TDR Targets

Basic information

Technical information

TDR Targets ID: 1318255
Name: 1-(2-methoxy-4-nitrophenyl)-3-(1,2,4-triazol- 4-yl)urea
MW: 278.224 | Formula: C10H10N6O4
H donors: 2 H acceptors: 5 LogP: 0.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1NC(=O)Nn1cnnc1)[N+](=O)[O-]
InChi: 1S/C10H10N6O4/c1-20-9-4-7(16(18)19)2-3-8(9)13-10(17)14-15-5-11-12-6-15/h2-6H,1H3,(H2,13,14,17)
InChiKey: IYTJKLNXJPYZDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-methoxy-4-nitro-phenyl)-3-(1,2,4-triazol-4-yl)urea
ZINC05041912
IVK/1127729

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Plasmodium falciparum	M18 aspartyl aminopeptidase	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Trypanosoma brucei	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Entamoeba histolytica	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Loa Loa (eye worm)	aspartyl aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Trypanosoma brucei	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Trypanosoma congolense	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Trypanosoma cruzi	metallo-peptidase, Clan MH, Family M20	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	Get druggable targets OG5_128020	All targets in OG5_128020
Leishmania infantum	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	Get druggable targets OG5_128020	All targets in OG5_128020
Trypanosoma brucei gambiense	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	Get druggable targets OG5_128020	All targets in OG5_128020
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Mycobacterium tuberculosis	Probable aminopeptidase PepC	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium parvum	possible aspartyl aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128020	All targets in OG5_128020
Plasmodium vivax	M18 aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Leishmania braziliensis	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	Get druggable targets OG5_128020	All targets in OG5_128020
Plasmodium yoelii	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Echinococcus granulosus	aspartyl aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium berghei	M18 aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Babesia bovis	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Mycobacterium leprae	PROBABLE AMINOPEPTIDASE PEPC	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Candida albicans	similar to vacuolar aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium knowlesi	M18 aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Leishmania major	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	Get druggable targets OG5_128020	All targets in OG5_128020
Candida albicans	similar to vacuolar aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Brugia malayi	Aspartyl aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	Get druggable targets OG5_128020	All targets in OG5_128020
Plasmodium falciparum	M18 aspartyl aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Theileria parva	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128020	All targets in OG5_128020
Schistosoma japonicum	ko:K01267 aspartyl aminopeptidase [EC3.4.11.21], putative	Get druggable targets OG5_128020	All targets in OG5_128020
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Neospora caninum	hypothetical protein	Get druggable targets OG5_128020	All targets in OG5_128020
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania donovani	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020
Echinococcus multilocularis	aspartyl aminopeptidase	Get druggable targets OG5_128020	All targets in OG5_128020
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Trypanosoma cruzi	aspartyl aminopeptidase, putative	Get druggable targets OG5_128020	All targets in OG5_128020

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0087	0.3326	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Leishmania major	pantothenate kinase subunit, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.1399	0.2936
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.1351	0.4015
Mycobacterium tuberculosis	Probable oxidoreductase	0.0127	0.5072	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0355	0.1484
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0355	0.0997
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2679	0.3864
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0355	0.0997
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0127	0.5072	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0316	0.0397
Brugia malayi	Smad1	0.0017	0.0316	0.0316
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0019	0.041	0.1163
Echinococcus multilocularis	p2X purinoceptor 4	0.0132	0.5259	0.7151
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.1351	0.4015
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.2679	0.3626
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0061	0.2244	0.4265
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.1399	0.416
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Brugia malayi	hypothetical protein	0.0037	0.1203	0.1203
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.044	0.0566
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0017	0.0355	0.0435
Brugia malayi	TAR-binding protein	0.0072	0.2679	0.2679
Trypanosoma brucei	Inositol phosphosphingolipids phospholipase C	0.0012	0.014	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0112	0.0112
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0355	0.0997
Schistosoma mansoni	inositol monophosphatase	0.0042	0.1399	0.1999
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0019	0.041	0.0559
Leishmania major	inositol phosphosphingolipid phospholipase C-Like	0.0012	0.014	0.0347
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0012	0.014	0.0347
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.4524	0.8888
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.1399	0.416
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Brugia malayi	MH1 domain containing protein	0.0017	0.0316	0.0316
