Detailed information for compound 1354308

Basic information

Technical information
  • TDR Targets ID: 1354308
  • Name: N-[3-[(3-cyano-6,8-dimethylquinolin-2-yl)amin o]propyl]-3,4,5-trimethoxybenzamide
  • MW: 448.514 | Formula: C25H28N4O4
  • H donors: 2 H acceptors: 3 LogP: 4.75 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2cc(C)cc(c2nc1NCCCNC(=O)c1cc(OC)c(c(c1)OC)OC)C
  • InChi: 1S/C25H28N4O4/c1-15-9-16(2)22-17(10-15)11-19(14-26)24(29-22)27-7-6-8-28-25(30)18-12-20(31-3)23(33-5)21(13-18)32-4/h9-13H,6-8H2,1-5H3,(H,27,29)(H,28,30)
  • InChiKey: QNBGGFDQZTVWIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[(3-cyano-6,8-dimethyl-2-quinolyl)amino]propyl]-3,4,5-trimethoxy-benzamide
  • N-[3-[(3-cyano-6,8-dimethyl-2-quinolyl)amino]propyl]-3,4,5-trimethoxybenzamide
  • N-[3-[(3-cyano-6,8-dimethyl-quinolin-2-yl)amino]propyl]-3,4,5-trimethoxy-benzamide
  • ASN 06540648
  • MLS000709895
  • SMR000287058

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Schistosoma mansoni hypothetical protein 0.0205 0.0278 0.4361
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0022 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0154
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0115
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0003 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.001
Leishmania major telomerase reverse transcriptase, putative 0.1949 0.2725 1
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0072 0.1509
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.001
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Echinococcus granulosus helicase 0.0007 0.0001 0.001
Entamoeba histolytica hypothetical protein 0.0026 0.0028 0.0524
Brugia malayi Flap endonuclease-1 0.0029 0.0033 0.0045
Loa Loa (eye worm) hypothetical protein 0.0168 0.0228 0.476
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.001
Echinococcus granulosus Chromo domain 0.0013 0.001 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0059 0.0215
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0004 0.0031
Echinococcus granulosus disco interacting protein 2 0.0043 0.0052 0.0819
Schistosoma mansoni helicase 0.0076 0.0098 0.1529
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0022 0.0458
Echinococcus granulosus dna polymerase eta 0.0022 0.0022 0.0343
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0016 0.006
Leishmania major DNA polymerase eta, putative 0.0007 0.0001 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.0218 0.0795
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0016 0.012
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0012 0.0046
Echinococcus granulosus smad 0.0009 0.0004 0.0066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0021 0.5
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.001 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0021 0.0479
Schistosoma mansoni gliotactin 0.0023 0.0023 0.0364
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0021 0.0498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0022 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Echinococcus granulosus dna polymerase kappa 0.0022 0.0022 0.0343
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0006
Onchocerca volvulus 0.0023 0.0023 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0048 0.0354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0016 0.006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0028 0.0101
Echinococcus granulosus neuroligin 0.0023 0.0023 0.0364
Brugia malayi Carboxylesterase family protein 0.0023 0.0023 0.0032
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0023 0.017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0021 0.0074
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0002
Brugia malayi hypothetical protein 0.0023 0.0023 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.0154
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0008 0.0029
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0023 0.0529
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Plasmodium falciparum importin beta, putative 0.0033 0.0037 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0009
Schistosoma mansoni cpg binding protein 0.007 0.009 0.1407
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0043 0.0052 0.0819
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Schistosoma mansoni hypothetical protein 0.0461 0.0639 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0033 0.012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0052 0.1094
Echinococcus granulosus carboxylesterase 5A 0.0134 0.018 0.2817
Echinococcus multilocularis muscleblind protein 1 0.0168 0.0228 0.1668
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.0023 0.0083
Loa Loa (eye worm) glutaminase 2 0.0308 0.0424 0.886
Schistosoma mansoni ap endonuclease 0.0021 0.0021 0.0331
Loa Loa (eye worm) BRM protein 0.0039 0.0046 0.0968
Schistosoma mansoni smad 0.0009 0.0004 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.0461 0.0639 0.4678
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0083 0.0115
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0022 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Leishmania major importin beta-1 subunit, putative 0.0026 0.0028 0.0104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0021 0.039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0115
Schistosoma mansoni Smad4 0.0009 0.0004 0.0066
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0085
Trichomonas vaginalis lymphoid specific helicase, putative 0.0014 0.0011 0.0253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0115
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0341 0.0469 0.1722
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0115
Schistosoma mansoni flap endonuclease-1 0.0027 0.0029 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0033 0.0681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0154
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0022 0.0244
Toxoplasma gondii hypothetical protein 0.0095 0.0125 0.046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0115
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0083 0.1306
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.001
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0022 0.016
