Detailed information for compound 1385810

Basic information

Technical information
  • TDR Targets ID: 1385810
  • Name: N-[1-[4-(2-fluorophenyl)piperazin-1-yl]-1-thi ophen-2-ylpropan-2-yl]-2-oxo-2-piperidin-1-yl acetamide
  • MW: 458.592 | Formula: C24H31FN4O2S
  • H donors: 1 H acceptors: 2 LogP: 3.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(c1cccs1)N1CCN(CC1)c1ccccc1F)NC(=O)C(=O)N1CCCCC1
  • InChi: 1S/C24H31FN4O2S/c1-18(26-23(30)24(31)29-11-5-2-6-12-29)22(21-10-7-17-32-21)28-15-13-27(14-16-28)20-9-4-3-8-19(20)25/h3-4,7-10,17-18,22H,2,5-6,11-16H2,1H3,(H,26,30)
  • InChiKey: FKLPZJFLFXNMDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-1-methyl-2-(2-thienyl)ethyl]-2-oxo-2-(1-piperidyl)acetamide
  • N-[2-[4-(2-fluorophenyl)-1-piperazinyl]-1-methyl-2-(2-thienyl)ethyl]-2-oxo-2-(1-piperidyl)acetamide
  • N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-1-methyl-2-(2-thienyl)ethyl]-2-keto-2-piperidino-acetamide
  • N-[1-[4-(2-fluorophenyl)piperazin-1-yl]-1-thiophen-2-yl-propan-2-yl]-2-oxo-2-piperidin-1-yl-ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0854 0.0957
Schistosoma mansoni serine/threonine protein kinase 0.0421 0.362 0.4054
Trypanosoma cruzi cdc2-related kinase 3 0.0121 0.0775 0.0846
Echinococcus granulosus fibroblast growth factor receptor 4 0.0251 0.2013 0.2013
Brugia malayi map kinase activated protein kinase protein 2 0.0421 0.362 0.3902
Onchocerca volvulus 0.007 0.0292 0.0527
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0182 0.0196
Schistosoma mansoni tyrosine kinase 0.0157 0.1122 0.1257
Echinococcus multilocularis casein kinase I delta 0.0068 0.0279 0.0313
Echinococcus multilocularis neuroglian 0.0041 0.0017 0.0019
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0251 0.2013 0.2013
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0063 0.0223 0.018
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Echinococcus granulosus casein kinase I alpha 0.0068 0.0279 0.0279
Entamoeba histolytica protein kinase, putative 0.0067 0.0269 0.0087
Trichomonas vaginalis STE family protein kinase 0.0085 0.0436 0.0367
Echinococcus multilocularis activin receptor type 0.0167 0.1211 0.1357
Brugia malayi Protein kinase domain containing protein 0.0148 0.1029 0.1109
Loa Loa (eye worm) hypothetical protein 0.0094 0.0517 0.0558
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0071 0.0302 0.0269
Echinococcus granulosus casein kinase ii subunit alpha 0.01 0.0582 0.0582
Brugia malayi Tyrosine-protein kinase abl-1 0.018 0.1336 0.144
Brugia malayi Protein kinase domain containing protein 0.0194 0.1471 0.1585
Entamoeba histolytica PH domain containing protein kinase, putative 0.0168 0.1223 0.1178
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0168 0.1223 0.1348
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0041 0.0017 0.0019
Entamoeba histolytica protein kinase domain containing protein 0.0125 0.0811 0.0707
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0085 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0179 0.0075
Entamoeba histolytica cell division protein kinase 2, putative 0.0121 0.0775 0.0666
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0083 0.0413 0.0439
Brugia malayi glutathione reductase 0.0046 0.0063 0.0068
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Brugia malayi Fibronectin type III domain containing protein 0.0085 0.0437 0.0471
Echinococcus granulosus N chimaerin 0.007 0.0289 0.0289
Schistosoma mansoni growth factor receptor-bound protein 0.0058 0.0182 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.028 0.0313
Brugia malayi Protein kinase domain containing protein 0.0094 0.052 0.056
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0982 0.8929 1
Echinococcus granulosus TGF beta receptor type 1 0.0132 0.0877 0.0877
Echinococcus multilocularis nervana 2 0.0135 0.0908 0.1017
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0302
Echinococcus multilocularis NCK adaptor protein 0.0058 0.0182 0.0204
Loa Loa (eye worm) hypothetical protein 0.0085 0.0437 0.0471
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0727 0.0697
Echinococcus multilocularis protein kinase c iota type 0.0275 0.2239 0.2508
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0157 0.1122 0.1257
Trypanosoma brucei protein kinase, putative 0.0063 0.0223 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1396 0.1563
Echinococcus multilocularis nervana 2 0.0135 0.0908 0.1017