Trypanosoma cruzi	metallo-peptidase, Clan MH, Family M20	0.0087	0.3326	1
Brugia malayi	Aspartyl aminopeptidase	0.0087	0.3326	0.3326
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0087	0.3326	0.4806
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0041	0.1351	0.4015
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0355	0.0704
Trypanosoma brucei	inositol/phosphatidylinositol phosphatase, putative	0.0012	0.014	0.0347
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0012	0.014	0.0167
Onchocerca volvulus		0.0057	0.2041	0.8872
Echinococcus multilocularis	aspartyl aminopeptidase	0.0087	0.3326	0.451
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0011	0.006	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.014	0.014
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0355	0.5
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0041	0.1351	0.4015
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0012	0.0112	0.0261
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.4524	0.8888
Giardia lamblia	hypothetical protein	0.0012	0.014	0.0516
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.014	0.0347
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0019	0.041	0.1163
Loa Loa (eye worm)	hypothetical protein	0.018	0.7344	0.7344
Loa Loa (eye worm)	Smad1	0.0017	0.0316	0.0316
Trypanosoma cruzi	endonuclease/exonuclease/phosphatase, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0012	0.014	0.0156
Echinococcus multilocularis	muscleblind protein	0.018	0.7344	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0019	0.041	0.1163
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.014	0.014
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.1399	0.416
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0012	0.014	0.0156
Schistosoma mansoni	hypothetical protein	0.017	0.6893	1
Plasmodium falciparum	glutathione reductase	0.005	0.1763	0.5093
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0218	0.0581
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0012	0.014	0.0347
Schistosoma mansoni	nocturnin	0.0012	0.014	0.0167
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.3579	0.3579
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0218	0.0581
Schistosoma mansoni	carbon catabolite repressor protein	0.0012	0.014	0.0167
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0012	0.014	0.0347
Brugia malayi	MH2 domain containing protein	0.0017	0.0316	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0041	0.1351	0.4015
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0218	0.0581
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Trypanosoma cruzi	Inositol phosphosphingolipids phospholipase C	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0061	0.2244	0.6685
Echinococcus multilocularis	subfamily M14A unassigned peptidase	0.0057	0.2041	0.2753
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0316	0.0423
Echinococcus granulosus	p2X purinoceptor 4	0.0132	0.5259	0.7151
Brugia malayi	RNA binding protein	0.0072	0.2679	0.2679
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0127	0.5072	1
Toxoplasma gondii	FATC domain-containing protein	0.0026	0.0709	0.1461
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.1399	0.5527
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0019	0.0411	0.1167
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0087	0.3326	1
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.014	0.014
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0355	0.0674
Echinococcus multilocularis	p2X purinoceptor 4	0.0132	0.5259	0.7151
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0061	0.2244	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0133	0.5312	0.7697
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0276	0.0342
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.1399	0.1876
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.014	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Leishmania major	RNA-editing complex protein MP100, putative	0.0012	0.014	0.0347
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0019	0.041	0.1163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0555	0.1603
Schistosoma mansoni	synaptojanin	0.0012	0.014	0.0167
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0355	0.0997
Toxoplasma gondii	thioredoxin reductase	0.005	0.1763	0.3715
Brugia malayi	MH2 domain containing protein	0.0017	0.0316	0.0316
Echinococcus granulosus	neutral sphingomyelinase	0.0012	0.014	0.0156
Echinococcus granulosus	muscleblind protein	0.018	0.7344	1
Schistosoma mansoni	cpg binding protein	0.0066	0.245	0.3531
Loa Loa (eye worm)	hypothetical protein	0.0012	0.014	0.014
Echinococcus multilocularis	synaptojanin 1	0.0012	0.014	0.0156
Schistosoma mansoni	neutral sphingomyelinase	0.0012	0.014	0.0167
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0012	0.014	0.0347
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.4524	0.8888
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.1203	0.1713
Schistosoma mansoni	hypothetical protein	0.0037	0.1203	0.1713
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.014	0.0347
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Entamoeba histolytica	hypothetical protein	0.0026	0.0709	0.1986
Echinococcus multilocularis	serine protein kinase ATM	0.0026	0.0709	0.0933
Trichomonas vaginalis	hypothetical protein	0.0041	0.1351	0.4015
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0011	0.006	0.0047
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0112	0.0261
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.4524	0.8888
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0019	0.041	0.0524
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0061	0.2244	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Entamoeba histolytica	hypothetical protein	0.0037	0.1203	0.3497
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.014	0.0347
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.014	0.0347
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.1763	0.5263
Mycobacterium tuberculosis	Probable aminopeptidase PepC	0.0087	0.3326	0.646
