Detailed information for compound 1382707

Basic information

Technical information
  • TDR Targets ID: 1382707
  • Name: 3-(3-aminophenyl)sulfonylaniline
  • MW: 248.301 | Formula: C12H12N2O2S
  • H donors: 2 H acceptors: 2 LogP: 1.36 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc(c1)S(=O)(=O)c1cccc(c1)N
  • InChi: 1S/C12H12N2O2S/c13-9-3-1-5-11(7-9)17(15,16)12-6-2-4-10(14)8-12/h1-8H,13-14H2
  • InChiKey: LJGHYPLBDBRCRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-(3-aminophenyl)sulfonylphenyl]amine
  • 599-61-1
  • 3,3′-Sulfonyldianiline
  • 3-Aminophenyl sulfone
  • A74602_ALDRICH
  • 3,3'-Diaminodiphenyl sulfone
  • 3,3'-Diaminophenyl sulfone
  • 3,3'-Sulfonylbis(aniline)
  • 3,3'-Sulfonyldianiline
  • 3,3'-Sulfonyldianiline-
  • Aniline, 3,3'-sulfonyldi-
  • Benzenamine, 3,3'-sulfonylbis-
  • Bis(m-aminophenyl) sulfone
  • NSC20610
  • Sulfone, bis(3-aminophenyl)
  • Sulfone, bis(m-aminophenyl)
  • WLN: ZR CSWR CZ
  • ZINC00154581
  • Oprea1_316800
  • MLS000080522
  • SBB003169
  • InChI=1/C12H12N2O2S/c13-9-3-1-5-11(7-9)17(15,16)12-6-2-4-10(14)8-12/h1-8H,13-14H
  • 3,3'-Diaminodifenylsulfon [Czech]
  • 3,3'-Sulfonylbisbenzenamine
  • 3,3'-Sulphonyldianiline
  • 4-13-00-01009 (Beilstein Handbook Reference)
  • AI3-52564
  • BRN 2215938
  • EINECS 209-967-5
  • NSC 20610
  • SMR000034089

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.1134 0.571
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0163
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.1134 0.1172
Onchocerca volvulus 0.0033 0.0333 0.0439
Brugia malayi hypothetical protein 0.0016 0.0061 0.0054
Toxoplasma gondii thioredoxin reductase 0.0052 0.0639 0.805
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0321 0.0286
Echinococcus granulosus flap endonuclease 1 0.0028 0.0267 0.0263
Entamoeba histolytica deoxycytidyl transferase, putative 0.0082 0.1134 1
Echinococcus multilocularis geminin 0.0344 0.5333 0.5331
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.0714 0.071
Mycobacterium ulcerans hypothetical protein 0.0026 0.0226 0.0145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0114
Brugia malayi hypothetical protein 0.0484 0.7577 0.7575
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0226 0.0145
Echinococcus multilocularis jun protein 0.0175 0.2614 0.2611
Brugia malayi steroid hormone receptor 0.0056 0.0714 0.0708
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0237 0.0232
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0237 0.023
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0522 0.0517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0714 0.0708
Toxoplasma gondii hypothetical protein 0.0061 0.0785 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0288 0.0281
Loa Loa (eye worm) hypothetical protein 0.0484 0.7577 0.7575
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.0714 0.071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0714 0.071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.0714 0.0943
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0039 0.0486
Loa Loa (eye worm) hypothetical protein 0.0114 0.1642 0.1637
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0237 0.0232
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0226 0.0145
Loa Loa (eye worm) hypothetical protein 0.017 0.2537 0.2533
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0267 0.0256
Schistosoma mansoni hypothetical protein 0.0635 1 1
Onchocerca volvulus 0.0027 0.0237 0.0312
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0021 0.0015
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0267 0.2079
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0061 0.0024
Leishmania major protein kinase, putative 0.0016 0.0061 0.006
Echinococcus multilocularis Ankyrin 0.0018 0.0091 0.0087
Loa Loa (eye worm) hypothetical protein 0.0129 0.1885 0.1879
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0096 0.1355 0.135
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.1134 0.3067
Brugia malayi hypothetical protein 0.0096 0.1355 0.135
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.1134 0.571
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0039 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0714 0.068
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0221 0.0509
Trypanosoma cruzi DNA polymerase eta, putative 0.0026 0.0221 0.0509
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.3483 0.3479
Brugia malayi nuclear receptor NHR-67 0.0027 0.0237 0.023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0323 0.0317
Echinococcus granulosus jun protein 0.0175 0.2614 0.2611
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0085
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0237 0.0312
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0089 0.0084
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0237 0.0232
Loa Loa (eye worm) hypothetical protein 0.003 0.0288 0.0281
Onchocerca volvulus Alhambra homolog 0.0032 0.0321 0.0424
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.0714 0.071
Plasmodium falciparum thioredoxin reductase 0.0052 0.0639 0.8127
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0237 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0114
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0098 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0061
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0098 0.0066
Trypanosoma brucei unspecified product 0.0057 0.0723 0.1916
Loa Loa (eye worm) hypothetical protein 0.0017 0.0089 0.0082
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0098 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0056 0.0714 0.068
Plasmodium falciparum thioredoxin reductase 0.0018 0.0098 0.1146
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0639 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.0714 0.0708
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0098 0.0163
Loa Loa (eye worm) glutaminase 2 0.0569 0.8938 0.8938
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.0714 0.0708
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0134 0.0127
Leishmania major hypothetical protein, conserved 0.0237 0.3608 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.0327
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0098 0.141
Brugia malayi nuclear hormone receptor 0.0056 0.0714 0.0708
