Detailed information for compound 1346499

Basic information

Technical information
  • TDR Targets ID: 1346499
  • Name: 3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-[4-(6- methyl-1,3-benzothiazol-2-yl)phenyl]pyrrolidi ne-2,5-dione
  • MW: 450.553 | Formula: C24H26N4O3S
  • H donors: 1 H acceptors: 4 LogP: 2.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)C1CC(=O)N(C1=O)c1ccc(cc1)c1sc2c(n1)ccc(c2)C
  • InChi: 1S/C24H26N4O3S/c1-16-2-7-19-21(14-16)32-23(25-19)17-3-5-18(6-4-17)28-22(30)15-20(24(28)31)27-10-8-26(9-11-27)12-13-29/h2-7,14,20,29H,8-13,15H2,1H3
  • InChiKey: SMSNAXGJBCDNLY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[4-(2-hydroxyethyl)-1-piperazinyl]-1-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]pyrrolidine-2,5-dione
  • 3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]pyrrolidine-2,5-quinone
  • MLS000706118
  • SMR000229269

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax unspecified product 0.046 0.1369 0.2055
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Echinococcus granulosus geminin 0.0205 0.0558 0.0429
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1449 0.4504 0.4501
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.046 0.1369 0.2055
Echinococcus granulosus cathepsin L cysteine protease 0.1135 0.3507 0.3418
Leishmania major cysteine peptidase A (CPA) 0.2123 0.6641 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1135 0.3507 0.3418
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2123 0.6641 0.6641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.046 0.1369 0.1252
Loa Loa (eye worm) hypothetical protein 0.3182 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Schistosoma mansoni hypothetical protein 0.0205 0.0558 0.0429
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Trypanosoma cruzi cruzipain precursor, putative 0.2123 0.6641 0.664
Plasmodium vivax serine-repeat antigen (SERA) 0.046 0.1369 0.2055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Loa Loa (eye worm) hypothetical protein 0.0674 0.2047 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Plasmodium falciparum serine repeat antigen 5 0.046 0.1369 0.2055
Plasmodium falciparum serine repeat antigen 8 0.046 0.1369 0.2055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Entamoeba histolytica cysteine proteinase, putative 0.2123 0.6641 1
Entamoeba histolytica cysteine protease, putative 0.046 0.1369 0.2062
Schistosoma mansoni cathepsin s 0.0674 0.2047 0.1938
Echinococcus multilocularis geminin 0.0205 0.0558 0.0429
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.046 0.1369 0.2055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Echinococcus multilocularis cysteine protease 0.2123 0.6641 0.6596
Trypanosoma cruzi cysteine peptidase, putative 0.2123 0.6641 0.664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Brugia malayi cathepsin Z-like cysteine proteinase 0.046 0.1369 0.1369
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0152 0.0152
Brugia malayi Cathepsin L-like cysteine proteinase 0.1449 0.4504 0.4504
Brugia malayi Cathepsin L-like precursor 0.0674 0.2047 0.2047
Plasmodium vivax serine-repeat antigen (SERA), putative 0.046 0.1369 0.2055
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Plasmodium falciparum serine repeat antigen 4 0.046 0.1369 0.2055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0152 0.0152
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.046 0.1369 0.2055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Echinococcus multilocularis cathepsin L 0.1135 0.3507 0.3418
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0898 0.0559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1449 0.4504 0.6487
Echinococcus multilocularis cathepsin L 0.046 0.1369 0.1252
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.046 0.1369 0.2055
Plasmodium falciparum serine repeat antigen 7 0.046 0.1369 0.2055
Toxoplasma gondii cathepsin CPL 0.2123 0.6641 1
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0134 0.0134
Plasmodium falciparum serine repeat antigen 6 0.046 0.1369 0.2055
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1135 0.3507 0.3503
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.046 0.1369 0.2055
Plasmodium vivax vivapain-2 0.2123 0.6641 1
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Brugia malayi cathepsin F-like cysteine proteinase 0.046 0.1369 0.1369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2123 0.6641 1
Toxoplasma gondii cathepsin CPC2 0.046 0.1369 0.2055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Entamoeba histolytica cysteine proteinase 1, putative 0.1135 0.3507 0.528
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Brugia malayi Cathepsin L-like precursor 0.1449 0.4504 0.4504
