Detailed information for compound 1313792

Basic information

Technical information
  • TDR Targets ID: 1313792
  • Name: 3-morpholin-4-yldiazenylbenzoic acid
  • MW: 235.239 | Formula: C11H13N3O3
  • H donors: 1 H acceptors: 2 LogP: 1.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cccc(c1)N=NN1CCOCC1
  • InChi: 1S/C11H13N3O3/c15-11(16)9-2-1-3-10(8-9)12-13-14-4-6-17-7-5-14/h1-3,8H,4-7H2,(H,15,16)
  • InChiKey: FJOJMDRFIZQWIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-morpholinoazobenzoic acid
  • MLS000713913
  • SMR000273394
  • 3-[(E)-4-Morpholinyldiazenyl]benzoic acid
  • Benzoic acid, 3-(4-morpholylazo)-
  • A2140/0089852
  • Oprea1_074780
  • 3-(Morpholin-4-ylazo)-benzoic acid
  • BAS 01117751
  • Oprea1_814416

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0064 0.0155
Schistosoma mansoni ap endonuclease 0.0023 0.0064 0.0198
Schistosoma mansoni calmodulin-related 0.0038 0.0124 0.0388
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0043 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0118 0.0369
Toxoplasma gondii EF hand domain-containing protein 0.0038 0.0124 0.3546
Echinococcus granulosus Myosin regulatory light chain 0.0038 0.0124 0.0345
Giardia lamblia Calmodulin 0.0038 0.0124 0.9963
Brugia malayi hypothetical protein 0.0286 0.1081 0.1062
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0064 0.0155
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0038 0.0124 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.008
Schistosoma mansoni hypothetical protein 0.0043 0.0144 0.0449
Brugia malayi CXXC zinc finger family protein 0.0035 0.011 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0022 0.0026
Trypanosoma cruzi centrin, putative 0.0038 0.0124 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0118 0.0369
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0064 0.0532
Trypanosoma cruzi centrin-3 0.0038 0.0124 0.0099
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0144 0.0407
Echinococcus multilocularis Calcium binding protein 0.0038 0.0124 0.0346
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0038 0.0124 1
Onchocerca volvulus 0.0038 0.0124 0.0023
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3201 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0118 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0118 0.0369
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0951 0.0931
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0012
Echinococcus multilocularis programmed cell death protein 0.0038 0.0124 0.0345
Echinococcus granulosus cpg binding protein 0.0037 0.0118 0.0324
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0118 0.0369
Brugia malayi RasGEF domain containing protein 0.0038 0.0124 0.0103
Echinococcus granulosus programmed cell death protein 0.0038 0.0124 0.0345
Toxoplasma gondii calmodulin CAM2 0.0038 0.0124 0.3533
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0036 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.011 0.0088
Giardia lamblia Programmed cell death protein-like protein 0.0038 0.0124 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0036 0.007
Schistosoma mansoni lamin 0.0033 0.0102 0.0318
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0022 0.0026
Toxoplasma gondii calcium binding protein precursor, putative 0.0038 0.0124 0.3546
Brugia malayi hypothetical protein 0.0043 0.0144 0.0122
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0038 0.0124 0.0023
Trypanosoma brucei centrin-3 0.0038 0.0124 0.0099
Echinococcus multilocularis lamin dm0 0.0033 0.0102 0.0275
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0102 0.008
Echinococcus multilocularis cpg binding protein 0.0037 0.0118 0.0324
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1086 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0064 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0064 0.0041
Loa Loa (eye worm) hypothetical protein 0.0286 0.1081 0.1061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0118 0.0326
Entamoeba histolytica calmodulin, putative 0.0038 0.0124 0.0362
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0124 0.0099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.011 0.0301
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0118 0.318
Onchocerca volvulus 0.0287 0.1086 0.0994
Echinococcus granulosus Calcium binding protein 0.0038 0.0124 0.0346
Schistosoma mansoni myosin regulatory light chain 0.0038 0.0124 0.0388
Trichomonas vaginalis calcium binding protein, putative 0.0038 0.0124 0.1096
Entamoeba histolytica hypothetical protein 0.0043 0.0144 0.0477
Onchocerca volvulus 0.0035 0.011 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0118 0.0326
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0102 0.008
Entamoeba histolytica hypothetical protein 0.0043 0.0144 0.0477
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1081 0.3347
Brugia malayi Neuronal calcium sensor family protein 1 0.0038 0.0124 0.0103
