Detailed information for compound 1317651

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 387.378 | Formula: C19H12F3N3OS
  • H donors: 1 H acceptors: 4 LogP: 5.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(O)nc(nc1c1ccccc1)SCc1cccc(c1)C(F)(F)F
  • InChi: 1S/C19H12F3N3OS/c20-19(21,22)14-8-4-5-12(9-14)11-27-18-24-16(13-6-2-1-3-7-13)15(10-23)17(26)25-18/h1-9H,11H2,(H,24,25,26)
  • InChiKey: VLQLCRVTTSCBBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor necrosis factor Starlite/ChEMBL No references
Homo sapiens nucleotide-binding oligomerization domain containing 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Human immunodeficiency virus 1 Envelope glycoprotein gp160 Starlite/ChEMBL No references
Homo sapiens nucleotide-binding oligomerization domain containing 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Leishmania major DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Giardia lamblia DINP protein human, muc B family 0.0045 0.0812 0.9559
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0176 0.0492
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0273 0.0273
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0176 0.0894
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0659 1
Schistosoma mansoni hypothetical protein 0.0102 0.197 0.197
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0522 0.0597
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0348 0.4293
Echinococcus granulosus dna polymerase kappa 0.0045 0.0812 0.0812
Onchocerca volvulus 0.0035 0.0593 0.3375
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0104 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0171 0.1214
Trypanosoma brucei unspecified product 0.0045 0.0812 0.5765
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.053 0.3764
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Brugia malayi Cam kinase protein 1 0.0031 0.0522 0.1458
Schistosoma mansoni hypothetical protein 0.0019 0.0273 0.0273
Leishmania major glucose transporter, lmgt3 0.0032 0.053 0.3764
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0767 0.1327
Loa Loa (eye worm) hypothetical protein 0.0031 0.0509 0.1422
Echinococcus multilocularis solute carrier family 22 0.0014 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0171 0.0171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0102 0.0102
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0659 0.3345
Onchocerca volvulus Cell death protein 3 homolog 0.0075 0.1411 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0577 0.7115
Echinococcus multilocularis caspase 2 0.0075 0.1411 0.1411
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0273 0.0762
Schistosoma mansoni hypothetical protein 0.0019 0.0273 0.0273
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.053 0.3764
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0176 0.1251
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0659 0.7759
Leishmania major DNA polymerase eta, putative 0.0074 0.1408 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.053 0.269
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0937 0.1621
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0747 0.1293
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Leishmania major protein kinase, putative 0.0031 0.0522 0.3706
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.053 0.269
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0176 0.0894
Schistosoma mansoni hypothetical protein 0.0019 0.0273 0.0273
Brugia malayi hypothetical protein 0.0014 0.0176 0.0492
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Leishmania major DNA polymerase eta, putative 0.0043 0.0767 0.5449
Echinococcus multilocularis zinc finger protein 0.0006 0.0011 0.0011
Toxoplasma gondii sugar transporter ST3 0.0014 0.0176 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0523 0.3717
Brugia malayi Sugar transporter family protein 0.0102 0.197 0.5506
Echinococcus multilocularis dna polymerase eta 0.0074 0.1408 0.1408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0522 0.1458
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0522 0.0597
Loa Loa (eye worm) hypothetical protein 0.018 0.3578 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0273 0.0273
Trypanosoma cruzi hexose transporter 0.0032 0.053 0.3764
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0176 0.0492
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.197 0.3408
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0509 0.0509
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0522 0.0597
Trichomonas vaginalis helicase, putative 0.0008 0.0044 0.0221
Toxoplasma gondii sugar transporter ST2 0.0014 0.0176 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0747 0.0855
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0812 0.9559
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0006 0.0011 0.0011
Echinococcus multilocularis muscleblind protein 1 0.018 0.3578 0.3578
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Giardia lamblia DNA damage repair protein 0.0014 0.0171 0.2013
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0522 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0348 0.2475
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0171 0.1214
Schistosoma mansoni protein kinase 0.0031 0.0522 0.0522
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0348 0.0348
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0044 0.0221
Toxoplasma gondii protein kinase, putative 0.0288 0.578 1
Schistosoma mansoni protein kinase 0.0031 0.0522 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0176 0.1251
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0659 0.468
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0102 0.0102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0044 0.0221
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0176 0.0176
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0522 0.0903
Echinococcus granulosus solute carrier family 22 0.0014 0.0176 0.0176
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0176 0.0201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Brugia malayi polk-prov protein 0.0014 0.0171 0.0478
Trypanosoma brucei unspecified product 0.0031 0.0523 0.3717
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trypanosoma brucei sugar transporter, putative 0.0014 0.0176 0.1251
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0613 0.0701
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0613 0.4351
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.3468 0.3468
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0171 0.1214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.053 0.3764
Schistosoma mansoni protein kinase 0.0031 0.0522 0.0522
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0812 0.2269
Echinococcus multilocularis solute carrier family 22 0.0014 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Brugia malayi CXXC zinc finger family protein 0.0035 0.0593 0.1657
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0176 0.1251
Loa Loa (eye worm) hypothetical protein 0.0074 0.1408 0.3935
