Detailed information for compound 1369936

Basic information

Technical information
  • TDR Targets ID: 1369936
  • Name: N-[(2S)-1-[[3-(dimethylsulfamoyl)-4-methylphe nyl]amino]-3-methyl-1-oxobutan-2-yl]-3-methyl benzamide
  • MW: 431.548 | Formula: C22H29N3O4S
  • H donors: 2 H acceptors: 4 LogP: 3.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@@H](C(=O)Nc1ccc(c(c1)S(=O)(=O)N(C)C)C)NC(=O)c1cccc(c1)C)C
  • InChi: 1S/C22H29N3O4S/c1-14(2)20(24-21(26)17-9-7-8-15(3)12-17)22(27)23-18-11-10-16(4)19(13-18)30(28,29)25(5)6/h7-14,20H,1-6H3,(H,23,27)(H,24,26)/t20-/m0/s1
  • InChiKey: PWMGYBSFVXCCIS-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S)-1-[[3-(dimethylsulfamoyl)-4-methyl-phenyl]carbamoyl]-2-methyl-propyl]-3-methyl-benzamide
  • N-[(1S)-1-[[[3-(dimethylsulfamoyl)-4-methylphenyl]amino]-oxomethyl]-2-methylpropyl]-3-methylbenzamide
  • N-[(2S)-1-[[3-(dimethylsulfamoyl)-4-methyl-phenyl]amino]-3-methyl-1-oxo-butan-2-yl]-3-methyl-benzamide
  • MLS001002377
  • SMR000368900
  • T5270666

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0112
Schistosoma mansoni DNA polymerase eta 0.0023 0.0148 0.0331
Echinococcus multilocularis calpain 5 0.0062 0.0546 0.0546
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0393 0.0901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Loa Loa (eye worm) fli-1 protein 0.0265 0.2644 0.6153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.008 0.0729 0.5031
Entamoeba histolytica cysteine proteinase, putative 0.008 0.0729 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0025 0.0164 0.0596
Plasmodium falciparum serine repeat antigen 1 0.0025 0.0164 0.1255
Plasmodium falciparum serine repeat antigen 6 0.0025 0.0164 0.1255
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0137 0.0239
Plasmodium vivax calpain, putative 0.0062 0.0546 0.7171
Brugia malayi fibroinase precursor 0.0025 0.0164 0.0367
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0253 0.0589
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0164 0.0367
Giardia lamblia Cathepsin L precursor 0.0025 0.0164 0.0596
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0164 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0039 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0025 0.0164 0.1097
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Loa Loa (eye worm) hypothetical protein 0.0164 0.1599 0.3721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0164 0.1255
Entamoeba histolytica cysteine protease, putative 0.0025 0.0164 0.1856
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.1057 0.8837
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0729 0.1627
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0164 0.1255
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.1199
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0133 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0164 0.0596
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0074 0.0174
Giardia lamblia Cysteine protease 0.0025 0.0164 0.0596
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0133 0.023
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0217 0.0427
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0137 0.0239
Plasmodium vivax vivapain-3 0.0047 0.0393 0.48
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0164 0.0367
Toxoplasma gondii cathepsin CPL 0.008 0.0729 0.4877
Plasmodium falciparum serine repeat antigen 8 0.0025 0.0164 0.1255
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0083 0.0238
Echinococcus granulosus cathepsin b 0.0426 0.4297 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0164 0.1097
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0019 0.01 0.0652
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0319
Schistosoma mansoni hypothetical protein 0.0033 0.0253 0.0575
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0133 0.0296
Loa Loa (eye worm) calpain 0.0062 0.0546 0.127
Echinococcus multilocularis cathepsin L 0.0047 0.0393 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0253 0.0253
Giardia lamblia Encystation-specific protease 0.0025 0.0164 0.0596
Echinococcus granulosus cathepsin l1 0.008 0.0729 0.1696
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0164 0.1255
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0908 0.2114
Schistosoma mansoni cathepsin C 0.0025 0.0164 0.0367
Schistosoma mansoni calpain C (C02 family) 0.0062 0.0546 0.1258
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0112
Loa Loa (eye worm) hypothetical protein 0.0145 0.1407 0.3275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0546 0.1199
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0319
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Entamoeba histolytica cysteine protease, putative 0.0025 0.0164 0.1856
Brugia malayi hypothetical protein 0.0152 0.1472 0.3417
Brugia malayi glutathione reductase 0.0049 0.0412 0.0945
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0112
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0164 0.1255
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Echinococcus granulosus calpain 5 0.0062 0.0546 0.127
Brugia malayi calpain family protein 1 0.0164 0.1599 0.3712
Schistosoma mansoni cathepsin F (C01 family) 0.008 0.0729 0.1684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0039 0.0039
Brugia malayi cathepsin L precursor 0.0025 0.0164 0.0367
Echinococcus multilocularis cathepsin l cysteine peptidase 0.008 0.0729 0.0729
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0546 0.3565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0164 0.1097
