Detailed information for compound 1311942

Basic information

Technical information
  • TDR Targets ID: 1311942
  • Name: 1',7',7'-trimethylspiro[3H-1,3-benzoxazine-2, 6'-bicyclo[2.2.1]heptane]-4-one
  • MW: 271.354 | Formula: C17H21NO2
  • H donors: 1 H acceptors: 1 LogP: 3.83 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC2(CC3C(C2(C)CC3)(C)C)Oc2c1cccc2
  • InChi: 1S/C17H21NO2/c1-15(2)11-8-9-16(15,3)17(10-11)18-14(19)12-6-4-5-7-13(12)20-17/h4-7,11H,8-10H2,1-3H3,(H,18,19)
  • InChiKey: GYYGSDATUUQLDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1',7',7'-trimethylspiro[3H-1,3-benzoxazine-2,2'-norbornane]-4-one
  • 1',7',7'-trimethyl-4-spiro[3H-1,3-benzoxazine-2,2'-norbornane]one
  • 1',7',7'-trimethyl-2,3-dihydrospiro(4H-1,3-benzoxazine-2,2'-bicyclo[2.2.1]heptane)-4-one
  • MLS000701521
  • SMR000224535
  • AB-321/43115426

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens phospholipase A2, group IB (pancreas) Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens autophagy related 4B, cysteine peptidase Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Peptidase family C54 containing protein Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis cysteine protease atg4b Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Phospholipase A2 homolog Get druggable targets OG5_134661 All targets in OG5_134661
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans potential protease similar to S. cerevisiae ATG4 (YNL223W) microtubule-binding anchor protein involved in attachment of autophag Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus granulosus Peptidase C54 Get druggable targets OG5_127111 All targets in OG5_127111
Leishmania infantum AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K08342 autophagy-related protein 4, putative Get druggable targets OG5_127111 All targets in OG5_127111
Leishmania braziliensis AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Entamoeba histolytica peptidase, C54 family Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans potential protease similar to S. cerevisiae ATG4 (YNL223W) microtubule-binding anchor protein involved in attachment of autophag Get druggable targets OG5_127111 All targets in OG5_127111
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni family C54 unassigned peptidase (C54 family) Get druggable targets OG5_127111 All targets in OG5_127111
Trypanosoma brucei gambiense peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana AUT2/APG4/ATG4 cysteine peptidase, putative,cysteine peptidase, Clan CA, family C54, putative Get druggable targets OG5_127111 All targets in OG5_127111
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134661 All targets in OG5_134661
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127111 All targets in OG5_127111
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Trypanosoma congolense AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma mansoni family C54 unassigned peptidase (C54 family) Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus multilocularis Peptidase C54 Get druggable targets OG5_127111 All targets in OG5_127111
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus granulosus cysteine protease atg4b Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K08342 autophagy-related protein 4, putative Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma mansoni autophagin-1 (C54 family) Get druggable targets OG5_127111 All targets in OG5_127111
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0083 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0083 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1338 0.335
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0059 0.0265 0.4841
Schistosoma mansoni hypothetical protein 0.0077 0.0375 0.0935
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0265 0.111
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1549 0.9361 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.1338 0.1336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0083 0.0261
Loa Loa (eye worm) hypothetical protein 0.0071 0.0338 0.1075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Trichomonas vaginalis esterase, putative 0.0105 0.0545 0.1991
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0083 0.0204
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0083 0.0261
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0545 0.1991
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0176 0.0979 0.2451
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0083 0.035
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0545 0.1991
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0021 0.0029 0.0099
Plasmodium vivax SET domain protein, putative 0.0058 0.0259 0.4734
Onchocerca volvulus 0.005 0.0211 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0083 0.035
Brugia malayi intermediate filament protein 0.0053 0.0224 0.0939
Brugia malayi Heterochromatin protein 1 0.0084 0.0417 0.1746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0125 0.045
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.1737
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0128 0.0461
Loa Loa (eye worm) hypothetical protein 0.005 0.0211 0.0669
Giardia lamblia Serine peptidase, putative 0.0021 0.0029 0.0775
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0257 0.147 0.3681
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.0545 0.1737
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0203 0.3479
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0545 1
Onchocerca volvulus 0.0053 0.0224 0.0711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0124 0.0307