Entamoeba histolytica hypothetical protein 0.0041 0.0048 0.0892
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Giardia lamblia DNA repair protein RAD52 0.0392 0.0541 0.1984
Giardia lamblia DINP protein human, muc B family 0.0022 0.0022 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0341 0.0469 0.1719
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0023 0.017
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0016 0.0256
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0033 0.012
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0023 0.0083
Giardia lamblia Telomerase catalytic subunit 0.1949 0.2725 1
Brugia malayi SET domain containing protein 0.0008 0.0002 0.0003
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0012 0.0008 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0003 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0021 0.0498
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0773
Trypanosoma brucei telomerase reverse transcriptase 0.1949 0.2725 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Plasmodium vivax DEAD/DEAH helicase, putative 0.0012 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.004
Toxoplasma gondii hypothetical protein 0.0055 0.0068 0.0251
Schistosoma mansoni hypothetical protein 0.0347 0.0478 0.7492
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.001 0.0072
Onchocerca volvulus 0.0043 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.0243 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0016 0.012
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0072 0.113
Trichomonas vaginalis glutaminase, putative 0.0308 0.0424 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0161 0.0218 0.0798
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Loa Loa (eye worm) acetylcholinesterase 1 0.0134 0.018 0.376
Brugia malayi Carboxylesterase family protein 0.0023 0.0023 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.0218 0.0798
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0021 0.021
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0072 0.113
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.001
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0072
Entamoeba histolytica hypothetical protein 0.0041 0.0048 0.0892
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0028 0.0669
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0083 0.0611
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0083 0.1306
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0007 0.0001 0.0013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0021 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0021
Trypanosoma brucei unspecified product 0.0015 0.0012 0.0046
Loa Loa (eye worm) BRM protein 0.0048 0.0059 0.1238
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0072
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0023 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0021 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.001
Mycobacterium ulcerans hypothetical protein 0.0179 0.0243 0.5726
Schistosoma mansoni acetylcholinesterase 0.0023 0.0023 0.0364
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Onchocerca volvulus 0.0023 0.0023 0.0023
Mycobacterium ulcerans glutaminase 0.0308 0.0424 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0048 0.0756
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0115
Echinococcus multilocularis helicase 0.0007 0.0001 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Echinococcus granulosus BRK domain containing protein 0.0013 0.001 0.0153
Leishmania major DNA polymerase kappa, putative 0.0022 0.0022 0.008
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0154
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0016 0.006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0022 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.0316 0.2313
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0072 0.113
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0115
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0023 0.0364
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0037 0.0271
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0022 0.0343
Echinococcus multilocularis smad 0.0009 0.0004 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus multilocularis BRK domain 0.0013 0.001 0.0072
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0007 0.0001 0.0005
Echinococcus granulosus Helicase SANT associated DNA binding 0.0007 0.0001 0.001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.0478 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0023 0.0364
Brugia malayi Carboxylesterase family protein 0.0134 0.018 0.0248
Entamoeba histolytica hypothetical protein 0.0041 0.0048 0.0892
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0072
Schistosoma mansoni DNA polymerase eta 0.0022 0.0022 0.0343
Brugia malayi Carboxylesterase family protein 0.0023 0.0023 0.0032
Echinococcus multilocularis neuroligin 0.0023 0.0023 0.017
Leishmania major DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0115
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0023 0.0364
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Echinococcus granulosus global transcription activator snf2l2 0.0076 0.0098 0.1529
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.0316 0.4946
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0001 0.0003
Loa Loa (eye worm) MBCTL1 0.0066 0.0083 0.1743
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0021 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Brugia malayi Smad1 0.0009 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0134 0.018 0.376
Brugia malayi Carboxylesterase family protein 0.0023 0.0023 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0012 0.0046
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0022 0.0343
Leishmania major mitochondrial DNA polymerase beta 0.0341 0.0469 0.1722
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0033 0.0602
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0022 0.0077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0134 0.018 0.376
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0012 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0048 0.0756
