Detailed information for compound 1353054

Basic information

Technical information
  • TDR Targets ID: 1353054
  • Name: N-[2-(1H-indol-3-yl)ethyl]-5-methylthiophene- 2-carboxamide
  • MW: 284.376 | Formula: C16H16N2OS
  • H donors: 2 H acceptors: 1 LogP: 3.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(s1)C(=O)NCCc1c[nH]c2c1cccc2
  • InChi: 1S/C16H16N2OS/c1-11-6-7-15(20-11)16(19)17-9-8-12-10-18-14-5-3-2-4-13(12)14/h2-7,10,18H,8-9H2,1H3,(H,17,19)
  • InChiKey: JUNWYDLGMKTCMB-UHFFFAOYSA-N  


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Synonyms

  • N-[2-(1H-indol-3-yl)ethyl]-5-methyl-thiophene-2-carboxamide
  • N-[2-(1H-indol-3-yl)ethyl]-5-methyl-2-thiophenecarboxamide
  • ZINC03451740
  • T5303777

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0048 0.0143
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0121 0.0448
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0048 0.1319
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0252 0.2515 0.67
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0216 0.0815
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1168 0.1676
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0028 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0028 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0028 0.0029
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0137 0.0181
Brugia malayi Cytochrome P450 family protein 0.0022 0.0155 0.0583
Brugia malayi steroid hormone receptor 0.001 0.0028 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0121 0.0437
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0365
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.022 0.0713
Schistosoma mansoni ap endonuclease 0.0019 0.0116 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0028 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0116 0.0151
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0048 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0137 0.4607
Entamoeba histolytica hypothetical protein 0.0012 0.0048 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0028 0.0076
Schistosoma mansoni kinase 0.0047 0.0413 0.0585
Echinococcus granulosus snurportin 1 0.0372 0.375 0.5404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0104
Entamoeba histolytica hypothetical protein 0.0043 0.0373 0.144
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0137 0.0187
Echinococcus granulosus nibrin 0.0012 0.0048 0.0052
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0189 0.0481
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0028 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.022 0.0831
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0044
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0024 0.0017
Echinococcus granulosus dna polymerase eta 0.0019 0.0121 0.0158
Entamoeba histolytica Ran family GTPase 0.0026 0.0189 0.0708
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0137 0.4607
Schistosoma mansoni amine oxidase 0.0021 0.0137 0.0187
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1674 0.2402
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0028 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0028 0.0076
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0012 0.0044
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0137 0.4607
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0024 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0028 0.0029
Brugia malayi topoisomerase 0.0012 0.0048 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0028 0.0076
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0884 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0028 0.0051
Entamoeba histolytica hypothetical protein 0.0028 0.0216 0.0815
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0545 0.2138
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0373 0.0527
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0028 0.0016
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0137 0.6018
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0024 0.0023
Schistosoma mansoni topbp1 0.0012 0.0048 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0028 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0564
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0116 0.0417
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0122 0.011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0121 0.03
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.039 0.1519
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0484
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0884 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.039 0.1018
Echinococcus multilocularis 0.0021 0.0137 0.0125
Trypanosoma brucei ATP-binding cassette protein, putative 0.001 0.0024 0.012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0116 0.104
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0189 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.039 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0048 0.0411
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0884 0.3484
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0012 0.0006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.022 0.0713
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0048 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.045 0.118
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0024 0.0012
Schistosoma mansoni hypothetical protein 0.0049 0.0432 0.0612
Onchocerca volvulus 0.0252 0.2515 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0884 0.2339
Loa Loa (eye worm) hypothetical protein 0.0119 0.1149 0.3046
Brugia malayi hypothetical protein 0.0012 0.0048 0.0155
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0024 0.0443
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.022 0.2386
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0121 0.0164
Schistosoma mansoni hypothetical protein 0.0019 0.0122 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.04 0.155
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0252 0.2515 0.9249
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.022 0.0713
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0048 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.022 0.0713
Giardia lamblia DINP protein human, muc B family 0.0019 0.0121 0.0395
Echinococcus granulosus expressed conserved protein 0.0112 0.1075 0.1536
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.045 0.0634
Schistosoma mansoni hypothetical protein 0.0041 0.0349 0.0493
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0028 0.0076
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0048 0.1319
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.022 0.2386
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0048 0.0155
