Detailed information for compound 1307236

Basic information

Technical information
  • TDR Targets ID: 1307236
  • Name: 1-[[2-(3-chlorophenyl)-5-methyl-1,3-oxazol-4- yl]methyl]-4-(6-methylpyridin-2-yl)piperazine
  • MW: 382.887 | Formula: C21H23ClN4O
  • H donors: 0 H acceptors: 2 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(n1)N1CCN(CC1)Cc1nc(oc1C)c1cccc(c1)Cl
  • InChi: 1S/C21H23ClN4O/c1-15-5-3-8-20(23-15)26-11-9-25(10-12-26)14-19-16(2)27-21(24-19)17-6-4-7-18(22)13-17/h3-8,13H,9-12,14H2,1-2H3
  • InChiKey: PBTWRPMLSWRJOV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[[2-(3-chlorophenyl)-5-methyl-oxazol-4-yl]methyl]-4-(6-methyl-2-pyridyl)piperazine
  • 1-[[2-(3-chlorophenyl)-5-methyl-4-oxazolyl]methyl]-4-(6-methyl-2-pyridyl)piperazine
  • MLS000733685
  • SMR000316765
  • 1-{[2-(3-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-4-(6-methylpyridin-2-yl)piperazine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.005 0.0076
Plasmodium falciparum lysine--tRNA ligase 0.0117 0.045 0.045
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0647 0.2819
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0081 0.1082
Onchocerca volvulus 0.0038 0.0091 0.1347
Echinococcus multilocularis lamin dm0 0.0059 0.0186 0.0504
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0026 0.0038 0.0057
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.1015 1
Entamoeba histolytica hypothetical protein 0.0117 0.045 0.2857
Onchocerca volvulus 0.0074 0.0254 0.6692
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Echinococcus multilocularis pyruvate kinase 0.0036 0.0081 0.022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0188
Trichomonas vaginalis sugar transport protein, putative 0.0074 0.0254 0.1106
Echinococcus granulosus GPCR family 2 0.0115 0.044 0.1192
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.003 0.0053 0.0711
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0022 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0155
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0037 0.0037
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0056 0.0171 0.2847
Toxoplasma gondii ABC1 family protein 0.0038 0.0091 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0117 0.045 0.5996
Loa Loa (eye worm) hypothetical protein 0.0161 0.0647 0.2819
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0347 0.0941
Schistosoma mansoni pyruvate kinase 0.0036 0.0081 0.022
Echinococcus granulosus TRP transient receptor potential channel 0.0077 0.0268 0.0727
Echinococcus multilocularis lysyl tRNA synthetase 0.0117 0.045 0.122
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0091 0.1215
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0161 0.0647 0.0976
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0158 0.0632 0.2718
Echinococcus granulosus geminin 0.0336 0.144 0.3904
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.005 0.0136
Echinococcus granulosus short transient receptor potential channel 6 0.0137 0.0539 0.1462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Leishmania major glucose transporter, lmgt3 0.0163 0.0656 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Leishmania major glucose transporter, lmgt1 0.0163 0.0656 0.8747
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0078 0.021
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0022 0.0108
Echinococcus granulosus lamin 0.0059 0.0186 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0165
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0074 0.0254 0.2413
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0186 0.0809
Plasmodium vivax sugar transporter, putative 0.0074 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0397
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0026 0.0038 0.0504
Loa Loa (eye worm) beta-lactamase 0.0038 0.0091 0.0397
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0161 0.0647 0.0647
Plasmodium falciparum calcium-dependent protein kinase 2 0.0161 0.0647 0.0647
Leishmania major glucose transporter/membrane transporter D2, putative 0.0163 0.0656 0.8747
Treponema pallidum prolyl-tRNA synthetase 0.0056 0.0171 0.1307
Schistosoma mansoni sugar transporter 0.0074 0.0254 0.0688
Echinococcus multilocularis geminin 0.0336 0.144 0.3904
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0038 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0078 0.0338
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0037 0.0491
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0081 0.0354
Onchocerca volvulus 0.0049 0.0143 0.3043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0397
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.003 0.0053 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trypanosoma brucei THT1 - hexose transporter, putative 0.0163 0.0656 0.8747
Echinococcus granulosus short transient receptor potential channel 6 0.0137 0.0539 0.1462
Brugia malayi beta-lactamase family protein 0.0038 0.0091 0.0348
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0131 0.0354
