Detailed information for compound 1306811

Basic information

Technical information
  • TDR Targets ID: 1306811
  • Name: methyl 3-(cyclohexylcarbamoylamino)thiophene- 2-carboxylate
  • MW: 282.359 | Formula: C13H18N2O3S
  • H donors: 2 H acceptors: 2 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1sccc1NC(=O)NC1CCCCC1
  • InChi: 1S/C13H18N2O3S/c1-18-12(16)11-10(7-8-19-11)15-13(17)14-9-5-3-2-4-6-9/h7-9H,2-6H2,1H3,(H2,14,15,17)
  • InChiKey: RQWRBEHMMJHPMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(cyclohexylamino)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester
  • 3-(cyclohexylcarbamoylamino)thiophene-2-carboxylic acid methyl ester
  • methyl 3-{[(cyclohexylamino)carbonyl]amino}thiophene-2-carboxylate
  • IVK/9152129
  • MLS000730153
  • SMR000308429

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.0352 0.0953
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0291 0.2897
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0046 0.01
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.012 0.1085 1
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0291 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0046 0.01
Entamoeba histolytica Ran family GTPase 0.0026 0.0102 0.0752
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0826 0.1742
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0291 0.321
Brugia malayi hypothetical protein 0.003 0.0152 0.0332
Echinococcus granulosus tar DNA binding protein 0.0076 0.063 0.1379
Plasmodium vivax protein kinase Crk2 0.0044 0.0291 0.2678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0046 0.0124
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0046 0.01
Echinococcus granulosus cyclin B3 1 0.0053 0.0389 0.0852
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0073
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.28 0.613
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0046 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0287 0.0628
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0456 0.4567 1
Schistosoma mansoni hypothetical protein 0.0058 0.044 0.0964
Trypanosoma brucei mitotic cyclin 6 0.0103 0.0906 1
Echinococcus granulosus cyclins 0.0053 0.0389 0.0852
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0073
Trichomonas vaginalis cyclin B, putative 0.0103 0.0906 0.1918
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0461 0.1008
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0373 0.3867
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0046 0.0124
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0152 0.1398
Trypanosoma cruzi cyclin 6, putative 0.0103 0.0906 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0197 0.2177
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0036 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.0033
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0291 0.0291
Brugia malayi Cyclin, N-terminal domain containing protein 0.0103 0.0906 0.1983
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0046 0.0124
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0291 0.0637
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0046 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0033 0.0073
Echinococcus granulosus cyclins 0.0053 0.0389 0.0852
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0102 0.0102
Leishmania major hypothetical protein, conserved 0.003 0.0152 0.1675
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0826 0.1742
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0113 0.1004 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0046 0.0124
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0165 0.1546 0.3385
Echinococcus multilocularis GPCR, family 2 0.0019 0.0033 0.0033
Mycobacterium tuberculosis Conserved protein 0.0456 0.4567 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0036 0.008
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0046 0.01
Echinococcus granulosus cyclins 0.0053 0.0389 0.0852
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0046 0.0046
Echinococcus granulosus dna polymerase eta 0.0019 0.0036 0.008
Trypanosoma brucei unspecified product 0.0019 0.0036 0.0402
Giardia lamblia G2/mitotic-specific cyclin B 0.0103 0.0906 0.1918
Brugia malayi nuclear hormone receptor 0.002 0.0046 0.01
Trichomonas vaginalis cyclins, putative 0.0103 0.0906 0.1918
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0089 0.0763 0.1671
Trichomonas vaginalis cyclin B, putative 0.0053 0.0389 0.0779
Entamoeba histolytica cyclin family protein 0.0053 0.0389 0.406
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.009 0.0774 0.0774
Echinococcus granulosus dna polymerase kappa 0.0019 0.0036 0.008
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.009 0.0774 0.2095
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0826 0.1808
Brugia malayi steroid hormone receptor 0.002 0.0046 0.01
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0291 0.0637
Loa Loa (eye worm) hypothetical protein 0.0041 0.0263 0.0712
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0046 0.01
Brugia malayi hypothetical protein 0.002 0.004 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0102 0.1124
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0046 0.01
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0089 0.0763 0.1671
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Echinococcus multilocularis cyclin B3 1 0.0053 0.0389 0.0389
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0165 0.1546 0.1546