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0121 0.0164
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0137 0.4607
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0044
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0284 0.0272
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0155 0.039
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0137 0.4607
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0121 0.1089
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.001 0.0024 0.0138
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0048 0.0143
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0122 0.011
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0116 0.0287
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0048 0.0143
Entamoeba histolytica ABC transporter, putative 0.001 0.0024 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.04 0.155
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0146 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0484
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0137 0.4607
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0146 0.4916
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0189 0.0667
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Trypanosoma brucei unspecified product 0.0013 0.0061 0.0484
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0122 0.0301
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0116 1
Schistosoma mansoni hypothetical protein 0.0205 0.2031 0.2923
Brugia malayi CHE-14 protein 0.0051 0.045 0.1761
Toxoplasma gondii exonuclease III APE 0.0019 0.0116 0.3841
Echinococcus multilocularis geminin 0.0205 0.2031 0.2021
Echinococcus granulosus GPCR family 2 0.0019 0.0122 0.0158
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0008
Echinococcus multilocularis protein dispatched 1 0.0058 0.0525 0.0513
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0012 0.0044
Brugia malayi ecdysteroid receptor 0.001 0.0028 0.0076
Trichomonas vaginalis ran, putative 0.0026 0.0189 0.0708
Leishmania major importin beta-1 subunit, putative 0.0028 0.0216 0.2339
Schistosoma mansoni hypothetical protein 0.0049 0.0432 0.0612
Brugia malayi hypothetical protein 0.0021 0.0137 0.0511
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0121 0.0437
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0252 0.2515 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0189 0.652
Echinococcus multilocularis dna polymerase eta 0.0019 0.0121 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0134 0.0491
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0365
Echinococcus multilocularis nibrin 0.0012 0.0048 0.0036
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.045 0.0439
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0116 0.1197
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0189 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0121 0.0448
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.039 0.0546
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0189 0.2031
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0028 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0137 0.0505
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0028 0.0029
Leishmania major GTP-binding protein, putative 0.0026 0.0189 0.2031
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0216 0.0815
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1674 0.1664
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0884 0.3492
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0116 0.3841
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0008
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0048 0.1319
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0028 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0189 0.2031
Echinococcus multilocularis GPCR, family 2 0.0019 0.0122 0.011
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0884 0.0873
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0028 0.0076
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0012 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0023
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1149 0.1138
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0048 0.0036
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.022 0.0713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0028 0.0051
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0012 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0189 0.1764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.1254
Trypanosoma cruzi ATP-binding cassette protein, putative 0.001 0.0024 0.0138
Trypanosoma cruzi ABC transporter, putative 0.001 0.0024 0.0138
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0272 0.272 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.022 1
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0048 0.0155
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0028 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0028 0.0076
Mycobacterium ulcerans hypothetical protein 0.0029 0.022 0.0713
Onchocerca volvulus 0.001 0.0028 0.0064
Echinococcus multilocularis snurportin 1 0.0372 0.375 0.3742
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0484
Schistosoma mansoni thyroid hormone receptor 0.001 0.0028 0.0029
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0116 0.0428
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.375 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0116 0.1197
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0024 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0028 0.0016
Schistosoma mansoni ap endonuclease 0.0019 0.0116 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0048 0.0411
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0189 0.0719
Mycobacterium ulcerans dehydrogenase 0.0021 0.0137 0.0429
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0048 0.0357
Echinococcus granulosus FTZ F1 alpha 0.001 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0104
Schistosoma mansoni DNA ligase IV 0.0012 0.0048 0.0058
Trypanosoma brucei RNA helicase, putative 0.0106 0.1016 1
Trypanosoma brucei ABC transporter, putative 0.001 0.0024 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0104
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0028 0.0064
Trypanosoma brucei polo-like protein kinase 0.0093 0.0884 0.8686
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0028 0.0029
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0252 0.2515 1
Entamoeba histolytica hypothetical protein 0.0043 0.0373 0.144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.1254
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0252 0.2515 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0284 0.1096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0122 0.0158
