TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 317.254 | Formula: C15H22Cl2N2O
H donors: 1 H acceptors: 1 LogP: 3.78 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)CCC(=O)Nc1ccc(cc1)Cl.Cl
InChi: 1S/C15H21ClN2O.ClH/c1-12-6-9-18(10-7-12)11-8-15(19)17-14-4-2-13(16)3-5-14;/h2-5,12H,6-11H2,1H3,(H,17,19);1H
InChiKey: FVSSDFKEPJEMJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0148	0.065
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.0588	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0118	0.054
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0148	0.065
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0011	0.0014
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0039	0.0053
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0011	0.0004
Schistosoma mansoni	microtubule-associated protein tau	0.1363	0.7453	1
Brugia malayi	TAR-binding protein	0.0123	0.0588	0.274
Entamoeba histolytica	hypothetical protein	0.0071	0.0302	0.138
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0011	0.0002
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0299	0.1369
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0264	0.0354
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0299	0.1398
Toxoplasma gondii	Ferredoxin-fold anticodon binding domain-containing protein	0.0182	0.0914	0.4123
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0169	0.0227
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0206	0.0276
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.1219	0.5746
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.0506	0.0678
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0068	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0291	0.1515	0.7145
Loa Loa (eye worm)	TAR-binding protein	0.0123	0.0588	0.2765
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0068	0.0272
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0108	0.0506	0.0497
Brugia malayi	RNA recognition motif domain containing protein	0.0123	0.0588	0.274
Treponema pallidum	ribonuclease H (rnhA)	0.0043	0.0144	0.037
Loa Loa (eye worm)	hypothetical protein	0.04	0.2119	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0131	0.0602
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0148	0.0389
Schistosoma mansoni	cpg binding protein	0.0028	0.0062	0.0083
Plasmodium falciparum	phenylalanine--tRNA ligase	0.015	0.0737	0.326
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.0588	0.0789
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0206	0.0276
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0148	0.065
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.0996	0.4689
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0011	0.0014
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0299	0.1369
Trypanosoma brucei	ingi protein (ORF1)	0.0047	0.0164	0.0727
Brugia malayi	phenylalanyl (f) trna synthetase protein 1	0.04	0.2119	1
Schistosoma mansoni	phosphoglucomutase	0.0043	0.0144	0.0193
Echinococcus granulosus	ribonuclease H1	0.0043	0.0144	0.0193
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.0588	0.0789
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0134	0.0584
Echinococcus granulosus	tar DNA binding protein	0.0123	0.0588	0.0789
Mycobacterium ulcerans	beta-lactamase	0.0071	0.0299	0.0291
Brugia malayi	Bromodomain containing protein	0.0038	0.0117	0.0505
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.0506	0.2347
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0068	0.0272
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.0299	0.0291
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0299	0.0401
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0406	0.1904
Loa Loa (eye worm)	RNA binding protein	0.0123	0.0588	0.2765
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0299	0.0291
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0299	0.0401
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.0299	0.0291
Schistosoma mansoni	hypothetical protein	0.0289	0.1506	0.202
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0239	0.1085
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0844	0.1132
Brugia malayi	beta-lactamase family protein	0.0071	0.0299	0.1369
Schistosoma mansoni	alpha glucosidase	0.0044	0.0148	0.0198
Brugia malayi	phenylalanyl-tRNA synthetase, mitochondrial precursor, putative	0.0182	0.0914	0.4283
Brugia malayi	RNase H family protein	0.0043	0.0144	0.0632
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0302	0.0405
Brugia malayi	phosphofructokinase	0.0108	0.0506	0.2347
Plasmodium falciparum	phenylalanine--tRNA ligase	0.0182	0.0914	0.4123
Brugia malayi	beta-lactamase	0.0071	0.0299	0.1369
Loa Loa (eye worm)	hypothetical protein	0.007	0.0296	0.1383
Mycobacterium tuberculosis	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	0.1822	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0461	0.2457	0.3297
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0299	0.1369
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0169	0.0783
Toxoplasma gondii	ribonuclease HI protein	0.0043	0.0144	0.037
Echinococcus granulosus	muscleblind protein	0.0291	0.1515	0.2033
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0148	0.065
Leishmania major	hypothetical protein, conserved	0.0071	0.0299	0.1369