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0226 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0232 0.054
Plasmodium falciparum carbonic anhydrase 0.0061 0.0785 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.0714 0.0708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.0714 0.0708
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0069 0.0065
Brugia malayi polk-prov protein 0.0026 0.0221 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.4339 0.4831
Trypanosoma brucei trypanothione reductase 0.0052 0.0639 0.1681
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0082 0.1134 0.1101
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Echinococcus multilocularis lamin 0.0033 0.0333 0.0329
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0237 0.0232
Entamoeba histolytica hypothetical protein 0.0075 0.1012 0.8883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0237 0.0232
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0714 0.068
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0232 0.054
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1485 0.1481
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0061 0.0785 0.0779
Brugia malayi nuclear receptor NHR-88 0.0027 0.0237 0.023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0237 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0104 0.0035
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0635 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0104 0.0035
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0039 0.0486
Brugia malayi bZIP transcription factor family protein 0.0175 0.2614 0.2609
Loa Loa (eye worm) hypothetical protein 0.003 0.0288 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0714 0.071
Onchocerca volvulus 0.0045 0.0532 0.0702
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0782 0.9958
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0232 0.288
Plasmodium vivax glutathione reductase, putative 0.0052 0.0639 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0089 0.0117
Schistosoma mansoni cpg binding protein 0.0032 0.0323 0.0288
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0082 0.1134 0.113
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.1134 0.3067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.1237 0.1234
Schistosoma mansoni hypothetical protein 0.0344 0.5333 0.5316
Loa Loa (eye worm) glutaminase 0.0569 0.8938 0.8938
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.142 0.1416
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0221 0.2438
Leishmania major carbonic anhydrase-like protein 0.0061 0.0785 0.2089
Brugia malayi jmjC domain containing protein 0.0104 0.1485 0.1479
Echinococcus granulosus death domain containing protein 0.0017 0.0089 0.0084
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.1702 0.8837
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Echinococcus granulosus aryl hydrocarbon receptor 0.013 0.1893 0.1889
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.0714 0.0708
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.0714 0.068
Echinococcus granulosus cpg binding protein 0.0034 0.0352 0.0348
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0816 0.0813
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0288 0.0281
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0226 0.0145
Echinococcus granulosus carbonic anhydrase II 0.0061 0.0785 0.0781
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.1134 0.1128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Echinococcus granulosus carbonic anhydrase 0.0061 0.0785 0.0781
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.1134 0.1128
Echinococcus multilocularis musashi 0.0033 0.0333 0.0329
Leishmania major DNA polymerase eta, putative 0.0082 0.1134 0.3067
Echinococcus granulosus lamin 0.0033 0.0333 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.142 0.1389
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0061 0.0785 0.0751
Schistosoma mansoni terminal deoxycytidyl transferase 0.0082 0.1134 0.1101
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0061 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0714 0.071
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.003
Schistosoma mansoni carbonic anhydrase 0.0061 0.0785 0.0751
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Schistosoma mansoni carbonic anhydrase-related 0.0061 0.0785 0.0751
Echinococcus granulosus single minded 2 0.0044 0.0524 0.052
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0061 0.0785 0.0779
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.0714 0.068
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0714 0.068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.142 0.1389
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Leishmania major DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0267 0.0638
Echinococcus multilocularis carbonic anhydrase II 0.0061 0.0785 0.0781
Echinococcus multilocularis lamin dm0 0.0033 0.0333 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0714 0.0708
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0458 0.0452
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.142 0.1415
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0898 0.0865
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0237 0.0201
Echinococcus granulosus carbonic anhydrase 0.0061 0.0785 0.0781
Loa Loa (eye worm) hypothetical protein 0.0484 0.7577 0.7575
Brugia malayi Bromodomain containing protein 0.0032 0.0321 0.0315
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.0714 0.071
Brugia malayi hypothetical protein 0.003 0.0288 0.0281
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0114 0.1634 0.1628
Loa Loa (eye worm) hypothetical protein 0.0114 0.1634 0.1628
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0458 0.0454
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.142 0.1415
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.4339 0.4831
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0816 0.0783
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0333 0.0327
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0121 0.0026
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0267 0.026
Brugia malayi nuclear hormone receptor 0.0027 0.0237 0.023
Echinococcus granulosus Ankyrin 0.0018 0.0091 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0114
