein 0.0102 0.1084 0.2325
Loa Loa (eye worm) hypothetical protein 0.0045 0.0362 0.0721
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Loa Loa (eye worm) cathepsin B 0.0161 0.1844 0.4011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0374 0.4542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0636 0.1107
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.0636 0.2067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0321 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1925 0.4227
Giardia lamblia Cathepsin L precursor 0.0066 0.0636 0.2067
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.024 0.046
Entamoeba histolytica cysteine protease, putative 0.0317 0.3816 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0636 0.1384
Loa Loa (eye worm) hypothetical protein 0.0215 0.2526 0.5526
Brugia malayi Bromodomain containing protein 0.0042 0.0328 0.0722
Onchocerca volvulus 0.0066 0.0636 0.0945
Echinococcus granulosus cathepsin b 0.0374 0.4542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0636 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.1844 0.4486
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Echinococcus granulosus cathepsin l cysteine peptidase 0.0317 0.3816 0.8389
Entamoeba histolytica cysteine proteinase 1, putative 0.0168 0.1925 0.459
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.049 0.1063
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0317 0.3816 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0321 1
Giardia lamblia Cathepsin B precursor 0.0066 0.0636 0.2067
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0037 0.0082
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0317 0.3816 0.8387
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.045
Onchocerca volvulus 0.0317 0.3816 0.8536
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0317 0.3816 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.056 0.1232
Echinococcus multilocularis cathepsin b 0.0374 0.4542 0.4525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0253 0.054
Entamoeba histolytica cysteine protease, putative 0.0066 0.0636 0.0901
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.049 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.0636 0.1107
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0102 0.1084 0.2387
Toxoplasma gondii cathepsin CPL 0.0317 0.3816 1
Giardia lamblia Cathepsin L precursor 0.0066 0.0636 0.2067
Plasmodium falciparum serine repeat antigen 1 0.0066 0.0636 0.1413
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Giardia lamblia Cysteine protease 0.0066 0.0636 0.2067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0636 0.1384
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.024 0.0511
Trypanosoma cruzi cysteine proteinase, putative 0.0168 0.1925 0.4227
Brugia malayi beta-lactamase family protein 0.0035 0.024 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Giardia lamblia Cathepsin L-like protease 0.0066 0.0636 0.2067
Onchocerca volvulus 0.0317 0.3816 0.8536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Brugia malayi hypothetical protein 0.0025 0.0112 0.0248
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0066 0.0636 0.1329
Plasmodium falciparum serine repeat antigen 6 0.0066 0.0636 0.1413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1844 0.4049
Leishmania major hypothetical protein, conserved 0.0035 0.024 0.0609
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.056 0.116
Onchocerca volvulus 0.0286 0.3427 0.7608
Plasmodium falciparum serine repeat antigen 8 0.0066 0.0636 0.1413
Plasmodium falciparum cysteine proteinase falcipain 3 0.0317 0.3816 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0066 0.0636 0.1107
Loa Loa (eye worm) hypothetical protein 0.0066 0.0636 0.1329
Echinococcus multilocularis cysteine protease 0.0317 0.3816 0.3796
Plasmodium falciparum serine repeat antigen 5 0.0066 0.0636 0.1413
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.045
Plasmodium vivax unspecified product 0.0168 0.1925 0.4894
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0066 0.0636 0.1413
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3427 0.8914
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0112 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0066 0.0636 0.1384
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0161 0.1844 0.4049
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0066 0.0636 0.1413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0636 0.1329
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Leishmania major cathepsin L-like protease 0.0317 0.3816 1
Brugia malayi hypothetical protein 0.0365 0.4429 0.9751
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0032 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0636 0.1399
Echinococcus granulosus cathepsin b 0.0374 0.4542 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0636 0.1384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.3816 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0317 0.3816 1
Giardia lamblia Hypothetical protein 0.0066 0.0636 0.2067
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0317 0.3816 1
Brugia malayi cathepsin L precursor 0.0066 0.0636 0.1399
Echinococcus multilocularis cathepsin L cysteine protease 0.0317 0.3816 0.3796
Echinococcus granulosus cathepsin L cysteine protease 0.0168 0.1925 0.4196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0321 0.063
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0066 0.0636 0.1413
Entamoeba histolytica cysteine proteinase, putative 0.0317 0.3816 1
Onchocerca volvulus 0.0317 0.3816 0.8536
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.1925 0.459
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.0636 0.1399
Plasmodium falciparum serine repeat antigen 2 0.0066 0.0636 0.1413
Onchocerca volvulus 0.0215 0.2526 0.5458
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0636 0.1329
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.045
Echinococcus granulosus geminin 0.0205 0.2393 0.5235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.3816 1
Brugia malayi Cathepsin L-like precursor 0.0317 0.3816 0.84
Entamoeba histolytica cysteine protease, putative 0.0168 0.1925 0.459

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 30.256 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.3778 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.5821 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.0441 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.7578 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.7578 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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