Detailed information for compound 1379039

Basic information

Technical information
  • TDR Targets ID: 1379039
  • Name: N-(2-phenylethyl)-4-pyrrolidin-1-ylsulfonylbe nzamide
  • MW: 358.455 | Formula: C19H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N1CCCC1)NCCc1ccccc1
  • InChi: 1S/C19H22N2O3S/c22-19(20-13-12-16-6-2-1-3-7-16)17-8-10-18(11-9-17)25(23,24)21-14-4-5-15-21/h1-3,6-11H,4-5,12-15H2,(H,20,22)
  • InChiKey: LAKHIWHSYWISDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-phenylethyl)-4-pyrrolidin-1-ylsulfonyl-benzamide
  • N-(2-phenylethyl)-4-1-pyrrolidinylsulfonylbenzamide
  • T5388691
  • ZINC06648690

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0068 0.0041 0.0104
Trichomonas vaginalis STE family protein kinase 0.0176 0.0338 0.2779
Trypanosoma cruzi casein kinase II, putative 0.0096 0.0116 0.0711
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1154 0.3028 0.3018
Echinococcus multilocularis neuroglian 0.0164 0.0305 0.0721
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0068 0.0286
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0219 0.0455 0.1095
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0481 0.1177 0.2891
Echinococcus multilocularis casein kinase I alpha 0.0066 0.0035 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0071 0.0139
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0095 0.0114 0.0099
Echinococcus multilocularis peroxidasin 0.0068 0.0042 0.0066
Brugia malayi phosphoinositide-dependent protein kinase I 0.0077 0.0065 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0193 0.0385 0.0922
Schistosoma mansoni protein kinase 0.0235 0.0499 0.1203
Plasmodium vivax glycogen synthase kinase 3, putative 0.0413 0.0991 0.841
Loa Loa (eye worm) hypothetical protein 0.0133 0.0219 0.0204
Echinococcus multilocularis suppressor of cytokine signaling 7 0.006 0.0019 0.0011
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0147 0.0257 0.0242
Brugia malayi serine/threonine protein kinase 6 0.0481 0.1177 0.1164
Schistosoma mansoni hypothetical protein 0.006 0.0019 0.0011
Echinococcus multilocularis SH2 domain containing protein 7 0.006 0.0019 0.0011
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0084 0.0085 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0116 0.0174 0.1368
Echinococcus multilocularis N chimaerin 0.0095 0.0114 0.0246
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0169 0.0319 0.0757
Brugia malayi serine/threonine-protein kinase PAK 7 0.1337 0.353 0.352
Echinococcus multilocularis raf serine:threonine protein kinase 0.0085 0.0086 0.0177
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0097 0.0121 0.0749
Brugia malayi Immunoglobulin I-set domain containing protein 0.0071 0.0048 0.0033
Loa Loa (eye worm) hypothetical protein 0.0133 0.0219 0.0204
Giardia lamblia Kinase, PLK 0.0219 0.0455 0.3677
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0041 0.0026
Giardia lamblia Kinase, STE STE20 0.0176 0.0338 0.2651
Echinococcus granulosus tyrosine protein kinase Fyn 0.0193 0.0385 0.0922
Trichomonas vaginalis CK1 family protein kinase 0.0066 0.0035 0.0174
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0111 0.0159 0.0357
Onchocerca volvulus 0.1205 0.3167 0.8492
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0481 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0031 0.0016
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0413 0.0991 0.2427
Schistosoma mansoni serine/threonine protein kinase 0.02 0.0405 0.097
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0071 0.0048 0.0081
Loa Loa (eye worm) hypothetical protein 0.0084 0.0085 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0088 0.0626
Loa Loa (eye worm) hypothetical protein 0.0068 0.0042 0.0027
Schistosoma mansoni neuroglian 0.0071 0.0048 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0413 0.0991 0.8397
Schistosoma mansoni hypothetical protein 0.0126 0.0201 0.0463
Onchocerca volvulus 0.0082 0.008 0.0208
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0085 0.0175
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.018 0.0349 0.0335
Brugia malayi Temporarily assigned gene name protein 59 0.013 0.0211 0.0196
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0074 0.0336
Entamoeba histolytica protein kinase domain containing protein 0.0481 0.1177 1
Schistosoma mansoni serine/threonine protein kinase 0.0392 0.0931 0.228
Brugia malayi Protein kinase domain containing protein 0.011 0.0157 0.0142
Brugia malayi Protein kinase domain containing protein 0.011 0.0157 0.0142
Echinococcus multilocularis tyrosine kinase 0.011 0.0157 0.0353
Echinococcus multilocularis casein kinase I alpha 0.0066 0.0035 0.005
Entamoeba histolytica protein kinase , putative 0.0481 0.1177 1
Plasmodium vivax unspecified product 0.0096 0.0116 0.095
Onchocerca volvulus 0.006 0.0019 0.0046
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0071 0.0048 0.0033
Onchocerca volvulus 0.1328 0.3505 0.94
Entamoeba histolytica protein kinase, putative 0.0413 0.0991 0.8417
Plasmodium falciparum glycogen synthase kinase 3 0.0413 0.0991 0.8368
Brugia malayi Protein kinase domain containing protein 0.0182 0.0355 0.034
Giardia lamblia Kinase, NEK 0.0132 0.0216 0.1586
Echinococcus granulosus neuroglian 0.0071 0.0048 0.0081
Trypanosoma brucei aurora B kinase 0.0481 0.1177 1
Trichomonas vaginalis STE family protein kinase 0.0176 0.0338 0.2779
Echinococcus granulosus peroxidasin 0.0068 0.0042 0.0066
Echinococcus granulosus tyrosine kinase 0.0169 0.0319 0.0757
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0066 0.0035 0.005
Echinococcus granulosus c src tyrosine kinase 0.0134 0.0223 0.0517
Schistosoma mansoni protein kinase 0.0235 0.0499 0.1203
Echinococcus multilocularis tensin 0.006 0.0019 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0041 0.0065
Brugia malayi Protein kinase domain containing protein 0.011 0.0157 0.0142
Plasmodium vivax protein kinase Crk2 0.0114 0.0168 0.1392
Brugia malayi Prion-like- 0.0068 0.0041 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0481 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0068 0.0577
Brugia malayi casein kinase 1, delta 0.0066 0.0035 0.002
Echinococcus multilocularis suppressor of cytokine signaling 6 0.006 0.0019 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Schistosoma mansoni hypothetical protein 0.006 0.0019 0.0011
Onchocerca volvulus 0.0062 0.0023 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0168 0.1429
Echinococcus granulosus fibroblast growth factor receptor 4 0.025 0.0541 0.1307
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0481 0.1177 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0096 0.0116 0.0711
Entamoeba histolytica casein kinase, putative 0.0066 0.0035 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.1205 0.3167 0.7842
Loa Loa (eye worm) AGC/AKT protein kinase 0.0186 0.0364 0.035
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0145 0.0251 0.0237