Giardia lamblia Cathepsin L-like protease 0.0025 0.0164 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.01 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Giardia lamblia Cathepsin B precursor 0.0025 0.0164 0.0596
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0076
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0019 0.01 0.0652
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0546 0.1199
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.1057 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Trypanosoma brucei calpain, putative 0.0019 0.01 0.0361
Brugia malayi cathepsin L-like precursor 0.0057 0.05 0.115
Loa Loa (eye worm) hypothetical protein 0.0106 0.0998 0.2323
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0253 0.0575
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0148 0.0482
Schistosoma mansoni calpain-2 (C02 family) 0.0019 0.01 0.0218
Toxoplasma gondii cathepsin CPC1 0.0025 0.0164 0.082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Plasmodium falciparum serine repeat antigen 5 0.0025 0.0164 0.1255
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0908 0.2102
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.0152 0.1472 0.3427
Schistosoma mansoni calpain-7 (C02 family) 0.0062 0.0546 0.1258
Schistosoma mansoni ets 0.0013 0.0039 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0172 0.1676 0.3899
Echinococcus multilocularis geminin 0.0184 0.1808 0.1808
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.05 0.109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Brugia malayi Cathepsin L-like precursor 0.008 0.0729 0.1684
Trypanosoma brucei antigen, putative 0.0062 0.0546 0.3565
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0083 0.5
Trypanosoma brucei cysteine peptidase C (CPC) 0.0149 0.1442 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0393 0.0839
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0504
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0148 0.0331
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0172 0.1676 0.389
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0164 0.0367
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Onchocerca volvulus 0.008 0.0729 0.4316
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.01 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0426 0.4297 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0035 0.0081
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.009
Echinococcus multilocularis cpg binding protein 0.003 0.0222 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0039 0.009
Entamoeba histolytica hypothetical protein 0.003 0.0217 0.2627
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0083 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Toxoplasma gondii FATC domain-containing protein 0.003 0.0217 0.1204
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0546 0.3565
Onchocerca volvulus 0.0102 0.0961 0.6093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Plasmodium falciparum cysteine proteinase falcipain 3 0.008 0.0729 1
Plasmodium falciparum serine repeat antigen 7 0.0025 0.0164 0.1255
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0217 0.1204
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0148 0.0331
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0393 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.1442 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0133 0.1415
Plasmodium falciparum calpain 0.0019 0.01 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0729 0.1627
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0393 0.48
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0164 0.0367
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0238
Onchocerca volvulus 0.008 0.0729 0.4316
Schistosoma mansoni ets-related 0.0265 0.2644 0.6148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Echinococcus granulosus cathepsin l1 0.0057 0.05 0.1163
Echinococcus multilocularis calpain family protein 1, d 0.0121 0.1153 0.1153
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0133 0.031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.008 0.0729 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0133 0.0371
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.001 0.0006 0.0014
Leishmania major DNA polymerase eta, putative 0.0023 0.0148 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0039 0.0039
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0164 0.0367
Brugia malayi Ets-domain containing protein 0.0087 0.0809 0.1872
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0019 0.01 0.0652
Onchocerca volvulus 0.0029 0.0205 0.0318
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.01 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0908 0.2102
Onchocerca volvulus 0.0057 0.05 0.2566
Echinococcus granulosus protein C ets 2 0.0013 0.0039 0.009
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0412 0.0958
Schistosoma mansoni hypothetical protein 0.0033 0.0253 0.0575
Giardia lamblia Cathepsin L-like protease 0.0025 0.0164 0.0596
Loa Loa (eye worm) hypothetical protein 0.0102 0.0961 0.2237
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Schistosoma mansoni hypothetical protein 0.0184 0.1808 0.4199
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0133 0.0133
Schistosoma mansoni calpain (C02 family) 0.0062 0.0546 0.1258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0133 0.0601
Loa Loa (eye worm) papain family cysteine protease containing protein 0.008 0.0729 0.1696
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0393 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0998 0.2312
