Detailed information for compound 1370292

Basic information

Technical information
  • TDR Targets ID: 1370292
  • Name: 1-cyclohexyl-4-[1-(1-cyclopentyltetrazol-5-yl )pentyl]piperazine
  • MW: 374.567 | Formula: C21H38N6
  • H donors: 0 H acceptors: 3 LogP: 4.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(c1nnnn1C1CCCC1)N1CCN(CC1)C1CCCCC1
  • InChi: 1S/C21H38N6/c1-2-3-13-20(21-22-23-24-27(21)19-11-7-8-12-19)26-16-14-25(15-17-26)18-9-5-4-6-10-18/h18-20H,2-17H2,1H3
  • InChiKey: RDWKFJIHDGZGEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-cyclohexyl-4-[1-(1-cyclopentyl-5-tetrazolyl)pentyl]piperazine
  • 1-cyclohexyl-4-[1-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)pentyl]piperazine
  • 1-Cyclohexyl-4-[1-(1-cyclopentyl-1H-tetrazol-5-yl)-pentyl]piperazine
  • 1-Cyclohexyl-4-[1-(1-cyclopentyl-1H-tetrazol-5-yl)-pentyl]-piperazine
  • MLS000073898
  • SMR000004850
  • ASN 05551453

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.089
Brugia malayi Glycosyl hydrolases family 31 protein 0.0031 0.0085 0.0117
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Entamoeba histolytica cysteine protease, putative 0.0012 0.0012 0.0361
Schistosoma mansoni cpg binding protein 0.0035 0.0099 0.0528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0123 0.0654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Echinococcus multilocularis cpg binding protein 0.0038 0.0112 0.0199
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1464 0.5626 1
Trichomonas vaginalis protein kinase inhibitor, putative 0.0055 0.0176 1
Brugia malayi Telomerase reverse transcriptase 0.1886 0.7259 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Echinococcus multilocularis cysteine protease 0.0012 0.0012 0.0022
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0048 0.0132
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0029 0.0075 0.0134
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0012 0.0012
Plasmodium falciparum plastid replication-repair enzyme 0.0017 0.0029 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0423 0.4045
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0017
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0062 0.0206 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.014 0.0505 0.4824
Brugia malayi DNA polymerase I family protein 0.0017 0.0029 0.004
Onchocerca volvulus 0.0035 0.0099 0.0099
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0099 0.0947
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0123 0.1171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0017 0.0029 0.0077
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0226 0.0793
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0036 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Plasmodium falciparum ataxin-2 like protein, putative 0.0064 0.0211 0.0737
Brugia malayi hypothetical protein 0.0064 0.0211 0.029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0046 0.0141 0.0251
Echinococcus granulosus dnaJ subfamily C 6 0.0055 0.0176 0.0831
Loa Loa (eye worm) DnaJ domain-containing protein 0.0055 0.0176 0.1682
Schistosoma mansoni lamin 0.0042 0.0126 0.0672
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0062 0.0206 0.097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Loa Loa (eye worm) PHD-finger family protein 0.0015 0.0023 0.0223
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0011 0.0016
Schistosoma mansoni methyl-cpg binding protein mbd 0.0012 0.0013 0.007
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.0123 0.0579
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.0123 0.0086
Schistosoma mansoni bromodomain containing protein 0.0048 0.0152 0.0808
Onchocerca volvulus 0.0012 0.0012 0.0012
Schistosoma mansoni lamin 0.0042 0.0126 0.0672
Onchocerca volvulus 0.0012 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.0057 0.0185 0.0254
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0017
Echinococcus granulosus twinkle protein mitochondrial 0.0012 0.0012 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0423 0.4045
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0048 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0154
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0012 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0123 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0123 0.0654
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0012 0.0013 0.0023
Toxoplasma gondii hypothetical protein 0.0021 0.0048 0.0132
Brugia malayi Intermediate filament tail domain containing protein 0.0042 0.0126 0.0173
Plasmodium vivax ataxin-2 like protein, putative 0.0064 0.0211 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0277
Treponema pallidum DNA polymerase I (polA) 0.0057 0.0186 0.877
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0042 0.0126 0.1203
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0113 0.0401 0.0713