Loa Loa (eye worm) myosin regulatory light chain 1 0.0038 0.0124 0.0102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0012
Schistosoma mansoni cpg binding protein 0.0035 0.011 0.0343
Plasmodium falciparum centrin-4 0.0038 0.0124 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0144 0.0407
Trichomonas vaginalis centrin, putative 0.0038 0.0124 0.1094
Trichomonas vaginalis kakapo, putative 0.0038 0.0124 0.1094
Echinococcus granulosus calcyphosin protein 0.0038 0.0124 0.0346
Trypanosoma cruzi centrin, putative 0.0038 0.0124 0.0099
Onchocerca volvulus 0.0058 0.0201 0.01
Leishmania major ferric reductase, putative 0.1602 0.6176 1
Echinococcus granulosus programmed cell death protein 6 0.0038 0.0124 0.0346
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0102
Loa Loa (eye worm) hypothetical protein 0.0988 0.38 0.3786
Trichomonas vaginalis calcium binding protein, putative 0.0038 0.0124 0.1094
Trichomonas vaginalis caltractin, putative 0.0038 0.0124 0.1096
Onchocerca volvulus 0.0037 0.0118 0.0017
Treponema pallidum hypothetical protein 0.0457 0.1746 1
Schistosoma mansoni cpg binding protein 0.0037 0.0118 0.0367
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0064 0.0532
Echinococcus granulosus lamin dm0 0.0033 0.0102 0.0275
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1081 0.3347
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0038 0.0124 0.1094
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.1602 0.6176 1
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.1602 0.6176 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3201 1
Echinococcus multilocularis lamin 0.0033 0.0102 0.0275
Echinococcus granulosus lamin 0.0033 0.0102 0.0275
Schistosoma mansoni intermediate filament proteins 0.0033 0.0102 0.0318
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0144 0.0449
Echinococcus multilocularis Myosin regulatory light chain 0.0038 0.0124 0.0345
Brugia malayi Pre-SET motif family protein 0.0037 0.0118 0.0097
Entamoeba histolytica hypothetical protein 0.0043 0.0144 0.0477
Entamoeba histolytica hypothetical protein 0.0457 0.1746 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0064 0.5
Brugia malayi Pre-SET motif family protein 0.0252 0.0951 0.0932
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0235 1
Schistosoma mansoni myosin light chain 0.0038 0.0124 0.0388
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0064 0.5
Echinococcus multilocularis programmed cell death protein 0.0038 0.0124 0.0345
Brugia malayi Myosin regulatory light chain 1 0.0038 0.0124 0.0103
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.1602 0.6176 1
Trichomonas vaginalis caltractin, putative 0.0038 0.0124 0.1096
Schistosoma mansoni survival motor neuron protein 0.0058 0.0201 0.0628
Schistosoma mansoni hypothetical protein 0.0058 0.0201 0.0628
Entamoeba histolytica grainin 2 0.0038 0.0124 0.0362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0014
Onchocerca volvulus 0.0038 0.0124 0.0023
Entamoeba histolytica grainin 2 0.0038 0.0124 0.036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0265 0.0829
Echinococcus multilocularis calcyphosin protein 0.0038 0.0124 0.0346
Toxoplasma gondii calmodulin, putative 0.0038 0.0124 0.3546
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0201 0.018
Echinococcus multilocularis programmed cell death protein 6 0.0038 0.0124 0.0346
Loa Loa (eye worm) myosin Light Chain family member 0.0038 0.0124 0.0102
Schistosoma mansoni lamin 0.0033 0.0102 0.0318
Trichomonas vaginalis centrin, putative 0.0038 0.0124 0.1094
Trichomonas vaginalis calmodulin, putative 0.0038 0.0124 0.1094
Trichomonas vaginalis centrin, putative 0.0038 0.0124 0.1094
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3201 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0099 0.0077
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0064 0.0042
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0043 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0102 0.008
Schistosoma mansoni cpg binding protein 0.0037 0.0118 0.0367
Trichomonas vaginalis calmodulin, putative 0.0038 0.0124 0.1094
Echinococcus granulosus intermediate filament protein 0.0033 0.0102 0.0275
Schistosoma mansoni myosin regulatory light chain 0.0038 0.0124 0.0388
Toxoplasma gondii centrin family protein 0.0038 0.0124 0.3533
Schistosoma mansoni ap endonuclease 0.0023 0.0064 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0124 0.1094
Brugia malayi Probable myosin regulatory light chain 0.0038 0.0124 0.0103
Plasmodium vivax SET domain protein, putative 0.0037 0.0118 0.9003
Echinococcus multilocularis musashi 0.0033 0.0102 0.0275
Trypanosoma brucei caltractin, putative 0.0038 0.0124 0.0099
Brugia malayi intermediate filament protein 0.0033 0.0102 0.008
Entamoeba histolytica hypothetical protein 0.0043 0.0144 0.0477

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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