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0826 0.9119
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.033 0.0648
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0036 0.008
Trichomonas vaginalis cyclins, putative 0.0103 0.0906 0.1918
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0275
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0046 0.01
Echinococcus multilocularis kinase protein 0.0089 0.0763 0.0763
Trichomonas vaginalis cyclin B3, putative 0.0053 0.0389 0.0779
Entamoeba histolytica hypothetical protein 0.0043 0.0287 0.288
Entamoeba histolytica hypothetical protein 0.0043 0.0287 0.288
Trichomonas vaginalis cyclin B, putative 0.0103 0.0906 0.1918
Onchocerca volvulus 0.0058 0.044 0.0872
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Brugia malayi Cyclin, N-terminal domain containing protein 0.0103 0.0906 0.1983
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.063 0.1705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0046 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Brugia malayi Cyclin, N-terminal domain containing protein 0.0165 0.1546 0.3385
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0291 0.0787
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0152 0.1675
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0291 0.321
Leishmania major DNA polymerase eta, putative 0.0019 0.0036 0.0402
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0287 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0046 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0046 0.01
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0291 0.0561
Echinococcus multilocularis cyclin b3 0.0053 0.0389 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0046 0.01
Entamoeba histolytica cyclin family protein 0.0053 0.0389 0.406
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0291 0.0561
Entamoeba histolytica hypothetical protein 0.0043 0.0287 0.288
Brugia malayi Protein kinase domain containing protein 0.0044 0.0291 0.0637
Leishmania major DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.063 0.1379
Trypanosoma cruzi CYC2-like cyclin, putative 0.0103 0.0906 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0152 0.1511
Loa Loa (eye worm) hypothetical protein 0.0103 0.0906 0.2451
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1332 0.3606
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0291 0.321
Schistosoma mansoni cyclins 0.0053 0.0389 0.0852
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0033 0.0073
Giardia lamblia Hypothetical protein 0.0456 0.4567 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0036 0.0036
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0291 0.0291
Mycobacterium leprae Conserved hypothetical protein 0.0456 0.4567 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.063 0.1379
Trichomonas vaginalis cyclin A, putative 0.0103 0.0906 0.1918
Leishmania major importin beta-1 subunit, putative 0.0028 0.0129 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0389 0.0779
Leishmania major cyclin 0.0103 0.0906 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0129 0.0204
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0046 0.01
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0152 0.1675
Entamoeba histolytica cyclin, putative 0.0103 0.0906 1
Leishmania major GTP-binding protein, putative 0.0026 0.0102 0.1124
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0402
Schistosoma mansoni kinase 0.0049 0.0343 0.0751
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0089 0.0763 0.0763
Giardia lamblia Kinase, PLK 0.0095 0.0826 0.1742
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0046 0.0046
Brugia malayi RNA, U transporter 1 0.0099 0.0864 0.1891
Mycobacterium ulcerans putative transglutaminase-like protein 0.0456 0.4567 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0046 0.01
Schistosoma mansoni cyclin B3 0.0165 0.1546 0.3385
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0046 0.0046
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0291 0.321
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0046 0.01
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0046 0.01
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0826 0.0826
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0046 0.01
Schistosoma mansoni survival motor neuron protein 0.0058 0.044 0.0964
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0291 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Echinococcus granulosus cyclins 0.0053 0.0389 0.0852
Trichomonas vaginalis cyclin D, putative 0.0053 0.0389 0.0779
Plasmodium falciparum cyclin 0.0053 0.0389 0.3587
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0291 0.321
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0046 0.01
Schistosoma mansoni nuclear hormone receptor 0.002 0.0046 0.01
Mycobacterium ulcerans hypothetical protein 0.0456 0.4567 1
Brugia malayi TAR-binding protein 0.0076 0.063 0.1379
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0046 0.01
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0102 0.0223
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0152 0.1675
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0291 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0046 0.0124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0046 0.01
Giardia lamblia Cyclin A 0.0053 0.0389 0.0779
Loa Loa (eye worm) hypothetical protein 0.006 0.0461 0.1247
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0036 0.008