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0158 0.0632 0.4015
Plasmodium falciparum calcium-dependent protein kinase 5 0.0161 0.0647 0.0647
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.044 0.1192
Schistosoma mansoni glycyl-tRNA synthetase 0.003 0.0053 0.0145
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.039 0.039
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0184 0.075 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0048 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.005 0.0219
Echinococcus multilocularis glycyl tRNA synthetase 0.003 0.0053 0.0145
Echinococcus multilocularis musashi 0.0059 0.0186 0.0504
Brugia malayi jmjC domain containing protein 0.0094 0.0347 0.1469
Giardia lamblia PHD finger protein 15 0.0029 0.005 0.0303
Echinococcus multilocularis solute carrier family 22 0.0074 0.0254 0.0688
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0397
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0599 0.9448
Giardia lamblia DINP protein human, muc B family 0.002 0.0012 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Giardia lamblia DNA repair protein RAD52 0.0366 0.1575 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0074 0.0254 0.1106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0091 0.0247
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0048 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0254 0.1106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.044 0.1917
Brugia malayi Sugar transporter family protein 0.0074 0.0254 0.106
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3688 1
Trichomonas vaginalis conserved hypothetical protein 0.0525 0.2295 1
Schistosoma mansoni transient receptor potential channel 4 0.0207 0.0856 0.2321
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Echinococcus multilocularis tumor protein p63 0.0337 0.1443 0.3913
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0091 0.0397
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0117 0.045 0.196
Mycobacterium tuberculosis Conserved protein 0.0038 0.0091 0.0793
Toxoplasma gondii sugar transporter ST2 0.0074 0.0254 0.0383
Mycobacterium ulcerans hypothetical protein 0.0038 0.0091 0.1514
Loa Loa (eye worm) hypothetical protein 0.0207 0.0856 0.373
Schistosoma mansoni glucose transport protein 0.0525 0.2295 0.6222
Giardia lamblia Glycyl-tRNA synthetase 0.003 0.0053 0.0323
Leishmania major myo-inositol/proton symporter (MIT) 0.0074 0.0254 0.3381
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Onchocerca volvulus 0.0059 0.0186 0.4457
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0158 0.0632 0.2718
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.021
Leishmania major hypothetical protein, conserved 0.0104 0.039 0.5197
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0037 0.0491
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0161 0.0647 0.1754
Schistosoma mansoni hypothetical protein 0.0525 0.2295 0.6222
Plasmodium falciparum calcium-dependent protein kinase 3 0.0161 0.0647 0.0647
Onchocerca volvulus 0.0059 0.0186 0.4457
Schistosoma mansoni sugar transporter 0.0074 0.0254 0.0688
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.0953 0.4152
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.003 0.0053 0.0145
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.003 0.0053 0.0183
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Trypanosoma cruzi hexose transporter, putative 0.0089 0.0322 0.4296
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0065 0.0212 0.0925
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0186 0.0809
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.005 0.0076
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0161 0.0647 0.2783
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0074 0.0254 0.0688
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0074 0.0254 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Onchocerca volvulus 0.0074 0.0254 0.6692
Chlamydia trachomatis proline--tRNA ligase 0.0056 0.0171 0.2847
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0602 0.2624
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0022 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Chlamydia trachomatis threonine--tRNA ligase 0.003 0.0053 0.0886
Echinococcus granulosus solute carrier family 22 0.0074 0.0254 0.0688
Trypanosoma cruzi hexose transporter 0.0163 0.0656 0.8747
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.003 0.0053 0.0711
Echinococcus multilocularis dna polymerase kappa 0.002 0.0012 0.0032
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0022 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0163 0.0656 0.286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.0793 0.3422
Giardia lamblia Threonyl-tRNA synthetase 0.003 0.0053 0.0323
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0074 0.0254 0.4213
Plasmodium vivax lysine--tRNA ligase, putative 0.0117 0.045 0.045
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0081 0.1082