Echinococcus multilocularis death associated protein kinase 1 0.0849 0.219 0.5411
Plasmodium falciparum protein kinase 5 0.0114 0.0168 0.1165
Onchocerca volvulus Tyrosine kinase homolog 0.1409 0.3729 1
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0159 0.1236
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0196 0.0392 0.0937
Trichomonas vaginalis STE family protein kinase 0.0154 0.0278 0.2262
Trichomonas vaginalis CMGC family protein kinase 0.0413 0.0991 0.8397
Brugia malayi serine/threonine-protein kinase 6 0.0481 0.1177 0.1164
Trypanosoma cruzi aurora B kinase, putative 0.0481 0.1177 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0111 0.0159 0.0144
Echinococcus granulosus protein kinase shaggy 0.0413 0.0991 0.2427
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0392 0.0931 0.0918
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Echinococcus granulosus serine threonine protein kinase nrc 0.0097 0.0121 0.0263
Echinococcus granulosus hypothetical protein 0.006 0.0019 0.0011
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0069 0.0044 0.0072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0193 0.0385 0.0922
Onchocerca volvulus 0.011 0.0157 0.0415
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Brugia malayi Tensin 0.006 0.0019 0.0004
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.006 0.0019 0.0011
Giardia lamblia Kinase, CMGC GSK 0.0413 0.0991 0.8368
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0071 0.0314
Plasmodium falciparum serine/threonine protein kinase, putative 0.0481 0.1177 1
Trypanosoma brucei protein kinase, putative 0.0079 0.0071 0.0314
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.006 0.0019 0.0004
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.0168 0.1165
Echinococcus granulosus activin receptor type 0.0078 0.0068 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0065 0.0428
Schistosoma mansoni tensin 0.006 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Trypanosoma brucei Casein kinase II 0.0096 0.0116 0.0711
Echinococcus granulosus SH2 domain containing protein 7 0.006 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.011 0.0157 0.0142
Brugia malayi protein kinase C3,putative 0.0146 0.0255 0.024
Loa Loa (eye worm) hypothetical protein 0.0082 0.008 0.0065
Entamoeba histolytica protein kinase, putative 0.0111 0.0159 0.1348
Schistosoma mansoni tyrosine kinase 0.0245 0.0526 0.1272
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0067 0.0038 0.0023
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0219 0.0455 0.1095
Entamoeba histolytica PH domain containing protein kinase, putative 0.0103 0.0136 0.1155
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0168 0.1318
Echinococcus granulosus casein kinase I delta 0.0066 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0201 0.0406 0.0392
Echinococcus multilocularis protein kinase c epsilon type 0.0147 0.0257 0.0602
Loa Loa (eye worm) AGC/NDR protein kinase 0.0111 0.0159 0.0144
Echinococcus granulosus tyrosine protein kinase Srms 0.011 0.0157 0.0353
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0193 0.0385 0.0922
Trypanosoma cruzi polo-like protein kinase, putative 0.0219 0.0455 0.3677
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0078 0.0068 0.0286
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0111 0.0159 0.0357
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0481 0.1177 0.2891
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0095 0.0114 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0086 0.0177
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0413 0.0991 0.0977
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.0168 0.0153
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0133 0.0219 0.0507
Trypanosoma brucei rac serine-threonine kinase, putative 0.0186 0.0364 0.2882
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0193 0.0385 0.0922
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0891 0.2305 0.5696
Echinococcus multilocularis 0.006 0.0019 0.0011
Echinococcus multilocularis Immunoglobulin 0.0133 0.0219 0.0507
Echinococcus multilocularis tyrosine protein kinase shark 0.011 0.0157 0.0353
Echinococcus granulosus neuroglian 0.0164 0.0305 0.0721
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0095 0.0114 0.0246
Echinococcus multilocularis nervana 2 0.0069 0.0044 0.0072
Brugia malayi Protein kinase domain 0.0176 0.0338 0.0323
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0413 0.0991 0.8368
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0392 0.0931 0.228
Brugia malayi protein-tyrosine kinase 0.0169 0.0319 0.0305
Echinococcus granulosus dual specificity 0.0118 0.0178 0.0405
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0176 0.0338 0.0803
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0178 0.0405
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0066 0.0035 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0159 0.0357
Loa Loa (eye worm) hypothetical protein 0.014 0.0238 0.0223
Loa Loa (eye worm) hypothetical protein 0.0082 0.008 0.0065
Echinococcus multilocularis signal transduction protein lnk realted 0.006 0.0019 0.0011
Brugia malayi STE20-like kinase MST 0.0253 0.0551 0.0536
Leishmania major protein kinase, putative 0.0481 0.1177 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0068 0.0041 0.0053
Entamoeba histolytica protein kinase, putative 0.0186 0.0364 0.3095
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0261 0.2119
Leishmania major protein kinase A catalytic subunit isoform 2 0.0068 0.0041 0.0053
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0079 0.0071 0.0314
Trichomonas vaginalis AGC family protein kinase 0.0481 0.1177 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0742 0.1895 0.4678
Onchocerca volvulus 0.0085 0.0088 0.023
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0413 0.0991 0.2427
Echinococcus granulosus casein kinase I alpha 0.0066 0.0035 0.005
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0079 0.0071 0.0056
Echinococcus granulosus tyrosine protein kinase shark 0.011 0.0157 0.0353
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0118 0.0178 0.0163
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.006 0.0019 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0395 0.0946
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0041 0.0053
Entamoeba histolytica hypothetical protein 0.0126 0.0201 0.1709
Echinococcus granulosus serine:threonine protein kinase MARK2 0.01 0.0127 0.028
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0481 0.1177 1
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.008 0.0074 0.0625
Toxoplasma gondii AGC kinase 0.0068 0.0041 0.0053
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Giardia lamblia Aurora kinase 0.0481 0.1177 1
Schistosoma mansoni tyrosine kinase 0.074 0.1888 0.4661
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0269 0.0593 0.1437