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0291 0.321
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Schistosoma mansoni coup transcription factor 0.002 0.0046 0.01
Echinococcus multilocularis snurportin 1 0.0372 0.3694 0.3694
Trypanosoma cruzi cyclin, putative 0.0103 0.0906 1
Plasmodium falciparum MO15-related protein kinase 0.012 0.1085 1
Mycobacterium ulcerans hypothetical protein 0.0456 0.4567 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0046 0.01
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0826 0.9082
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0826 0.9119
Schistosoma mansoni ran 0.0026 0.0102 0.0223
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0152 0.1398
Mycobacterium leprae Conserved hypothetical protein 0.0456 0.4567 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0046 0.01
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0908 0.1923
Mycobacterium tuberculosis Conserved hypothetical protein 0.0456 0.4567 1
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0291 0.321
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0291 0.0637
Schistosoma mansoni hypothetical protein 0.0043 0.0287 0.0628
Trichomonas vaginalis cyclins, putative 0.0103 0.0906 0.1918
Brugia malayi MH2 domain containing protein 0.0144 0.1332 0.2917
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0102 0.1014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0036 0.0402
Onchocerca volvulus 0.0103 0.0906 0.1901
Entamoeba histolytica hypothetical protein 0.0028 0.0129 0.1063
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0291 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0129 0.1422
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0291 0.0291
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.008
Toxoplasma gondii hypothetical protein 0.004 0.0256 0.2548
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0826 0.2235
Brugia malayi hypothetical protein 0.0286 0.28 0.613
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0046 0.01
Trichomonas vaginalis ran, putative 0.0026 0.0102 0.0144
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0129 0.0204
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0033
Schistosoma mansoni ran 0.0026 0.0102 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0098
Plasmodium falciparum importin beta, putative 0.0035 0.0197 0.1817
Trypanosoma cruzi cyclin, putative 0.0103 0.0906 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0937
Trichomonas vaginalis cyclins, putative 0.0053 0.0389 0.0779
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0197 0.0197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0073
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0046 0.0046
Echinococcus granulosus Transglutaminase 0.0456 0.4567 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0046 0.01
Entamoeba histolytica cyclin, putative 0.0053 0.0389 0.406
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0046 0.0124
Schistosoma mansoni hypothetical protein 0.0205 0.196 0.4291
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0402
Brugia malayi ecdysteroid receptor 0.002 0.0046 0.01
Schistosoma mansoni hypothetical protein 0.0372 0.3694 0.8088
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0826 0.1742
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0089 0.0763 0.0763
Schistosoma mansoni tar DNA-binding protein 0.0076 0.063 0.1379
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0197 0.1965
Mycobacterium tuberculosis Hypothetical protein 0.0456 0.4567 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0197 0.0534
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0076 0.063 0.1379
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0046 0.01
Loa Loa (eye worm) TAR-binding protein 0.0076 0.063 0.1705
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0089 0.0763 0.0763
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.044 0.0964
Schistosoma mansoni hypothetical protein 0.0041 0.0263 0.0576
Trichomonas vaginalis peptide N-glycanase, putative 0.0456 0.4567 1
Trichomonas vaginalis cyclins, putative 0.0063 0.0486 0.0991
Plasmodium falciparum protein kinase 5 0.0044 0.0291 0.2678
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0197 0.2177
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0036 0.0036
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0291 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Echinococcus granulosus GPCR family 2 0.0019 0.0033 0.0073
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0046 0.01
Brugia malayi cell division control protein 2 homolog 0.0044 0.0291 0.0637
Brugia malayi Importin beta-1 subunit 0.0035 0.0197 0.0432
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0046 0.01
Echinococcus multilocularis kinase protein 0.0089 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0076 0.063 0.1379
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1332 0.3606
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0046 0.01
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0046 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0402
Schistosoma mansoni DNA polymerase eta 0.0019 0.0036 0.008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0102 0.1124
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0291 0.2926
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0826 0.1742
Echinococcus granulosus snurportin 1 0.0372 0.3694 0.8088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0102 0.1124
