Detailed information for compound 1340070

Basic information

Technical information
  • TDR Targets ID: 1340070
  • Name: N,N'-bis(3-chlorophenyl)-1-methylpyrazole-3,5 -dicarboxamide
  • MW: 389.235 | Formula: C18H14Cl2N4O2
  • H donors: 2 H acceptors: 3 LogP: 3.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)NC(=O)c1nn(c(c1)C(=O)Nc1cccc(c1)Cl)C
  • InChi: 1S/C18H14Cl2N4O2/c1-24-16(18(26)22-14-7-3-5-12(20)9-14)10-15(23-24)17(25)21-13-6-2-4-11(19)8-13/h2-10H,1H3,(H,21,25)(H,22,26)
  • InChiKey: HWFFDKDTIUMJOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N'-bis(3-chlorophenyl)-1-methyl-pyrazole-3,5-dicarboxamide
  • STOCK1S-12169
  • Oprea1_866553
  • Oprea1_461958
  • 1-Methyl-1H-pyrazole-3,5-dicarboxylic acid bis-[(3-chloro-phenyl)-amide]
  • BAS 00344839
  • ZINC00821585

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.0019 0.0126 0.026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1071 0.1068
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.23 1
Schistosoma mansoni ap endonuclease 0.0019 0.0126 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0397 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0083 0.1491 0.3047
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Giardia lamblia Cathepsin B precursor 0.0067 0.1157 1
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0041
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0132 0.0097
Plasmodium falciparum cysteine proteinase falcipain 1 0.0045 0.0683 0.4296
Onchocerca volvulus 0.0083 0.1491 0.2855
Toxoplasma gondii cathepsin CPC2 0.0019 0.0132 0.0288
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0067 0.1157 0.3211
Schistosoma mansoni cathepsin s 0.0026 0.0272 0.0267
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0272 0.0268
Toxoplasma gondii preprocathepsin c precursor, putative 0.0019 0.0132 0.0288
Schistosoma mansoni cpg binding protein 0.0061 0.1021 0.1169
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0683 0.4079
Loa Loa (eye worm) fibroinase 0.0083 0.1491 0.1487
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0822 0.3737
Giardia lamblia Cathepsin L precursor 0.0019 0.0132 0.0533
Echinococcus multilocularis survival motor neuron protein 1 0.0482 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0126 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0083 0.1491 0.1487
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0126 0.0368
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0683 0.4079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.2354 0.2774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0175 0.3447 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.3988 0.3985
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0648 0.072
Echinococcus granulosus cpg binding protein 0.0061 0.1021 0.1018
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1071 0.104
Giardia lamblia Cathepsin B precursor 0.0067 0.1157 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.0132 0.0407
Loa Loa (eye worm) hypothetical protein 0.0047 0.0719 0.0715
Brugia malayi Pre-SET motif family protein 0.0032 0.0397 0.0363
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0026 0.0272 0.0238
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0738 0.0735
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1078 0.1047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0683 0.4296
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0215 0.0211
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0121 0.0086
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0045 0.0683 0.1805
Onchocerca volvulus 0.0027 0.0307 0.0369
Plasmodium vivax glutathione reductase, putative 0.0048 0.0738 0.469
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0346 0.0342
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0126 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0041
Schistosoma mansoni lamin 0.0027 0.0307 0.0309
Plasmodium vivax unspecified product 0.0045 0.0683 0.4296
Schistosoma mansoni ap endonuclease 0.0019 0.0126 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0019 0.0132 0.0269
Giardia lamblia Cathepsin L-like protease 0.0019 0.0132 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0269
Onchocerca volvulus 0.0083 0.1491 0.2855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0269
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0132 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0683 0.1395
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.23 1
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Brugia malayi mbt repeat family protein 0.0047 0.0719 0.0686
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0045 0.0683 0.0761
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0719 0.0715
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0719 0.0715
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0719 0.0715
Plasmodium falciparum serine repeat antigen 7 0.0019 0.0132 0.0407
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0041
Loa Loa (eye worm) hypothetical protein 0.0057 0.094 0.0936
Plasmodium falciparum serine repeat antigen 8 0.0019 0.0132 0.0407
Loa Loa (eye worm) hypothetical protein 0.0146 0.2845 0.2843
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0126 0.0122
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0074 0.007
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0019 0.0132 0.0407
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0307 0.0303
Giardia lamblia Hypothetical protein 0.0019 0.0132 0.0533
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0307 0.0303
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0397 0.0393
Toxoplasma gondii cathepsin B 0.0067 0.1157 0.5412
Giardia lamblia Cathepsin L precursor 0.0019 0.0132 0.0533
Brugia malayi Cathepsin L-like precursor 0.0083 0.1491 0.1461
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.2638 0.2612
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Plasmodium falciparum thioredoxin reductase 0.0048 0.0738 0.469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.4268 0.4266
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0132 0.0097