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0157 0.1122 0.1257
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0129 0.0854 0.0854
Trichomonas vaginalis AGC family protein kinase 0.014 0.0954 0.0955
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.01 0.0582 0.0627
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0041 0.0017 0.0019
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0058 0.0182 0.0204
Leishmania major protein kinase A catalytic subunit isoform 1 0.0071 0.0302 0.0269
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0398
Schistosoma mansoni protein kinase 0.0068 0.0279 0.0313
Loa Loa (eye worm) hypothetical protein 0.0083 0.0414 0.0446
Echinococcus granulosus myotubularin protein 13 0.0043 0.0041 0.0041
Echinococcus granulosus calcium activated potassium channel 0.0094 0.052 0.052
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.0319 0.0319
Plasmodium vivax casein kinase 1, putative 0.0068 0.0279 0.0294
Trichomonas vaginalis CK1 family protein kinase 0.0068 0.0279 0.0189
Echinococcus multilocularis Protein kinase C, brain isozyme 0.023 0.1805 0.2022
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.0359 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.052 0.0582
Schistosoma mansoni tyrosine kinase 0.0261 0.2108 0.236
Brugia malayi STE20-like kinase MST 0.0271 0.2201 0.2372
Echinococcus granulosus Protein kinase C brain isozyme 0.023 0.1805 0.1805
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0413 0.0462
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0421 0.362 0.3902
Plasmodium falciparum calcium-dependent protein kinase 2 0.0077 0.0356 0.033
Echinococcus granulosus tyrosine protein kinase Lyn 0.0185 0.138 0.138
Loa Loa (eye worm) AUR protein kinase 0.0982 0.8929 0.9624
Trichomonas vaginalis AGC family protein kinase 0.0982 0.8929 1
Brugia malayi Protein kinase domain containing protein 0.0192 0.1448 0.1561
Brugia malayi Kinase associated domain 1 family protein 0.0067 0.0262 0.0282
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1029 0.1153
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0477 0.4147 0.4147
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0135 0.0908 0.1017
Echinococcus granulosus growth factor receptor bound protein 2 0.0058 0.0182 0.0182
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0085 0.0436 0.0489
Echinococcus granulosus titin 0.0048 0.0086 0.0086
Brugia malayi serine/threonine-protein kinase plk-2 0.0286 0.234 0.2522
Echinococcus granulosus titin 0.0048 0.0086 0.0086
Onchocerca volvulus 0.0067 0.027 0.0484
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0121 0.0775 0.0803
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0077 0.0356 0.033
Echinococcus granulosus mitogen activated protein kinase 3 0.0083 0.0413 0.0413
Echinococcus granulosus serine/threonine protein kinase 0.0168 0.1223 0.1223
Trypanosoma cruzi cdc2-related kinase 3 0.0121 0.0775 0.0846
Echinococcus multilocularis casein kinase I alpha 0.0068 0.0279 0.0313
Brugia malayi bone morphogenetic protein type 1 receptor 0.014 0.0954 0.1028
Echinococcus granulosus twitchin 0.0128 0.0842 0.0842
Brugia malayi Pre-SET motif family protein 0.0251 0.2011 0.2168
Loa Loa (eye worm) hypothetical protein 0.0082 0.0412 0.0444
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0424 0.3651 0.3651
Echinococcus multilocularis casein kinase I alpha 0.0068 0.0279 0.0313
Loa Loa (eye worm) hypothetical protein 0.0077 0.0356 0.0383
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0239 0.1898 0.1898
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Plasmodium falciparum protein kinase 5 0.0121 0.0775 0.0803
Trypanosoma cruzi casein kinase II, putative 0.01 0.0582 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Trypanosoma cruzi polo-like protein kinase, putative 0.0286 0.234 0.2602
Echinococcus multilocularis mitogen activated protein kinase 3 0.0083 0.0413 0.0462
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0083 0.0413 0.0439
Echinococcus multilocularis rac serine:threonine kinase 0.0168 0.1223 0.1369
Loa Loa (eye worm) hypothetical protein 0.0132 0.0884 0.0953
Giardia lamblia Kinase, CMGC CDK 0.0121 0.0775 0.0573
Brugia malayi Thioredoxin reductase 0.0046 0.0063 0.0068
Brugia malayi Protein kinase domain containing protein 0.0376 0.319 0.3438
Loa Loa (eye worm) hypothetical protein 0.0151 0.1064 0.1147
Echinococcus granulosus insulin receptor 0.0474 0.4122 0.4122
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0069 0.0077