Trichomonas vaginalis cyclin B, putative 0.0103 0.0906 0.1918
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0036 0.0402
Echinococcus multilocularis geminin 0.0205 0.196 0.196
Mycobacterium tuberculosis Long conserved protein 0.0456 0.4567 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0826 0.9119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0046 0.01
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0046 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0152 0.1398
Echinococcus multilocularis Transglutaminase 0.0456 0.4567 0.4567
Schistosoma mansoni importin beta-1 0.0035 0.0197 0.0432
Echinococcus multilocularis cyclins 0.0053 0.0389 0.0389
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.008
Loa Loa (eye worm) cyclin domain-containing protein 0.0165 0.1546 0.4185
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0046 0.01
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0046 0.0046
Echinococcus multilocularis tar DNA binding protein 0.0076 0.063 0.063
Trichomonas vaginalis cyclin D, putative 0.0053 0.0389 0.0779
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0291 0.0291
Schistosoma mansoni thyroid hormone receptor 0.002 0.0046 0.01
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0073
Giardia lamblia Transglutaminase/protease, putative 0.0456 0.4567 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.008
Brugia malayi Protein kinase domain containing protein 0.009 0.0774 0.1694
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0826 0.1808
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0826 0.1742
Trypanosoma brucei polo-like protein kinase 0.0095 0.0826 0.9119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0046 0.01
Onchocerca volvulus 0.0456 0.4567 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0103 0.0906 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0036 0.008
Giardia lamblia Hypothetical protein 0.0053 0.0389 0.0779
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.009 0.0774 0.1694
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Brugia malayi hypothetical protein 0.0043 0.0287 0.0628
Schistosoma mansoni hypothetical protein 0.0456 0.4567 1
Echinococcus granulosus cyclins 0.0053 0.0389 0.0852
Schistosoma mansoni tar DNA-binding protein 0.0076 0.063 0.1379
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0291 0.0787
Loa Loa (eye worm) RNA binding protein 0.0076 0.063 0.1705
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0046 0.0046
Brugia malayi Thioredoxin family protein 0.0456 0.4567 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0263 0.0576
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0223
Entamoeba histolytica hypothetical protein 0.0043 0.0287 0.288
Echinococcus granulosus cyclin b3 0.0053 0.0389 0.0852
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0287 0.0628
Schistosoma mansoni cyclin B 0.0103 0.0906 0.1983
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0461 0.1247
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0036 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0826 0.1808
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Trichomonas vaginalis cyclin B, putative 0.0103 0.0906 0.1918
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.033 0.0648
Echinococcus granulosus importin subunit beta 1 0.0035 0.0197 0.0432
Echinococcus multilocularis cyclin B 0.0103 0.0906 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0046 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0073
Loa Loa (eye worm) hypothetical protein 0.0286 0.28 0.7579
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0461 0.1008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0402
Loa Loa (eye worm) hypothetical protein 0.0103 0.0906 0.2451
Schistosoma mansoni hypothetical protein 0.0205 0.196 0.4291
Schistosoma mansoni thyroid hormone receptor 0.002 0.0046 0.01
Loa Loa (eye worm) hypothetical protein 0.0043 0.028 0.0757
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0826 0.1725
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0046 0.01
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0291 0.0637
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0046 0.01
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0291 0.321
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0129 0.0204
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0826 0.1742
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.28 0.28
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0089 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0124
Echinococcus granulosus cyclin B 0.0103 0.0906 0.1983
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0091
Trichomonas vaginalis cyclins, putative 0.0103 0.0906 0.1918
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0033 0.0091
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0036
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3694 1
Brugia malayi RNA binding protein 0.0076 0.063 0.1379
Plasmodium vivax importin-beta 2, putative 0.0035 0.0197 0.1817
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0291 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0046 0.01
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0102 0.0937
Echinococcus granulosus geminin 0.0205 0.196 0.4291
Mycobacterium ulcerans transglutaminase family protein 0.0456 0.4567 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.005 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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