Brugia malayi chromobox protein homolog 3 0.0047 0.0191 0.08
Leishmania major cathepsin L-like protease 0.0062 0.0281 0.5135
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.0545 0.0561
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0128 0.0461
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0545 0.1361
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0022 0.0038 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0083 0.035
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0059 0.0265 0.0263
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Brugia malayi Inositol-1 0.0036 0.0125 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0128 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0257 0.147 0.3681
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.0545 0.1361
Schistosoma mansoni ap endonuclease 0.0019 0.0021 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0259 0.4734
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0107 0.0384
Brugia malayi Phospholipase A2 family protein 0.0111 0.0581 0.2437
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.399 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0244 0.1395 0.5846
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0203 0.3708
Brugia malayi hypothetical protein 0.0049 0.0203 0.0852
Brugia malayi MH1 domain containing protein 0.0024 0.0052 0.0219
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0338 0.6186
Mycobacterium ulcerans lipase LipD 0.0105 0.0545 0.0561
Giardia lamblia Thymus-specific serine protease precursor 0.0021 0.0029 0.0775
Echinococcus granulosus lamin 0.0053 0.0224 0.0557
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0083 0.0204
Echinococcus granulosus intermediate filament protein 0.0053 0.0224 0.0557
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0353 0.0351
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0021 0.0029 0.0498
Echinococcus multilocularis Peptidase C54 0.0071 0.0338 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0083 0.0261
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.1737
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0392
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0077 0.0375 0.1571
Echinococcus granulosus Dipeptidyl peptidase 9 0.0059 0.0265 0.0659
Onchocerca volvulus 0.0053 0.0224 0.0711
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0224 0.0939
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0124 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0213 0.0773
Loa Loa (eye worm) Smad1 0.0024 0.0052 0.0161
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0338 0.1231
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0059 0.0265 0.4654
Echinococcus multilocularis cysteine protease atg4b 0.0071 0.0338 0.0336
Entamoeba histolytica hypothetical protein 0.0178 0.0989 1
Brugia malayi nuclear receptor NHR-88 0.003 0.0083 0.035
Loa Loa (eye worm) MH2 domain-containing protein 0.0359 0.2097 0.6704
Brugia malayi Serine carboxypeptidase S28 family protein 0.0021 0.0029 0.0122
Echinococcus granulosus chromobox protein 1 0.0084 0.0417 0.104
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.1396 0.3494
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Schistosoma mansoni transcription factor LCR-F1 0.0178 0.0989 0.2473
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0224 0.0711
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0176 0.0979 0.2451
Schistosoma mansoni hypothetical protein 0.0167 0.0923 0.2309
Echinococcus granulosus FTZ F1 alpha 0.003 0.0083 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0343 0.0855
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0083 0.0204
Brugia malayi MH2 domain containing protein 0.0024 0.0052 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Schistosoma mansoni ap endonuclease 0.0019 0.0021 0.0048
Mycobacterium leprae Probable lipase LipE 0.0105 0.0545 0.0479
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0038 0.0089
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0338 0.1231
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.399 0.3989
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0385 0.2251 0.564
Schistosoma mansoni alpha-glucosidase 0.0143 0.0775 0.1939
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.0545 0.0561
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0545 0.1991
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0083 0.0081
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0083 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0083 0.035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.0545 0.0561
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0021 0.035
Loa Loa (eye worm) transcription factor SMAD2 0.0359 0.2097 0.6704
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0029 0.0274
Brugia malayi hypothetical protein 0.0244 0.1396 0.5849
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0124 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0083 0.0261
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0071 0.0338 0.0842
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0071 0.0338 0.0842
Brugia malayi beta-lactamase 0.0105 0.0545 0.2283
Entamoeba histolytica peptidase, C54 family 0.0071 0.0338 0.3403
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0128 0.2316
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0021 0.0048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.226
Loa Loa (eye worm) hypothetical protein 0.0244 0.1395 0.4458
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0059 0.0265 0.4654
Schistosoma mansoni alpha glucosidase 0.0037 0.0128 0.0315