Schistosoma mansoni kinase 0.0306 0.253 0.2834
Schistosoma mansoni tyrosine kinase 0.0157 0.1122 0.1257
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0728 1
Brugia malayi RhoGAP domain containing protein 0.007 0.0289 0.0312
Schistosoma mansoni tyrosine kinase 0.0073 0.0327 0.0366
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0069 0.0069
Toxoplasma gondii AGC kinase 0.0071 0.0302 0.0269
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0051 0.0112 0.0121
Schistosoma mansoni tyrosine kinase 0.0251 0.2013 0.2254
Trichomonas vaginalis CK1 family protein kinase 0.0068 0.0279 0.0189
Schistosoma mansoni neuroglian 0.0041 0.0017 0.0019
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0239 0.1898 0.2126
Echinococcus granulosus casein kinase I delta 0.0068 0.0279 0.0279
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0302 0.0338
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0131 0.0876 0.0981
Schistosoma mansoni vesicular amine transporter 0.0082 0.0412 0.0461
Schistosoma mansoni hypothetical protein 0.0067 0.0262 0.0294
Schistosoma mansoni protein kinase 0.0232 0.1829 0.2048
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0667 0.5953 0.6416
Echinococcus granulosus neuroglian 0.0041 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0389 0.3317 0.3715
Schistosoma mansoni nephrin 0.0103 0.0609 0.0683
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.234 0.262
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0083 0.0413 0.0439
Echinococcus multilocularis dual specificity 0.0125 0.0811 0.0908
Echinococcus granulosus c src tyrosine kinase 0.0094 0.0517 0.0517
Entamoeba histolytica protein kinase, putative 0.0085 0.0436 0.0278
Trichomonas vaginalis set domain proteins, putative 0.0286 0.234 0.2527
Schistosoma mansoni cell adhesion molecule 0.0105 0.0626 0.0701
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0132 0.0877 0.0877
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0071 0.0302 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1805 0.2022
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0125 0.0811 0.0843
Brugia malayi p70 ribosomal S6 kinase beta 0.0282 0.2307 0.2486
Brugia malayi Protein kinase domain containing protein 0.0148 0.1029 0.1109
Trypanosoma cruzi cdc2-related kinase 1 0.0121 0.0775 0.0846
Schistosoma mansoni atypical protein kinase C 0.0282 0.2302 0.2578
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.007 0.0289 0.0289
Schistosoma mansoni tyrosine kinase 0.0474 0.4122 0.4617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0398
Brugia malayi Protein kinase domain 0.0085 0.0436 0.047
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0132 0.0877 0.0918
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0069 0.028 0.028
Echinococcus multilocularis mitogen activated protein kinase 14 0.0165 0.1192 0.1334
Entamoeba histolytica serine/threonine protein kinase, putative 0.0286 0.234 0.2457
Echinococcus multilocularis aurora kinase A 0.0982 0.8929 1
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0043 0.004 0.0045
Loa Loa (eye worm) hypothetical protein 0.0071 0.0302 0.0325
Echinococcus granulosus casein kinase I alpha 0.0068 0.0279 0.0279
Echinococcus multilocularis mitogen activated protein kinase 11 0.0165 0.1192 0.1334
Echinococcus multilocularis tyrosine protein kinase Blk 0.0131 0.0876 0.0981
Giardia lamblia Kinase, PLK 0.0286 0.234 0.2382
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0182 0.0196
Brugia malayi Protein kinase domain containing protein 0.017 0.1243 0.134
Loa Loa (eye worm) TK protein kinase 0.027 0.2186 0.2356
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0982 0.8929 0.8929
Leishmania major protein kinase, putative 0.0982 0.8929 1
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0051 0.0112 0.0121
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0728 1
Schistosoma mansoni protein kinase 0.0982 0.8929 1
Schistosoma mansoni adapter molecule crk 0.0058 0.0182 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.319 0.3572
Plasmodium falciparum calcium-dependent protein kinase 3 0.0077 0.0356 0.033
Brugia malayi C1-like domain containing protein 0.0154 0.1085 0.1169
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0121 0.0775 0.0835
Loa Loa (eye worm) hypothetical protein 0.0085 0.0437 0.0471
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0125 0.0811 0.0886
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0082 0.0412 0.0461