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0857 0.0853
Loa Loa (eye worm) hypothetical protein 0.0032 0.0397 0.0393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3447 0.4091
Echinococcus multilocularis lamin dm0 0.0027 0.0307 0.0303
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0019 0.0132 0.0407
Echinococcus multilocularis cathepsin L cysteine protease 0.0083 0.1491 0.1487
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0019 0.0132 0.0407
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0083 0.1491 0.1487
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0215 0.0211
Echinococcus multilocularis lamin 0.0027 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0272 0.0268
Giardia lamblia Cathepsin B precursor 0.0019 0.0132 0.0533
Loa Loa (eye worm) cathepsin B 0.0067 0.1157 0.1153
Brugia malayi hypothetical protein 0.0033 0.0432 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1078 0.1238
Brugia malayi Cathepsin L-like precursor 0.0083 0.1491 0.1461
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0719 0.0715
Onchocerca volvulus 0.0058 0.0951 0.1721
Giardia lamblia Cysteine protease 0.0019 0.0132 0.0533
Echinococcus granulosus GPCR family 2 0.0063 0.1071 0.1068
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0126 0.0368
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0126 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0132 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0132 0.0269
Schistosoma mansoni hypothetical protein 0.0043 0.0648 0.072
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0019 0.0132 0.0041
Entamoeba histolytica hypothetical protein 0.0019 0.0132 0.0041
Brugia malayi hypothetical protein 0.0052 0.0822 0.0789
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.0132 0.0407
Onchocerca volvulus 0.0083 0.1491 0.2855
Loa Loa (eye worm) hypothetical protein 0.02 0.3988 0.3985
Plasmodium falciparum cysteine proteinase falcipain 3 0.0083 0.1491 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0822 0.5279
Echinococcus granulosus lamin dm0 0.0027 0.0307 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0019 0.0132 0.0269
Echinococcus multilocularis cathepsin b 0.0175 0.3447 0.3444
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0019 0.0132 0.0407
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1078 0.1075
Brugia malayi Thioredoxin reductase 0.0048 0.0738 0.0706
Echinococcus granulosus cathepsin L 0.0045 0.0683 0.0679
Schistosoma mansoni lamin 0.0027 0.0307 0.0309
Echinococcus granulosus survival motor neuron protein 1 0.0482 1 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0074 0.5
Loa Loa (eye worm) hypothetical protein 0.0482 1 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0857 0.0853
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0719 0.1234
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0083 0.1491 0.1487
Echinococcus granulosus lamin 0.0027 0.0307 0.0303
Onchocerca volvulus Cathepsin F homolog 0.0083 0.1491 0.2855
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0738 0.2985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0128
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0725 0.0692
Loa Loa (eye worm) hypothetical protein 0.0052 0.0822 0.0818
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0822 0.5279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.1157 0.1333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0074 0.0028
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0132 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Brugia malayi Muscleblind-like protein 0.0146 0.2845 0.282
Echinococcus multilocularis geminin 0.0205 0.4086 0.4084
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0019 0.0132 0.0128
Leishmania major cysteine peptidase A (CPA) 0.0083 0.1491 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Giardia lamblia Cathepsin L precursor 0.0019 0.0132 0.0533
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0857 0.0853
Plasmodium falciparum serine repeat antigen 6 0.0019 0.0132 0.0407
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0725 0.0721
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0074 0.007
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.1491 0.1461
Echinococcus granulosus cysteine protease 0.0045 0.0683 0.0679
Loa Loa (eye worm) hypothetical protein 0.0027 0.0296 0.0292
Trypanosoma cruzi cysteine proteinase, putative 0.0045 0.0683 0.1805
Loa Loa (eye worm) hypothetical protein 0.0026 0.0272 0.0268
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0857 0.0825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0725 0.0812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Echinococcus multilocularis cathepsin L 0.0019 0.0132 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0132 0.0269
Schistosoma mansoni hypothetical protein 0.0137 0.2638 0.3117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Echinococcus granulosus cathepsin l1 0.0083 0.1491 0.1487
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.1491 0.1487
Schistosoma mansoni hypothetical protein 0.0063 0.1071 0.123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0725 0.0721
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2797 0.2794
Loa Loa (eye worm) cysteine protease 0.0083 0.1491 0.1487
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0132 0.0097
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.0132 0.0097
Plasmodium falciparum glutathione reductase 0.0048 0.0738 0.469
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0719 0.0715
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.2075 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0132 0.0097
Toxoplasma gondii thioredoxin reductase 0.0048 0.0738 0.3321
Plasmodium falciparum serine repeat antigen 4 0.0019 0.0132 0.0407
Schistosoma mansoni cathepsin B (C01 family) 0.0019 0.0132 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0397 0.0417
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0132 0.0533
Brugia malayi cathepsin B-like cysteine proteinase 0.0175 0.3447 0.3423
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0083 0.1491 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0397 0.1613