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0284 0.2706
Onchocerca volvulus 0.0021 0.0137 0.05
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0012 0.0008
Echinococcus multilocularis protein patched 0.0051 0.045 0.0439
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0216 0.0815
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0137 0.0181
Schistosoma mansoni hypothetical protein 0.0205 0.2031 0.2923
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.0012
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0137 0.4607
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0028 0.0023
Onchocerca volvulus 0.0012 0.0048 0.0143
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0116 0.0375
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0884 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0122 0.0158
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1149 0.1643
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0028 0.0029
Schistosoma mansoni hypothetical protein 0.0019 0.0122 0.0164
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0028 0.0023
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0121 0.0446
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0116 0.3841
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0048 0.0143
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1149 0.454
Echinococcus granulosus microtubule associated protein 2 0.0681 0.6929 1
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0137 0.0429
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0116 0.1197
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0373 0.0521
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0028 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.039 0.0552
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0121 0.0375
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0028 0.0023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0121 0.0446
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0137 0.0511
Schistosoma mansoni topbp1 0.0012 0.0048 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0016
Trypanosoma brucei unspecified product 0.0019 0.0121 0.1089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0146 0.0458
Brugia malayi hypothetical protein 0.0043 0.0373 0.145
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0028 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0028 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0048 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0028 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0028 0.0023
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0012 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.0012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0545 0.2138
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0012 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.022 0.0713
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.039 0.0546
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0734
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0189 0.652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.039 0.0552
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0048 0.0143
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0884 0.3484
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1149 0.4547
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0252 0.2515 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0028 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.03
Loa Loa (eye worm) hypothetical protein 0.006 0.0545 0.1432
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0028 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0028 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0122 0.0449
Entamoeba histolytica hypothetical protein 0.0043 0.0373 0.144
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0048 0.0143
Schistosoma mansoni hypothetical protein 0.0372 0.375 0.5406
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0028 0.0016
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0252 0.2515 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0116 0.0417
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0116 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0137 0.0125
Leishmania major DNA polymerase eta, putative 0.0019 0.0121 0.1254
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0024 0.0041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0146 0.0535
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.1254
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0028 0.0076
Loa Loa (eye worm) hypothetical protein 0.0051 0.045 0.118
Schistosoma mansoni hypothetical protein 0.0019 0.0122 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Leishmania major DNA polymerase kappa, putative 0.0019 0.0121 0.1254
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.6929 0.6925
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0024 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Brugia malayi nuclear hormone receptor 0.001 0.0028 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0137 0.4607
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0146 0.4916
Echinococcus granulosus Protein patched homolog 1 0.0051 0.045 0.0634
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0349 0.1356
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.001 0.0024 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.022 0.0713
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.022 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0028 0.0016
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0048 0.01
Loa Loa (eye worm) hypothetical protein 0.0062 0.0569 0.1496
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0048 0.0052
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0137 0.0187
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0121 0.1254
Schistosoma mansoni amine oxidase 0.0021 0.0137 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Echinococcus granulosus dna polymerase kappa 0.0019 0.0121 0.0158
Plasmodium falciparum ABC transporter G family member 2 0.001 0.0024 0.0443
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0284 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0252 0.2515 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0564
Loa Loa (eye worm) hypothetical protein 0.0041 0.0349 0.0908
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0884 0.3484
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0116 0.0105
Onchocerca volvulus 0.0029 0.022 0.0831
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0252 0.2515 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0104
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0216 0.2339
Brugia malayi RNA, U transporter 1 0.0099 0.0944 0.3731