Entamoeba histolytica protein kinase, putative 0.0077 0.0356 0.0186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0017 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0063 0.0052
Echinococcus granulosus roundabout 2 0.0123 0.0799 0.0799
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0149 0.1044 0.1044
Onchocerca volvulus 0.0132 0.0884 0.168
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0071 0.0302 0.0269
Trichomonas vaginalis STE family protein kinase 0.0084 0.0422 0.0352
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0421 0.362 0.362
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0162 0.1166 0.1289
Echinococcus granulosus rho-associated protein kinase 1 0.0346 0.2906 0.2906
Giardia lamblia Kinase, NEK 0.014 0.0954 0.078
Echinococcus granulosus cyclin dependent kinase 5 0.0121 0.0775 0.0775
Entamoeba histolytica protein kinase, putative 0.0078 0.0369 0.0201
Echinococcus granulosus ephrin type A receptor 4 A 0.0105 0.0626 0.0626
Echinococcus multilocularis serine threonine protein kinase 0.0192 0.1452 0.1626
Echinococcus granulosus mitogen activated protein kinase 0.0083 0.0413 0.0413
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0302
Schistosoma mansoni tyrosine kinase 0.0213 0.1648 0.1845
Toxoplasma gondii CMGC kinase, CK2 family 0.01 0.0582 0.0585
Echinococcus multilocularis cyclin dependent kinase 19 0.017 0.1243 0.1392
Entamoeba histolytica protein kinase domain containing protein 0.0982 0.8929 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0063 0.0223 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0112 0.0126
Brugia malayi Protein kinase domain containing protein 0.0125 0.0811 0.0874
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Entamoeba histolytica protein kinase, putative 0.0125 0.0811 0.0707
Echinococcus multilocularis tyrosine protein kinase Abl 0.018 0.1336 0.1496
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0017 0.0019
Echinococcus granulosus casein kinase i 0.0068 0.0279 0.0279
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0067 0.027 0.027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0071 0.0302 0.0315
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0477 0.4147 0.4644
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0286 0.234 0.262
Schistosoma mansoni tyrosine kinase 0.0389 0.3317 0.3715
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0877 0.0867
Echinococcus multilocularis casein kinase I alpha 0.0068 0.0279 0.0313
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0154 0.1085 0.1169
Echinococcus granulosus epidermal growth factor receptor 0.0651 0.5802 0.5802
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.017 0.1243 0.134
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0129 0.0854 0.0957
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0338
Echinococcus granulosus nervana 2 0.0135 0.0908 0.0908
Echinococcus granulosus cyclin dependent kinase 1 0.0121 0.0775 0.0775
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0071 0.0302 0.0315
Loa Loa (eye worm) TK protein kinase 0.0131 0.0876 0.0944
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0068 0.0279 0.0301
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0239 0.1894 0.1894
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0082 0.0412 0.0461
Echinococcus multilocularis 0.0189 0.1424 0.1595
Brugia malayi Tyrosine-protein kinase abl-1 0.014 0.0954 0.1028
Schistosoma mansoni titin 0.0048 0.0086 0.0096
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0041 0.0017 0.0019
Echinococcus granulosus mitogen activated protein kinase 11 0.0165 0.1192 0.1192
Schistosoma mansoni tyrosine kinase 0.0067 0.027 0.0302
Echinococcus multilocularis mitogen activated protein kinase 0.0083 0.0413 0.0462
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0413 0.0341
Trypanosoma cruzi polo-like protein kinase, putative 0.0286 0.234 0.2602
Echinococcus multilocularis myotubularin protein 13 0.0043 0.0041 0.0046
Plasmodium falciparum serine/threonine protein kinase, putative 0.0982 0.8929 1
Schistosoma mansoni cell adhesion molecule 0.0041 0.0017 0.0019
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.021 0.1621 0.1621
Schistosoma mansoni growth factor receptor-bound protein 0.0058 0.0182 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0356 0.0398
Schistosoma mansoni protein kinase 0.0077 0.0356 0.0398
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0356 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0982 0.8929 1