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0558 0.084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3182 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Entamoeba histolytica cysteine proteinase 2 0.1135 0.3507 0.528
Schistosoma mansoni cathepsin C 0.046 0.1369 0.1252
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0152 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.1449 0.4504 0.4429
Plasmodium falciparum serine repeat antigen 1 0.046 0.1369 0.2055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3182 1 1
Plasmodium falciparum serine repeat antigen 9 0.046 0.1369 0.2055
Brugia malayi cathepsin F-like cysteine proteinase 0.0674 0.2047 0.2047
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Entamoeba histolytica cysteine proteinase, putative 0.1135 0.3507 0.528
Brugia malayi Cathepsin L-like precursor 0.2123 0.6641 0.6641
Brugia malayi jmjC domain containing protein 0.0071 0.0134 0.0134
Entamoeba histolytica cysteine proteinase, putative 0.1135 0.3507 0.528
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0898 0.0559
Brugia malayi Cathepsin L-like precursor 0.2123 0.6641 0.6641
Echinococcus multilocularis cathepsin b 0.3182 1 1
Brugia malayi Papain family cysteine protease containing protein 0.1135 0.3507 0.3507
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0006
Brugia malayi cahepsin L-like non-peptiedase homolog 0.046 0.1369 0.1369
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3014 0.2919
Onchocerca volvulus Cathepsin L homolog 0.046 0.1369 0.2062
Plasmodium vivax serine-repeat antigen (SERA), putative 0.046 0.1369 0.2055
Echinococcus granulosus cathepsin b 0.3182 1 1
Plasmodium vivax unspecified product 0.0674 0.2047 0.3076
Trypanosoma cruzi major cysteine proteinase, putative 0.046 0.1369 0.1364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.046 0.1369 0.1252
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.046 0.1369 0.2055
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.046 0.1369 0.2055
Entamoeba histolytica cysteine proteinase, putative 0.1135 0.3507 0.528
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Onchocerca volvulus 0.2123 0.6641 1
Onchocerca volvulus Cathepsin L homolog 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1449 0.4504 0.6487
Plasmodium vivax vivapain-2 0.2123 0.6641 1
Brugia malayi Cathepsin L-like precursor 0.2123 0.6641 0.6641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Schistosoma mansoni hypothetical protein 0.0205 0.0558 0.0429
Trypanosoma brucei cysteine peptidase C (CPC) 0.1302 0.4039 0.6077
Trypanosoma cruzi cysteine protease, putative 0.1135 0.3507 0.3503
Onchocerca volvulus 0.046 0.1369 0.2062
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.046 0.1369 0.2055
Loa Loa (eye worm) hypothetical protein 0.1449 0.4504 0.4504
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2123 0.6641 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.046 0.1369 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.046 0.1369 0.1333
Entamoeba histolytica papain family cysteine protease domain containing protein 0.046 0.1369 0.2062
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0152 0.0152
Schistosoma mansoni cathepsin S (C01 family) 0.046 0.1369 0.1252
Brugia malayi jmjC domain containing protein 0.0071 0.0134 0.0134
Loa Loa (eye worm) ctsf protein 0.2123 0.6641 0.6641
Trypanosoma cruzi cysteine peptidase, putative 0.0674 0.2047 0.2042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.046 0.1369 0.1333
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.046 0.1369 0.2055
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.046 0.1369 0.1252
Loa Loa (eye worm) cathepsin B 0.1302 0.4039 0.4039
Brugia malayi RNA binding protein 0.0076 0.0152 0.0152
Giardia lamblia Cathepsin B precursor 0.1302 0.4039 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Plasmodium falciparum serine repeat antigen 3 0.046 0.1369 0.2055
Onchocerca volvulus 0.2123 0.6641 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.046 0.1369 0.2055
Onchocerca volvulus 0.2123 0.6641 1
Brugia malayi Cathepsin L-like precursor 0.2123 0.6641 0.6641
Entamoeba histolytica cysteine protease, putative 0.2123 0.6641 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.2123 0.6641 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0898 0.0559
Onchocerca volvulus 0.2123 0.6641 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.046 0.1369 0.2055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.046 0.1369 0.1333
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2123 0.6641 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.2123 0.6641 0.6596
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.046 0.1369 0.1333
Entamoeba histolytica cysteine protease, putative 0.046 0.1369 0.2062
Echinococcus granulosus cathepsin L cysteine proteinase 0.2123 0.6641 0.6596