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.0506	0.0678
Brugia malayi	beta-lactamase family protein	0.0071	0.0299	0.1369
Plasmodium vivax	phenylalanine--tRNA ligase, putative	0.0131	0.0634	0.276
Brugia malayi	6-phosphofructokinase	0.0108	0.0506	0.2347
Loa Loa (eye worm)	phosphofructokinase	0.0108	0.0506	0.2374
Brugia malayi	Muscleblind-like protein	0.0291	0.1515	0.7136
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0169	0.2264
Trypanosoma cruzi	phenylalanyl-tRNA synthetase alpha chain, putative	0.04	0.2119	1
Trypanosoma brucei	RNA helicase, putative	0.0161	0.0798	0.3734
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0299	0.0401
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0996	0.1336
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0148	0.065
Trichomonas vaginalis	esterase, putative	0.0071	0.0299	0.1369
Echinococcus granulosus	zinc finger protein	0.0021	0.0023	0.0031
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0068	0.0272
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0148	0.065
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0299	0.1369
Wolbachia endosymbiont of Brugia malayi	phenylalanyl-tRNA synthetase subunit alpha	0.1822	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0239	0.1115
Brugia malayi	MH2 domain containing protein	0.0237	0.1219	0.5732
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.0996	0.1336
Brugia malayi	hypothetical protein	0.0071	0.0302	0.138
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0108	0.0506	0.2134
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0068	0.0272
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0148	0.065
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0068	0.0272
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.0996	0.4671
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0206	0.0276
Trypanosoma brucei	hypothetical protein, conserved	0.0047	0.0164	0.0727
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0148	0.065
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0148	0.065
Echinococcus multilocularis	geminin	0.0164	0.0813	0.109
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0169	0.0227
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0148	0.065
Schistosoma mansoni	hypothetical protein	0.0164	0.0813	0.109
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0299	0.1369
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.0299	0.0291
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0104	0.014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0406	0.0545
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0844	0.1132
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0068	0.0059
Mycobacterium ulcerans	lipase LipD	0.0071	0.0299	0.0291
Entamoeba histolytica	hypothetical protein	0.0071	0.0302	0.138
Onchocerca volvulus		0.0071	0.0299	0.5007
Entamoeba histolytica	hypothetical protein	0.0071	0.0302	0.138
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0011	0.0002
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.0299	0.0291
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0148	0.065
Toxoplasma gondii	ABC1 family protein	0.0071	0.0299	0.1128
Schistosoma mansoni	hypothetical protein	0.0019	0.0011	0.0015
Schistosoma mansoni	hypothetical protein	0.0161	0.0798	0.1071
Echinococcus granulosus	cpg binding protein	0.0032	0.0081	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0169	0.0783
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0011	0.0014
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0169	0.0227
Echinococcus multilocularis	phenylalanyl tRNA synthetase	0.0182	0.0914	0.1226
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0187	0.0943	0.1265
Echinococcus granulosus	microtubule associated protein 2	0.1363	0.7453	1
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.0506	0.2347
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0062	0.0275
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0148	0.065
Mycobacterium ulcerans	phenylalanyl-tRNA synthetase subunit alpha	0.1822	1	1
Schistosoma mansoni	hypothetical protein	0.0164	0.0813	0.109
Echinococcus granulosus	dna polymerase eta	0.0019	0.0011	0.0014
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.0299	0.0291
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0299	0.1128
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.0506	0.2374
Treponema pallidum	phenylalanyl-tRNA synthetase subunit alpha	0.04	0.2119	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0011	0.0002
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0068	0.0272
Schistosoma mansoni	zinc finger protein	0.0021	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.006	0.0239	0.1115
Echinococcus multilocularis	ribonuclease H1	0.0043	0.0144	0.0193
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0406	0.0545
Echinococcus granulosus	6 phosphofructokinase	0.0108	0.0506	0.0678
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.0299	0.0291
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0299	0.1369
Schistosoma mansoni	cpg binding protein	0.0032	0.0081	0.0109
Echinococcus granulosus	GPCR family 2	0.0019	0.0011	0.0015
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0062	0.0242
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.0299	0.0291