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0068 0.0041 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Brugia malayi Protein kinase domain containing protein 0.0114 0.0168 0.0153
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0095 0.0114 0.0246
Schistosoma mansoni protein kinase C mu 0.0145 0.0251 0.0588
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0096 0.0116 0.095
Loa Loa (eye worm) SRC-1 0.0193 0.0385 0.0371
Giardia lamblia Kinase, NEK 0.0132 0.0216 0.1586
Entamoeba histolytica casein kinase, putative 0.0096 0.0116 0.0989
Brugia malayi Casein kinase II, alpha chain 0.0096 0.0116 0.0102
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0066 0.0035 0.005
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.028 0.0659
Schistosoma mansoni tensin-related 0.006 0.0019 0.0011
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0168 0.1429
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0035 0.005
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0178 0.1248
Brugia malayi Immunoglobulin I-set domain containing protein 0.0071 0.0048 0.0033
Loa Loa (eye worm) TK/EGFR protein kinase 0.152 0.4034 0.4025
Entamoeba histolytica hypothetical protein 0.0126 0.0201 0.1709
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0057 0.048
Echinococcus granulosus casein kinase I alpha 0.0066 0.0035 0.005
Echinococcus multilocularis casein kinase ii subunit alpha 0.0096 0.0116 0.0252
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.0168 0.0381
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0392 0.0931 0.228
Schistosoma mansoni tyrosine kinase 0.0134 0.0223 0.0517
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.0168 0.0381
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0319 0.0732 0.1783
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0159 0.0357
Entamoeba histolytica protein kinase, putative 0.0481 0.1177 1
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0159 0.1236
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0069 0.0043 0.0028
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0187 0.0367 0.0875
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0071 0.0048 0.0081
Schistosoma mansoni tyrosine kinase 0.074 0.1888 0.4661
Echinococcus multilocularis protein kinase c iota type 0.0229 0.0483 0.1165
Loa Loa (eye worm) hypothetical protein 0.013 0.0211 0.0196
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0134 0.0223 0.0517
Schistosoma mansoni tyrosine-protein kinase zap-70 0.006 0.0019 0.0011
Loa Loa (eye worm) CDC7 protein kinase 0.0085 0.0088 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0367 0.0875
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0257 0.0602
Echinococcus granulosus tyrosine kinase 0.011 0.0157 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0367 0.0875
Brugia malayi RhoGAP domain containing protein 0.0095 0.0114 0.0099
Brugia malayi Protein kinase domain containing protein 0.0077 0.0065 0.005
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0097 0.0121 0.0263
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.0019 0.0004
Brugia malayi casein kinase I 0.0066 0.0035 0.002
Brugia malayi C1-like domain containing protein 0.0145 0.0251 0.0237
Brugia malayi protein unc-22 0.0062 0.0023 0.0008
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0261 0.0571 0.1384
Echinococcus multilocularis neuroglian 0.0071 0.0048 0.0081
Plasmodium vivax casein kinase 1, putative 0.0066 0.0035 0.0257
Echinococcus granulosus tyrosine protein kinase Src42A 0.0193 0.0385 0.0922
Schistosoma mansoni serine/threonine-protein kinase 0.0103 0.0136 0.0301
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.0085 0.0175
Giardia lamblia Kinase, CMGC CDK 0.0114 0.0168 0.1165
Echinococcus multilocularis serine:threonine protein kinase N2 0.0111 0.0159 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0159 0.1236
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0127 0.028
Echinococcus multilocularis casein kinase I delta 0.0066 0.0035 0.005
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0193 0.0385 0.0922
Onchocerca volvulus 0.0122 0.019 0.0504
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.121 0.3182 0.7881
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0035 0.005
Onchocerca volvulus 0.006 0.0019 0.0046
Echinococcus granulosus c-Jun N-terminal kinases 0.0261 0.0571 0.1384
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0413 0.0991 0.8368
Schistosoma mansoni protein kinase 0.0066 0.0035 0.005
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1154 0.3028 0.3018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0041 0.0026
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.0168 0.1165
Loa Loa (eye worm) hypothetical protein 0.0117 0.0175 0.016
Brugia malayi serine/threonine kinase 12 0.0481 0.1177 0.1164
Echinococcus multilocularis myosin iiia 0.008 0.0074 0.0146
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.0168 0.1165
Schistosoma mansoni tyrosine kinase 0.0134 0.0223 0.0517
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.0168 0.0381
Echinococcus multilocularis dual specificity 0.0118 0.0178 0.0405
Echinococcus multilocularis suppressor of cytokine signaling 7 0.006 0.0019 0.0011
Loa Loa (eye worm) CAMK/PKD protein kinase 0.011 0.0157 0.0142
Schistosoma mansoni titin 0.0068 0.0041 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0118 0.0178 0.1248
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.028 0.0659
Echinococcus granulosus tensin C1 domain containing phosphatase 0.006 0.0019 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0071 0.0314
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0168 0.1318
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0041 0.0053
Echinococcus granulosus nervana 2 0.0069 0.0044 0.0072
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.006 0.0019 0.0011
Trypanosoma brucei protein kinase, putative 0.0413 0.0991 0.8368
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.0168 0.0381
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0041 0.0026
Echinococcus granulosus CDC7 cell division cycle 7 0.0085 0.0088 0.0181
Echinococcus multilocularis rho associated protein kinase 0.1205 0.3167 0.7842
Loa Loa (eye worm) hypothetical protein 0.0066 0.0035 0.0019
Schistosoma mansoni suppressor of cytokine signaling 0.006 0.0019 0.0011
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0253 0.0551 0.0536
Toxoplasma gondii AGC kinase 0.018 0.0349 0.2749
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Brugia malayi Protein kinase domain containing protein 0.011 0.0157 0.0142
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0068 0.0041 0.0065
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1154 0.3028 0.3018
Echinococcus granulosus NDR protein kinase 0.0111 0.0159 0.0357
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.028 0.2143
Echinococcus granulosus protein kinase c iota type 0.0229 0.0483 0.1165