Echinococcus multilocularis lamin 0.0053 0.0224 0.0222
Mycobacterium ulcerans TetR family transcriptional regulator 0.1549 0.9361 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1338 0.335
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0083 0.035
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0075 0.0314
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Loa Loa (eye worm) hypothetical protein 0.0063 0.0288 0.0915
Loa Loa (eye worm) prolyl oligopeptidase 0.0176 0.0979 0.3129
Schistosoma mansoni hypothetical protein 0.0178 0.0989 0.2473
Loa Loa (eye worm) hypothetical protein 0.0045 0.0179 0.0568
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0207 0.0869
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0021 0.007
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0128 0.0402
Brugia malayi Pre-SET motif family protein 0.0407 0.2386 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0246 0.0611
Echinococcus granulosus cysteine protease atg4b 0.0071 0.0338 0.0842
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0128 0.0461
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0083 0.0261
Schistosoma mansoni autophagin-1 (C54 family) 0.0071 0.0338 0.0842
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0259 0.0257
Onchocerca volvulus 0.0037 0.0129 0.0405
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0028 0.0072 0.1297
Entamoeba histolytica peptidase, C54 family 0.0028 0.0072 0.0714
Entamoeba histolytica peptidase, C54 family 0.0028 0.0072 0.0714
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0545 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0248 0.4531
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.226
Echinococcus granulosus microtubule associated protein 2 0.0669 0.399 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0083 0.0081
Onchocerca volvulus 0.0105 0.0545 0.1737
Schistosoma mansoni survival motor neuron protein 0.005 0.0207 0.0515
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0235 0.1338 0.5609
Onchocerca volvulus 0.0096 0.0489 0.1559
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.2386 0.763
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.0008
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0052 0.0161
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0125 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.1291 0.4125
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Loa Loa (eye worm) fli-1 protein 0.0224 0.1271 0.406
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0203 0.3708
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.1737
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0385 0.2251 0.225
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.0545 0.0561
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0083 0.035
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0021 0.0029 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0182 0.1017 0.325
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0353 0.1124
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0124 0.2255
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0128 0.0461
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.0545 0.2283
Echinococcus granulosus Smad4 0.0024 0.0052 0.0126
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0545 0.1991
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0545 0.1361
Mycobacterium tuberculosis Conserved protein 0.0105 0.0545 0.0561
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0128 0.1274
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0083 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0259 0.0644
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0281 0.5135
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0083 0.0261
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0259 0.0644
Brugia malayi Serine protease Z688.6 precursor 0.0021 0.0029 0.0122
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0545 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Brugia malayi hypothetical protein 0.0045 0.0179 0.0752
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0128 0.0461
Onchocerca volvulus 0.0182 0.1017 0.325
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0257 0.147 0.47
Brugia malayi hypothetical protein 0.0032 0.0097 0.0406
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1549 0.9361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0128 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0124 0.0449
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0259 0.0644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.1338 0.1336
Brugia malayi ecdysteroid receptor 0.003 0.0083 0.035
Schistosoma mansoni tar DNA-binding protein 0.0257 0.147 0.3681
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0128 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0191 0.0693
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0124 0.0307
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0244 0.1395 0.4458
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0028 0.0072 0.0982
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0124 0.1974
Schistosoma mansoni tar DNA-binding protein 0.0257 0.147 0.3681
Onchocerca volvulus Phospholipase A2 homolog 0.0528 0.3126 1
Entamoeba histolytica peptidase, C54 family 0.0028 0.0072 0.0714
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0059 0.0265 0.0659
Entamoeba histolytica hypothetical protein 0.0178 0.0989 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.0545 0.0561
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0021 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0545 1