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1875 0.8848
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.0206 0.0718
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0031 0.0085 0.0269
Trypanosoma brucei glucosidase, putative 0.0031 0.0085 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0145 0.0508
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0012 0.0361
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0012 0.0017
Brugia malayi Glycosyl hydrolases family 31 protein 0.0012 0.001 0.0013
Onchocerca volvulus Cathepsin F homolog 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0379
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0766
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0012 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0022 0.0051 0.0489
Leishmania major telomerase reverse transcriptase, putative 0.0709 0.2706 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0062 0.0206 0.0366
Trypanosoma brucei glycosyl hydrolase-like protein 0.0012 0.001 0.0005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.0012 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0085 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0043 0.013 0.045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0123 0.0169
Giardia lamblia Telomerase catalytic subunit 0.0709 0.2706 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0031
Trypanosoma brucei telomerase reverse transcriptase 0.0709 0.2706 1
Echinococcus multilocularis cysteine protease 0.0012 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0702
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0085 0.4516
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0041 0.0122 0.0408
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.014 0.0505 0.0897
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 0.0718
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0017
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0107 0.0365
Loa Loa (eye worm) hypothetical protein 0.0041 0.0123 0.1175
Echinococcus granulosus methyl CpG binding domain protein 2 0.0012 0.0013 0.0062
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0165 0.1576
Brugia malayi intermediate filament protein 0.0042 0.0126 0.0173
Loa Loa (eye worm) fibroinase 0.0012 0.0012 0.0118
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0709 0.2706 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0015 0.0143
Brugia malayi MH2 domain containing protein 0.0119 0.0423 0.0583
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0085 0.4516
Brugia malayi Probable ClpP-like protease 0.0062 0.0206 0.0283
Echinococcus granulosus neutral alpha glucosidase AB 0.0031 0.0085 0.04
Echinococcus multilocularis dnaJ subfamily C 6 0.0055 0.0176 0.0313
Leishmania major cathepsin L-like protease 0.0012 0.0012 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Echinococcus granulosus cytoplasmic intermediate filament protein 0.002 0.0043 0.0201
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0017
Echinococcus multilocularis zinc finger protein 0.0016 0.0028 0.005
Brugia malayi follicle stimulating hormone receptor 0.028 0.1047 0.1442
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 1
Echinococcus granulosus cathepsin l1 0.0012 0.0012 0.0058
Schistosoma mansoni cpg binding protein 0.0038 0.0112 0.0598
Leishmania major cysteine peptidase A (CPA) 0.0012 0.0012 0.0015
Onchocerca volvulus 0.0012 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0065
Brugia malayi DnaJ domain containing protein 0.0055 0.0176 0.0243
Echinococcus granulosus histone lysine methyltransferase setb 0.0013 0.0016 0.0076
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0041 0.0122 0.0422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Echinococcus granulosus lamin 0.0042 0.0126 0.0594
Onchocerca volvulus 0.0012 0.0012 0.0012
Echinococcus granulosus cathepsin L cysteine proteinase 0.0012 0.0012 0.0058
Echinococcus multilocularis lamin dm0 0.0042 0.0126 0.0224
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0026 0.0067 0.0118
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0017
Onchocerca volvulus 0.0012 0.0012 0.0012
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0057 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0013 0.0016 0.0029
Echinococcus granulosus lysosomal alpha glucosidase 0.014 0.0505 0.2382
Echinococcus multilocularis tumor protein p63 0.0557 0.2119 0.3767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Leishmania major alpha glucosidase II subunit, putative 0.0031 0.0085 0.0284
Onchocerca volvulus 0.0012 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0064 0.0211 0.0751
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0026 0.0067 0.0314
Loa Loa (eye worm) hypothetical protein 0.0042 0.0126 0.1203