Echinococcus multilocularis epidermal growth factor receptor 0.152 0.4034 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0083 0.0082 0.0576
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0088 0.0626
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Plasmodium falciparum NIMA related kinase 1 0.0132 0.0216 0.1586
Echinococcus granulosus hemicentin 1 0.0068 0.0041 0.0065
Schistosoma mansoni tensin 0.006 0.0019 0.0011
Schistosoma mansoni tensin 0.006 0.0019 0.0011
Echinococcus granulosus tyrosine protein kinase Fyn 0.0193 0.0385 0.0922
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0261 0.0571 0.0557
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0069 0.0044 0.0072
Schistosoma mansoni tyrosine kinase 0.0841 0.2167 0.5354
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0148 0.026 0.0609
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.0216 0.1586
Brugia malayi SH2 domain containing protein 0.011 0.0157 0.0142
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1154 0.3028 0.7497
Brugia malayi SRC-1 0.0193 0.0385 0.0371
Echinococcus multilocularis aurora kinase A 0.0481 0.1177 0.2891
Brugia malayi SH2 domain containing protein 0.011 0.0157 0.0142
Brugia malayi intracellular kinase 0.0413 0.0991 0.0977
Loa Loa (eye worm) hypothetical protein 0.0069 0.0043 0.0028
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0097 0.0121 0.0749
Schistosoma mansoni vesicular amine transporter 0.0133 0.0219 0.0507
Echinococcus granulosus contactin 0.0071 0.0048 0.0081
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.006 0.0019 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0132 0.0216 0.1732
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0065 0.0428
Entamoeba histolytica protein kinase domain containing protein 0.0413 0.0991 0.8417
Echinococcus granulosus mitogen activated protein kinase 11 0.0155 0.028 0.0659
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0062 0.0023 0.0008
Loa Loa (eye worm) CAMK protein kinase 0.0062 0.0023 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Brugia malayi Variant SH3 domain containing protein 0.0095 0.0114 0.0099
Brugia malayi Protein kinase domain containing protein 0.0197 0.0395 0.0381
Echinococcus multilocularis serine:threonine protein kinase N2 0.0111 0.0159 0.0357
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0219 0.0455 0.3677
Schistosoma mansoni titin 0.0062 0.0023 0.002
Echinococcus multilocularis Immunoglobulin 0.0133 0.0219 0.0507
Entamoeba histolytica protein kinase, putative 0.0066 0.0035 0.03
Entamoeba histolytica SH2-protein kinase domain containing protein 0.011 0.0157 0.1333
Echinococcus multilocularis serine threonine protein kinase 0.0152 0.0272 0.0639
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0085 0.007
Schistosoma mansoni tyrosine kinase 0.0841 0.2167 0.5354
Echinococcus granulosus tyrosine protein kinase Fps85D 0.011 0.0157 0.0353
Trichomonas vaginalis AGC family protein kinase 0.0186 0.0364 0.3006
Brugia malayi Protein kinase domain containing protein 0.1154 0.3028 0.3018
Loa Loa (eye worm) hypothetical protein 0.0251 0.0543 0.0529
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0068 0.0041 0.0053
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.0168 0.0381
Schistosoma mansoni tyrosine kinase 0.0891 0.2305 0.5696
Echinococcus multilocularis twitchin 0.0059 0.0016 0.0003
Schistosoma mansoni nephrin 0.0071 0.0048 0.0081
Echinococcus granulosus tyrosine protein kinase Blk 0.0169 0.0319 0.0757
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0168 0.0381
Echinococcus granulosus signal transduction protein lnk realted 0.006 0.0019 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0023 0.002
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.025 0.0541 0.1307
Brugia malayi Protein kinase domain containing protein 0.0186 0.0364 0.035
Brugia malayi STAT protein, DNA binding domain containing protein 0.006 0.0019 0.0004
Echinococcus multilocularis tyrosine protein kinase Abl 0.0214 0.0443 0.1064
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Echinococcus multilocularis lachesin 0.0068 0.0041 0.0065
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.0168 0.1165
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Echinococcus multilocularis activin receptor type 0.0078 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0193 0.0385 0.0922
Trichomonas vaginalis AGC family protein kinase 0.0481 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0058 0.0043
Schistosoma mansoni tyrosine kinase 0.0259 0.0566 0.1371
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0176 0.0338 0.0803
Entamoeba histolytica protein kinase 2, putative 0.0097 0.0121 0.1026
Entamoeba histolytica protein kinase, putative 0.016 0.0293 0.249
Giardia lamblia Kinase, CMGC CDK 0.0114 0.0168 0.1165
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0189 0.0434
Schistosoma mansoni serine/threonine-protein kinase 0.0103 0.0136 0.0301
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0077 0.0065 0.0124
Onchocerca volvulus 0.011 0.0157 0.0415
Schistosoma mansoni tyrosine kinase 0.0118 0.0179 0.0407
Giardia lamblia Kinase, CMGC GSK 0.0413 0.0991 0.8368
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0111 0.0159 0.0357
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Brugia malayi Peroxidasin 0.0068 0.0042 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0481 0.1177 0.2891
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Schistosoma mansoni tyrosine kinase 0.0891 0.2305 0.5696
Echinococcus granulosus SH2 domain containing adapter protein F 0.006 0.0019 0.0011
Toxoplasma gondii aurora kinase 0.0481 0.1177 1
Echinococcus granulosus titin 0.0062 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0135 0.0225 0.0211
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0057 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0168 0.0381
Onchocerca volvulus 0.006 0.0019 0.0046
Brugia malayi Immunoglobulin I-set domain containing protein 0.0135 0.0225 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0571 0.1384
Onchocerca volvulus 0.006 0.0019 0.0046
Brugia malayi Immunoglobulin I-set domain containing protein 0.0071 0.0048 0.0033
Schistosoma mansoni hypothetical protein 0.0126 0.0201 0.0463
Leishmania major protein kinase, putative 0.0078 0.0068 0.0286
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Echinococcus multilocularis Glutaredoxin protein 5 0.0069 0.0044 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Loa Loa (eye worm) AUR protein kinase 0.0481 0.1177 0.1164
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.0168 0.0153
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.006 0.0019 0.0004
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0235 0.0499 0.1203
Brugia malayi Furin-like cysteine rich region family protein 0.152 0.4034 0.4025
Trichomonas vaginalis STE family protein kinase 0.0176 0.0338 0.2779