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0775 0.0868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0398
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0119 0.0757 0.0816
Echinococcus granulosus serine threonine protein kinase nrc 0.0162 0.1166 0.1166
Entamoeba histolytica protein kinase, putative 0.0288 0.2363 0.2484
Echinococcus multilocularis Immunoglobulin 0.0082 0.0412 0.0461
Entamoeba histolytica protein kinase 2, putative 0.0162 0.1166 0.1113
Loa Loa (eye worm) AUR protein kinase 0.0982 0.8929 0.9624
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0051 0.0112 0.0121
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0067 0.027 0.0302
Echinococcus multilocularis calcium dependent protein kinase 0.0049 0.0098 0.011
Brugia malayi intracellular kinase 0.0132 0.0877 0.0945
Brugia malayi Sex muscle abnormal protein 5 0.0058 0.0182 0.0196
Entamoeba histolytica protein kinase, putative 0.0282 0.2307 0.2419
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0157 0.1122 0.1257
Giardia lamblia Kinase, STE STE20 0.0084 0.0422 0.0165
Echinococcus multilocularis titin 0.0048 0.0086 0.0096
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0251 0.2013 0.2254
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0279 0.2278 0.2551
Echinococcus multilocularis neuroglian 0.0101 0.0585 0.0655
Onchocerca volvulus 0.0319 0.2649 0.5117
Loa Loa (eye worm) hypothetical protein 0.0121 0.0774 0.0834
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0157 0.1122 0.1257
Loa Loa (eye worm) TK/EPH protein kinase 0.0124 0.0808 0.0871
Echinococcus multilocularis TGF beta receptor type 1 0.0132 0.0877 0.0982
Brugia malayi Protein kinase domain containing protein 0.0121 0.0775 0.0835
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0071 0.0302 0.0269
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Giardia lamblia Kinase, CMGC GSK 0.0132 0.0877 0.0691
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.01 0.0582 0.0634
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0121 0.0775 0.0803
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0376 0.319 0.3438
Brugia malayi Protein kinase domain containing protein 0.0067 0.027 0.0291
Brugia malayi protein kinase C3,putative 0.0155 0.1098 0.1184
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0121 0.0775 0.0803
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0041 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0299 0.2463 0.2654
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0618 0.8342
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0077 0.0356 0.038
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0132 0.0877 0.0982
Onchocerca volvulus Serine\/threonine kinase homolog 0.0286 0.234 0.4515
Trypanosoma brucei polo-like protein kinase 0.0286 0.234 0.2567
Giardia lamblia Kinase, NEK 0.014 0.0954 0.078
Schistosoma mansoni protein kinase 0.0132 0.0877 0.0982
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0376 0.319 0.3572
Entamoeba histolytica p21-activated kinase 0.0091 0.0493 0.0343
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0082 0.0412 0.0461
Entamoeba histolytica protein kinase, putative 0.0982 0.8929 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1064 0.1147
Echinococcus multilocularis N chimaerin 0.007 0.0289 0.0324
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0618 0.8342
Onchocerca volvulus 0.0132 0.0877 0.1666
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0083 0.0413 0.0445
Echinococcus granulosus tyrosine kinase 0.0131 0.0876 0.0876
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0148 0.1029 0.1029
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0398
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0071 0.0302 0.0269
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0165 0.1192 0.1313
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0186 0.1396 0.1504
Echinococcus multilocularis protein kinase shaggy 0.0132 0.0877 0.0982
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0854 0.0957
Brugia malayi serine/threonine-protein kinase 6 0.0982 0.8929 0.9624
Echinococcus multilocularis serine:threonine protein kinase 38 0.0148 0.1029 0.1153
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1358 0.1521
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0376 0.319 0.3438
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0271 0.2201 0.2372
Trypanosoma brucei protein kinase, putative 0.0083 0.0413 0.0394