Schistosoma mansoni hypothetical protein 0.0014 0.0162 0.0162
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0522 0.0597
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0812 0.412
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0348 0.1769
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0162 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Onchocerca volvulus 0.0075 0.1411 1
Echinococcus multilocularis General substrate transporter 0.0088 0.1676 0.1676
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0812 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0509 0.1422
Plasmodium falciparum protein kinase 6 0.0432 0.8741 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0176 0.0176
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Plasmodium vivax sugar transporter, putative 0.0014 0.0176 0.0201
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0849 0.0971
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0506 0.0579
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0659 0.114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0044 0.0221
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0812 0.0812
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0031
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0522 0.0597
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0348 0.0603
Schistosoma mansoni bromodomain containing protein 0.0006 0.0011 0.0011
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0348 0.2475
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0176 0.2169
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Loa Loa (eye worm) inositol-1 0.0038 0.0659 0.1841
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0348 0.4104
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0171 0.1214
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3255 0.3724
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0726 0.2028
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0273 0.0273
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.1408 1
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0171 0.1214
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0747 0.5309
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0747 0.0855
Leishmania major DNA damage repair protein, putative 0.0014 0.0171 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Schistosoma mansoni glucose transport protein 0.0102 0.197 0.197
Brugia malayi hypothetical protein 0.002 0.0285 0.0797
Loa Loa (eye worm) hypothetical protein 0.0023 0.0348 0.0974
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0176 0.0305
Echinococcus granulosus solute carrier family 22 0.0014 0.0176 0.0176
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0812 0.5765
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0613 0.4351
Entamoeba histolytica protein kinase, putative 0.0031 0.0522 0.6145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0593 0.1657
Giardia lamblia Sugar-proton symporter 0.0014 0.0176 0.2074
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0522 0.0597
Schistosoma mansoni sugar transporter 0.0014 0.0176 0.0176
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0273 0.0273
Brugia malayi Sugar transporter family protein 0.0014 0.0176 0.0492
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0509 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.197 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0659 0.468
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0747 0.8803
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0509 0.0509
Schistosoma mansoni sugar transporter 0.0014 0.0176 0.0176
Leishmania major hypothetical protein, conserved 0.0014 0.0176 0.1251
Leishmania major DNA polymerase kappa, putative 0.0014 0.0171 0.1214
Schistosoma mansoni cpg binding protein 0.0037 0.0633 0.0633
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0747 0.5309
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Trypanosoma cruzi hexose transporter, putative 0.0032 0.053 0.3764
Loa Loa (eye worm) hypothetical protein 0.018 0.3578 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0171 0.1214
Schistosoma mansoni cpg binding protein 0.0037 0.0633 0.0633
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0613 0.106
Trichomonas vaginalis glucose transporter, putative 0.0032 0.053 0.269
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0348 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Loa Loa (eye worm) hypothetical protein 0.0019 0.0273 0.0762
Plasmodium falciparum protein kinase 7 0.0288 0.578 0.6612
Schistosoma mansoni glucose transport protein 0.0102 0.197 0.197
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0937 0.4756
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0812 0.2269
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 0.8741 1
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0171 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0032 0.053 0.269
Brugia malayi Bromodomain containing protein 0.0006 0.0011 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0659 0.3345
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0509 0.0509
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0059 0.0059
Echinococcus granulosus General substrate transporter 0.0088 0.1676 0.1676
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.01 0.0278
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0849 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0348 0.6034
Trypanosoma cruzi hexose transporter, putative 0.0032 0.053 0.3764
Toxoplasma gondii sugar transporter ST1 0.0014 0.0176 0.0305
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0176 0.2169
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0176 0.0894
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0659 0.468
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0171 0.0296
Echinococcus granulosus GPCR family 2 0.0019 0.0273 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0102 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.053 0.269
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Schistosoma mansoni hypothetical protein 0.0041 0.0726 0.0726
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0747 0.2089
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0176 0.0176
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0176 0.2672
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0812 0.5765
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Leishmania major hypothetical protein, conserved 0.003 0.0506 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0659 0.0659
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0176 0.1251
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0577 1
Brugia malayi hypothetical protein 0.0075 0.1411 0.3945
Brugia malayi hypothetical protein 0.003 0.0506 0.1415
Loa Loa (eye worm) hypothetical protein 0.0014 0.0171 0.0478
Mycobacterium ulcerans sugar transporter 0.0014 0.0176 0.2169
Schistosoma mansoni inositol monophosphatase 0.0038 0.0659 0.0659
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0506 0.0876