Echinococcus granulosus epidermal growth factor receptor 0.152 0.4034 1
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.0168 0.1165
Echinococcus multilocularis casein kinase I delta 0.0066 0.0035 0.005
Entamoeba histolytica protein kinase, putative 0.0088 0.0096 0.0816
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0071 0.0048 0.0081
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0041 0.0026
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0079 0.0071 0.0314
Echinococcus multilocularis PAK box P21 Rho binding 0.0126 0.0201 0.0463
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0133 0.0219 0.0507
Echinococcus multilocularis mitogen activated protein kinase 3 0.0079 0.0071 0.0139
Brugia malayi Tyrosine-protein kinase abl-1 0.0214 0.0443 0.0428
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.017 0.032 0.0759
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0126 0.0201 0.0186
Trypanosoma brucei protein kinase, putative 0.0078 0.0068 0.0286
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0196 0.0392 0.0377
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0193 0.0385 0.0922
Brugia malayi P21-Rho-binding domain containing protein 0.0126 0.0201 0.0186
Schistosoma mansoni tyrosine kinase 0.0193 0.0385 0.0922
Schistosoma mansoni protein kinase 0.0176 0.0338 0.0803
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Loa Loa (eye worm) AUR protein kinase 0.0481 0.1177 0.1164
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0155 0.028 0.0265
Loa Loa (eye worm) hypothetical protein 0.017 0.032 0.0305
Entamoeba histolytica hypothetical protein 0.0118 0.0178 0.151
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0097 0.0121 0.0986
Plasmodium falciparum protein kinase, putative 0.0078 0.0068 0.0286
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Echinococcus multilocularis tyrosine protein kinase Blk 0.0169 0.0319 0.0757
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.0168 0.1165
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Echinococcus granulosus ephrin type A receptor 4 A 0.0115 0.0169 0.0382
Entamoeba histolytica protein kinase, putative 0.0481 0.1177 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.006 0.0019 0.0011
Echinococcus granulosus tyrosine protein kinase otk 0.0068 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0113 0.0163 0.0149
Schistosoma mansoni nck2/grb4 0.0084 0.0085 0.0175
Echinococcus multilocularis roundabout 2 0.0071 0.0048 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2547 0.6299
Schistosoma mansoni adapter molecule crk 0.0084 0.0085 0.0175
Schistosoma mansoni protein kinase 0.0126 0.0201 0.0463
Schistosoma mansoni tyrosine kinase 0.011 0.0157 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0065 0.0124
Schistosoma mansoni protein kinase 0.0078 0.0068 0.0132
Echinococcus multilocularis 0.0455 0.1106 0.2714
Brugia malayi cell division control protein 2 homolog 0.0114 0.0168 0.0153
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0068 0.0286
Giardia lamblia Kinase, NEK 0.0132 0.0216 0.1586
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0071 0.0048 0.0081
Schistosoma mansoni tyrosine kinase 0.152 0.4034 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0238 0.0223
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0118 0.0179 0.1256
Brugia malayi P38 map kinase family protein 2 0.0155 0.028 0.0265
Schistosoma mansoni tyrosine kinase 0.0193 0.0385 0.0922
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0066 0.0035 0.005
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0197 0.0395 0.0381
Echinococcus multilocularis SH2 motif 0.006 0.0019 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0145 0.0251 0.0237
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1154 0.3028 0.812
Giardia lamblia Kinase, CDC7 0.0085 0.0088 0.046
Echinococcus granulosus tyrosine protein kinase Src64B 0.0193 0.0385 0.0922
Brugia malayi Immunoglobulin I-set domain containing protein 0.0281 0.0627 0.0612
Echinococcus multilocularis ephrin type A receptor 4 A 0.0115 0.0169 0.0382
Echinococcus granulosus tensin 0.006 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0174 0.0333 0.0318
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.006 0.0019 0.0011
Echinococcus granulosus protein kinase c epsilon type 0.0147 0.0257 0.0602
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.029 0.065 0.0636
Entamoeba histolytica p21-activated kinase 0.0182 0.0353 0.3001
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0111 0.0159 0.0357
Loa Loa (eye worm) hypothetical protein 0.0135 0.0225 0.0211
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0116 0.0989
Onchocerca volvulus 0.0117 0.0175 0.0463
Brugia malayi Stress-activated protein kinase jnk-1 0.0261 0.0571 0.0557
Trypanosoma cruzi Protein kinase B 0.0103 0.0136 0.0882
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0041 0.0226
Echinococcus multilocularis tyrosine protein kinase otk 0.0068 0.0041 0.0065
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0155 0.028 0.2143
Onchocerca volvulus 0.014 0.0238 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0088 0.0181
Trypanosoma brucei polo-like protein kinase 0.0219 0.0455 0.3677
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.01 0.0127 0.028
Schistosoma mansoni tyrosine kinase 0.0841 0.2167 0.5354
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0148 0.026 0.0245
Schistosoma mansoni protein kinase 0.0096 0.0116 0.0252
Schistosoma mansoni kinase 0.0125 0.0196 0.0451
Schistosoma mansoni cell adhesion molecule 0.0172 0.0327 0.0775
Echinococcus multilocularis NCK adaptor protein 0.0084 0.0085 0.0175
Trichomonas vaginalis CK1 family protein kinase 0.0066 0.0035 0.0174
Brugia malayi Protein kinase c protein 2 0.0104 0.0139 0.0124
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.006 0.0019 0.0011
Echinococcus multilocularis tyrosine protein kinase Srms 0.0169 0.0319 0.0757
Loa Loa (eye worm) hypothetical protein 0.0071 0.0048 0.0033
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.0085 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0041 0.0065
Schistosoma mansoni shc transforming protein 0.006 0.0019 0.0011
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0196 0.0392 0.0937
Echinococcus granulosus serine:threonine protein kinase 0.0069 0.0043 0.0069
Brugia malayi Protein kinase domain containing protein 0.0111 0.0159 0.0144
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.369 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0071 0.0482
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0176 0.0338 0.0803
Echinococcus granulosus PAK box P21 Rho binding 0.0126 0.0201 0.0463
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1547 0.4109 0.41
Loa Loa (eye worm) hypothetical protein 0.014 0.0238 0.0223
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0079 0.0071 0.0314
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Echinococcus multilocularis tensin 0.006 0.0019 0.0011