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0151 0.0602 0.9494
Onchocerca volvulus 0.0074 0.0254 0.6692
Echinococcus granulosus lamin dm0 0.0059 0.0186 0.0504
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0022 0.0373
Echinococcus granulosus glycyl tRNA synthetase 0.003 0.0053 0.0145
Schistosoma mansoni sugar transporter 0.0074 0.0254 0.0688
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0143 0.0387
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0037 0.0056
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Schistosoma mansoni lysyl-tRNA synthetase 0.0117 0.045 0.122
Schistosoma mansoni intermediate filament proteins 0.0059 0.0186 0.0504
Schistosoma mansoni pyruvate kinase 0.0036 0.0081 0.022
Plasmodium vivax CDK-related protein kinase 6, putative 0.2229 1 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0151 0.0602 0.2624
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0254 0.1106
Toxoplasma gondii facilitative glucose transporter GT1 0.0525 0.2295 0.3461
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.039 0.5197
Schistosoma mansoni hypothetical protein 0.0047 0.0131 0.0354
Plasmodium vivax calcium-dependent protein kinase, putative 0.0161 0.0647 0.0647
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0091 0.0247
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0026 0.0038 0.0504
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Brugia malayi beta-lactamase 0.0038 0.0091 0.0348
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.01 0.037 0.3572
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0074 0.0254 0.0254
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0354 0.1501
Brugia malayi major facilitator superfamily protein 0.0074 0.0254 0.106
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0091 0.0397
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0003 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0091 0.0793
Plasmodium falciparum calcium-dependent protein kinase 1 0.0161 0.0647 0.0647
Giardia lamblia Prolyl-tRNA synthetase 0.0158 0.0632 0.4005
Brugia malayi Sugar transporter family protein 0.0074 0.0254 0.106
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0091 0.0793
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.039 0.0588
Onchocerca volvulus 0.0074 0.0254 0.6692
Brugia malayi Latrophilin receptor protein 2 0.0115 0.044 0.1875
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0078 0.021
Loa Loa (eye worm) hypothetical protein 0.0104 0.039 0.1699
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.003 0.0053 0.0416
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0602 0.2624
Echinococcus multilocularis synaptic vesicle 2 protein 0.0074 0.0254 0.0688
Schistosoma mansoni ap endonuclease 0.0023 0.0022 0.0061
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0525 0.2295 0.6222
Toxoplasma gondii sugar transporter ST3 0.0074 0.0254 0.0383
Giardia lamblia Hexose transporter 0.0074 0.0254 0.1597
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0793 0.215
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Echinococcus granulosus peregrin 0.0029 0.005 0.0136
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0151 0.0602 0.5887
Leishmania major hypothetical protein, conserved 0.0026 0.0038 0.0504
Trichomonas vaginalis glucose transporter, putative 0.0163 0.0656 0.286
Schistosoma mansoni DNA polymerase eta 0.002 0.0012 0.0032
Trypanosoma brucei THT1 - hexose transporter, putative 0.0163 0.0656 0.8747
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.044 0.1875
Onchocerca volvulus 0.0038 0.0091 0.1347
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0131 0.0354
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0037 0.01
Mycobacterium tuberculosis Conserved protein 0.0038 0.0091 0.0793
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0012 0.0193
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.044 0.1192
Onchocerca volvulus 0.0074 0.0254 0.6692
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0599 0.586
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0022 0.0373
Giardia lamblia Thioredoxin reductase 0.0151 0.0602 0.3814
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Schistosoma mansoni lamin 0.0059 0.0186 0.0504
Onchocerca volvulus 0.0038 0.0091 0.1347
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0161 0.0647 0.8623
Trypanosoma cruzi hexose transporter, putative 0.0074 0.0254 0.3381
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.039 0.039
Schistosoma mansoni transient receptor potential channel 0.0137 0.0539 0.1462
Leishmania major protein kinase, putative 0.0161 0.0647 0.8623
Schistosoma mansoni glucose transporter 0.0074 0.0254 0.0688
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0141
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0454 0.1978
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0602 0.2624
Chlamydia trachomatis thioredoxin reductase 0.0151 0.0602 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0091 0.0247
