Detailed information for compound 1360284

Basic information

Technical information
  • TDR Targets ID: 1360284
  • Name: [1-[2-(2-methoxyphenoxy)ethyl]indol-3-yl]-thi ophen-2-ylmethanone
  • MW: 377.456 | Formula: C22H19NO3S
  • H donors: 0 H acceptors: 1 LogP: 4.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1OCCn1cc(c2c1cccc2)C(=O)c1cccs1
  • InChi: 1S/C22H19NO3S/c1-25-19-9-4-5-10-20(19)26-13-12-23-15-17(16-7-2-3-8-18(16)23)22(24)21-11-6-14-27-21/h2-11,14-15H,12-13H2,1H3
  • InChiKey: CSTJASMLGHUGHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [1-[2-(2-methoxyphenoxy)ethyl]indol-3-yl]-(2-thienyl)methanone
  • [1-[2-(2-methoxyphenoxy)ethyl]-3-indolyl]-(2-thienyl)methanone
  • [1-[2-(2-methoxyphenoxy)ethyl]indol-3-yl]-thiophen-2-yl-methanone
  • NCGC00101603-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0076 0.0076
Trichomonas vaginalis esterase, putative 0.0035 0.0121 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0257
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0337
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0303 0.1069
Schistosoma mansoni survival motor neuron protein 0.0094 0.0565 0.0565
Brugia malayi MH2 domain containing protein 0.0144 0.0939 0.2062
Onchocerca volvulus Glycogen phosphorylase homolog 0.0605 0.4406 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0262 0.1823 0.3964
Brugia malayi beta-lactamase family protein 0.0035 0.0121 0.0187
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.013 0.013
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0053 0.0256 0.0564
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0121 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0071 0.0143
Onchocerca volvulus Huntingtin homolog 0.024 0.1657 0.3659
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0295 0.0295
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0414 0.0414
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0088 0.0088
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0257
Echinococcus granulosus geminin 0.0331 0.2347 0.2347
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0127 0.0127
Plasmodium vivax SET domain protein, putative 0.0029 0.0076 0.4344
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0256 0.0256
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0256 0.0496
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0121 0.0141
Schistosoma mansoni bromodomain containing protein 0.0062 0.0322 0.0322
Echinococcus granulosus GPCR family 2 0.0031 0.0088 0.0088
Schistosoma mansoni chromobox protein 0.0068 0.0369 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0121 0.2661
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0342 0.0693
Brugia malayi Ets-domain containing protein 0.0071 0.0389 0.0801
Onchocerca volvulus 0.0232 0.16 0.3527
Brugia malayi beta-lactamase family protein 0.0035 0.0121 0.0187
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0565 0.1204
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0068 0.0068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0303 0.0303
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0389 0.0389
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0121 0.013
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0342 0.0342
Brugia malayi hypothetical protein 0.024 0.1657 0.3704
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.024 0.1657 0.3749
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0076 0.1328
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.124 0.124
Brugia malayi mbt repeat family protein 0.0047 0.0207 0.0384
Loa Loa (eye worm) glycogen phosphorylase 0.0605 0.4406 1
Entamoeba histolytica hypothetical protein 0.0043 0.0182 0.013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0201 0.044
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0121 0.013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0121 0.0121
Echinococcus multilocularis chromobox protein 1 0.0068 0.0369 0.0369
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0939 0.2118
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0121 1
Schistosoma mansoni hypothetical protein 0.0331 0.2347 0.2347
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0127 0.2859
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0127 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0088 0.0088
Echinococcus multilocularis microtubule associated protein 2 0.135 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0121 0.0121
Schistosoma mansoni microtubule-associated protein tau 0.135 1 1
Echinococcus granulosus chromobox protein 1 0.0068 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0069 0.0377 0.0838
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0167
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0022 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0088 0.0112
Schistosoma mansoni hypothetical protein 0.0043 0.0182 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0143 0.0193
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0207 0.0453
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0088
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0165 0.0243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0295 0.0295
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0121 0.013
Echinococcus multilocularis glycogen phosphorylase 0.0605 0.4406 0.4406
Entamoeba histolytica hypothetical protein 0.0043 0.0182 0.013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0047 0.0207 0.0453
Echinococcus multilocularis Glycosyl transferase, family 35 0.0605 0.4406 0.4406
Plasmodium falciparum phd finger protein, putative 0.0029 0.0071 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0262 0.1823 0.3964
Entamoeba histolytica glycogen phosphorylase, putative 0.0262 0.1823 0.3964