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Schistosoma mansoni hypothetical protein 0.0067 0.0262 0.0294
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0068 0.0275 0.0296
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0582 0.0445
Entamoeba histolytica protein kinase, putative 0.0288 0.2363 0.2484
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0728 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.007 0.0289 0.0324
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.021 0.1622 0.1748
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Schistosoma mansoni tyrosine kinase 0.0651 0.5802 0.6497
Echinococcus granulosus protein kinase c iota type 0.0275 0.2239 0.2239
Plasmodium falciparum casein kinase 2, alpha subunit 0.01 0.0582 0.0585
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0077 0.0356 0.0356
Brugia malayi Stress-activated protein kinase jnk-1 0.0279 0.2278 0.2455
Brugia malayi casein kinase I 0.0068 0.0279 0.0301
Echinococcus multilocularis c src tyrosine kinase 0.0094 0.0517 0.0579
Trypanosoma cruzi casein kinase, putative 0.0068 0.0279 0.0289
Plasmodium falciparum casein kinase 1 0.0068 0.0279 0.0244
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0085 0.0436 0.0436
Echinococcus multilocularis twitchin 0.0045 0.0061 0.0068
Echinococcus multilocularis serine:threonine protein kinase N2 0.0148 0.1029 0.1153
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0356
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0071 0.0302 0.0315
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0244 0.1945 0.2097
Brugia malayi SH2 domain containing protein 0.0067 0.027 0.0291
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2011 0.2168
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0077 0.0356 0.0356
Echinococcus granulosus tyrosine protein kinase Fyn 0.0157 0.1122 0.1122
Leishmania major casein kinase, putative 0.0068 0.0279 0.0244
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0071 0.0302 0.0325
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0877 0.0867
Schistosoma mansoni protein kinase 0.0232 0.1829 0.2048
Trypanosoma brucei Casein kinase II 0.01 0.0582 0.0585
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0135 0.0908 0.0908
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0068 0.0279 0.0289
Onchocerca volvulus 0.0286 0.234 0.4517
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0413 0.0341
Brugia malayi phosphoinositide-dependent protein kinase I 0.008 0.0389 0.042
Giardia lamblia Kinase, CMGC MAPK 0.0083 0.0413 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0017 0.0019
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0454 0.3935 0.4406
Echinococcus granulosus calcium dependent protein kinase 0.0049 0.0098 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0775 0.0752
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.008 0.0389 0.042
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0086 0.0096
Plasmodium falciparum protein kinase, putative 0.0063 0.0223 0.018
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1029 0.104
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Trichomonas vaginalis STE family protein kinase 0.0085 0.0436 0.0367
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0058 0.0182 0.0196
Echinococcus granulosus cyclin dependent kinase 0.0121 0.0775 0.0775
Giardia lamblia Kinase, STE STE20 0.0085 0.0436 0.0182
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.007 0.0289 0.0324
Trypanosoma brucei cdc2-related kinase 1 0.0121 0.0775 0.0803
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0157 0.1122 0.1257
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0302
Brugia malayi SH2 domain containing protein 0.0067 0.027 0.0291
Echinococcus granulosus serine:threonine protein kinase 0.0116 0.0727 0.0727
Onchocerca volvulus 0.0089 0.0474 0.0881
Echinococcus granulosus mitogen activated protein kinase 14 0.0165 0.1192 0.1192
Entamoeba histolytica protein kinase domain containing protein 0.0132 0.0877 0.0783
Brugia malayi P38 map kinase family protein 2 0.0165 0.1192 0.1284
Echinococcus granulosus tyrosine protein kinase shark 0.0067 0.027 0.027
Trypanosoma cruzi Protein kinase B 0.0168 0.1223 0.1348
Echinococcus multilocularis casein kinase I delta 0.0068 0.0279 0.0313
Echinococcus granulosus roundabout 2 0.0041 0.0017 0.0017
Plasmodium falciparum NIMA related kinase 1 0.014 0.0954 0.1005
Onchocerca volvulus 0.0048 0.0086 0.0125