Echinococcus multilocularis GPCR, family 2 0.0115 0.044 0.1192
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0037 0.0111
Echinococcus multilocularis transient receptor potential gamma protein 0.0207 0.0856 0.2321
Leishmania major DNA polymerase eta, putative 0.002 0.0012 0.0155
Plasmodium vivax glycine--tRNA ligase, putative 0.003 0.0053 0.0053
Onchocerca volvulus 0.0074 0.0254 0.6692
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Onchocerca volvulus 0.0074 0.0254 0.6692
Echinococcus granulosus lysyl tRNA synthetase 0.0117 0.045 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0165
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.003 0.0053 0.0711
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Schistosoma mansoni lamin 0.0059 0.0186 0.0504
Schistosoma mansoni protein kinase 0.0161 0.0647 0.1754
Trichomonas vaginalis glucose transporter, putative 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.0059 0.0186 0.0809
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0117 0.045 0.7471
Loa Loa (eye worm) hypothetical protein 0.0157 0.0631 0.2749
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0037 0.0161
Schistosoma mansoni glucose transport protein 0.0525 0.2295 0.6222
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0849 0.3758 0.3758
Trypanosoma brucei glucose transporter 2A 0.0163 0.0656 0.8747
Echinococcus multilocularis short transient receptor potential channel 6 0.0137 0.0539 0.1462
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0074 0.0254 0.4213
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0184 0.075 0.1132
Brugia malayi hypothetical protein 0.0074 0.0254 0.106
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0081 0.0354
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0155
Echinococcus multilocularis pyruvate kinase 0.0018 0.0003 0.0007
Trichomonas vaginalis esterase, putative 0.0038 0.0091 0.0397
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0161 0.0647 0.0647
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0081 0.0729
Plasmodium vivax hypothetical protein, conserved 0.0029 0.005 0.005
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.003 0.0053 0.008
Onchocerca volvulus 0.0074 0.0254 0.6692
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0032 0.0141
Brugia malayi Major Facilitator Superfamily protein 0.0074 0.0254 0.106
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0091 0.1215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0793 0.215
Leishmania major hypothetical protein, conserved 0.0026 0.0038 0.0504
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.003 0.0053 0.0339
Plasmodium falciparum mitogen-activated protein kinase 2 0.0849 0.3758 0.3758
Loa Loa (eye worm) threonyl-tRNA synthetase 0.003 0.0053 0.0233
Chlamydia trachomatis lysine--tRNA ligase 0.0117 0.045 0.7471
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.1311 1
Schistosoma mansoni protein kinase 0.0161 0.0647 0.1754
Toxoplasma gondii exonuclease III APE 0.0023 0.0022 0.0034
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.005 0.0136
Loa Loa (eye worm) hypothetical protein 0.0077 0.0268 0.1168
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0793 0.215
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0151 0.0602 1
Plasmodium falciparum pyruvate kinase 0.0036 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0081 0.0081
Giardia lamblia Sugar-proton symporter 0.0074 0.0254 0.1597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0793 0.215
Echinococcus multilocularis peregrin 0.0029 0.005 0.0136
Echinococcus granulosus synaptic vesicle 2 protein 0.0074 0.0254 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0022 0.0299
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0003 0.0003
Echinococcus multilocularis solute carrier family 22 0.0074 0.0254 0.0688
Loa Loa (eye worm) hypothetical protein 0.0248 0.1043 0.4546
Brugia malayi Calcitonin receptor-like protein seb-1 0.0363 0.1563 0.6796
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0037 0.0161
Echinococcus granulosus jumonji domain containing protein 0.004 0.0101 0.0275
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Echinococcus multilocularis pyruvate kinase 0.0036 0.0081 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Onchocerca volvulus 0.0074 0.0254 0.6692
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0188
Echinococcus granulosus solute carrier family 22 0.0074 0.0254 0.0688
Echinococcus granulosus General substrate transporter 0.0451 0.1961 0.5317
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0091 0.0247
Echinococcus granulosus muscleblind protein 0.0157 0.0631 0.1711
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0158 0.0632 0.2755
Schistosoma mansoni survival motor neuron protein 0.0096 0.0354 0.0961
Loa Loa (eye worm) sugar transporter 0.0074 0.0254 0.1106
Echinococcus multilocularis short transient receptor potential channel 6 0.0137 0.0539 0.1462
Schistosoma mansoni hypothetical protein 0.0336 0.144 0.3904
Entamoeba histolytica hypothetical protein 0.0104 0.0391 0.2481