Echinococcus granulosus zinc finger protein 0.0016 0.0028 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0064 0.0211 0.0751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Schistosoma mansoni hypothetical protein 0.0029 0.0075 0.0401
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Leishmania major cathepsin L-like protease 0.0012 0.0012 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0012 0.0163
Toxoplasma gondii RNA-directed DNA polymerase 0.0709 0.2706 1
Onchocerca volvulus 0.0082 0.028 0.028
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0012 0.0066
Schistosoma mansoni cellular tumor antigen P53 0.0082 0.028 0.1495
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0124
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0041 0.0122 0.0422
Schistosoma mansoni peptidase Clp (S14 family) 0.0062 0.0206 0.1097
Trichomonas vaginalis maltase-glucoamylase, putative 0.0031 0.0085 0.4516
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.1047 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0085 0.4516
Leishmania major cathepsin L-like protease 0.0012 0.0012 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0012 0.0163
Schistosoma mansoni intermediate filament proteins 0.0042 0.0126 0.0672
Brugia malayi Glycosyl hydrolases family 31 protein 0.014 0.0505 0.0696
Onchocerca volvulus 0.0042 0.0126 0.0126
Brugia malayi PHD-finger family protein 0.002 0.0043 0.0059
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0041 0.0122 0.0422
Loa Loa (eye worm) twinkle helicase 0.0012 0.0012 0.0117
Plasmodium falciparum ataxin-2 like protein, putative 0.0064 0.0211 0.0737
Schistosoma mansoni alpha-glucosidase 0.012 0.043 0.2291
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0145 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0249 0.133
Plasmodium vivax telomerase reverse transcriptase, putative 0.0709 0.2706 1
Leishmania major cathepsin L-like protease 0.0012 0.0012 0.0015
Plasmodium falciparum telomerase reverse transcriptase 0.0709 0.2706 1
Brugia malayi hypothetical protein 0.0041 0.0124 0.017
Schistosoma mansoni zinc finger protein 0.0016 0.0028 0.0149
Schistosoma mansoni thyroid hormone receptor 0.0122 0.0436 0.2327
Brugia malayi CXXC zinc finger family protein 0.0035 0.0099 0.0137
Echinococcus granulosus fetal alzheimer antigen falz 0.0018 0.0036 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0012 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0123 0.0578
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0013 0.0016 0.0086
Schistosoma mansoni hypothetical protein 0.0494 0.1875 1
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0085 0.0284
Onchocerca volvulus 0.0081 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0031 0.0085 0.081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0031 0.0085 0.4516
Echinococcus multilocularis twinkle protein, mitochondrial 0.0012 0.0012 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0145 0.0508
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0118
Onchocerca volvulus 0.0042 0.0126 0.0126
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.0123 0.0086
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0031 0.0085 1
Leishmania major cathepsin L-like protease 0.0047 0.0145 0.0508
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.002 0.0042 0.011
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0062 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0408
Trypanosoma cruzi PAB1-binding protein , putative 0.0064 0.0211 0.0751
Leishmania major cathepsin L-like protease 0.0047 0.0145 0.0508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0044
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0046 0.0141 0.0667
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0085 0.4516
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0041 0.0122 0.0408
Toxoplasma gondii helicase, putative 0.0017 0.0029 0.0062
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0012 0.0012
Schistosoma mansoni methyl-cpg binding protein mbd 0.0012 0.0013 0.007
Leishmania major glycosyl hydrolase-like protein 0.0012 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0113 0.0401 0.214
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.0123 0.4744
Schistosoma mansoni alpha-glucosidase 0.012 0.043 0.2291
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0006 0.0062
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0017 0.0029 0.0077
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.1965
Onchocerca volvulus 0.0012 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.0028 0.0073 0.0101
Echinococcus granulosus cathepsin l cysteine peptidase 0.0012 0.0012 0.0058
Mycobacterium ulcerans DNA polymerase I 0.0057 0.0186 0.7675
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0113 0.0401 0.1893
Leishmania major cathepsin L-like protease 0.0047 0.0145 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0017 0.0029 0.0077