Leishmania major	ribonuclease H1, putative	0.0043	0.0144	0.0632
Plasmodium vivax	phenylalanine--tRNA ligase alpha subunit, putative	0.04	0.2119	1
Brugia malayi	mbt repeat family protein	0.0048	0.0169	0.0751
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0236	0.0317
Onchocerca volvulus		0.0071	0.0299	0.5007
Brugia malayi	RNase H family protein	0.0043	0.0144	0.0632
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0003	0.0005
Schistosoma mansoni	phenylalanyl-tRNA synthetase subunit alpha	0.04	0.2119	0.2843
Echinococcus multilocularis	zinc finger protein	0.0021	0.0023	0.0031
Loa Loa (eye worm)	MBCTL1	0.0054	0.0206	0.0955
Loa Loa (eye worm)	hypothetical protein	0.0044	0.015	0.0693
Mycobacterium leprae	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	0.0268	0.1391	1
Echinococcus multilocularis	cpg binding protein	0.0032	0.0081	0.0109
Trypanosoma brucei	phenylalanyl-tRNA synthetase alpha chain, putative	0.04	0.2119	1
Echinococcus multilocularis	6 phosphofructokinase	0.0108	0.0506	0.0678
Brugia malayi	RNase H family protein	0.0043	0.0144	0.0632
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0068	0.0059
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0148	0.065
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0003	0.0005
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0206	0.0924
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0206	0.0276
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0011	0.0014
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0187	0.0943	0.1265
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0299	0.0291
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0003	0.0005
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0169	0.0227
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0299	0.0401
Echinococcus granulosus	phenylalanyl tRNA synthetase alpha chain B	0.04	0.2119	0.2843
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0011	0.0015
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0003	0.0005
Trypanosoma brucei	ingi protein (ORF1)	0.0047	0.0164	0.0727
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.1219	0.5746
Onchocerca volvulus		0.0114	0.0536	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0406	0.0545
Echinococcus granulosus	phenylalanyl tRNA synthetase	0.0182	0.0914	0.1226
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0506	0.2347
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.0299	0.0291
Schistosoma mansoni	phenylalanyl-tRNA synthetase subunit alpha	0.0131	0.0634	0.0851
Brugia malayi	PHD-finger family protein	0.0026	0.0052	0.0197
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0011	0.0002
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0169	0.0227
Schistosoma mansoni	hypothetical protein	0.0021	0.002	0.0026
Loa Loa (eye worm)	phenylalanyl-tRNA synthetase	0.0182	0.0914	0.4302
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0047	0.0164	0.0727
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0011	0.0014
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0506	0.2347
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0011	0.0015
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0169	0.0227
Leishmania major	phenylalanyl-tRNA synthetase alpha chain, putative	0.04	0.2119	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0011	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0291	0.1515	0.7145
Schistosoma mansoni	phosphoglucomutase	0.0043	0.0144	0.0193
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0123	0.0588	0.2765
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0011	0.0015
Mycobacterium ulcerans	6-phosphofructokinase	0.0108	0.0506	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0038
Echinococcus granulosus	neuropeptide receptor A26	0.0461	0.2457	0.3297
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0244	0.0328
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0406	0.1876
Onchocerca volvulus		0.0048	0.0169	0.2264
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0244	0.0328
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0996	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0299	0.1398
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0299	0.0291
Echinococcus multilocularis	phenylalanyl tRNA synthetase alpha chain B	0.04	0.2119	0.2843
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0302	0.0405
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0148	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0034
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0068	0.0272
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.002	0.0077
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.0299	0.0291
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0011	0.0004
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0206	0.0276
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0169	0.0227
Trypanosoma brucei	glucosidase, putative	0.0044	0.0148	0.065
Leishmania major	ATP-dependent phosphofructokinase	0.0108	0.0506	0.2347
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0299	0.1398
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0011	0.0014
Trypanosoma brucei	unspecified product	0.0047	0.0164	0.0727
Giardia lamblia	Ribonuclease H	0.0043	0.0144	0.0632