Loa Loa (eye worm) beta-lactamase 0.0105 0.0545 0.1737
Onchocerca volvulus Phospholipase A2 homolog 0.0111 0.0581 0.1855
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0021 0.035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0077 0.0375 0.0373
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0125 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0083 0.0204
Onchocerca volvulus 0.0021 0.0029 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0083 0.0204
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0029 0.0274
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0178 0.0989 0.2473
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0021 0.0029 0.0068
Leishmania major cathepsin L-like protease 0.0062 0.0281 0.5135
Toxoplasma gondii ABC1 family protein 0.0105 0.0545 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Schistosoma mansoni coup transcription factor 0.003 0.0083 0.0204
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0021 0.0029 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0083 0.0204
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0672 0.4004 0.4265
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0083 0.035
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0124 0.0307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0259 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0029 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0259 0.0644
Mycobacterium ulcerans transcriptional regulator 0.1549 0.9361 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.016
Echinococcus multilocularis smad 0.0024 0.0052 0.005
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0083 0.0204
Loa Loa (eye worm) hypothetical protein 0.0528 0.3126 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0107 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0083 0.035
Onchocerca volvulus 0.0105 0.0545 0.1737
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0052 0.0126
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.0545 0.0561
Leishmania major hypothetical protein, conserved 0.0105 0.0545 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0125 0.1979
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0083 0.035
Brugia malayi Fli-1 protein 0.0224 0.1271 0.5325
Schistosoma mansoni smad1 5 8 and 0.0024 0.0052 0.0126
Schistosoma mansoni hypothetical protein 0.0077 0.0375 0.0935
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0128 0.0461
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0058 0.014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0021 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0257 0.147 0.47
Brugia malayi Smad1 0.0024 0.0052 0.0219
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0028 0.0072 0.1297
Echinococcus granulosus tumor protein p63 0.0345 0.2008 0.503
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0545 0.0479
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0128 0.1274
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.0545 0.0561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Brugia malayi MH2 domain containing protein 0.0024 0.0052 0.0219
Entamoeba histolytica hypothetical protein 0.0178 0.0989 1
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0417 0.1327
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0338 0.1231
Echinococcus multilocularis tar DNA binding protein 0.0257 0.147 0.1469
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0021 0.0029 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0281 0.5135
Brugia malayi hypothetical protein 0.0182 0.1017 0.4264
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0083 0.035
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0021 0.0088
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0213 0.0773
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0405
Brugia malayi MH2 domain containing protein 0.0359 0.2097 0.8787
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.0545 0.0543
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0124 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0083 0.035
Brugia malayi Calcitonin receptor-like protein seb-1 0.0244 0.1395 0.5846
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0052 0.0126
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0125 0.045
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0083 0.0081
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0211 0.0524
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0083 0.0261
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0077 0.0375 0.0373
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0338 0.1231
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0124 0.0521
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0083 0.0204
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0021 0.0944
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0213 0.0674
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0059 0.0265 0.4841
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.0008
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0385 0.2251 0.564
Toxoplasma gondii exonuclease III APE 0.0019 0.0021 0.035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0077 0.0375 0.0935
Loa Loa (eye worm) hypothetical protein 0.0167 0.0923 0.2947
Brugia malayi MH1 domain containing protein 0.0024 0.0052 0.0219
Entamoeba histolytica hypothetical protein 0.0178 0.0989 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0052 0.005
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0021 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0083 0.0204