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0023 0.0548
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1949 0.2725 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0033 0.0116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0134 0.018 0.2817
Schistosoma mansoni importin beta-1 0.0033 0.0037 0.0579
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0154
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0016 0.0057
Onchocerca volvulus 0.0023 0.0023 0.0023
Brugia malayi Importin beta-1 subunit 0.0033 0.0037 0.0051
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1949 0.2725 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0004 0.0089
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0072 0.0529
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0072
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0023 0.0302
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0023 0.0548
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1365 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0022 0.0343
Brugia malayi Carboxylesterase family protein 0.0134 0.018 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Plasmodium falciparum Snf2-related CBP activator, putative 0.0007 0.0001 0.0002
Loa Loa (eye worm) carboxylesterase 0.0023 0.0023 0.0485
Echinococcus multilocularis snurportin 1 0.0347 0.0478 0.3505
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0023 0.0166
Entamoeba histolytica hypothetical protein 0.0112 0.0148 0.2731
Loa Loa (eye worm) helicase DNA-binding protein 0.0013 0.001 0.0204
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0033 0.0768
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0021 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0115
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.0154
Brugia malayi polk-prov protein 0.0007 0.0001 0.0001
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0023 0.0364
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.018 0.3768
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0022 0.0244
Echinococcus granulosus cpg binding protein 0.0072 0.0092 0.1447
Loa Loa (eye worm) CXXC zinc finger family protein 0.007 0.009 0.1878
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0004 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.001
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0072 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0054
Trypanosoma brucei unspecified product 0.0022 0.0022 0.008
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0004 0.0089
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0033 0.012
Brugia malayi glutaminase DH11.1 0.0308 0.0424 0.0583
Onchocerca volvulus 0.007 0.009 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0154
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0072 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.001
Brugia malayi SNF2 family N-terminal domain containing protein 0.0007 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0016 0.006
Toxoplasma gondii RNA-directed DNA polymerase 0.1949 0.2725 1
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0115
Schistosoma mansoni hypothetical protein 0.0007 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.001
Echinococcus multilocularis carboxylesterase 5A 0.0134 0.018 0.1318
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0021 0.0078
Brugia malayi MH2 domain containing protein 0.0135 0.018 0.0248
Loa Loa (eye worm) carboxylesterase 0.0023 0.0023 0.0485
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0001 0.0002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0016 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0341 0.0469 0.1719
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0066 0.0083 0.1743
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.008 0.0295
Echinococcus granulosus dnaJ subfamily B 0.0461 0.0639 1
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0023 0.0364
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0022 0.0077
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0014 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0059 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Brugia malayi BRM protein 0.0076 0.0098 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0022 0.008
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0001 0.0013
Schistosoma mansoni cpg binding protein 0.0072 0.0092 0.1447
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0022 0.016
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0193
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0115
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0016 0.012
Echinococcus granulosus importin subunit beta 1 0.0033 0.0037 0.0579
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0059 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0007
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0028 0.0669
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0021 0.0074
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0016 0.0256
Brugia malayi Disco-interacting protein 2 homolog 0.0043 0.0052 0.0072
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0022 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.001
Echinococcus multilocularis acetylcholinesterase 0.0134 0.018 0.1318
Plasmodium vivax importin-beta 2, putative 0.0033 0.0037 0.0136
Schistosoma mansoni hypothetical protein 0.0354 0.0489 0.7652
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0028 0.0669
Loa Loa (eye worm) Smad1 0.0009 0.0004 0.0089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0021 0.0331
Schistosoma mansoni helicase 0.0007 0.0001 0.001
Plasmodium falciparum telomerase reverse transcriptase 0.1949 0.2725 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0016 0.012
Echinococcus granulosus geminin 0.0205 0.0278 0.4361
Echinococcus multilocularis geminin 0.0205 0.0278 0.204
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0073 0.0266
Leishmania major DNA damage repair protein, putative 0.0007 0.0001 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0022 0.0517
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0054
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.0023 0.0083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0021 0.0074