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0121 0.0121
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0303 0.0303
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0369 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0076
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0342 0.0342
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.059 0.1261
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0137 0.0137
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.012 0.012
Schistosoma mansoni ets-related 0.0215 0.1474 0.1474
Brugia malayi jmjC domain containing protein 0.0036 0.013 0.0207
Loa Loa (eye worm) fli-1 protein 0.0215 0.1474 0.3335
Onchocerca volvulus 0.003 0.0081 0.0025
Brugia malayi hypothetical protein 0.0462 0.3332 0.7541
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0121 0.013
Echinococcus granulosus chromobox protein 1 0.0068 0.0369 0.0369
Brugia malayi Bromodomain containing protein 0.0038 0.0138 0.0226
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0342 0.076
Entamoeba histolytica glycogen phosphorylase, putative 0.0605 0.4406 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0121 0.0141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0121 0.013
Brugia malayi Bromodomain containing protein 0.0073 0.0408 0.0844
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0257
Loa Loa (eye worm) inositol-1 0.0036 0.0127 0.0271
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0303 0.0303
Mycobacterium tuberculosis Conserved protein 0.0035 0.0121 0.013
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0389 0.0389
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0303 0.1185
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0022 0.0022
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0207 0.0207
Echinococcus granulosus glycogen phosphorylase 0.0605 0.4406 0.4406
Toxoplasma gondii ABC1 family protein 0.0035 0.0121 0.3056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0257
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0127 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0183
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0201 0.0201
Onchocerca volvulus 0.0094 0.0565 0.114
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0143 0.0168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1388 0.3138
Schistosoma mansoni chromobox protein 0.0068 0.0369 0.0369
Echinococcus granulosus peregrin 0.0031 0.0088 0.0088
Schistosoma mansoni gabp alpha 0.0071 0.0389 0.0389
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0121 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0342 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0182 0.0182
Echinococcus multilocularis geminin 0.0331 0.2347 0.2347
Trichomonas vaginalis glycogen phosphorylase, putative 0.0605 0.4406 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0369 0.0712
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0303 0.8706
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0939 0.2118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0201 0.0201
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0088 0.0088
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0462 0.3332 0.7558
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0121 0.0141
Echinococcus multilocularis Protein lozenge 0.0054 0.0265 0.0265
Trichomonas vaginalis glycogen phosphorylase, putative 0.0605 0.4406 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0257
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0127 0.2859
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.059 0.1261
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0207 0.0207
Entamoeba histolytica hypothetical protein 0.0043 0.0182 0.013
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0008
Onchocerca volvulus 0.004 0.016 0.0205
Giardia lamblia Glycogen phosphorylase 0.0605 0.4406 1
Brugia malayi mbt repeat family protein 0.0047 0.0207 0.0384
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0342 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0127 0.2859
Echinococcus multilocularis glycogen phosphorylase 0.0605 0.4406 0.4406
Brugia malayi beta-lactamase 0.0035 0.0121 0.0187
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0127 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0143 0.0193
Echinococcus multilocularis GPCR, family 2 0.0031 0.0088 0.0088
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0121 0.0187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.059 0.1324
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0256 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0121 0.0141
Entamoeba histolytica glycogen phosphorylase, putative 0.0605 0.4406 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0127 0.2859
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.124 0.124
Schistosoma mansoni inositol monophosphatase 0.0036 0.0127 0.0127
Onchocerca volvulus 0.0035 0.0121 0.0116
Echinococcus multilocularis peregrin 0.0031 0.0088 0.0088
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0331 0.2347 0.2347
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0389 0.0867
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0358 0.0729
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0071 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.013 0.013
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0121 0.0141
Loa Loa (eye worm) hypothetical protein 0.0098 0.059 0.1324
Loa Loa (eye worm) hypothetical protein 0.0434 0.3117 0.7069
Loa Loa (eye worm) MBCTL1 0.0053 0.0256 0.0564
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0257
Schistosoma mansoni hypothetical protein 0.0284 0.1991 0.1991
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0088 0.0112