Brugia malayi Latrophilin receptor protein 2 0.0077 0.0375 0.1571
Schistosoma mansoni chromobox protein 0.0084 0.0417 0.104
Echinococcus multilocularis musashi 0.0053 0.0224 0.0222
Loa Loa (eye worm) hypothetical protein 0.0047 0.0191 0.0604
Echinococcus granulosus tar DNA binding protein 0.0257 0.147 0.3681
Brugia malayi prolyl oligopeptidase family protein 0.0176 0.0979 0.4105
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0128 0.0461
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0128 0.0461
Loa Loa (eye worm) RNA binding protein 0.0257 0.147 0.47
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0083 0.0204
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0021 0.0029 0.0498
Echinococcus granulosus smad 0.0024 0.0052 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.0257 0.147 0.6162
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0417 0.1521
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.02 0.3645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.1338 0.335
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0124 0.0122
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0038 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0083 0.035
Brugia malayi follicle stimulating hormone receptor 0.0227 0.1291 0.541
Loa Loa (eye worm) hypothetical protein 0.0049 0.0203 0.0644
Schistosoma mansoni hypothetical protein 0.0077 0.0375 0.0935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1338 0.335
Loa Loa (eye worm) hypothetical protein 0.0111 0.0581 0.1855
Echinococcus multilocularis chromobox protein 1 0.0084 0.0417 0.0415
Entamoeba histolytica peptidase, C54 family 0.0028 0.0072 0.0714
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0021 0.0029 0.0498
Schistosoma mansoni Smad4 0.0024 0.0052 0.0126
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0059 0.0265 0.4841
Schistosoma mansoni hypothetical protein 0.0077 0.0375 0.0935
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0083 0.035
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0203 0.3708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0059 0.0265 0.4841
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0086
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0125 0.1244
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0083 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0178 0.0989 0.0987
Loa Loa (eye worm) hypothetical protein 0.0058 0.0259 0.0822
Echinococcus multilocularis chromobox protein 1 0.0084 0.0417 0.0415
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0203 0.3708
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0916 0.0915
Echinococcus multilocularis tumor protein p63 0.0345 0.2008 0.2007
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.0545 0.0561
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0125 0.0111
Mycobacterium ulcerans beta-lactamase 0.0105 0.0545 0.0561
Brugia malayi Pre-SET motif family protein 0.0058 0.0259 0.1085
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.1396 0.1394
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.1737
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0176 0.0979 0.3129
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0176 0.0979 0.0978
Schistosoma mansoni thyroid hormone receptor 0.003 0.0083 0.0204
Brugia malayi latrophilin 2 splice variant baaae 0.0167 0.0923 0.3868
Schistosoma mansoni tar DNA-binding protein 0.0257 0.147 0.3681
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0083 0.0261
Trichomonas vaginalis set domain proteins, putative 0.0463 0.2729 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.1338 0.335
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0191 0.0693
Onchocerca volvulus 0.0105 0.0545 0.1737
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0083 0.0261
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0191 0.0604
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0338 0.6047
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0052 0.0161
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0224 0.0711
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0417 0.1521
Schistosoma mansoni alpha-glucosidase 0.0143 0.0775 0.1939
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0124 0.0449
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0235 0.1338 0.4277
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0021 0.0029 0.0068
Brugia malayi beta-lactamase family protein 0.0105 0.0545 0.2283
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0124 0.2255
Onchocerca volvulus 0.005 0.0207 0.0657
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0083 0.0081
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0281 0.5135
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0125 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0083 0.0261
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.1737
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0128 0.2316
Schistosoma mansoni intermediate filament proteins 0.0053 0.0224 0.0557
Trypanosoma brucei glucosidase, putative 0.0037 0.0128 0.2037
Brugia malayi Serine protease Z688.6 precursor 0.0021 0.0029 0.0122
Schistosoma mansoni inositol monophosphatase 0.0036 0.0125 0.0308
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0916 0.2927
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0916 0.0915
Loa Loa (eye worm) hypothetical protein 0.0244 0.1396 0.4461
Schistosoma mansoni lamin 0.0053 0.0224 0.0557
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0083 0.035
Loa Loa (eye worm) hypothetical protein 0.0053 0.0224 0.0711
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0128 0.0461