Echinococcus granulosus acetylcholinesterase 0.0134 0.018 0.2817
Onchocerca volvulus 0.0023 0.0023 0.0023
Brugia malayi mbt repeat family protein 0.0058 0.0072 0.0099
Schistosoma mansoni helicase 0.0007 0.0001 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.018 0.3768
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0083 0.0611
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0023 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0001 0.0003
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0023 0.0354
Onchocerca volvulus 0.0011 0.0007 0.0007
Plasmodium vivax telomerase reverse transcriptase, putative 0.1949 0.2725 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0113
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0016 0.006
Brugia malayi Telomerase reverse transcriptase 0.5186 0.7266 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0083 0.1306
Schistosoma mansoni cpg binding protein 0.0072 0.0092 0.1447
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.0023 0.0083
Toxoplasma gondii exonuclease III APE 0.0021 0.0021 0.0078
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0115
Plasmodium falciparum flap endonuclease 1 0.0029 0.0033 0.012
Onchocerca volvulus 0.0023 0.0023 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0022 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0016 0.012
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0004 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0016 0.0342
Echinococcus multilocularis Smad4 0.0009 0.0004 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0037 0.0136
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0033 0.012
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0037 0.0136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Echinococcus granulosus snurportin 1 0.0347 0.0478 0.7492
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0023 0.017
Echinococcus granulosus flap endonuclease 1 0.0029 0.0033 0.051
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0033 0.0239
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0022 0.008
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.001
Loa Loa (eye worm) carboxylesterase 0.0134 0.018 0.376
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0088 0.1374
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0458
Loa Loa (eye worm) glutaminase 0.0308 0.0424 0.886
Echinococcus multilocularis Chromo domain 0.0013 0.001 0.0072
Trypanosoma brucei unspecified product 0.0015 0.0012 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0022 0.003
Brugia malayi RNA, U transporter 1 0.0092 0.0121 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Schistosoma mansoni glutaminase 0.0308 0.0424 0.6638
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.0153
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0016 0.0023
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0115
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0022 0.0498
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0021 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0023 0.0418
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0019
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0004 0.0066
Schistosoma mansoni hypothetical protein 0.0041 0.0048 0.0756
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0016 0.006
Entamoeba histolytica hypothetical protein 0.0041 0.0048 0.0892
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0022 0.008
Brugia malayi CXXC zinc finger family protein 0.007 0.009 0.0124
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0022 0.0077
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0072 0.0072
Echinococcus granulosus muscleblind protein 0.0168 0.0228 0.3566
Echinococcus multilocularis global transcription activator snf2l2 0.0076 0.0098 0.0715
Loa Loa (eye worm) hypothetical protein 0.0058 0.0072 0.1509
Onchocerca volvulus 0.0058 0.0072 0.0072
Echinococcus multilocularis cpg binding protein 0.0072 0.0092 0.0677
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0022 0.0498
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0016 0.0057
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0112 0.0148 0.2731
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.0023 0.0083
Brugia malayi mbt repeat family protein 0.0058 0.0072 0.0099
Schistosoma mansoni ap endonuclease 0.0021 0.0021 0.0331
Loa Loa (eye worm) hypothetical protein 0.0168 0.0228 0.476
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0023 0.0364
Echinococcus granulosus acetylcholinesterase 0.0134 0.018 0.2817
Echinococcus multilocularis muscleblind protein 0.0168 0.0228 0.1668
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0021 0.0078
Plasmodium vivax helicase, putative 0.0007 0.0001 0.0002
Leishmania major DNA polymerase eta, putative 0.0022 0.0022 0.008
Leishmania major modification methylase-like protein 0.0022 0.0023 0.0083
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0023 0.0302
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0023 0.0364
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0054
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0072 0.113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0059 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0125 0.046
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0392 0.0541 1
Schistosoma mansoni hypothetical protein 0.0205 0.0278 0.4361
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0019
Echinococcus multilocularis acetylcholinesterase 0.0134 0.018 0.1318
Brugia malayi hypothetical protein 0.0041 0.0048 0.0066
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0037 0.0136
Brugia malayi isocitrate dehydrogenase 0.0018 0.0016 0.0023
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0023 0.0354
Echinococcus granulosus Smad4 0.0009 0.0004 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0485
Brugia malayi Muscleblind-like protein 0.0168 0.0228 0.0313
Echinococcus multilocularis disco interacting protein 2 0.0043 0.0052 0.0383
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0115
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0021 0.0442
Echinococcus multilocularis dna polymerase eta 0.0022 0.0022 0.016
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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