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0025 0.0164 0.1255
Loa Loa (eye worm) hypothetical protein 0.0121 0.1153 0.2683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Schistosoma mansoni cathepsin F (C01 family) 0.008 0.0729 0.1684
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0062 0.0546 0.1199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma brucei kinesin, putative 0.0043 0.0354 0.2188
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0149 0.1442 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0164 0.1255
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0426 0.4297 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0025 0.0164 0.082
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0133 0.031
Onchocerca volvulus 0.008 0.0729 0.4316
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0998 0.2312
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0019 0.01 0.0652
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0134 0.0375
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0133 0.0371
Loa Loa (eye worm) hypothetical protein 0.0072 0.0653 0.152
Plasmodium vivax glutathione reductase, putative 0.0049 0.0412 0.5097
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0172 0.1676 0.1676
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0134 0.0231
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0019 0.01 0.0152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0998 0.2323
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0133 0.0296
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.0137 0.0305
Entamoeba histolytica cysteine protease, putative 0.0025 0.0164 0.1856
Plasmodium falciparum glutathione reductase 0.0049 0.0412 0.5097
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.0137 0.0305
Echinococcus multilocularis cathepsin b 0.0426 0.4297 0.4297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Brugia malayi Cathepsin L-like precursor 0.008 0.0729 0.1684
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0217 0.0492
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0393 0.0839
Brugia malayi Ets-domain containing protein 0.0087 0.0809 0.1872
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0729 0.1627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0133 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0238
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0083 0.0178
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0253 0.0253
Loa Loa (eye worm) ctsf protein 0.008 0.0729 0.1696
Trypanosoma brucei trypanothione reductase 0.0049 0.0412 0.2602
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0025 0.0164 0.1255
Echinococcus multilocularis hypothetical protein 0.0062 0.0546 0.0546
Schistosoma mansoni hypothetical protein 0.0184 0.1808 0.4199
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.1199
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0174 0.0326
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.1057 0.8837
Plasmodium vivax vivapain-2 0.008 0.0729 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0148 0.0345
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0148 0.0989
Echinococcus granulosus dna polymerase eta 0.0023 0.0148 0.0345
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0083 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0164 0.1097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Trypanosoma brucei cysteine peptidase, putative 0.0019 0.01 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.05 0.3436
Toxoplasma gondii thioredoxin reductase 0.0049 0.0412 0.2602
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0729 0.1627
Entamoeba histolytica cysteine protease, putative 0.008 0.0729 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0025 0.0164 0.1097
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0412 0.5097
Loa Loa (eye worm) hypothetical protein 0.0057 0.05 0.1163
Giardia lamblia Cathepsin B precursor 0.0025 0.0164 0.0596
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0164 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Entamoeba histolytica calpain large subunit domain III containing protein 0.0043 0.0354 0.4601
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0546 0.3565
Onchocerca volvulus 0.0152 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0253 0.0589
Giardia lamblia DINP protein human, muc B family 0.0023 0.0148 0.0482
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0133 0.0601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0112
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.01 0.0152
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.1057 0.8837
Giardia lamblia Cathepsin B precursor 0.0149 0.1442 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.1199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0809 0.1883
Brugia malayi transcription factor E74 isoform 0.0013 0.0039 0.0076
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0546 0.1199
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0164 0.1097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0164 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0148 0.0709
Toxoplasma gondii cathepsin B 0.0149 0.1442 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Schistosoma mansoni calpain-7 (C02 family) 0.0062 0.0546 0.1258
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0164 0.0367
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0133 0.0371
Brugia malayi calpain 5 0.0043 0.0354 0.0811