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1116 0.3119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0176 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0348 0.2475
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0812 0.0812
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0171 0.0296
Entamoeba histolytica protein kinase, putative 0.0031 0.0522 0.6145
Echinococcus granulosus zinc finger protein 0.0006 0.0011 0.0011
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0522 0.1458
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0659 0.468
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0659 0.3345
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0509 0.5992
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0059 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0278 0.4818
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0236 0.1679
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0176 0.0492
Schistosoma mansoni zinc finger protein 0.0006 0.0011 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.3367 0.3367
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0812 0.0812
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0522 0.0522
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0613 0.4351
Schistosoma mansoni sugar transporter 0.0014 0.0176 0.0176
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.014 0.039
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Entamoeba histolytica hypothetical protein 0.0023 0.0348 0.4104
Echinococcus granulosus apoptotic protease activating factor 1 0.0075 0.1411 0.1411
Entamoeba histolytica hypothetical protein 0.0042 0.0747 0.8803
Leishmania major glucose transporter, lmgt1 0.0032 0.053 0.3764
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0522 0.0903
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0522 0.0597
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0937 0.4756
Trypanosoma brucei unspecified product 0.0031 0.0523 0.3717
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.1408 0.3935
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0747 0.3794
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0176 0.1251
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0273 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0747 0.3794
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0348 1
Brugia malayi beta-NAC-like protein 0.0042 0.0747 0.2089
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0176 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Loa Loa (eye worm) hypothetical protein 0.0031 0.0509 0.1422
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0348 0.0399
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0171 0.0196
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Schistosoma mansoni hypothetical protein 0.0019 0.0273 0.0273
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0044 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0348 0.0974
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0059 0.0059
Trypanosoma brucei glucose transporter 2A 0.0032 0.053 0.3764
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0522 0.1458
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.1408 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0506 0.3595
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1389 0.1389
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0506 0.0579
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0348 0.0348
Trypanosoma cruzi hexose transporter, putative 0.0032 0.053 0.3764
Brugia malayi PHD-finger family protein 0.0006 0.0011 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0006 0.0011 0.0011
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0506 0.3595
Leishmania major basic transcription factor 3a, putative 0.0042 0.0747 0.5309
Loa Loa (eye worm) hypothetical protein 0.0041 0.0726 0.2028
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0659 0.8117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0812 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0522 0.1458
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Schistosoma mansoni cpg binding protein 0.0035 0.0593 0.0593
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0613 0.4351
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0482 0.0482
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0044 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0523 0.3717
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0767 0.5449
Echinococcus granulosus dna polymerase eta 0.0074 0.1408 0.1408
Trypanosoma brucei glucose transporter 1E 0.0032 0.053 0.3764
Schistosoma mansoni hypothetical protein 0.0075 0.1411 0.1411
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0171 0.1214
Loa Loa (eye worm) sugar transporter 0.0102 0.197 0.5506
Loa Loa (eye worm) hypothetical protein 0.0075 0.1411 0.3945
Echinococcus multilocularis apoptotic protease activating factor 1 0.0075 0.1411 0.1411
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0613 0.0701
Echinococcus multilocularis transcription factor btf3 0.0042 0.0747 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0171 0.1214
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0176 0.0492
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0278 0.3428
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0273 0.0762
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3255 0.5632
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0176 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0523 0.3717
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0348 0.0399
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.053 0.3764
Giardia lamblia Hexose transporter 0.0014 0.0176 0.2074
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0747 0.3794
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0291 0.1477
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0522 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0506 0.3595
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0176 0.0176
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0162 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0812 0.5765
Echinococcus granulosus muscleblind protein 0.018 0.3578 0.3578
Schistosoma mansoni caspase-7 (C14 family) 0.0075 0.1411 0.1411
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Schistosoma mansoni sugar transporter 0.0014 0.0176 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0812 1
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0104 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Loa Loa (eye worm) hypothetical protein 0.006 0.1116 0.3119
Plasmodium vivax hexose transporter 0.0102 0.197 0.2253
Echinococcus granulosus transcription factor btf3 0.0042 0.0747 0.0747
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0059
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0812 0.0812
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0812 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0509 0.2583
Trichomonas vaginalis glucose transporter, putative 0.0032 0.053 0.269