Giardia lamblia Cathepsin B precursor 0.1302 0.4039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.046 0.1369 0.1333
Trypanosoma cruzi cysteine proteinase, putative 0.1135 0.3507 0.3503
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Plasmodium vivax serine-repeat antigen (SERA) 0.046 0.1369 0.2055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.046 0.1369 0.1369
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0 0.5
Brugia malayi Cathepsin L-like precursor 0.2123 0.6641 0.6641
Loa Loa (eye worm) hypothetical protein 0.0674 0.2047 0.2047
Loa Loa (eye worm) hypothetical protein 0.0674 0.2047 0.2047
Brugia malayi cathepsin L-like cysteine proteinase 0.046 0.1369 0.1369
Brugia malayi TAR-binding protein 0.0076 0.0152 0.0152
Echinococcus multilocularis cathepsin b 0.3182 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3182 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.046 0.1369 0.1252
Entamoeba histolytica papain family cysteine protease domain containing protein 0.046 0.1369 0.2062
Plasmodium falciparum cysteine proteinase falcipain 1 0.1135 0.3507 0.5276
Plasmodium vivax unspecified product 0.1135 0.3507 0.5276
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0898 0.0898
Brugia malayi fibroinase precursor 0.046 0.1369 0.1369
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0898 0.0898
Echinococcus granulosus cysteine protease 0.1135 0.3507 0.3418
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Echinococcus granulosus cathepsin l1 0.1449 0.4504 0.4429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Entamoeba histolytica cysteine proteinase, putative 0.2123 0.6641 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.046 0.1369 0.1252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1302 0.4039 0.3957
Brugia malayi Papain family cysteine protease containing protein 0.046 0.1369 0.1369
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2123 0.6641 0.6596
Brugia malayi Papain family cysteine protease containing protein 0.2123 0.6641 0.6641
Trypanosoma cruzi cysteine peptidase, putative 0.2123 0.6641 0.664
Brugia malayi cathepsin Z-like cysteine proteinase 0.046 0.1369 0.1369
Entamoeba histolytica cysteine protease, putative 0.046 0.1369 0.2062
Plasmodium vivax vivapain-1 0.1135 0.3507 0.5276
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0152 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1135 0.3507 0.4847
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Onchocerca volvulus 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.046 0.1369 0.1333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1302 0.4039 0.6081
Entamoeba histolytica cysteine proteinase, putative 0.1135 0.3507 0.528
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0 0.5
Plasmodium vivax vivapain-3 0.1135 0.3507 0.5276
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0674 0.2047 0.2047
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0593 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.046 0.1369 0.1333
Trichomonas vaginalis conserved hypothetical protein 0.046 0.1369 0.1333
Loa Loa (eye worm) papain family cysteine protease containing protein 0.046 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.046 0.1369 0.1369
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0674 0.2047 0.2047
Brugia malayi Papain family cysteine protease containing protein 0.1135 0.3507 0.3507
Brugia malayi Papain family cysteine protease containing protein 0.046 0.1369 0.1369
Brugia malayi cathepsin L-like precursor 0.1449 0.4504 0.4504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Trypanosoma cruzi cysteine peptidase, putative 0.1135 0.3507 0.3503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Entamoeba histolytica cysteine proteinase, putative 0.1449 0.4504 0.6782
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0152 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.046 0.1369 0.1333
Onchocerca volvulus 0.2123 0.6641 1
Brugia malayi Cathepsin L-like precursor 0.1449 0.4504 0.4504
Loa Loa (eye worm) papain family cysteine protease containing protein 0.046 0.1369 0.1369
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0898 0.0559
Echinococcus granulosus tar DNA binding protein 0.0076 0.0152 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0152 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0898 0.0559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.046 0.1369 0.2055
Leishmania major hypothetical protein, conserved 0.003 0.0006 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.046 0.1369 0.1333
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.046 0.1369 0.1333
Entamoeba histolytica hypothetical protein 0.046 0.1369 0.2062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.046 0.1369 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.046 0.1369 0.1333