Trypanosoma brucei calpain-like protein, putative 0.0062 0.0546 0.3565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0133 0.023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.1057 0.8837
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0039 0.009
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0148 0.0595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Schistosoma mansoni gabp alpha 0.0087 0.0809 0.1872
Trypanosoma brucei Calpain-like protein 1.1 0.0019 0.01 0.0361
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0164 0.0367
Brugia malayi calpain 5 0.0019 0.01 0.0218
Trypanosoma brucei unspecified product 0.0016 0.0074 0.0174
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.3408
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0148 0.0595
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0393 0.5158
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0361
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0164 0.1255
Onchocerca volvulus 0.008 0.0729 0.4316
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Echinococcus multilocularis dna polymerase eta 0.0023 0.0148 0.0148
Giardia lamblia Cathepsin B precursor 0.0025 0.0164 0.0596
Loa Loa (eye worm) cysteine protease 0.008 0.0729 0.1696
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0393 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Leishmania major DNA polymerase kappa, putative 0.0023 0.0148 0.0482
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0546 0.1199
Onchocerca volvulus Cathepsin L homolog 0.008 0.0729 0.4316
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.01 0.0152
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0164 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0217 0.1469
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.3408
Mycobacterium tuberculosis Probable reductase 0.0112 0.1057 0.8837
Plasmodium falciparum serine repeat antigen 3 0.0025 0.0164 0.1255
Giardia lamblia GTOR 0.0022 0.0133 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Giardia lamblia Cysteine protease 0.0025 0.0164 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.3565
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0148 0.1633
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0164 0.1255
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0164 0.0596
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0062 0.0546 0.1199
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Plasmodium falciparum serine repeat antigen 4 0.0025 0.0164 0.1255
Schistosoma mansoni cpg binding protein 0.0029 0.0205 0.0464
Loa Loa (eye worm) hypothetical protein 0.0075 0.0679 0.1579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Echinococcus granulosus cathepsin L cysteine proteinase 0.008 0.0729 0.1696
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0035 0.0067
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Echinococcus multilocularis cysteine protease 0.008 0.0729 0.0729
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0471 0.3029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0148 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0148 0.0266
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0035 0.0067
Echinococcus granulosus cpg binding protein 0.003 0.0222 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0164 0.1097
Echinococcus granulosus calpain A 0.0172 0.1676 0.3899
Brugia malayi CXXC zinc finger family protein 0.0029 0.0205 0.0464
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.05 0.115
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0393 0.2692
Onchocerca volvulus 0.008 0.0729 0.4316
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0164 0.0367
Loa Loa (eye worm) hypothetical protein 0.0426 0.4297 1
Trypanosoma cruzi cruzipain precursor, putative 0.008 0.0729 0.1627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Giardia lamblia Cathepsin B precursor 0.0149 0.1442 1
Trypanosoma brucei Calpain-like protein 1.2 0.0019 0.01 0.0361
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Giardia lamblia Cathepsin B precursor 0.0025 0.0164 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0164 0.1097
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0164 0.1255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0025 0.0164 0.1097
Leishmania major hypothetical protein, unknown function 0.0019 0.01 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0908 0.0908
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0076
Schistosoma mansoni hypothetical protein 0.0019 0.01 0.0218
Giardia lamblia Cathepsin L precursor 0.0025 0.0164 0.0596
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.001 0.0006 0.0006
Giardia lamblia Cathepsin L precursor 0.0025 0.0164 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Echinococcus granulosus cathepsin l cysteine peptidase 0.008 0.0729 0.1696
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0081
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0133 0.0601
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0137 0.0319
Trypanosoma brucei calpain, putative 0.0019 0.01 0.0361
Loa Loa (eye worm) cathepsin B 0.0149 0.1442 0.3356
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0164 0.0302
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0019 0.01 0.0152
Entamoeba histolytica cysteine protease, putative 0.0025 0.0164 0.1856
Giardia lamblia Cathepsin B precursor 0.0025 0.0164 0.0596
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Plasmodium falciparum cysteine proteinase falcipain 2a 0.008 0.0729 1
Entamoeba histolytica calpain family cysteine protease, putative 0.0019 0.01 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0164 0.1097