Schistosoma mansoni patched 1 0.0051 0.045 0.0639
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0121 0.1254
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.045 0.1751
Entamoeba histolytica hypothetical protein 0.0043 0.0373 0.144
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0048 0.0411
Schistosoma mansoni ran 0.0026 0.0189 0.0262
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0121 0.1089
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0048 0.0411
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0365
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.0301
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0116 0.0417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0028 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0343
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0343
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0137 0.1436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0545 0.1432
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0252 0.2515 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0028 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0121 0.1089
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0137 0.9141
Schistosoma mansoni ABC transporter 0.0008 0.0009 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0137 0.0505
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0024 0.0012
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0137 0.0429
Plasmodium falciparum importin beta, putative 0.0035 0.0284 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0365
Leishmania major UDP-galactopyranose mutase 0.0021 0.0137 0.1436
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.022 0.0809
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0137 0.0125
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0121 0.0437
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0048 0.0143
Schistosoma mansoni hypothetical protein 0.0106 0.1016 0.1457
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0134 0.0491
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0116 0.0428
Brugia malayi AMP-binding enzyme family protein 0.0029 0.022 0.0842
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0028 0.0029
Schistosoma mansoni coup transcription factor 0.001 0.0028 0.0029
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0024 0.0041
Schistosoma mansoni importin beta-1 0.0035 0.0284 0.0399
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0252 0.2515 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0012 0.0044
Echinococcus multilocularis expressed conserved protein 0.0112 0.1075 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0048 0.0143
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0365
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) oxidoreductase 0.0008 0.0012 0.0008
Schistosoma mansoni hypothetical protein 0.0043 0.0373 0.0527
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0137 0.1436
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.2931 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0252 0.2515 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.039 0.0378
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0373 0.0361
Schistosoma mansoni hypothetical protein 0.0049 0.0432 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0028 0.0076
Mycobacterium ulcerans oxidoreductase 0.0021 0.0137 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0028 0.0076
Schistosoma mansoni DNA polymerase eta 0.0019 0.0121 0.0164
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0284 0.2706
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0252 0.2515 0.8575
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.022 0.2386
Schistosoma mansoni hypothetical protein 0.0019 0.0122 0.0164
Plasmodium vivax importin-beta 2, putative 0.0035 0.0284 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0028 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0029 0.022 0.0842
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0122 0.0449
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Schistosoma mansoni thyroid hormone receptor 0.001 0.0028 0.0029
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0116 0.0358
Schistosoma mansoni ran 0.0026 0.0189 0.0262
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0343
Brugia malayi hypothetical protein 0.0012 0.0048 0.0155
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0189 0.652
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0121 0.0375
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.6929 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0884 0.1261
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0028 0.0076
Brugia malayi SWIRM domain containing protein 0.0021 0.0137 0.0511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.022 0.0831
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.001 0.0024 0.0443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.022 0.0809
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0051
Schistosoma mansoni hypothetical protein 0.0049 0.0432 0.0612
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0028 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0884 0.1266
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0028 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0134 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0121 0.1089
Brugia malayi DKFZp564C0469 protein 0.0012 0.0048 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.039 0.0552
Giardia lamblia Kinase, PLK 0.0093 0.0884 0.3456
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.2931 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0121 0.011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0121 0.011
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0008 0.0008 0.0029
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0048 0.1319
Echinococcus granulosus geminin 0.0205 0.2031 0.2918
Brugia malayi AMP-binding enzyme family protein 0.0029 0.022 0.0842
Trypanosoma brucei unspecified product 0.0013 0.0061 0.0484
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.022 0.0831
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0134 0.0491
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0343
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0121 0.1089
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0048 0.1722
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0121 0.1254
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0137 0.4607
Echinococcus granulosus importin subunit beta 1 0.0035 0.0284 0.0393
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0121 0.0158

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 12.99 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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