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0659 0.0659
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0171 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0278 0.3428
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0509 0.881
Schistosoma mansoni glucose transport protein 0.0102 0.197 0.197
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0812 0.5765
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0812 0.412
Brugia malayi Sugar transporter family protein 0.0014 0.0176 0.0492
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0176 0.0176
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0937 0.1621
Loa Loa (eye worm) sugar transporter 0.0014 0.0176 0.0492
Echinococcus granulosus solute carrier family 22 0.0014 0.0176 0.0176
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.197 0.197
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0812 0.0812
Schistosoma mansoni bromodomain containing protein 0.0006 0.0011 0.0011
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.3468 0.3468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1116 0.3119
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0176 0.2169
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0506 0.0579
Brugia malayi hypothetical protein 0.0014 0.0176 0.0492
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0522 0.0522
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0348 0.4293
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0044 0.0221
Brugia malayi Inositol-1 0.0038 0.0659 0.1841
Echinococcus granulosus solute carrier family 22 0.0014 0.0176 0.0176
Plasmodium falciparum hexose transporter 0.0102 0.197 0.2253
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0348 0.0348
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0171 0.1214
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0176 0.0492
Trypanosoma brucei glucose transporter, putative 0.0032 0.053 0.3764
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0044 0.0221
Echinococcus multilocularis solute carrier family 22 0.0014 0.0176 0.0176
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.197 0.197
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0482 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.053 0.269
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1116 0.3119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Loa Loa (eye worm) hypothetical protein 0.0075 0.1411 0.3945
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3255 0.3724
Brugia malayi Muscleblind-like protein 0.018 0.3578 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0391 0.1094
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0014 0.0176 0.0492
Schistosoma mansoni DNA polymerase eta 0.0074 0.1408 0.1408
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0176 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0044 0.0221
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0176 0.2169
Brugia malayi Cell death protein 3 precursor 0.0075 0.1411 0.3945
Echinococcus multilocularis muscleblind protein 0.018 0.3578 0.3578
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus granulosus caspase 2 0.0075 0.1411 0.1411
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0044 0.0221
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0522 0.0903
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0176 0.2169
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0522 0.0597
Mycobacterium ulcerans hypothetical protein 0.0014 0.0171 0.2106
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0104 0.1278
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0937 0.1072
Loa Loa (eye worm) acetyltransferase 0.0175 0.3468 0.9693
Schistosoma mansoni hypothetical protein 0.0059 0.1091 0.1091
Schistosoma mansoni transcription factor btf3 0.0042 0.0747 0.0747
Echinococcus multilocularis cpg binding protein 0.0037 0.0633 0.0633
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0509 0.0509
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0522 0.3706
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0509 0.5992
Echinococcus granulosus cpg binding protein 0.0037 0.0633 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0849 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0273 0.0762
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0747 0.5309
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0522 0.0522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0937 0.0937
Leishmania major glucose transporter, lmgt2 0.0032 0.053 0.3764
Brugia malayi major facilitator superfamily protein 0.0014 0.0176 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0031
Schistosoma mansoni inositol monophosphatase 0.0038 0.0659 0.0659
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.3468 0.9693
Schistosoma mansoni glucose transporter 0.0014 0.0176 0.0176
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0613 0.4351
Loa Loa (eye worm) hypothetical protein 0.003 0.0506 0.1415
Brugia malayi hypothetical protein 0.0014 0.0176 0.0492
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0812 0.5765
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0176 0.0894
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.1316 0.2277
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0176 0.0492

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.97 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 6.335 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 6.55 uM PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD1. uHTS luminescence assay for the identification of compounds that inhibit NOD1, utilizing an NF-kB-mediated luciferase reporter gene activity as a measure of NOD1 modulation (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1849, AID1852, AID2250, AID2255, AID2260, AID2261, AID2264, AID2333, AID2334, AID2335, AID2337, AID2466, AID2469, AID2475, AID2483, AID2485, AID2503, AID2505, AID2789, AID2792, AID2793, AID2798, AID2799, AID2800, AID2801] ChEMBL. No reference
IC50 (functional) = 6.48 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] ChEMBL. No reference
IC50 (functional) = 7.5 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2469, AID2475, AID2799, AID2800] ChEMBL. No reference
IC50 (functional) = 8.05 uM PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] ChEMBL. No reference
IC50 (binding) = 10.4 uM PUBCHEM_BIOASSAY: uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1991, AID434967] ChEMBL. No reference
IC50 (functional) = 13.193 uM PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID1849, AID2260, AID2335, AID2469, AID2503, AID2800] ChEMBL. No reference
IC50 (functional) = 19.04978 uM PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay. Cytotoxicity counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2466, AID2469, AID2475, AID2503, AID2793, AID2798, AID2799, AID2800] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337] ChEMBL. No reference
IC50 (functional) 42.73 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) 0.0891 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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