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0126 0.0201 0.0463
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0155 0.028 0.2143
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0455 0.1095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0041 0.0026
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.0168 0.1165
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0127 0.028
Echinococcus multilocularis serine:threonine protein kinase 0.0069 0.0043 0.0069
Brugia malayi serine/threonine-protein kinase plk-2 0.0219 0.0455 0.0441
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0169 0.0319 0.0757
Brugia malayi hypothetical protein 0.006 0.0019 0.0004
Echinococcus granulosus lachesin 0.0068 0.0041 0.0065
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.0019 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0071 0.0482
Echinococcus multilocularis fibroblast growth factor receptor 4 0.025 0.0541 0.1307
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0116 0.0873
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0043 0.0239
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.008 0.0074 0.0625
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0219 0.0455 0.0441
Schistosoma mansoni cell adhesion molecule 0.0071 0.0048 0.0081
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0041 0.0026
Onchocerca volvulus 0.1177 0.309 0.8286
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Onchocerca volvulus 0.006 0.0019 0.0046
Trichomonas vaginalis STE family protein kinase 0.0176 0.0338 0.2779
Echinococcus multilocularis SHC transforming protein 3 0.006 0.0019 0.0011
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1029 0.2683 0.6638
Brugia malayi P21-Rho-binding domain containing protein 0.0126 0.0201 0.0186
Echinococcus granulosus serine:threonine protein kinase MARK2 0.01 0.0127 0.028
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0148 0.026 0.0245
Entamoeba histolytica casein kinase 1, putative 0.0066 0.0035 0.0299
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0085 0.007
Echinococcus granulosus protein kinase C gamma type 0.0152 0.0272 0.0639
Brugia malayi p70 ribosomal S6 kinase beta 0.018 0.0349 0.0335
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0119 0.0182 0.0415
Trichomonas vaginalis CMGC family protein kinase 0.0085 0.0088 0.0626
Brugia malayi Fibronectin type III domain containing protein 0.0135 0.0225 0.0211
Loa Loa (eye worm) AUR protein kinase 0.0481 0.1177 0.1164
Giardia lamblia Kinase, CMGC CK2 0.0096 0.0116 0.0711
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0189 0.1499
Entamoeba histolytica protein kinase, putative 0.0109 0.0154 0.1306
Echinococcus granulosus NCK adaptor protein 0.0084 0.0085 0.0175
Echinococcus multilocularis serine:threonine protein kinase 3 0.0253 0.0551 0.1333
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.006 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Echinococcus granulosus cyclin dependent kinase 0.0114 0.0168 0.0381
Brugia malayi map kinase activated protein kinase protein 2 0.0392 0.0931 0.0918
Echinococcus granulosus aurora kinase A 0.0481 0.1177 0.2891
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0065 0.0428
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0481 0.1177 1
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0068 0.0041 0.0309
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0413 0.0991 0.8368
Echinococcus multilocularis insulin receptor 0.074 0.1888 0.4661
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0068 0.0041 0.0053
Echinococcus granulosus mitogen activated protein kinase 14 0.0155 0.028 0.0659
Echinococcus granulosus tyrosine protein kinase Fyn 0.0193 0.0385 0.0922
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0742 0.1895 0.4678
Schistosoma mansoni signal transduction protein lnk-related 0.006 0.0019 0.0011
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Entamoeba histolytica protein kinase, putative 0.0176 0.0338 0.2871
Schistosoma mansoni protein kinase 0.0176 0.0338 0.0803
Brugia malayi Protein kinase domain containing protein 0.0069 0.0043 0.0028
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0152 0.0272 0.0257
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0081 0.0077 0.0155
Echinococcus multilocularis roundabout 2 0.0203 0.0413 0.0989
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0413 0.0991 0.2427
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.121 0.3182 0.7881
Echinococcus granulosus epidermal growth factor receptor 0.0891 0.2305 0.5696
Echinococcus multilocularis rac serine:threonine kinase 0.0103 0.0136 0.0301
Echinococcus granulosus SH2 motif 0.006 0.0019 0.0011
Giardia lamblia Kinase, CMGC MAPK 0.0079 0.0071 0.0314
Loa Loa (eye worm) TK/ABL protein kinase 0.0319 0.0732 0.0718
Onchocerca volvulus 0.011 0.0157 0.0415
Echinococcus granulosus casein kinase ii subunit alpha 0.0096 0.0116 0.0252
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0178 0.1248
Schistosoma mansoni septate junction protein 0.0068 0.0041 0.0065
Schistosoma mansoni protein kinase 0.0154 0.0278 0.0654
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.025 0.0541 0.1307
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0235 0.0499 0.1203
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0068 0.0041 0.0065
Echinococcus granulosus nervana 2 0.0069 0.0044 0.0072
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0176 0.0338 0.0803
Echinococcus multilocularis serine:threonine protein kinase 38 0.0111 0.0159 0.0357
Toxoplasma gondii CMGC kinase, CK2 family 0.0096 0.0116 0.0711
Leishmania major casein kinase II, putative 0.0096 0.0116 0.0711
Echinococcus multilocularis mitogen activated protein kinase 0.0079 0.0071 0.0139
Echinococcus multilocularis epidermal growth factor receptor 0.0891 0.2305 0.5696
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Echinococcus granulosus titin 0.0062 0.0023 0.002
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0068 0.0286
Echinococcus multilocularis hemicentin 1 0.0068 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0026
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0095 0.0114 0.0246
Echinococcus granulosus mitogen activated protein kinase 3 0.0079 0.0071 0.0139
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0122 0.0189 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0159 0.0357
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0126 0.0201 0.0463
Echinococcus granulosus serine:threonine protein kinase N2 0.0111 0.0159 0.0357
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Echinococcus granulosus roundabout 2 0.0071 0.0048 0.0081
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.0085 0.007
Schistosoma mansoni GTPase activating protein 0.006 0.0019 0.0011
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0126 0.0201 0.0463
Echinococcus granulosus roundabout 2 0.0071 0.0048 0.0081