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0506	0.2347
Echinococcus multilocularis	muscleblind protein 1	0.0291	0.1515	0.2033
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0506	0.2347
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0039	0.0053
Echinococcus multilocularis	muscleblind protein	0.0291	0.1515	0.2033
Onchocerca volvulus	Ribonuclease H1 homolog	0.0043	0.0144	0.1732
Trypanosoma cruzi	ribonuclease H1, putative	0.0043	0.0144	0.0632
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0148	0.0682
Plasmodium falciparum	phenylalanine--tRNA ligase alpha subunit	0.04	0.2119	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0011	0.0014
Trichomonas vaginalis	phenylalanyl-tRNA synthetase alpha chain, putative	0.04	0.2119	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0406	0.0545
Brugia malayi	mbt repeat family protein	0.0048	0.0169	0.0751
Plasmodium vivax	phenylalanine--tRNA ligase, putative	0.0182	0.0914	0.4123
Brugia malayi	RNA binding protein	0.0123	0.0588	0.274
Toxoplasma gondii	phenylalanyl-tRNA synthetase alpha chain A, putative	0.04	0.2119	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0302	0.138
Schistosoma mansoni	hypothetical protein	0.0041	0.0134	0.018
Giardia lamblia	Phenylalanyl-tRNA synthetase alpha chain	0.04	0.2119	1
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0506	0.2347
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0011	0.0038
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0506	0.2347
Schistosoma mansoni	phosphoglucomutase	0.0043	0.0144	0.0193
Schistosoma mansoni	hypothetical protein	0.0019	0.0011	0.0015
Trypanosoma cruzi	ribonuclease H1, putative	0.0043	0.0144	0.0632
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0011	0.0014
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0299	0.0291
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0148	0.065
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0299	0.1398
Trichomonas vaginalis	phenylalanyl-tRNA synthetase alpha chain, putative	0.0131	0.0634	0.2956
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0299	0.1398
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0043	0.0144	0.0135
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0299	0.1369
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0406	0.0545
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0148	0.065
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0011	0.0034
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.0506	0.2374
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0108	0.0506	0.189
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0302	0.0405
Echinococcus multilocularis	microtubule associated protein 2	0.1363	0.7453	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0104	0.014
Schistosoma mansoni	cpg binding protein	0.0032	0.0081	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0299	0.1398
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0039	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0134	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0206	0.0955
Trypanosoma brucei	ribonuclease H1	0.0043	0.0144	0.0632
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0299	0.1369
Brugia malayi	6-phosphofructokinase	0.0108	0.0506	0.2347
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0406	0.0545
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0506	0.2347
Echinococcus multilocularis	tar DNA binding protein	0.0123	0.0588	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0299	0.1398
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0214	0.0712
Echinococcus multilocularis	neuropeptide s receptor	0.0461	0.2457	0.3297
Onchocerca volvulus		0.0071	0.0299	0.5007
Schistosoma mansoni	phenylalanyl-tRNA synthetase mitochondrial	0.0182	0.0914	0.1226
Schistosoma mansoni	hypothetical protein	0.0019	0.0011	0.0015
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0068	0.0272
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0148	0.0198
Schistosoma mansoni	hypothetical protein	0.0019	0.0011	0.0015
Entamoeba histolytica	phenylalanyl-tRNA synthetase alpha subunit, putative	0.04	0.2119	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0299	0.1369
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.0588	0.0789
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0011	0.0015
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0406	0.0545
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0239	0.1085
Trichomonas vaginalis	ribonuclease H1, putative	0.0043	0.0144	0.0632
Trichomonas vaginalis	phenylalanyl-tRNA synthetase alpha chain, putative	0.0131	0.0634	0.2956
Echinococcus multilocularis	neuropeptide receptor A26	0.0461	0.2457	0.3297
Schistosoma mansoni	hypothetical protein	0.0071	0.0302	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0299	0.1398
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0454	0.2419	0.2412
Brugia malayi	Bromodomain containing protein	0.0076	0.0329	0.1508
Echinococcus granulosus	geminin	0.0164	0.0813	0.109
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.0588	0.0789

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3696 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1481411

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1360046