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Schistosoma mansoni carbonic anhydrase-related 0.0061 0.0785 0.0751
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0026 0.0221 0.2438
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0098 0.0163
Echinococcus granulosus carbonic anhydrase 0.0061 0.0785 0.0781
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.009 0.0084
Brugia malayi MH2 domain containing protein 0.013 0.1904 0.1898
Entamoeba histolytica hypothetical protein 0.0075 0.1012 0.8883
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.1913 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0093
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0098 0.141
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0232 0.3544
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1012 0.1008
Onchocerca volvulus 0.0484 0.7577 1
Schistosoma mansoni coup transcription factor 0.0056 0.0714 0.068
Mycobacterium ulcerans hypothetical protein 0.0027 0.0248 0.017
Brugia malayi Flap endonuclease-1 0.0028 0.0267 0.026
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0061 0.006
Brugia malayi hypothetical protein 0.0027 0.0237 0.023
Brugia malayi nuclear receptor RXR 0.0027 0.0237 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.142 0.1416
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0635 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.0714 0.0708
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0221 0.0509
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0121 0.0128
Echinococcus multilocularis peregrin 0.0032 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.003 0.0288 0.0281
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0061 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0089 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0237 0.0201
Schistosoma mansoni cpg binding protein 0.0034 0.0352 0.0317
Mycobacterium ulcerans putative regulatory protein 0.0044 0.0524 0.0482
Echinococcus multilocularis dna polymerase eta 0.0082 0.1134 0.113
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0237 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0221 0.0509
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0288 0.0252
Echinococcus multilocularis aryl hydrocarbon receptor 0.013 0.1893 0.1889
Brugia malayi hypothetical protein 0.0017 0.0083 0.0076
Echinococcus multilocularis carbonic anhydrase 0.0061 0.0785 0.0781
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.4339 0.4831
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0226 0.0145
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.1702 0.8837
Giardia lamblia DINP protein human, muc B family 0.0082 0.1134 1
Plasmodium falciparum glutathione reductase 0.0052 0.0639 0.8127
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0282 0.4339 0.4335
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0237 0.023
Brugia malayi hypothetical protein 0.0027 0.0237 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.2941 0.3261
Trypanosoma brucei chrX additional, unordered contigs 0.0026 0.0221 0.0509
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0061 0.006
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0248 0.0243
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0039 0.0035
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.1913 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0321 0.3785
Schistosoma mansoni DNA polymerase eta 0.0082 0.1134 0.1101
Loa Loa (eye worm) hypothetical protein 0.003 0.0288 0.0281
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.1134 0.3067
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.0714 0.071
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0635 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0232 0.2587
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0226 0.0145
Trichomonas vaginalis glutaminase, putative 0.0569 0.8938 1
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0089 0.0084
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0069 0.0065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.0714 0.071
Entamoeba histolytica hypothetical protein 0.0075 0.1012 0.8883
Schistosoma mansoni single-minded 0.006 0.0774 0.0741
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0221 0.0509
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0321 0.0317
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.0714 0.068
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0061 0.0785 0.0779
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0267 0.0263
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0237 0.0201
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0226 0.0892
Schistosoma mansoni eyes absent homolog 0.0096 0.1355 0.1324
Schistosoma mansoni hypothetical protein 0.0142 0.2089 0.206
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0267 0.0638
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0714 0.0943
Brugia malayi Death domain containing protein 0.0017 0.0089 0.0082
Trypanosoma brucei hypothetical protein, conserved 0.0237 0.3608 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0232 0.054
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0089 0.0082
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0237 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0639 0.0635
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0639 0.0635
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.1702 0.8837
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.4339 0.4831
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0039 0.0033
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0816 0.081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0098 0.0163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0232 0.0226
Mycobacterium ulcerans hypothetical protein 0.0027 0.0248 0.017
Schistosoma mansoni hypothetical protein 0.0344 0.5333 0.5316
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0221 0.0509
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.0714 0.0708
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0114
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0098 0.0533
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0237 0.0201
Plasmodium falciparum glutathione reductase 0.0018 0.0098 0.1146