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.1399	0.1876
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0061	0.2244	1
Plasmodium falciparum	M18 aspartyl aminopeptidase	0.0087	0.3326	1
Entamoeba histolytica	hypothetical protein	0.0037	0.1203	0.3497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.014	0.0245
Plasmodium vivax	exodeoxyribonuclease III, putative	0.0012	0.014	0.0347
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Leishmania major	hypothetical protein, conserved	0.0012	0.014	0.0347
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0709	0.207
Echinococcus granulosus	synaptojanin 1	0.0012	0.014	0.0156
Brugia malayi	CXXC zinc finger family protein	0.0063	0.2297	0.2297
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.1399	0.416
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Entamoeba histolytica	aminopeptidase, putative	0.0087	0.3326	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0276	0.0342
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0355	0.0997
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Trypanosoma brucei	trypanothione reductase	0.005	0.1763	0.5263
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	helicase, putative	0.0014	0.0218	0.0581
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0012	0.014	0.0156
Trypanosoma brucei	RNA editing exonuclease 2	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Plasmodium vivax	glutathione reductase, putative	0.005	0.1763	0.5263
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.043	0.043
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Schistosoma mansoni	Smad4	0.0017	0.0316	0.0423
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.3579	0.4855
Echinococcus granulosus	cpg binding protein	0.0066	0.245	0.3313
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0276	0.0342
Onchocerca volvulus		0.0063	0.2297	1
Echinococcus granulosus	p2X purinoceptor 4	0.0132	0.5259	0.7151
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.1763	0.329
Echinococcus multilocularis	cpg binding protein	0.0066	0.245	0.3313
Brugia malayi	glutathione reductase	0.005	0.1763	0.1763
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0019	0.041	0.0524
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0276	0.0365
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0061	0.2244	0.6719
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2679	0.3864
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.3579	0.5174
Echinococcus granulosus	tar DNA binding protein	0.0072	0.2679	0.3626
Loa Loa (eye worm)	RNA binding protein	0.0072	0.2679	0.2679
Trypanosoma cruzi	inositol 5-phosphatase 1, putative	0.0012	0.014	0.0347
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.1763	0.1763
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0355	0.045
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0087	0.3326	0.4806
Mycobacterium tuberculosis	Probable reductase	0.0115	0.4524	0.8888
Schistosoma mansoni	hypothetical protein	0.017	0.6893	1
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0012	0.014	0.014
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Brugia malayi	Carboxypeptidase A2 precursor	0.001	0.0026	0.0026
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0019	0.041	0.1163
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0157	0.0157
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.1203	0.1608
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0355	0.0997
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0061	0.2244	0.6719
Loa Loa (eye worm)	zinc carboxypeptidase	0.001	0.0026	0.0026
Echinococcus granulosus	traf and tnf receptor associated protein	0.0012	0.014	0.0156
Schistosoma mansoni	cpg binding protein	0.0066	0.245	0.3531
Echinococcus granulosus	serine protein kinase ATM	0.0026	0.0709	0.0933
Leishmania major	hypothetical protein, conserved	0.0012	0.014	0.0347
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.014	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.006	0.0104
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0355	0.0997
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Schistosoma mansoni	synaptojanin	0.0012	0.014	0.0167
Plasmodium falciparum	thioredoxin reductase	0.005	0.1763	0.5093
Echinococcus granulosus	subfamily M14A unassigned peptidase	0.0057	0.2041	0.2753
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0355	0.0997
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0019	0.041	0.1163
Onchocerca volvulus		0.0012	0.014	0.0504
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0316	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0355	0.0479
Entamoeba histolytica	hypothetical protein	0.0037	0.1203	0.3497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.1351	0.4015
Schistosoma mansoni	ap endonuclease	0.0061	0.2244	0.3229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0218	0.0581
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0019	0.041	0.1163
Brugia malayi	MH1 domain containing protein	0.0017	0.0316	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0019	0.041	0.1163
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.014	0.014
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0355	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0087	0.3326	0.3326
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0026	0.0709	0.207
Schistosoma mansoni	P2X receptor subunit	0.0132	0.5259	0.7621
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0012	0.014	0.0156
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2679	0.3864
Loa Loa (eye worm)	zinc carboxypeptidase	0.001	0.0026	0.0026
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.1399	0.416
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.3579	0.4855
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2679	0.3864
Echinococcus multilocularis	Smad4	0.0017	0.0316	0.0397
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0019	0.041	0.1163
Onchocerca volvulus		0.0057	0.2041	0.8872
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.041	0.041
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0012	0.014	0.0347