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0126 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Plasmodium vivax vivapain-1 0.0045 0.0683 0.4296
Plasmodium vivax unspecified product 0.0026 0.0272 0.1402
Echinococcus granulosus dnaJ subfamily B 0.0405 0.8351 0.8351
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0128
Toxoplasma gondii cathepsin CPL 0.0083 0.1491 0.708
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0083 0.1491 1
Onchocerca volvulus 0.0032 0.0397 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0683 0.1395
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.1491 0.4201
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0822 0.5279
Schistosoma mansoni hypothetical protein 0.0288 0.5867 0.7008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Entamoeba histolytica cysteine proteinase 2 0.0045 0.0683 0.4079
Plasmodium vivax SET domain protein, putative 0.0032 0.0397 0.2278
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0067 0.1157 0.2364
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0126 1
Trichomonas vaginalis set domain proteins, putative 0.0242 0.4893 1
Schistosoma mansoni hypothetical protein 0.0063 0.1071 0.123
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1078 0.1238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0397 0.0393
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0822 0.5279
Loa Loa (eye worm) hypothetical protein 0.0063 0.1071 0.1068
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0738 0.469
Schistosoma mansoni intermediate filament proteins 0.0027 0.0307 0.0309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0725 0.0721
Entamoeba histolytica cysteine proteinase 1, putative 0.0045 0.0683 0.4079
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.1491 0.4201
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0019 0.0132 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0269
Brugia malayi Cathepsin L-like precursor 0.0083 0.1491 0.1461
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0051 0.0047
Echinococcus multilocularis muscleblind protein 0.0146 0.2845 0.2843
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0132 0.0128
Onchocerca volvulus 0.0027 0.0307 0.0369
Loa Loa (eye worm) glutathione reductase 0.0048 0.0738 0.0735
Brugia malayi mbt repeat family protein 0.0047 0.0719 0.0686
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1078 0.1075
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0683 0.4079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0132 0.0097
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.3734 0.3732
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1078 0.1075
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0126 0.0257
Onchocerca volvulus 0.0083 0.1491 0.2855
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1078 0.1238
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0738 0.0735
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0051 0.0047
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0683 0.065
Giardia lamblia Cysteine protease 0.0019 0.0132 0.0533
Loa Loa (eye worm) hypothetical protein 0.0057 0.094 0.0936
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0126 0.0122
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Echinococcus multilocularis cysteine protease 0.0083 0.1491 0.1487
Plasmodium vivax vivapain-2 0.0083 0.1491 1
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1071 0.1068
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.3827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0269
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.3827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0725 0.0812
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Giardia lamblia Cathepsin L precursor 0.0019 0.0132 0.0533
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0019 0.0132 0.0407
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.3827
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2845 0.2843
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Echinococcus granulosus tar DNA binding protein 0.0064 0.1078 0.1075
Trypanosoma brucei cysteine peptidase C (CPC) 0.0067 0.1157 0.7643
Giardia lamblia Cysteine protease 0.0019 0.0132 0.0533
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0857 0.0853
Schistosoma mansoni hypothetical protein 0.0205 0.4086 0.4862
Echinococcus granulosus cathepsin L 0.0019 0.0132 0.0128
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.094 0.5963
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0175 0.3447 0.4091
Schistosoma mansoni hypothetical protein 0.0405 0.8351 1
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.3827
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0719 0.0805
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0126 0.0481
Giardia lamblia Hypothetical protein 0.0019 0.0132 0.0533
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0648 0.0644
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.3734 0.3732
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1071 0.1068
Trypanosoma cruzi cruzipain precursor, putative 0.0083 0.1491 0.4201
Trypanosoma cruzi cysteine proteinase, putative 0.0045 0.0683 0.1805
Echinococcus granulosus muscleblind protein 0.0146 0.2845 0.2843
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2041 0.8837
Echinococcus multilocularis cpg binding protein 0.0061 0.1021 0.1018
Onchocerca volvulus 0.0083 0.1491 0.2855
Loa Loa (eye worm) MBCTL1 0.0053 0.0857 0.0853
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0128
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0019 0.0132 0.0407
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0132 0.0097
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0126 0.0368
Toxoplasma gondii cathepsin CPC1 0.0019 0.0132 0.0288
Echinococcus multilocularis musashi 0.0027 0.0307 0.0303
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0719 0.0805
Onchocerca volvulus 0.0083 0.1491 0.2855
Echinococcus multilocularis cathepsin b 0.0175 0.3447 0.3444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Giardia lamblia Encystation-specific protease 0.0019 0.0132 0.0533