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0061 0.0785 0.0779
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1904 0.1898
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0221 0.0509
Schistosoma mansoni netrin receptor unc5 0.0017 0.0089 0.0053
Echinococcus granulosus dna polymerase kappa 0.0082 0.1134 0.113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0046
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0267 0.0638
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0061 0.0785 0.0779
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.1913 1
Onchocerca volvulus 0.0137 0.2012 0.2656
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0221 0.0509
Echinococcus multilocularis cpg binding protein 0.0034 0.0352 0.0348
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0039 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0082 0.1134 0.113
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0288 0.0283
Mycobacterium ulcerans glutaminase 0.0569 0.8938 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0333 0.0329
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0098 0.1146
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.1237 0.1234
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.0714 0.068
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0237 0.023
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0098 0.0163
Schistosoma mansoni lozenge 0.0061 0.0784 0.0751
Brugia malayi glutathione reductase 0.0052 0.0639 0.0633
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0046
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0062 0.0058
Brugia malayi Thioredoxin reductase 0.0052 0.0639 0.0633
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0226 0.1706
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.1702 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0723 0.1916
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0061 0.0785 0.0779
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.0039 0.0395
Leishmania major DNA damage repair protein, putative 0.0026 0.0221 0.0509
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0237 0.0232
Trypanosoma brucei unspecified product 0.0057 0.0723 0.1916
Trypanosoma brucei unspecified product 0.0082 0.1134 0.3067
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0226 0.0523
Brugia malayi PHD-finger family protein 0.0032 0.0321 0.0315
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0226 0.022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0226 0.0892
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0248 0.017
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0866 0.086
Plasmodium falciparum DNA repair protein REV1, putative 0.0026 0.0221 0.2737
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0056
Schistosoma mansoni flap endonuclease-1 0.0026 0.0223 0.0187
Onchocerca volvulus 0.0129 0.1885 0.2487
Schistosoma mansoni glutaminase 0.0569 0.8938 0.8934
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0237 0.0232
Onchocerca volvulus 0.0032 0.0323 0.0426
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Schistosoma mansoni aryl hydrocarbon receptor 0.0174 0.2607 0.2579
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Leishmania major trypanothione reductase 0.0052 0.0639 0.1681
Brugia malayi ecdysteroid receptor 0.0056 0.0714 0.0708
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0458 0.0423
Loa Loa (eye worm) hypothetical protein 0.0055 0.0687 0.0681
Echinococcus multilocularis 0.0014 0.0039 0.0035
Brugia malayi follicle stimulating hormone receptor 0.0229 0.3483 0.3479
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.0714 0.0708
Schistosoma mansoni hypothetical protein 0.0635 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1904 0.1898
Trichomonas vaginalis DNA polymerase eta, putative 0.0082 0.1134 0.123
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0237 0.0232
Treponema pallidum NADH oxidase 0.0018 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.022
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0098 0.0782
Leishmania major DNA polymerase eta, putative 0.0026 0.0221 0.0509
Onchocerca volvulus 0.0026 0.0226 0.0298
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0098 0.6117
Brugia malayi nuclear receptor RXR 0.003 0.0288 0.0281
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.0714 0.068
Schistosoma mansoni intermediate filament proteins 0.0033 0.0333 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0096 0.1355 0.135
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0248 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.0714 0.0708
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0321 0.496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.142 0.1416
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0091 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0215
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.1134 0.3067
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0522 0.0517
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0226 0.0145
Loa Loa (eye worm) hypothetical protein 0.0032 0.0321 0.0315
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0061 0.006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0121 1
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0639 0.0633
Echinococcus granulosus dna polymerase eta 0.0082 0.1134 0.113
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0061 0.0785 0.2089
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0333 0.0327
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.1134 0.1172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0121 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0714 0.0708
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0061 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0723 0.1916
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.0714 0.0708
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0232 0.288
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0714 0.0708
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0061 0.0785 0.0779
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0098 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0175 0.2614 0.2611
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.0714 0.0708
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0061 0.0785 0.0779