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0128 0.2316
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0338 0.1231
Echinococcus granulosus Peptidase C54 0.0071 0.0338 0.0842
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0021 0.5
Echinococcus multilocularis GPCR, family 2 0.0077 0.0375 0.0373
Brugia malayi Peptidase family C54 containing protein 0.0071 0.0338 0.1416
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0021 0.0029 0.0498
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.1737
Leishmania major hypothetical protein, conserved 0.0049 0.0203 0.3708
Echinococcus granulosus GPCR family 2 0.0077 0.0375 0.0935
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.016
Echinococcus granulosus lamin dm0 0.0053 0.0224 0.0557
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0124 0.2255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0021 0.0029 0.0099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0083 0.0204
Schistosoma mansoni smad1 5 8 and 0.0024 0.0052 0.0126
Loa Loa (eye worm) hypothetical protein 0.0052 0.0218 0.0692
Brugia malayi steroid hormone receptor 0.003 0.0083 0.035
Echinococcus multilocularis Smad4 0.0024 0.0052 0.005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0916 0.3841
Onchocerca volvulus 0.0072 0.0343 0.1092
Mycobacterium ulcerans hypothetical protein 0.0105 0.0545 0.0561
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0028 0.0072 0.1297
Loa Loa (eye worm) inositol-1 0.0036 0.0125 0.0393
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0203 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0124 0.1241
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.0545 0.0561
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0021 0.0029 0.0099
Leishmania major cathepsin L-like protease 0.0062 0.0281 0.5135
Schistosoma mansoni hypothetical protein 0.005 0.0207 0.0515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0083 0.0261
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0545 0.1991
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0203 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0338 0.6186
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0101 0.0086
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0052 0.0126
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0916 0.2292
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0124 0.0122
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1549 0.9361 1
Brugia malayi RNA binding protein 0.0257 0.147 0.6162
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0075 0.0233
Schistosoma mansoni smad 0.0024 0.0052 0.0126
Onchocerca volvulus 0.003 0.0083 0.0261
Schistosoma mansoni gabp alpha 0.0074 0.0353 0.0881
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0077 0.0375 0.0935
Schistosoma mansoni thyroid hormone receptor 0.003 0.0083 0.0204
Echinococcus multilocularis lamin dm0 0.0053 0.0224 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0029 0.0099
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0125 0.226
Onchocerca volvulus 0.0463 0.2729 0.8728
Schistosoma mansoni chromobox protein 0.0084 0.0417 0.104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0021 0.0193
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0028 0.0072 0.1297
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0281 0.5135
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0124 0.0307
Schistosoma mansoni lamin 0.0053 0.0224 0.0557
Plasmodium falciparum cysteine protease ATG4, putative 0.0028 0.0072 0.3499
Schistosoma mansoni ets-related 0.0224 0.1271 0.318
Echinococcus granulosus chromobox protein 1 0.0084 0.0417 0.104
Brugia malayi hypothetical protein 0.0178 0.0989 0.4143
Brugia malayi beta-lactamase family protein 0.0105 0.0545 0.2283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0083 0.0204
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0052 0.005
Brugia malayi Ets-domain containing protein 0.0074 0.0353 0.1481
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0083 0.035
Schistosoma mansoni nuclear hormone receptor 0.003 0.0083 0.0204
Schistosoma mansoni inositol monophosphatase 0.0036 0.0125 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0261
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0002 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0083 0.0204
Loa Loa (eye worm) hypothetical protein 0.0077 0.0375 0.1194
Schistosoma mansoni smad1 5 8 and 0.0024 0.0052 0.0126
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0128 0.0315
Brugia malayi Ets-domain containing protein 0.0074 0.0353 0.1481
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0353 0.0881
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0083 0.0204
Brugia malayi TAR-binding protein 0.0257 0.147 0.6162
Brugia malayi nuclear hormone receptor 0.003 0.0083 0.035
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0124 0.0449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0281 0.4959
Mycobacterium tuberculosis Conserved protein 0.0105 0.0545 0.0561
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0077 0.0375 0.1194
Mycobacterium tuberculosis Conserved protein 0.0105 0.0545 0.0561
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0083 0.0204

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 11 uM PUBCHEM_BIOASSAY: Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504462, AID504475] ChEMBL. No reference
IC50 (functional) = 14.8 uM PUBCHEM_BIOASSAY: Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504462, AID504475] ChEMBL. No reference
Potency (binding) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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