Echinococcus granulosus serine:threonine protein kinase N2 0.0148 0.1029 0.1029
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0041 0.0017 0.0019
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0148 0.1029 0.1153
Giardia lamblia Kinase, AGC PKA 0.0162 0.1166 0.1025
Schistosoma mansoni tyrosine kinase 0.0094 0.0517 0.0579
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0148 0.1029 0.1153
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0116 0.0731 0.0788
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0063 0.0047
Trichomonas vaginalis STE family protein kinase 0.0085 0.0436 0.0367
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0131 0.0876 0.0876
Brugia malayi Protein kinase domain containing protein 0.0474 0.4122 0.4443
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0182 0.1358 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.052 0.0582
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.014 0.0954 0.1028
Loa Loa (eye worm) hypothetical protein 0.0089 0.0474 0.0511
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0121 0.0775 0.0835
Loa Loa (eye worm) gastrulation defective protein 1 0.0143 0.0985 0.1062
Echinococcus multilocularis tyrosine protein kinase shark 0.0067 0.027 0.0302
Echinococcus multilocularis Immunoglobulin 0.0082 0.0412 0.0461
Loa Loa (eye worm) TK/EGFR protein kinase 0.0651 0.5802 0.6253
Giardia lamblia Kinase, AGC PKA 0.0071 0.0302 0.0026
Loa Loa (eye worm) hypothetical protein 0.0085 0.0437 0.0471
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0132 0.0877 0.096
Echinococcus granulosus neuroglian 0.0101 0.0585 0.0585
Brugia malayi Protein kinase domain containing protein 0.008 0.0389 0.042
Loa Loa (eye worm) hypothetical protein 0.0089 0.0474 0.0511
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0154 0.1085 0.1169
Echinococcus multilocularis growth factor receptor bound protein 2 0.0058 0.0182 0.0204
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0071 0.0302 0.0269
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0138 0.0149
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0063 0.0223 0.0226
Trypanosoma cruzi p21-activated kinase 3, putative 0.0051 0.0112 0.0102
Loa Loa (eye worm) AGC/NDR protein kinase 0.0148 0.1029 0.1109
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0165 0.1192 0.1284
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0041 0.0017 0.0017
Echinococcus multilocularis tyrosine protein kinase HCK 0.0099 0.0571 0.0639
Trypanosoma cruzi casein kinase, putative 0.0068 0.0279 0.0289
Schistosoma mansoni protein kinase 0.0061 0.0212 0.0238
Onchocerca volvulus 0.0067 0.027 0.0484
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0093
Plasmodium falciparum calcium-dependent protein kinase 4 0.0077 0.0356 0.033
Trichomonas vaginalis CK1 family protein kinase 0.0068 0.0279 0.0189
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0085 0.0436 0.0489
Onchocerca volvulus 0.0126 0.0827 0.1569
Echinococcus granulosus tyrosine protein kinase Srms 0.0067 0.027 0.027
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0338
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0069 0.028 0.0313
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.008 0.0389 0.0389
Giardia lamblia Kinase, CMGC CDK 0.0121 0.0775 0.0573
Echinococcus multilocularis cyclin dependent kinase 1 0.0121 0.0775 0.0868
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0083 0.0413 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0302 0.0338
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.0437 0.0471
Echinococcus granulosus casein kinase I delta 0.0068 0.0279 0.0279
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0085 0.0436 0.0436
Brugia malayi protein unc-22 0.0048 0.0086 0.0093
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0282 0.2307 0.2486
Echinococcus granulosus NCK adaptor protein 0.0058 0.0182 0.0182
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0618 0.8342
Loa Loa (eye worm) hypothetical protein 0.0081 0.0394 0.0424
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0157 0.1122 0.1257
Brugia malayi Temporarily assigned gene name protein 59 0.0141 0.0963 0.1038
Schistosoma mansoni nephrin 0.0041 0.0017 0.0019
Brugia malayi Protein kinase domain containing protein 0.0116 0.0727 0.0783
Entamoeba histolytica casein kinase, putative 0.01 0.0582 0.0445
Echinococcus multilocularis PAK box P21 Rho binding 0.0061 0.0212 0.0238