Echinococcus multilocularis SH2 motif 0.006 0.0019 0.0011
Schistosoma mansoni roundabout 0.0068 0.0041 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0618 0.5
Brugia malayi cytokine inducible SH2-containing protein 5 0.006 0.0019 0.0004
Brugia malayi tRNA modification GTPase TrmE family protein 0.006 0.0019 0.0004
Echinococcus multilocularis titin 0.0062 0.0023 0.002
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.0085 0.007
Leishmania major protein kinase A catalytic subunit 0.0068 0.0041 0.0053
Trichomonas vaginalis AGC family protein kinase 0.0481 0.1177 1
Schistosoma mansoni cell adhesion molecule 0.0071 0.0048 0.0081
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0148 0.026 0.0609
Echinococcus multilocularis casein kinase I alpha 0.0066 0.0035 0.005
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.0168 0.0381
Brugia malayi hypothetical protein 0.0135 0.0225 0.0211
Echinococcus multilocularis mitogen activated protein kinase 11 0.0155 0.028 0.0659
Loa Loa (eye worm) TK protein kinase 0.0109 0.0154 0.0139
Echinococcus multilocularis mitogen activated protein kinase 14 0.0155 0.028 0.0659
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0066 0.0035 0.002
Toxoplasma gondii AGC kinase 0.0068 0.0041 0.0053
Echinococcus granulosus Immunoglobulin 0.0133 0.0219 0.0507
Entamoeba histolytica protein kinase, putative 0.0154 0.0278 0.2361
Entamoeba histolytica protein kinase, putative 0.0186 0.0364 0.3095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0023 0.0008
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0068 0.0041 0.0053
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0069 0.0044 0.0029
Giardia lamblia Kinase, AGC AKT 0.0113 0.0163 0.1123
Entamoeba histolytica protein kinase, putative 0.0118 0.0178 0.151
Entamoeba histolytica protein kinase, putative 0.016 0.0293 0.249
Onchocerca volvulus 0.011 0.0157 0.0415
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.0216 0.1802
Entamoeba histolytica serine/threonine protein kinase, putative 0.0219 0.0455 0.3866
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0392 0.0937
Echinococcus granulosus SHC transforming protein 3 0.006 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0086 0.0091 0.0077
Schistosoma mansoni ste20-related kinase 0.0201 0.0407 0.0976
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0016 0.0003
Echinococcus granulosus N chimaerin 0.0095 0.0114 0.0246
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0193 0.0385 0.0922
Echinococcus granulosus casein kinase I alpha 0.0066 0.0035 0.005
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.01 0.0127 0.028
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.0168 0.1165
Schistosoma mansoni ephrin receptor 0.0115 0.0169 0.0382
Echinococcus granulosus Protein kinase C brain isozyme 0.0187 0.0367 0.0875
Echinococcus multilocularis PAK box P21 Rho binding 0.0154 0.0278 0.0654
Brugia malayi Hr1 repeat family protein 0.0111 0.0159 0.0144
Brugia malayi hypothetical protein 0.011 0.0157 0.0142
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0041 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Loa Loa (eye worm) TK/EPH protein kinase 0.0132 0.0217 0.0202
Loa Loa (eye worm) hypothetical protein 0.006 0.0019 0.0004
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0068 0.0041 0.0026
Echinococcus granulosus tyrosine protein kinase Lyn 0.0221 0.0462 0.1113
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0041 0.0053
Schistosoma mansoni atypical protein kinase C 0.0235 0.05 0.1207
Schistosoma mansoni tyrosine kinase 0.0176 0.0339 0.0805
Onchocerca volvulus 0.011 0.0157 0.0415
Schistosoma mansoni nephrin 0.0166 0.0311 0.0737
Schistosoma mansoni tyrosine kinase 0.025 0.0541 0.1307
Loa Loa (eye worm) hypothetical protein 0.0148 0.0261 0.0247
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0413 0.0991 0.0977
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1337 0.353 0.352
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0269 0.0593 0.1437
Loa Loa (eye worm) AGC/PKA protein kinase 0.0068 0.0041 0.0026
Brugia malayi ephrin receptor 1 precursor 0.008 0.0075 0.006
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0065 0.005
Echinococcus granulosus suppressor of cytokine signaling 6 0.006 0.0019 0.0011
Brugia malayi Protein kinase domain containing protein 0.074 0.1888 0.1876
Echinococcus granulosus expressed conserved protein 0.006 0.0019 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0189 0.1499
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.006 0.0019 0.0046
Trichomonas vaginalis STE family protein kinase 0.0132 0.0216 0.1732
Schistosoma mansoni serine/threonine protein kinase 0.1154 0.3028 0.7497
Entamoeba histolytica protein kinase, putative 0.018 0.0349 0.2966
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0168 0.1318
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0068 0.0041 0.0053
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.0168 0.0153
Loa Loa (eye worm) hypothetical protein 0.009 0.0101 0.0086
Onchocerca volvulus Serine\/threonine kinase homolog 0.0219 0.0455 0.1215
Schistosoma mansoni hypothetical protein 0.0126 0.0201 0.0463
Brugia malayi Protein kinase domain containing protein 0.0118 0.0178 0.0163
Schistosoma mansoni tensin-related 0.006 0.0019 0.0011
Schistosoma mansoni serine/threonine kinase 0.0111 0.0159 0.0357
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0118 0.0178 0.1248
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.008 0.0074 0.0336
Echinococcus multilocularis CDC7 cell division cycle 7 0.0085 0.0088 0.0181
Schistosoma mansoni protein kinase 0.0481 0.1177 0.2891
Echinococcus granulosus suppressor of cytokine signaling 7 0.006 0.0019 0.0011
Giardia lamblia Kinase, AGC PKA 0.0068 0.0041 0.0053
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0081 0.0077 0.0155
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Echinococcus granulosus serine:threonine protein kinase 0.0069 0.0043 0.0069
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.012 0.0183 0.0168
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0077 0.0065 0.005
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0066 0.0035 0.002
Brugia malayi protein kinase C II. 0.0147 0.0257 0.0242
Trypanosoma cruzi polo-like protein kinase, putative 0.0219 0.0455 0.3677
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0193 0.0385 0.0922
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0077 0.0065 0.0124
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0176 0.0338 0.0803
Echinococcus granulosus raf serine:threonine protein kinase 0.0085 0.0086 0.0177
Entamoeba histolytica protein kinase, putative 0.0077 0.0065 0.055
Loa Loa (eye worm) protein-tyrosine phosphatase 0.006 0.0019 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.1547 0.4109 0.41
Onchocerca volvulus 0.011 0.0157 0.0415
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.0019 0.0004