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0019	0.041	0.1163
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.1203	0.1608
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0709	0.207
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0012	0.014	0.0156
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0012	0.014	0.0504
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0012	0.014	0.0156
Loa Loa (eye worm)	inositol-1	0.0042	0.1399	0.1399
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.3579	0.5174
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0061	0.2244	0.3031
Echinococcus multilocularis	p2X purinoceptor 4	0.0132	0.5259	0.7151
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.014	0.014
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Leishmania major	trypanothione reductase	0.005	0.1763	0.5263
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.0411	0.1167
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0157	0.0157
Trypanosoma cruzi	target of rapamycin kinase 3	0.0019	0.041	0.1163
Schistosoma mansoni	smad	0.0017	0.0316	0.0423
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0316	0.0423
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.3579	0.5174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0019	0.041	0.0559
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.2679	0.2679
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0026	0.0709	0.0995
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0061	0.2244	0.6719
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.006
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0019	0.041	0.107
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0011	0.006	0.005
Schistosoma mansoni	cpg binding protein	0.0063	0.2297	0.3307
Echinococcus multilocularis	geminin	0.017	0.6893	0.9384
Schistosoma mansoni	P2X receptor subunit	0.0132	0.5259	0.7621
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0061	0.2244	0.3031
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0019	0.041	0.0821
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0355	0.0704
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.1399	0.5527
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0012	0.0112	0.0184
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0042	0.1399	0.4099
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0012	0.014	0.0156
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0019	0.041	0.1163
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0218	0.0581
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0019	0.041	0.107
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Schistosoma mansoni	subfamily M14A unassigned peptidase (M14 family)	0.0057	0.2041	0.2934
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0355	0.0997
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0355	0.0997
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0127	0.5072	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1623	0.1623
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0061	0.2244	0.2244
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0012	0.014	0.0156
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0087	0.3326	1
Brugia malayi	CCR4	0.0012	0.014	0.014
Giardia lamblia	GTOR	0.0019	0.041	0.173
Loa Loa (eye worm)	transcription factor SMAD2	0.0242	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.1203	0.3497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Echinococcus granulosus	aspartyl aminopeptidase	0.0087	0.3326	0.451
Entamoeba histolytica	inositol polyphosphate 5-phosphatase, putative	0.0012	0.014	0.0245
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0012	0.014	0.0347
Loa Loa (eye worm)	glutathione reductase	0.005	0.1763	0.1763
Entamoeba histolytica	inositol polyphosphate-5-phosphatase, putative	0.0012	0.014	0.0245
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0019	0.041	0.1163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.1763	0.2374
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.2679	0.2679
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0218	0.0581
Treponema pallidum	NADH oxidase	0.0017	0.0355	0.1021
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.1399	0.416
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0119	0.4702	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0063	0.2297	0.2297
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.041	0.041
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.014	0.0347
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.3579	0.4855
Loa Loa (eye worm)	hypothetical protein	0.018	0.7344	0.7344
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0316	0.0397
Echinococcus multilocularis	smad	0.0017	0.0316	0.0397
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0011	0.006	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.044	0.044
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0316	0.0316
Echinococcus granulosus	Smad4	0.0017	0.0316	0.0397
Schistosoma mansoni	ap endonuclease	0.0061	0.2244	0.3229
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Brugia malayi	Thioredoxin reductase	0.005	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Leishmania major	hypothetical protein, conserved	0.0012	0.014	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Leishmania major	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	0.0087	0.3326	1
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0316	0.0423
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0316	0.0397
Echinococcus multilocularis	muscleblind protein 1	0.018	0.7344	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.4524	0.8888
Loa Loa (eye worm)	hypothetical protein	0.0012	0.014	0.014
Echinococcus granulosus	smad	0.0017	0.0316	0.0397
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0276	0.0342
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.044	0.0566
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.3579	0.3579
Echinococcus multilocularis	neutral sphingomyelinase	0.0012	0.014	0.0156
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0355	0.0997