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0793 0.215
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0091 0.0793
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Entamoeba histolytica protein kinase, putative 0.0161 0.0647 0.4109
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0062 0.0271
Schistosoma mansoni sugar transporter 0.0074 0.0254 0.0688
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0647 0.1754
Mycobacterium ulcerans hypothetical protein 0.0026 0.0038 0.0628
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0366 0.1575 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.039 0.5197
Echinococcus multilocularis calcium dependent protein kinase 0.0151 0.0602 0.1632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0091 0.0793
Echinococcus granulosus pyruvate kinase 0.0018 0.0003 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0081 0.1348
Leishmania major threonyl-tRNA synthetase, putative 0.003 0.0053 0.0711
Plasmodium falciparum phd finger protein, putative 0.0029 0.005 0.005
Leishmania major DNA polymerase kappa, putative 0.002 0.0012 0.0155
Treponema pallidum thioredoxin reductase (trxB) 0.0151 0.0602 0.4593
Echinococcus granulosus Sugar transporter ERD6 protein 0.0074 0.0254 0.0688
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0081 0.0305
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0077 0.0268 0.0727
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0091 0.0091
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Brugia malayi Muscleblind-like protein 0.0157 0.0631 0.2712
Echinococcus multilocularis muscleblind protein 0.0157 0.0631 0.1711
Brugia malayi Major Facilitator Superfamily protein 0.0074 0.0254 0.106
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0184 0.075 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.044 0.1917
Plasmodium falciparum hexose transporter 0.0525 0.2295 0.2295
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1311 0.8326
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0012 0.0074
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0081 0.1082
Loa Loa (eye worm) hypothetical protein 0.0058 0.0181 0.0788
Toxoplasma gondii glycyl-tRNA synthetase 0.003 0.0053 0.008
Echinococcus granulosus calcium dependent protein kinase 0.0151 0.0602 0.1632
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0091 0.1215
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0233
Echinococcus granulosus solute carrier family 22 0.0074 0.0254 0.0688
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0032 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0254 0.1106
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0022 0.0299
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0022 0.0299
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Mycobacterium ulcerans beta-lactamase 0.0038 0.0091 0.1514
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0347 0.0941
Schistosoma mansoni hypothetical protein 0.0115 0.044 0.1192
Schistosoma mansoni transient receptor potential channel 0.0207 0.0856 0.2321
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0259 0.0703
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0158 0.0632 0.1714
Toxoplasma gondii sugar transporter ST1 0.0074 0.0254 0.0383
Brugia malayi Transient-receptor-potential like protein 0.0077 0.0268 0.1123
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0151 0.0602 0.2624
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.003 0.0053 0.0711
Schistosoma mansoni hypothetical protein 0.0115 0.044 0.1192
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0037 0.0491
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0078 0.021
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0117 0.045 0.7471
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0081 0.0354
Brugia malayi lysyl-tRNA synthetase 0.0117 0.045 0.1919
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0081 0.0354
Loa Loa (eye worm) hypothetical protein 0.0157 0.0631 0.2749
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0038 0.0504
Leishmania major pyruvate kinase 0.0036 0.0081 0.1082
Plasmodium vivax hexose transporter 0.0525 0.2295 0.2295
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0184 0.075 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Echinococcus multilocularis lamin 0.0059 0.0186 0.0504
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0022 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0012 0.0155
Echinococcus granulosus transient receptor potential gamma protein 0.0207 0.0856 0.2321
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0081 0.0354
Trypanosoma cruzi hexose transporter, putative 0.0163 0.0656 0.8747
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.003 0.0053 0.0339
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0081 0.0693
Leishmania major hypothetical protein, conserved 0.0074 0.0254 0.3381
Entamoeba histolytica protein kinase, putative 0.0161 0.0647 0.4109