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0061 0.0024
Brugia malayi nuclear receptor NHR-88 0.0056 0.0714 0.0708
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0098 0.0163
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0061 0.0024
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0061 0.0024
Schistosoma mansoni lamin 0.0033 0.0333 0.0298
Loa Loa (eye worm) hypothetical protein 0.0061 0.0785 0.0779
Echinococcus multilocularis Protein lozenge 0.0061 0.0784 0.078
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0237 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.4339 0.4831
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.0221 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0226 0.022
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0267 0.3053
Plasmodium falciparum flap endonuclease 1 0.0028 0.0267 0.3328
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0723 0.1916
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0248 0.0584
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0226 0.1706
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0082 0.1134 0.123
Loa Loa (eye worm) runx1 0.0061 0.0784 0.0778
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0098 0.0163
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Onchocerca volvulus 0.0027 0.0237 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.0714 0.0708
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1012 0.0979
Mycobacterium tuberculosis Probable reductase 0.0118 0.1702 0.8837
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0226 0.0523
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.4339 0.4831
Schistosoma mansoni carbonic anhydrase-related 0.0061 0.0785 0.0751
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0288 0.0283
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0221 0.0509
Mycobacterium tuberculosis Conserved protein 0.0027 0.0248 0.0827
Echinococcus multilocularis carbonic anhydrase 0.0061 0.0785 0.0781
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.0714 0.0708
Echinococcus multilocularis thyroid hormone receptor alpha 0.0056 0.0714 0.071
Echinococcus granulosus FTZ F1 alpha 0.0056 0.0714 0.071
Brugia malayi CXXC zinc finger family protein 0.0032 0.0323 0.0317
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0061 0.006
Schistosoma mansoni jumonji domain containing protein 0.0083 0.114 0.1108
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0098 0.0163
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0061 0.0785 0.0751
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0098 0.1146
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0248 0.0243
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0061 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.0714 0.068
Brugia malayi hypothetical protein 0.0026 0.0232 0.0226
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0226 0.0707
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0226 0.0523
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.0714 0.071
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0248 0.0584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0323 0.0317
Brugia malayi tailless protein 0.0027 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0237 0.0232
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0061 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0221 0.0509
Brugia malayi conserved hypotetical protein 0.0027 0.0237 0.023
Schistosoma mansoni lamin 0.0033 0.0333 0.0298
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0748 0.0742
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0714 0.071
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0061 0.0785 0.2089
Echinococcus multilocularis carbonic anhydrase 0.0061 0.0785 0.0781
Mycobacterium ulcerans hypothetical protein 0.0026 0.0221 0.014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0226 0.1706
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0524 0.052
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0267 0.4095
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0089 0.0053
Leishmania major hypothetical protein, conserved 0.0026 0.0232 0.054
Brugia malayi jmjC domain containing protein 0.004 0.0458 0.0452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.142 0.1389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0714 0.0708
Loa Loa (eye worm) glutathione reductase 0.0052 0.0639 0.0633
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0524 0.0518
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0226 0.0145
Onchocerca volvulus 0.0033 0.0333 0.0439
Schistosoma mansoni jun-related protein 0.0142 0.2089 0.206
Onchocerca volvulus 0.0056 0.0714 0.0943
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0104 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0056 0.0714 0.071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0226 0.0707
Brugia malayi hypothetical protein 0.0137 0.2012 0.2007
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.2941 0.3261
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0237 0.0312
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.1134 0.3067
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1485 0.1481
Brugia malayi Uncoordinated protein 44 0.0017 0.0089 0.0082
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.2781 0.3671
Echinococcus multilocularis dna polymerase kappa 0.0082 0.1134 0.113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.0714 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.1134 0.3067
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0237 0.023
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0321 0.0317
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0237 0.0232
Brugia malayi PAS domain containing protein 0.006 0.0774 0.0768
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.3608 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0039 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0639 0.1681
Schistosoma mansoni nuclear receptor 0.0027 0.0237 0.0201
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0816 0.0812
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0105 0.0069
Loa Loa (eye worm) carbonic anhydrase 3 0.0061 0.0785 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0061 0.0024