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0133 0.023
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.01 0.0152
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0164 0.0367
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0164 0.0381
Echinococcus granulosus cysteine protease 0.0047 0.0393 0.0914
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.1186 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0112
Schistosoma mansoni hypothetical protein 0.0033 0.0253 0.0575
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0164 0.0367
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0393 0.5158
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0148 0.0709
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0192
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0019 0.01 0.0652
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0036 0.007
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.3408
Trypanosoma brucei unspecified product 0.0016 0.0074 0.0174
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0164 0.1255
Giardia lamblia Cysteine protease 0.0025 0.0164 0.0596
Plasmodium vivax unspecified product 0.0047 0.0393 0.48
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0148 0.0266
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0393 0.5158
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0039 0.009
Echinococcus granulosus serine protein kinase ATM 0.003 0.0217 0.0505
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0393 0.5158
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0164 0.1097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0164 0.0367
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0381
Toxoplasma gondii hypothetical protein 0.0019 0.01 0.0361
Entamoeba histolytica protein kinase, putative 0.0043 0.0354 0.4601
Trypanosoma brucei Calpain-like protein CALP1.3 0.0019 0.01 0.0361
Giardia lamblia Cathepsin L precursor 0.0025 0.0164 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0217 0.0492
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0039 0.009
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0133 0.023
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0148 0.0148
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0148 0.0266
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0148 0.0266
Plasmodium falciparum serine repeat antigen 2 0.0025 0.0164 0.1255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0164 0.1097
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0148 0.0331
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0019 0.01 0.0361
Brugia malayi Cathepsin L-like precursor 0.008 0.0729 0.1684
Giardia lamblia Hypothetical protein 0.0025 0.0164 0.0596
Loa Loa (eye worm) calpain D 0.0019 0.01 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Trichomonas vaginalis calpain, putative 0.0019 0.01 0.0652
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0133 0.031
Echinococcus granulosus calpain 0.0062 0.0546 0.127
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0062 0.0546 0.1199
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0083 0.0238
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0083 0.5
Echinococcus granulosus geminin 0.0184 0.1808 0.4207
Brugia malayi Cathepsin L-like precursor 0.0022 0.0137 0.0305
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0217 0.0217
Echinococcus multilocularis protein C ets 2 0.0013 0.0039 0.0039
Schistosoma mansoni ets-related 0.0013 0.0039 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0653 0.1508
Brugia malayi Thioredoxin reductase 0.0049 0.0412 0.0945
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0381
Brugia malayi Ets-domain containing protein 0.0013 0.0039 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Leishmania major calpain family cysteine protease-like protein 0.0019 0.01 0.0126
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Entamoeba histolytica cysteine protease, putative 0.0025 0.0164 0.1856
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0148 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Echinococcus granulosus calpain 7 C02 family 0.0062 0.0546 0.127
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0393 0.0839
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0361
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0412 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0083 0.0532
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0148 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.01 0.0152
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0164 0.0381
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0019 0.01 0.0361
Echinococcus granulosus GPCR family 2 0.0033 0.0253 0.0589
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.1186 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Brugia malayi calpain family protein 1 0.0164 0.1599 0.3712
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0112
Echinococcus multilocularis cathepsin L cysteine protease 0.008 0.0729 0.0729
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0164 0.0367
Brugia malayi cathepsin B-like cysteine proteinase 0.0426 0.4297 1
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0164 0.0367
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0164 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0083 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Schistosoma mansoni cathepsin s 0.0022 0.0137 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.1186 1
Brugia malayi Cathepsin L-like precursor 0.008 0.0729 0.1684