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0074 0.0254 0.4213
Trichomonas vaginalis myo-inositol transporter, putative 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.0363 0.1563 0.6813
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.0128 0.0499 0.2173
Giardia lamblia Lysyl-tRNA synthetase 0.0117 0.045 0.2845
Toxoplasma gondii transporter, major facilitator family protein 0.0074 0.0254 0.0383
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.1311 0.8323
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3688 1
Toxoplasma gondii protein kinase, putative 0.1484 0.663 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Mycobacterium leprae Probable lipase LipE 0.0038 0.0091 0.0897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0793 0.215
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0091 0.0793
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.005 0.0136
Loa Loa (eye worm) hypothetical protein 0.0049 0.0143 0.0622
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0078 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0793 0.215
Loa Loa (eye worm) glycyl-tRNA synthetase 0.003 0.0053 0.0233
Toxoplasma gondii lysine-tRNA ligase 0.0117 0.045 0.0679
Brugia malayi hypothetical protein 0.0104 0.039 0.1657
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0158 0.0632 0.1714
Schistosoma mansoni hypothetical protein 0.0029 0.005 0.0136
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0081 0.1019
Mycobacterium ulcerans lipase LipD 0.0038 0.0091 0.1514
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.003 0.0053 0.0886
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.0391 0.2481
Loa Loa (eye worm) hypothetical protein 0.013 0.0508 0.2213
Echinococcus multilocularis transient receptor potential ion channel A 0.02 0.0825 0.2237
Schistosoma mansoni protein kinase 0.0161 0.0647 0.1754
Giardia lamblia Pyruvate kinase 0.0036 0.0081 0.05
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0091 0.0397
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0158 0.0632 0.1714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Schistosoma mansoni ap endonuclease 0.0023 0.0022 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0038 0.0504
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Trypanosoma cruzi sugar transporter, putative 0.0074 0.0254 0.3381
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Loa Loa (eye worm) hypothetical protein 0.0158 0.0632 0.2755
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Schistosoma mansoni pyruvate kinase 0.0018 0.0003 0.0007
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0151 0.0602 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0254 0.1106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0091 0.1514
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0103 0.0385 0.1676
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0022 0.0022
Onchocerca volvulus 0.0096 0.0354 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0012 0.0032
Schistosoma mansoni hypothetical protein 0.0336 0.144 0.3904
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0012 0.0155
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3688 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0074 0.0254 0.2413
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Onchocerca volvulus 0.0074 0.0254 0.6692
Chlamydia trachomatis pyruvate kinase 0.0036 0.0081 0.1348
Brugia malayi jmjC domain containing protein 0.0035 0.0078 0.0289
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0032
Trypanosoma brucei glucose transporter, putative 0.0163 0.0656 0.8747
Onchocerca volvulus 0.0074 0.0254 0.6692
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0656 0.286
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0026 0.0038 0.0504
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0037 0.01
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0091 0.0348
Brugia malayi Cam kinase protein 1 0.0161 0.0647 0.2783
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.205 0.5559
Brugia malayi follicle stimulating hormone receptor 0.0228 0.0953 0.4122
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0091 0.1514
Echinococcus multilocularis General substrate transporter 0.0451 0.1961 0.5317
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Onchocerca volvulus 0.0074 0.0254 0.6692
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0397
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.039 0.5197
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Echinococcus granulosus transient receptor potential ion channel A 0.02 0.0825 0.2237
Echinococcus multilocularis solute carrier family 22 0.0074 0.0254 0.0688
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0184 0.075 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0037 0.01
Brugia malayi major facilitator superfamily protein 0.0074 0.0254 0.106
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1311 0.8326
Brugia malayi hypothetical protein 0.0067 0.0223 0.0927
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0012 0.0155