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0018 0.0036 0.0065
Schistosoma mansoni alpha glucosidase 0.0031 0.0085 0.0452
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0012 0.0022
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.0206 0.0718
Echinococcus multilocularis lysosomal alpha glucosidase 0.014 0.0505 0.0897
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0017 0.0029 0.0077
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0041 0.0122 0.0422
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0012 0.0022
Loa Loa (eye worm) intermediate filament protein 0.0042 0.0126 0.1203
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0031 0.0085 0.4516
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0709 0.2706 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.028 0.2678
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0012 0.0015
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.001 0.0005
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0017 0.0029 0.0062
Schistosoma mansoni zinc finger protein 0.0011 0.0008 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Trichomonas vaginalis DNA polymerase I, putative 0.0017 0.0029 0.1168
Schistosoma mansoni DNA polymerase I 0.0017 0.0029 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Loa Loa (eye worm) ctsf protein 0.0012 0.0012 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0012 0.0361
Loa Loa (eye worm) hypothetical protein 0.0064 0.0211 0.2014
Leishmania major cathepsin L-like protease 0.0012 0.0012 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0123 0.0218
Toxoplasma gondii LsmAD domain-containing protein 0.0064 0.0211 0.0737
Echinococcus multilocularis musashi 0.0042 0.0126 0.0224
Loa Loa (eye worm) cysteine protease 0.0012 0.0012 0.0118
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0017 0.0029 0.0077
Echinococcus granulosus lamin dm0 0.0042 0.0126 0.0594
Schistosoma mansoni hypothetical protein 0.0055 0.0176 0.0939
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.001 0.0005
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.0123 0.0218
Echinococcus multilocularis lamin 0.0042 0.0126 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1875 0.3333
Echinococcus granulosus cpg binding protein 0.0038 0.0112 0.0529
Brugia malayi cytoplasmic intermediate filament protein 0.0022 0.0051 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0379
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0017 0.0029 0.2587
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.002 0.0043 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0123 0.0654
Echinococcus multilocularis neutral alpha glucosidase AB 0.0031 0.0085 0.0151
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0029 0.0075 0.0355
Trichomonas vaginalis sucrase-isomaltase, putative 0.0031 0.0085 0.4516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Plasmodium vivax plastid replication-repair enzyme, putative 0.0017 0.0029 0.0062
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0057 0.0186 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0145 0.0508
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0085 0.4516
Schistosoma mansoni cpg binding protein 0.0038 0.0112 0.0598
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0013 0.0016 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0163
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0031 0.0085 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0012 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0122 0.0436 0.2327
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0062 0.0206 0.0718
Echinococcus granulosus intermediate filament protein 0.0042 0.0126 0.0594
Trypanosoma brucei PAB1-binding protein , putative 0.0064 0.0211 0.0751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0012 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0123 0.0578
Echinococcus multilocularis thyroid hormone receptor alpha 0.0122 0.0436 0.0776
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0017
Echinococcus granulosus tumor protein p63 0.0557 0.2119 1
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0145 0.0508

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 43.807 um PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). (Class of assay: confirmatory) [Related pubchem assays: 1952 (Screening assay (GPR7 antagonists).), 1880 (Summary AID.)] ChEMBL. No reference
IC50 (functional) > 43.807 um PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based high throughput dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1). (Class of assay: confirmatory) [Related pubchem assays: 1880 (Summary AID.), 2148 (Screening assay (MCHR1 antagonists).), 1952 (Screening assay (GPR7 antagonists).), 1861 (Screening assay (GPR7 antagonists).)] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.