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0393 0.0914
Giardia lamblia Cathepsin L precursor 0.0025 0.0164 0.0596
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0148 0.0331
Brugia malayi calpain 7 0.0062 0.0546 0.1258
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0019 0.01 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0164 0.0381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0039 0.0039
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0039 0.009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0148 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0148 0.0709
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0253 0.0575
Echinococcus multilocularis cysteine protease 0.008 0.0729 0.0729
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0148 1
Trypanosoma cruzi kinesin, putative 0.0043 0.0354 0.0749
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0172 0.1676 0.389
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0133 0.0296
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0393 0.0901
Echinococcus granulosus calpain A 0.0062 0.0546 0.127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0393 0.2465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0539 0.1241
Plasmodium falciparum serine repeat antigen 9 0.0025 0.0164 0.1255
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0133 0.0371
Echinococcus multilocularis GPCR, family 2 0.0033 0.0253 0.0253
Entamoeba histolytica cysteine protease, putative 0.0025 0.0164 0.1856
Schistosoma mansoni Mername-AA248 (C02 family) 0.0062 0.0546 0.1258
Giardia lamblia Cathepsin L precursor 0.0025 0.0164 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.008 0.0729 0.5031
Plasmodium falciparum thioredoxin reductase 0.0049 0.0412 0.5097
Plasmodium vivax unspecified product 0.0022 0.0137 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0729 0.4877
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0133 0.023
Brugia malayi Cathepsin L-like precursor 0.008 0.0729 0.1684
Schistosoma mansoni elf1 0.0013 0.0039 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0039 0.009
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0393 0.5158
Leishmania major kinesin, putative 0.0043 0.0354 0.1997
Leishmania major trypanothione reductase 0.0049 0.0412 0.2422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0164 0.1097
Leishmania major hypothetical protein, conserved 0.0019 0.01 0.0126
Echinococcus granulosus dna polymerase kappa 0.0023 0.0148 0.0345
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.1442 0.3346
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0319
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.008 0.0729 0.1696
Echinococcus multilocularis cathepsin b 0.0426 0.4297 0.4297
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0412 0.0958
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0253 0.0589
Brugia malayi Cathepsin L-like precursor 0.008 0.0729 0.1684
Echinococcus multilocularis cathepsin L 0.0025 0.0164 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0083 0.0238
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.01 0.0152
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0083 0.0532
Onchocerca volvulus Cathepsin L homolog 0.008 0.0729 0.4316
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0908 0.2114
Giardia lamblia Cysteine protease 0.0025 0.0164 0.0596
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0412 0.2985
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0164 0.1097
Echinococcus multilocularis cathepsin L cysteine protease 0.008 0.0729 0.0729
Entamoeba histolytica hypothetical protein 0.0025 0.0164 0.1856
Echinococcus multilocularis calpain 0.0062 0.0546 0.0546
Echinococcus multilocularis calpain 7 (C02 family) 0.0062 0.0546 0.0546
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0036 0.007
Loa Loa (eye worm) hypothetical protein 0.0057 0.05 0.1163
Echinococcus granulosus cathepsin b 0.0426 0.4297 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0164 0.1255
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0133 0.0601
Treponema pallidum NADH oxidase 0.0017 0.0083 0.5
Trichomonas vaginalis calpain, putative 0.0019 0.01 0.0652
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0164 0.1856
Schistosoma mansoni hypothetical protein 0.0033 0.0253 0.0575
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0019 0.01 0.0361
Echinococcus multilocularis cathepsin l cysteine peptidase 0.008 0.0729 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0164 0.0367
Trypanosoma brucei unspecified product 0.0023 0.0148 0.0709
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0035 0.0035
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0025 0.0164 0.1255
Loa Loa (eye worm) calpain family protein 1 0.0121 0.1153 0.2683
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0039 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0908 0.2102
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0164 0.0596
Plasmodium vivax vivapain-1 0.0047 0.0393 0.48
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0412 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.01 0.0152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0809 0.0809
Toxoplasma gondii cathepsin CPC2 0.0025 0.0164 0.082
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0178
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0205 0.0478
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0025 0.0164 0.1097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0426 0.4297 1
Loa Loa (eye worm) calpain 5 0.0043 0.0354 0.0824