Echinococcus granulosus pyruvate kinase 0.0036 0.0081 0.022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.044 0.1192
Loa Loa (eye worm) hypothetical protein 0.0471 0.205 0.8934
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0117 0.045 0.5996
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0081 0.0305
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.039 0.039
Echinococcus granulosus pyruvate kinase 0.0018 0.0003 0.0007
Echinococcus granulosus pyruvate kinase 0.0036 0.0081 0.022
Leishmania major glucose transporter, lmgt2 0.0163 0.0656 0.8747
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0219
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0037 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0091 0.0397
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0155
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.0117 0.045 0.196
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Echinococcus granulosus pyruvate kinase 0.0018 0.0003 0.0007
Onchocerca volvulus 0.0074 0.0254 0.6692
Echinococcus multilocularis pyruvate kinase 0.0018 0.0003 0.0007
Brugia malayi Sugar transporter family protein 0.0525 0.2295 1
Echinococcus granulosus solute carrier family 22 0.0074 0.0254 0.0688
Mycobacterium tuberculosis Conserved protein 0.0038 0.0091 0.0793
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0849 0.3758 0.5667
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.044 0.1192
Mycobacterium ulcerans glycyl-tRNA synthetase 0.003 0.0053 0.0886
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0158 0.0632 0.1714
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0022 0.0143
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0117 0.045 0.6932
Echinococcus granulosus intermediate filament protein 0.0059 0.0186 0.0504
Onchocerca volvulus 0.0074 0.0254 0.6692
Mycobacterium ulcerans sugar transporter 0.0074 0.0254 0.4213
Treponema pallidum threonyl-tRNA synthetase 0.003 0.0053 0.0407
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Plasmodium falciparum proline--tRNA ligase 0.0184 0.075 0.075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0022 0.0061
Trypanosoma cruzi hexose transporter, putative 0.0163 0.0656 0.8747
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0037 0.0234
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0186 0.0763
Brugia malayi latrophilin 2 splice variant baaae 0.0248 0.1043 0.4519
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.01 0.037 0.5587
Onchocerca volvulus Putative transporter 0.0074 0.0254 0.6692
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0631 0.1711
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Trichomonas vaginalis chaperonin, putative 0.0026 0.0037 0.0161
Brugia malayi intermediate filament protein 0.0059 0.0186 0.0763
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0003 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0163 0.0656 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0163 0.0656 0.286
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0037 0.01
Echinococcus granulosus dna polymerase kappa 0.002 0.0012 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0022 0.0299
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0081 0.1019
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.205 0.5559
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0161 0.0647 0.2819
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0037 0.01
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Brugia malayi MH2 domain containing protein 0.0118 0.0454 0.1937
Trypanosoma brucei THT1 - hexose transporter, putative 0.0163 0.0656 0.8747
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0184 0.075 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0091 0.0897
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.01 0.037 0.3572
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0012 0.0051
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0074 0.0254 0.3381
Onchocerca volvulus 0.0074 0.0254 0.6692
Leishmania major hypothetical protein, conserved 0.0038 0.0091 0.1215
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0155
Brugia malayi hypothetical protein 0.0074 0.0254 0.106
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0656 0.286
Leishmania major lysyl-tRNA synthetase, putative 0.0117 0.045 0.5996
Schistosoma mansoni hypothetical protein 0.0248 0.1043 0.2829
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.003 0.0053 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0254 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1311 0.5714
Loa Loa (eye worm) hypothetical protein 0.0049 0.0143 0.0625
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.003 0.0053 0.0233
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0454 0.1978
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0397
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0091 0.0793
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0161 0.0647 0.0647