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2123 0.6641 0.6641
Entamoeba histolytica cysteine protease, putative 0.046 0.1369 0.2062
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3182 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2123 0.6641 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1135 0.3507 0.5276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2123 0.6641 1
Brugia malayi Cathepsin L-like precursor 0.2123 0.6641 0.6641
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.046 0.1369 0.1333
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.046 0.1369 0.1252
Giardia lamblia Cathepsin B precursor 0.1302 0.4039 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.046 0.1369 0.1333
Loa Loa (eye worm) hypothetical protein 0.046 0.1369 0.1369
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.046 0.1369 0.1252
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Loa Loa (eye worm) fibroinase 0.2123 0.6641 0.6641
Trypanosoma cruzi cysteine peptidase, putative 0.2123 0.6641 0.664
Entamoeba histolytica cysteine protease, putative 0.046 0.1369 0.2062
Schistosoma mansoni cathepsin F (C01 family) 0.2123 0.6641 0.6596
Plasmodium falciparum serine repeat antigen 2 0.046 0.1369 0.2055
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0152 0.0018
Trypanosoma cruzi cruzipain precursor, putative 0.0674 0.2047 0.2042
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1302 0.4039 0.4035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1369 0.1369
Mycobacterium ulcerans hypothetical protein 0.0029 0 0.5
Trypanosoma cruzi major cysteine proteinase, putative 0.046 0.1369 0.1364
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0593 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.046 0.1369 0.1369
Loa Loa (eye worm) cysteine protease 0.2123 0.6641 0.6641
Onchocerca volvulus 0.2123 0.6641 1
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Trypanosoma cruzi cysteine proteinase, putative 0.1135 0.3507 0.3503
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.046 0.1369 0.1333
Brugia malayi hypothetical protein 0.003 0.0006 0.0006
Leishmania major cathepsin L-like protease 0.2123 0.6641 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.046 0.1369 0.1369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.046 0.1369 0.1333
Trypanosoma cruzi cysteine peptidase, putative 0.2123 0.6641 0.664
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.5
Toxoplasma gondii cathepsin B 0.1302 0.4039 0.6077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1135 0.3507 0.4847
Onchocerca volvulus Cathepsin F homolog 0.2123 0.6641 1
Echinococcus granulosus cathepsin L 0.046 0.1369 0.1252
Onchocerca volvulus Cathepsin L homolog 0.2123 0.6641 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.1449 0.4504 0.4504
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1135 0.3507 0.3418
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.5
Echinococcus granulosus cathepsin l1 0.2123 0.6641 0.6596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.046 0.1369 0.1333
Entamoeba histolytica cysteine protease, putative 0.1135 0.3507 0.528
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1135 0.3507 0.3418
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1302 0.4039 0.5721
Toxoplasma gondii cathepsin CPC1 0.046 0.1369 0.2055
Loa Loa (eye worm) hypothetical protein 0.2123 0.6641 0.6641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.046 0.1369 0.1333
Echinococcus multilocularis cysteine protease 0.2123 0.6641 0.6596
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0898 0.0559
Loa Loa (eye worm) hypothetical protein 0.046 0.1369 0.1369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1135 0.3507 0.5276
Brugia malayi cathepsin L precursor 0.046 0.1369 0.1369
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3182 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0 0.5
Entamoeba histolytica cysteine protease, putative 0.046 0.1369 0.2062
Echinococcus granulosus cathepsin L 0.1135 0.3507 0.3418
Echinococcus granulosus cathepsin b 0.3182 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2123 0.6641 0.6596
Loa Loa (eye worm) hypothetical protein 0.1449 0.4504 0.4504
Onchocerca volvulus 0.1449 0.4504 0.6782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.046 0.1369 0.1333
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0152 0.0018
Echinococcus multilocularis cathepsin L cysteine protease 0.2123 0.6641 0.6596
Schistosoma mansoni cathepsin B (C01 family) 0.046 0.1369 0.1252
Echinococcus multilocularis cathepsin L cysteine protease 0.2123 0.6641 0.6596
Schistosoma mansoni cathepsin F (C01 family) 0.2123 0.6641 0.6596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2123 0.6641 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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