Echinococcus granulosus jumonji domain containing protein 0.004 0.0155 0.0155
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0342 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0121 0.013
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0207 0.0315
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0094 0.0565 0.0565
Brugia malayi Inositol-1 0.0036 0.0127 0.0201
Schistosoma mansoni hypothetical protein 0.0029 0.0071 0.0071
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0342 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1549 0.8412
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0067 0.0358 0.0795
Loa Loa (eye worm) hypothetical protein 0.0042 0.017 0.0368
Echinococcus multilocularis chromobox protein 1 0.0068 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0299 0.0662
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0071 0.0071
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0262 0.1823 1
Brugia malayi chromobox protein homolog 3 0.0038 0.0143 0.0238
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0165 0.0218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0308
Mycobacterium tuberculosis Conserved protein 0.0035 0.0121 0.013
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0256 0.0256
Echinococcus granulosus glycogen phosphorylase 0.0605 0.4406 0.4406
Brugia malayi hypothetical protein 0.0434 0.3117 0.7048
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0121 0.2661
Loa Loa (eye worm) beta-lactamase 0.0035 0.0121 0.0257
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.013 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0201 0.0201
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0022 0.0022
Chlamydia trachomatis glycogen phosphorylase 0.0605 0.4406 0.5
Echinococcus granulosus Glycosyl transferase family 35 0.0605 0.4406 0.4406
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0088
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0207 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0303 0.1069
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.3332 0.3332
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0262 0.1823 1
Brugia malayi PHD-finger family protein 0.0029 0.0071 0.0072
Trichomonas vaginalis set domain proteins, putative 0.0232 0.16 0.3544
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0342 0.0502
Loa Loa (eye worm) hypothetical protein 0.0434 0.3117 0.7069
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0127 0.0155
Schistosoma mansoni lozenge 0.0054 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.024 0.1657 0.3749
Brugia malayi Pre-SET motif family protein 0.0204 0.1388 0.3089
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0303 1
Schistosoma mansoni glycogen phosphorylase 0.0605 0.4406 0.4406
Schistosoma mansoni hypothetical protein 0.0067 0.0358 0.0358
Onchocerca volvulus 0.0434 0.3117 0.7026
Brugia malayi Bromodomain containing protein 0.0031 0.0088 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0071 0.0143
Loa Loa (eye worm) hypothetical protein 0.0049 0.0224 0.0491
Brugia malayi hypothetical protein 0.0043 0.0182 0.0328
Brugia malayi Pre-SET motif family protein 0.0029 0.0076 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0121 0.0257
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.3332 0.3332
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0201 0.0201
Entamoeba histolytica hypothetical protein 0.0043 0.0182 0.013
Leishmania major hypothetical protein, conserved 0.0035 0.0121 0.2661
Brugia malayi jmjC domain containing protein 0.0094 0.0559 0.119
Brugia malayi Heterochromatin protein 1 0.0068 0.0369 0.0755
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.016 0.016
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0256 0.0256
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0137 0.0137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0182 0.0182
Onchocerca volvulus 0.0035 0.0121 0.0116
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0127 0.3285
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0071 0.3703
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0127 0.0035
Schistosoma mansoni inositol monophosphatase 0.0036 0.0127 0.0127
Loa Loa (eye worm) runx1 0.0054 0.0265 0.0585
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0369 0.0821
Mycobacterium leprae Probable lipase LipE 0.0035 0.0121 1
Onchocerca volvulus 0.0047 0.0207 0.0315
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0207 0.0207
Schistosoma mansoni glycogen phosphorylase 0.0605 0.4406 0.4406
Onchocerca volvulus Huntingtin homolog 0.024 0.1657 0.3659
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0207 0.0207
Brugia malayi Ets-domain containing protein 0.0071 0.0389 0.0801
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0303 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0121 0.2661
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0303 0.1069
Brugia malayi hypothetical protein 0.0025 0.0041 0.0004
Mycobacterium tuberculosis Conserved protein 0.0035 0.0121 0.013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0075
Brugia malayi Fli-1 protein 0.0215 0.1474 0.3287
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0071 0.1132
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0071 0.1132
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0088
Onchocerca volvulus 0.0035 0.0121 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0088 0.0183
Schistosoma mansoni glycogen phosphorylase 0.0262 0.1823 0.1823
Brugia malayi carbohydrate phosphorylase 0.0605 0.4406 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0691
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0165 0.0243

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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