Loa Loa (eye worm) STAT protein 0.006 0.0019 0.0004
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0066 0.0035 0.002
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0111 0.0159 0.0144
Echinococcus multilocularis hemicentin 1 0.0068 0.0041 0.0065
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.006 0.0019 0.0011
Loa Loa (eye worm) TK/ROR protein kinase 0.0081 0.0077 0.0062
Echinococcus multilocularis c src tyrosine kinase 0.0134 0.0223 0.0517
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1154 0.3028 0.7497
Echinococcus granulosus insulin receptor 0.074 0.1888 0.4661
Entamoeba histolytica protein kinase domain containing protein 0.0413 0.0991 0.8417
Echinococcus granulosus SH2 motif 0.006 0.0019 0.0011
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0071 0.0048 0.0081
Onchocerca volvulus 0.006 0.0019 0.0046
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.0168 0.1165
Echinococcus granulosus tyrosine protein kinase ABL1 0.0319 0.0732 0.1783
Schistosoma mansoni vav2 0.01 0.0129 0.0284
Loa Loa (eye worm) hypothetical protein 0.009 0.0101 0.0086
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0096 0.0116 0.0102
Loa Loa (eye worm) TK/INSR protein kinase 0.074 0.1888 0.1876
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.026 0.0609
Echinococcus multilocularis protein kinase shaggy 0.0413 0.0991 0.2427
Brugia malayi WH1 domain containing protein 0.0126 0.0201 0.0186
Echinococcus granulosus serine/threonine protein kinase 0.0103 0.0136 0.0301
Onchocerca volvulus 0.0066 0.0035 0.0089
Echinococcus granulosus casein kinase i 0.0066 0.0035 0.005
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0193 0.0385 0.0922
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.0455 0.3787
Echinococcus multilocularis serine:threonine protein kinase 0.0069 0.0043 0.0069
Echinococcus granulosus serine:threonine protein kinase 3 0.0253 0.0551 0.1333
Loa Loa (eye worm) TK protein kinase 0.0281 0.0627 0.0612
Echinococcus granulosus Glutaredoxin protein 5 0.0069 0.0044 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0041 0.0065
Entamoeba histolytica PH domain containing protein kinase, putative 0.0103 0.0136 0.1155
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0097 0.0121 0.0263
Loa Loa (eye worm) TK/FER protein kinase 0.011 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0135 0.0225 0.0211
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0079 0.0071 0.0314
Brugia malayi MAP kinase sur-1 0.0079 0.0071 0.0056
Leishmania major protein kinase A catalytic subunit isoform 1 0.0068 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.0201 0.0406 0.0392
Echinococcus granulosus tyrosine protein kinase Src42A 0.0119 0.0182 0.0415
Echinococcus multilocularis casein kinase i 0.0066 0.0035 0.005
Leishmania major protein kinase, putative 0.008 0.0074 0.0336
Entamoeba histolytica protein kinase, putative 0.0118 0.0178 0.151
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0071 0.0482
Loa Loa (eye worm) hypothetical protein 0.0133 0.0219 0.0204
Echinococcus multilocularis SH2 motif 0.006 0.0019 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0041 0.0026
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0098 0.0124 0.011
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0103 0.0136 0.0882
Loa Loa (eye worm) TK protein kinase 0.0169 0.0319 0.0305
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0126 0.0201 0.0463
Onchocerca volvulus 0.0065 0.0031 0.0078
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0079 0.0071 0.0314
Giardia lamblia Kinase, STE STE20 0.008 0.0074 0.0336
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.0168 0.0381
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0122 0.0189 0.0434
Trichomonas vaginalis STE family protein kinase 0.008 0.0074 0.0504
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0145 0.0251 0.0237
Brugia malayi Protein kinase domain containing protein 0.011 0.0157 0.0142
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0071 0.0048 0.0081
Trichomonas vaginalis CK1 family protein kinase 0.0066 0.0035 0.0174
Onchocerca volvulus 0.0413 0.0991 0.2653
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0178 0.151
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.0085 0.0175
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.011 0.0157 0.0353
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0133 0.0219 0.0507
Giardia lamblia Kinase, AGC PKA 0.0097 0.0121 0.0749
Entamoeba histolytica protein kinase, putative 0.0066 0.0035 0.03
Brugia malayi Protein kinase domain containing protein 0.0111 0.0159 0.0144
Schistosoma mansoni SH2A 0.006 0.0019 0.0011
Echinococcus multilocularis tyrosine protein kinase HCK 0.0109 0.0154 0.0345
Loa Loa (eye worm) hypothetical protein 0.0122 0.019 0.0175
Echinococcus granulosus mitogen activated protein kinase 0.0079 0.0071 0.0139
Echinococcus multilocularis nervana 2 0.0069 0.0044 0.0072
Echinococcus granulosus rho-associated protein kinase 1 0.1205 0.3167 0.7842
Brugia malayi Protein kinase domain containing protein 0.0085 0.0088 0.0073
Echinococcus granulosus defective proboscis extension response 0.0133 0.0219 0.0507
Echinococcus granulosus roundabout 2 0.0203 0.0413 0.0989
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0071 0.0482
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0085 0.0175
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0193 0.0385 0.0922
Echinococcus multilocularis roundabout 2 0.0071 0.0048 0.0081
Echinococcus granulosus twitchin 0.0192 0.0381 0.0911
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0079 0.0071 0.0314
Brugia malayi SH2 domain containing protein 0.006 0.0019 0.0004
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0074 0.0336
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0155 0.028 0.2143
Brugia malayi Tyrosine-protein kinase abl-1 0.0129 0.0209 0.0194
Echinococcus granulosus casein kinase I delta 0.0066 0.0035 0.005
Echinococcus granulosus tyrosine protein kinase HCK 0.0109 0.0154 0.0345
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0088 0.0096 0.0816
Schistosoma mansoni septate junction protein 0.0068 0.0041 0.0065
Brugia malayi Variant SH3 domain containing protein 0.0067 0.0038 0.0023
Brugia malayi Protein kinase domain containing protein 0.0195 0.0389 0.0375
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0068 0.0041 0.0065
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0176 0.0338 0.0803
Entamoeba histolytica SH2 domain containing protein 0.006 0.0019 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0189 0.0434
Schistosoma mansoni cell adhesion molecule 0.0068 0.0041 0.0065
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0068 0.0041 0.0053
Schistosoma mansoni suppressor of cytokine signaling 0.006 0.0019 0.0011
Onchocerca volvulus 0.0085 0.0088 0.023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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