Entamoeba histolytica	aspartyl aminopeptidase, putative	0.0087	0.3326	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0355	0.0997
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0061	0.2244	0.6602
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0019	0.041	0.1163
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0218	0.0581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.041	0.041
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0012	0.014	0.0347
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Loa Loa (eye worm)	zinc carboxypeptidase	0.001	0.0026	0.0026
Trypanosoma cruzi	RNA-editing complex protein MP100, putative	0.0012	0.014	0.0347
Toxoplasma gondii	exonuclease III APE	0.0061	0.2244	0.4742
Loa Loa (eye worm)	zinc carboxypeptidase	0.001	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0026
Entamoeba histolytica	sphingomyelinase C precursor, putative	0.0012	0.014	0.0245
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Trypanosoma brucei	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0012	0.014	0.0347
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0087	0.3326	1
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0061	0.2244	0.6719
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Trypanosoma brucei	DNA-(apurinic or apyrimidinic site) lyase, putative	0.0012	0.014	0.0347
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Brugia malayi	Zinc carboxypeptidase family protein	0.001	0.0026	0.0026
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.3579	0.4855
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0012	0.014	0.014
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.014	0.0245
Echinococcus granulosus	geminin	0.017	0.6893	0.9384
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.4524	0.8579
Loa Loa (eye worm)	aspartyl aminopeptidase	0.0087	0.3326	0.3326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.1763	0.2374
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0061	0.2244	0.6719
Onchocerca volvulus	Subfamily M14A unassigned peptidase homolog	0.0057	0.2041	0.8872
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0061	0.2244	1
Brugia malayi	Inositol-1	0.0042	0.1399	0.1399
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.041	0.041
Schistosoma mansoni	P2X receptor subunit	0.0132	0.5259	0.7621
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0019	0.041	0.1163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Schistosoma mansoni	hypothetical protein	0.0012	0.014	0.0167
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0355	0.045
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0026	0.0709	0.0709
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0355	0.0997
Giardia lamblia	Inositol 5-phosphatase 4	0.0012	0.014	0.0516
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0012	0.014	0.0347
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0019	0.041	0.0524
Brugia malayi	exodeoxyribonuclease III family protein	0.0061	0.2244	0.2244
Leishmania major	inositol/phosphatidylinositol phosphatase, putative	0.0012	0.014	0.0347
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Brugia malayi	Muscleblind-like protein	0.018	0.7344	0.7344
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.014	0.0347
Loa Loa (eye worm)	MH2 domain-containing protein	0.0242	1	1
Trypanosoma cruzi	aspartyl aminopeptidase, putative	0.0087	0.3326	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0019	0.041	0.0524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0112	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2679	0.3864
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0355	0.0997
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.2679	0.2679
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0355	0.0674
Plasmodium falciparum	glutathione reductase	0.0017	0.0355	0.0674
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.014	0.014
Schistosoma mansoni	cript-related	0.0012	0.014	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0087	0.3326	0.3326
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0316	0.0316
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.1211	0.2171
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0218	0.0581
Trichomonas vaginalis	ap endonuclease, putative	0.0061	0.2244	0.6719
Leishmania major	endonuclease/exonuclease protein-like protein	0.0012	0.014	0.0347
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.1763	0.5263
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.1399	0.416
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0355	0.0674
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0087	0.3326	1
Trichomonas vaginalis	ap endonuclease, putative	0.0061	0.2244	0.6719
Schistosoma mansoni	inositol monophosphatase	0.0042	0.1399	0.1999
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0218	0.0581
Echinococcus granulosus	p2X purinoceptor 4	0.0132	0.5259	0.7151
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0011	0.006	0.0047
Mycobacterium leprae	PROBABLE AMINOPEPTIDASE PEPC	0.0087	0.3326	0.5478
Plasmodium vivax	M18 aspartyl aminopeptidase, putative	0.0087	0.3326	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.041	0.1163
Onchocerca volvulus		0.0012	0.014	0.0504
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0316	0.0397
Schistosoma mansoni	P2X receptor subunit	0.0132	0.5259	0.7621
Onchocerca volvulus		0.0057	0.2041	0.8872
Onchocerca volvulus		0.0057	0.2041	0.8872

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.35284 um	PUBCHEM_BIOASSAY: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). (Class of assay: confirmatory) [Related PubChem assays: 2170 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)]	ChEMBL.	No reference
IC50 (binding)	> 59.642 um	PUBCHEM_BIOASSAY: QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). (Class of assay: confirmatory) [Related pubchem assays: 2178 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)]	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (binding)	15.8489 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1472465

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1318255