Plasmodium falciparum serine repeat antigen 1 0.0019 0.0132 0.0407
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0132 0.0533
Onchocerca volvulus 0.0098 0.1818 0.3542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0683 0.4296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3447 0.4091
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.094 0.2567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0269
Trypanosoma brucei trypanothione reductase 0.0048 0.0738 0.469
Brugia malayi cathepsin F-like cysteine proteinase 0.0019 0.0132 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0126 0.0154
Echinococcus granulosus cathepsin b 0.0175 0.3447 0.3444
Giardia lamblia Cathepsin B precursor 0.0067 0.1157 1
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.094 0.0936
Trypanosoma cruzi major cysteine proteinase, putative 0.0019 0.0132 0.0171
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2638 0.2635
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0397 0.0417
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0083 0.1491 0.1487
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Brugia malayi cathepsin L-like cysteine proteinase 0.0019 0.0132 0.0097
Brugia malayi CXXC zinc finger family protein 0.0058 0.0951 0.0919
Giardia lamblia Cathepsin B precursor 0.0019 0.0132 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Giardia lamblia Cathepsin L precursor 0.0019 0.0132 0.0533
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0951 0.0947
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.0132 0.0407
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0045 0.0683 0.0761
Schistosoma mansoni cpg binding protein 0.0058 0.0951 0.1085
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0019 0.0132 0.0097
Onchocerca volvulus 0.0047 0.0719 0.1234
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0648 0.0644
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0132 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0307 0.0303
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0272 0.0589
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.8351 0.8351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Trypanosoma cruzi major cysteine proteinase, putative 0.0019 0.0132 0.0171
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2041 0.8837
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3447 0.4091
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.0132 0.0097
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0019 0.0132 0.0097
Schistosoma mansoni cathepsin S (C01 family) 0.0019 0.0132 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0272 0.0268
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0719 0.0805
Brugia malayi Cathepsin L-like precursor 0.0083 0.1491 0.1461
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0126 0.0368
Echinococcus granulosus cathepsin L cysteine protease 0.0045 0.0683 0.0679
Plasmodium falciparum serine repeat antigen 2 0.0019 0.0132 0.0407
Schistosoma mansoni hypothetical protein 0.0023 0.0215 0.0198
Onchocerca volvulus Cathepsin L homolog 0.0083 0.1491 0.2855
Plasmodium falciparum serine repeat antigen 5 0.0019 0.0132 0.0407
Brugia malayi Cathepsin L-like precursor 0.0057 0.094 0.0908
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0132 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.1491 0.1735
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.1491 0.4201
Trypanosoma cruzi cysteine protease, putative 0.0045 0.0683 0.1805
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0019 0.0132 0.0407
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1071 0.1068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1071 0.104
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0126 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0126 0.0257
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0132 0.0533
Giardia lamblia Cathepsin L precursor 0.0019 0.0132 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.1491 0.4201
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.1491 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0307 0.0273
Echinococcus granulosus geminin 0.0205 0.4086 0.4084
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0269
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0132 0.0097
Schistosoma mansoni cpg binding protein 0.0061 0.1021 0.1169
Onchocerca volvulus 0.0083 0.1491 0.2855
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0126 0.0154
Mycobacterium tuberculosis Probable reductase 0.0109 0.2041 0.8837
Giardia lamblia Cathepsin L-like protease 0.0019 0.0132 0.0533
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.1491 1
Brugia malayi cathepsin L-like precursor 0.0057 0.094 0.0908
Brugia malayi hypothetical protein 0.0043 0.0648 0.0615
Schistosoma mansoni hypothetical protein 0.0063 0.1071 0.123
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.0132 0.0407
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0126 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Echinococcus granulosus cathepsin L cysteine proteinase 0.0083 0.1491 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0132 0.0269
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1078 0.1238
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0019 0.0132 0.0407
Plasmodium falciparum serine repeat antigen 3 0.0019 0.0132 0.0407
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Giardia lamblia Cathepsin B precursor 0.0019 0.0132 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0683 0.1805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Schistosoma mansoni cathepsin C 0.0019 0.0132 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1078 0.1238
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0019 0.0132 0.0097
Brugia malayi intermediate filament protein 0.0027 0.0307 0.0273
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0272 0.0238
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0019 0.0132 0.0407
Loa Loa (eye worm) hypothetical protein 0.0083 0.1491 0.1487
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2041 0.8837
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0019 0.0132 0.0407