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0248 0.017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Echinococcus granulosus lamin dm0 0.0033 0.0333 0.0329
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0288 0.0252
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0082 0.1134 0.1128
Schistosoma mansoni zinc finger protein 0.0027 0.0237 0.0201
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0321 0.0315
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.0714 0.071
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0237 0.0232
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0429 0.0425
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0016 0.0069 0.0063
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0221 0.0509
Loa Loa (eye worm) hypothetical protein 0.0061 0.0785 0.0779
Trypanosoma brucei carbonic anhydrase-like protein 0.0061 0.0785 0.2089
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.3608 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0237 0.023
Plasmodium falciparum phd finger protein, putative 0.0032 0.0321 0.4031
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0089 0.0084
Brugia malayi Protein kinase domain containing protein 0.0017 0.0089 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0714 0.068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Echinococcus granulosus peregrin 0.0032 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0061 0.0785 0.0779
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0104 0.0035
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0061 0.0785 0.0779
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.023
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0333 0.0327
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0816 0.0813
Schistosoma mansoni hypothetical protein 0.0061 0.0785 0.0751
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Schistosoma mansoni hypothetical protein 0.0032 0.0321 0.0286
Leishmania major protein kinase, putative 0.0016 0.0061 0.006
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0098 0.0782
Schistosoma mansoni cpg binding protein 0.0034 0.0352 0.0317
Giardia lamblia PHD finger protein 15 0.0032 0.0321 0.2578
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2781 0.3081
Echinococcus granulosus geminin 0.0344 0.5333 0.5331
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0061 0.0024
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.0714 0.0708
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.022
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0714 0.0943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1012 0.1008
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0061 0.006
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0121 0.178
Schistosoma mansoni hypothetical protein 0.0017 0.0089 0.0053
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0082 0.1134 0.1128
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0061 0.0024
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.0714 0.071
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0098 0.0091
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0816 0.0812
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0639 0.2985
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0221 0.2438
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0248 0.0234
Brugia malayi glutaminase DH11.1 0.0569 0.8938 0.8938
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0062 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0288 0.0281
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0321 0.3785
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1134 0.3067
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0248 0.017
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0098 0.0066
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0121 0.1447
Brugia malayi ecdysone receptor 0.0027 0.0237 0.023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.009 0.0084
Brugia malayi hypothetical protein 0.003 0.0288 0.0281
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0267 0.2079
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0458 0.0423
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.0714 0.071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0714 0.0708
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.0714 0.071
Loa Loa (eye worm) hypothetical protein 0.003 0.0288 0.0281
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.1702 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.0714 0.0708
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0248 0.0584
Brugia malayi hypothetical protein 0.0075 0.1012 0.1006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0714 0.0708
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0816 0.2177
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.1913 1
Brugia malayi intermediate filament protein 0.0033 0.0333 0.0327
Leishmania major DNA polymerase kappa, putative 0.0026 0.0221 0.0509
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0175 0.2614 0.2611
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0098 0.5
Entamoeba histolytica hypothetical protein 0.0075 0.1012 0.8883
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.022
Loa Loa (eye worm) DR-78 0.0027 0.0237 0.023
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0282 0.4339 0.4335
Loa Loa (eye worm) hypothetical protein 0.0056 0.0714 0.0708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.0714 0.0708
Schistosoma mansoni hypothetical protein 0.0075 0.1012 0.0979
Schistosoma mansoni nuclear receptor 0.0027 0.0237 0.0201
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0089 0.0084
Plasmodium vivax DNA repair protein REV1, putative 0.0026 0.0221 0.3368
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.1702 0.886
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.142 0.1416
Giardia lamblia DNA damage repair protein 0.0026 0.0221 0.1661
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0816 0.3959
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.0714 0.0708

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT1A6 ChEMBL. 10836148
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT1A9 ChEMBL. 10836148
Potency (functional) 0.0692 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.1306 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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