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0164 0.1255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Trichomonas vaginalis calpain, putative 0.0019 0.01 0.0652
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Loa Loa (eye worm) calpain family protein 1 0.0164 0.1599 0.3721
Trypanosoma brucei Calpain-like protein 2 0.0019 0.01 0.0361
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0164 0.1856
Plasmodium vivax unspecified product 0.0025 0.0164 0.1255
Trypanosoma brucei hypothetical protein 0.0019 0.01 0.0361
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0148 0.0709
Trypanosoma cruzi conserved protein 0.0019 0.01 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.008 0.0729 0.5031
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0164 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0393 0.2692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.05 0.115
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0133 0.1415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0393 0.2465
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0381
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0253 0.0589
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0133 0.0601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0908 0.2102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0381
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0062 0.0546 0.3565
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0393 0.0901
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.1442 0.3301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0035 0.0201
Plasmodium vivax vivapain-2 0.008 0.0729 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0908 0.2114
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0809 0.1883
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0729 0.1684
Trichomonas vaginalis hypothetical protein 0.0019 0.01 0.0652
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0039 0.0039
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.1186 1
Onchocerca volvulus 0.008 0.0729 0.4316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.008 0.0729 0.5031
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0074 0.0174
Brugia malayi Cathepsin L-like precursor 0.0057 0.05 0.115
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.05 0.6698
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0393 0.0839
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Giardia lamblia Hypothetical protein 0.0025 0.0164 0.0596
Echinococcus multilocularis ets variant gene 4 0.0013 0.0039 0.0039
Echinococcus granulosus cathepsin L 0.0047 0.0393 0.0914
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0039 0.009
Onchocerca volvulus Cathepsin F homolog 0.008 0.0729 0.4316
Onchocerca volvulus 0.008 0.0729 0.4316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.05 0.3436
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0049 0.0302
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0164 0.1255
Brugia malayi Fli-1 protein 0.0265 0.2644 0.6148
Giardia lamblia Cathepsin B precursor 0.0149 0.1442 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0019 0.01 0.0152
Entamoeba histolytica cysteine proteinase, putative 0.008 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0381
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0133 0.0601
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0426 0.4297 1
Brugia malayi calpain D 0.0019 0.01 0.0218
Loa Loa (eye worm) hypothetical protein 0.0057 0.05 0.1163
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0164 0.1097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0426 0.4297 1
Trypanosoma cruzi kinesin, putative 0.0043 0.0354 0.0749
Leishmania major calpain protease-like protein 0.0019 0.01 0.0126
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0133 0.0133
Loa Loa (eye worm) glutathione reductase 0.0049 0.0412 0.0958
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0133 0.0884
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0072 0.0653 0.1508
Echinococcus granulosus cathepsin L 0.0025 0.0164 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0049 0.0302
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0164 0.0367
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0148 0.0266
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0083 0.5
Leishmania major cathepsin L-like protease 0.008 0.0729 0.4752
Entamoeba histolytica cysteine protease, putative 0.0047 0.0393 0.5158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0164 0.1097
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0393 0.5158
Loa Loa (eye worm) fibroinase 0.008 0.0729 0.1696
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0126
Leishmania major cysteine peptidase A (CPA) 0.008 0.0729 0.4752
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0083 0.0112
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0039 0.0076
Echinococcus multilocularis calpain A 0.0172 0.1676 0.1676
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0039 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.01 0.0361
Loa Loa (eye worm) hypothetical protein 0.008 0.0729 0.1696
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0133 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0074 0.0174
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.1599 0.3712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0164 0.1097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0148 0.0709
Brugia malayi Cathepsin L-like precursor 0.0057 0.05 0.115

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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