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Schistosoma mansoni hypothetical protein 0.0063 0.1071 0.123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0269
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2797 0.2794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Plasmodium falciparum serine repeat antigen 9 0.0019 0.0132 0.0407
Echinococcus granulosus cathepsin l1 0.0057 0.094 0.0936
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0725 0.0721
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1071 0.1068
Loa Loa (eye worm) hypothetical protein 0.0175 0.3447 0.3444
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0126 0.0122
Brugia malayi Cathepsin L-like precursor 0.0026 0.0272 0.0238
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0857 0.0971
Echinococcus multilocularis cysteine protease 0.0083 0.1491 0.1487
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Giardia lamblia Cathepsin B precursor 0.0019 0.0132 0.0533
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0738 0.0735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0272 0.0589
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0738 0.197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Echinococcus multilocularis cathepsin L 0.0045 0.0683 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.094 0.192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Onchocerca volvulus 0.0057 0.094 0.1697
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2041 0.8837
Brugia malayi MH2 domain containing protein 0.0144 0.2797 0.2771
Giardia lamblia Cysteine protease 0.0019 0.0132 0.0533
Echinococcus multilocularis GPCR, family 2 0.0063 0.1071 0.1068
Leishmania major hypothetical protein, conserved 0.0052 0.0822 0.5279
Brugia malayi Cathepsin L-like precursor 0.0057 0.094 0.0908
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.3988 0.3967
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0683 0.065
Onchocerca volvulus Cathepsin L homolog 0.0083 0.1491 0.2855
Brugia malayi RNA binding protein 0.0064 0.1078 0.1047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Entamoeba histolytica cysteine protease, putative 0.0083 0.1491 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0307 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0857 0.0853
Plasmodium vivax unspecified product 0.0019 0.0132 0.0407
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0019 0.0132 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0019 0.0132 0.0269
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2041 0.8837
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0397 0.0393
Echinococcus granulosus cathepsin b 0.0175 0.3447 0.3444
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0051 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0725 0.0812
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0822 0.2218
Brugia malayi TAR-binding protein 0.0064 0.1078 0.1047
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0035 0.0031
Loa Loa (eye worm) ctsf protein 0.0083 0.1491 0.1487
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1818 0.1789
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0683 0.4079
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0083 0.1491 0.3047
Leishmania major cathepsin L-like protease 0.0083 0.1491 1
Entamoeba histolytica cysteine protease, putative 0.0045 0.0683 0.4079
Leishmania major trypanothione reductase 0.0048 0.0738 0.469
Brugia malayi cathepsin L precursor 0.0019 0.0132 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0019 0.0132 0.0269
Brugia malayi Pre-SET motif family protein 0.0213 0.4268 0.4248
Schistosoma mansoni survival motor neuron protein 0.0098 0.1818 0.2129
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0067 0.1157 0.7643
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0074 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.094 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1491 0.3047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0128
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0074 0.0151
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.3988 0.3967
Brugia malayi fibroinase precursor 0.0019 0.0132 0.0097
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0051 0.0047
Onchocerca volvulus 0.0242 0.4893 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0019 0.0132 0.0533
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0045 0.0683 0.0761
Loa Loa (eye worm) hypothetical protein 0.0146 0.2845 0.2843
Brugia malayi Cathepsin L-like precursor 0.0083 0.1491 0.1461
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.094 0.0908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0269
Giardia lamblia Cathepsin B precursor 0.0019 0.0132 0.0533
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.23 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.1078 0.1075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0725 0.0721
Plasmodium vivax vivapain-2 0.0083 0.1491 1
Schistosoma mansoni hypothetical protein 0.0098 0.1818 0.2129
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.1491 0.1735
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.23 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0083 0.1491 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.094 0.192
Schistosoma mansoni hypothetical protein 0.0205 0.4086 0.4862
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Brugia malayi glutathione reductase 0.0048 0.0738 0.0706
Plasmodium vivax vivapain-3 0.0045 0.0683 0.4296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0397 0.0417
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0822 0.2218
Brugia malayi Cathepsin L-like precursor 0.0083 0.1491 0.1461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.1491 0.3047
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0074 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1491 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0126 0.0122
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0041

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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