Detailed information for compound 1360286

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.44 | Formula: C21H24N4O3
  • H donors: 3 H acceptors: 3 LogP: 2.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)C(=O)Nc1ccccc1)NNC(=O)c1ccccc1C
  • InChi: 1S/C21H24N4O3/c1-15-7-5-6-10-18(15)20(27)24-23-19(26)16-11-13-25(14-12-16)21(28)22-17-8-3-2-4-9-17/h2-10,16H,11-14H2,1H3,(H,22,28)(H,23,26)(H,24,27)
  • InChiKey: MBJGRZUGBPOJOQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0253 0.2234 0.8922
Schistosoma mansoni hypothetical protein 0.0205 0.1722 0.2981
Brugia malayi carbohydrate phosphorylase 0.0584 0.5777 1
Schistosoma mansoni glycogen phosphorylase 0.0584 0.5777 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2504 1
Echinococcus multilocularis glycogen phosphorylase 0.0584 0.5777 0.5777
Echinococcus granulosus geminin 0.0205 0.1722 0.2981
Giardia lamblia Glycogen phosphorylase 0.0584 0.5777 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0 0.5
Toxoplasma gondii ABC1 family protein 0.0043 0 0.5
Chlamydia trachomatis glycogen phosphorylase 0.0584 0.5777 0.5
Mycobacterium leprae conserved hypothetical protein 0.0043 0 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0043 0 0.5
Echinococcus granulosus glycogen phosphorylase 0.0584 0.5777 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0584 0.5777 1
Schistosoma mansoni hypothetical protein 0.0205 0.1722 0.2981
Schistosoma mansoni glycogen phosphorylase 0.0253 0.2234 0.3867
Echinococcus granulosus glycogen phosphorylase 0.0584 0.5777 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0 0.5
Echinococcus multilocularis Glycosyl transferase, family 35 0.0584 0.5777 0.5777
Onchocerca volvulus Glycogen phosphorylase homolog 0.0584 0.5777 1
Echinococcus multilocularis geminin 0.0205 0.1722 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0 0.5
Mycobacterium leprae Probable lipase LipE 0.0043 0 0.5
Schistosoma mansoni glycogen phosphorylase 0.0584 0.5777 1
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0253 0.2234 1
Loa Loa (eye worm) glycogen phosphorylase 0.0584 0.5777 1
Leishmania major hypothetical protein, conserved 0.0043 0 0.5
Echinococcus multilocularis glycogen phosphorylase 0.0584 0.5777 0.5777
Entamoeba histolytica glycogen phosphorylase, putative 0.0584 0.5777 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0584 0.5777 1
Echinococcus granulosus Glycosyl transferase family 35 0.0584 0.5777 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0584 0.5777 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2593 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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