Plasmodium falciparum threonine--tRNA ligase 0.003 0.0053 0.0053
Trypanosoma brucei glucose transporter 1E 0.0163 0.0656 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0163 0.0656 0.286
Echinococcus multilocularis pyruvate kinase 0.0018 0.0003 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0189 0.0824
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0647 0.1754
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0525 0.2295 0.6222
Onchocerca volvulus 0.0074 0.0254 0.6692
Schistosoma mansoni hypothetical protein 0.0115 0.044 0.1192
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0091 0.0397
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0158 0.0632 1
Trypanosoma brucei unspecified product 0.002 0.0012 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0165
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0012 0.0051
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0101 0.0275
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0161 0.0647 0.0976
Echinococcus multilocularis solute carrier family 22 0.0074 0.0254 0.0688
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0062 0.0222
Loa Loa (eye worm) hypothetical protein 0.0158 0.0632 0.2755
Loa Loa (eye worm) sugar transporter 0.0525 0.2295 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0037 0.0111
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0599 0.9955
Brugia malayi Bromodomain containing protein 0.0029 0.005 0.0169
Brugia malayi hypothetical protein 0.0471 0.205 0.8928
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.0793 0.3455
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0155
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Plasmodium falciparum protein kinase 7 0.1484 0.663 0.663
Plasmodium vivax threonine--tRNA ligase, putative 0.003 0.0053 0.0053
Echinococcus multilocularis pyruvate kinase 0.0028 0.0047 0.0128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0363 0.1563 0.6796
Brugia malayi beta-lactamase family protein 0.0038 0.0091 0.0348
Schistosoma mansoni hypothetical protein 0.0096 0.0354 0.0961
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0091 0.0793
Schistosoma mansoni transient receptor potential channel 0.0137 0.0539 0.1462
Entamoeba histolytica thioredoxin reductase, putative 0.0151 0.0602 0.3824
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Brugia malayi PHD-finger family protein 0.0029 0.005 0.0169
Echinococcus granulosus dna polymerase eta 0.002 0.0012 0.0032
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0012 0.0193
Leishmania major pyruvate kinase 0.0036 0.0081 0.1082
Echinococcus granulosus Threonyl tRNA synthetase C 0.003 0.0053 0.0145
Trypanosoma cruzi glucose transporter, putative 0.0074 0.0254 0.3381
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0022 0.0126
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0012 0.0051
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0081 0.1082
Mycobacterium ulcerans integral membrane transport protein 0.0074 0.0254 0.4213
Brugia malayi Major Facilitator Superfamily protein 0.0074 0.0254 0.106
Plasmodium vivax proline--tRNA ligase, putative 0.0184 0.075 0.075
Echinococcus granulosus tumor protein p63 0.0337 0.1443 0.3913
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0022 0.0061
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0037 0.0037
Brugia malayi hypothetical protein 0.0074 0.0254 0.106
Schistosoma mansoni hypothetical protein 0.0115 0.044 0.1192
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0155
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0022 0.0098
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0081 0.1019
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0091 0.0397
Echinococcus multilocularis dna polymerase eta 0.002 0.0012 0.0032
Schistosoma mansoni glucose transport protein 0.0525 0.2295 0.6222
Loa Loa (eye worm) major facilitator superfamily transporter 0.0074 0.0254 0.1106
Plasmodium falciparum calcium-dependent protein kinase 4 0.0161 0.0647 0.0647
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0363 0.1563 0.6813
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0081 0.0122
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.003 0.0053 0.0886
Trichomonas vaginalis sugar transporter, putative 0.0074 0.0254 0.1106
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0161 0.0647 0.2819
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0161 0.0647 0.0976
Loa Loa (eye worm) hypothetical protein 0.0074 0.0254 0.1106
Trichomonas vaginalis glucose transporter, putative 0.0163 0.0656 0.286
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.1032
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0022 0.0171
Brugia malayi glycyl-tRNA synthetase 0.003 0.0053 0.0183
Trypanosoma brucei sugar transporter, putative 0.0074 0.0254 0.3381
Schistosoma mansoni lysyl-tRNA synthetase 0.0117 0.045 0.122
Mycobacterium ulcerans threonyl-tRNA synthetase 0.003 0.0053 0.0886

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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