Loa Loa (eye worm) AUR protein kinase 0.0982 0.8929 0.9624
Echinococcus multilocularis protein kinase c epsilon type 0.0186 0.1396 0.1563
Onchocerca volvulus Tyrosine kinase homolog 0.0583 0.5155 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0071 0.0302 0.0325
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0162 0.1166 0.1284
Brugia malayi MAP kinase sur-1 0.0083 0.0413 0.0445
Brugia malayi cell division control protein 2 homolog 0.0121 0.0775 0.0835
Echinococcus granulosus Glutaredoxin protein 5 0.0135 0.0914 0.0914
Echinococcus granulosus tyrosine protein kinase Fyn 0.0157 0.1122 0.1122
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0413 0.0341
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0162 0.1166 0.1166
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0048 0.0086 0.0093
Loa Loa (eye worm) hypothetical protein 0.0058 0.0179 0.0193
Trypanosoma brucei cdc2-related kinase 3 0.0121 0.0775 0.0803
Brugia malayi Protein kinase domain containing protein 0.0067 0.027 0.0291
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0084 0.0422 0.045
Brugia malayi serine/threonine-protein kinase PAK 7 0.0244 0.1945 0.2097
Loa Loa (eye worm) AGC/PKN protein kinase 0.0148 0.1029 0.1109
Schistosoma mansoni serine/threonine kinase 0.0148 0.1029 0.1153
Schistosoma mansoni protein kinase 0.014 0.0954 0.1068
Loa Loa (eye worm) glutathione reductase 0.0046 0.0063 0.0068
Brugia malayi Protein kinase domain containing protein 0.1018 0.9278 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0085 0.0436 0.0489
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0182 0.1358 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.2278 0.2551
Onchocerca volvulus 0.0067 0.027 0.0484
Loa Loa (eye worm) hypothetical protein 0.0116 0.0727 0.0783
Echinococcus granulosus tyrosine protein kinase HCK 0.0099 0.0571 0.0571
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0982 0.8929 1
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0061 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0618 0.8342
Onchocerca volvulus 0.053 0.4648 0.9012
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0775 0.0868
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0116 0.0727 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.052 0.0462
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0232 0.1829 0.1829
Onchocerca volvulus 0.0067 0.027 0.0484
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0982 0.8929 1
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0084 0.0422 0.0262
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0072 0.0311 0.0335
Echinococcus granulosus epidermal growth factor receptor 0.0424 0.3651 0.3651
Schistosoma mansoni serine/threonine-protein kinase 0.0169 0.1228 0.1376
Echinococcus multilocularis myosin iiia 0.0084 0.0422 0.0473
Echinococcus granulosus dual specificity 0.0125 0.0811 0.0811
Trichomonas vaginalis AGC family protein kinase 0.008 0.0389 0.0314
Toxoplasma gondii AGC kinase 0.0282 0.2307 0.253
Brugia malayi Protein kinase domain containing protein 0.021 0.1622 0.1748
Schistosoma mansoni serine/threonine-protein kinase 0.0168 0.1223 0.1369
Echinococcus granulosus protein kinase C gamma type 0.0192 0.1452 0.1452
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0094 0.0517 0.0579
Brugia malayi hypothetical protein 0.0085 0.0437 0.0471
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0279 0.2278 0.2455
Echinococcus granulosus contactin 0.0041 0.0017 0.0017
Loa Loa (eye worm) AGC/AKT protein kinase 0.0288 0.2363 0.2547
Plasmodium falciparum calcium-dependent protein kinase 5 0.0077 0.0356 0.033
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1029 0.104
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Toxoplasma gondii aurora kinase 0.0982 0.8929 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0063 0.0068
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.007 0.0289 0.0324
Trypanosoma brucei protein kinase, putative 0.0132 0.0877 0.0918
Loa Loa (eye worm) AGC/PKA protein kinase 0.0071 0.0302 0.0325
Brugia malayi Protein kinase domain containing protein 0.0067 0.027 0.0291
Mycobacterium tuberculosis Probable reductase 0.0104 0.0618 0.8342
Echinococcus multilocularis serine:threonine protein kinase N2 0.0148 0.1029 0.1153
Echinococcus granulosus casein kinase I alpha 0.0068 0.0279 0.0279
Echinococcus multilocularis epidermal growth factor receptor 0.0651 0.5802 0.6497
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0286 0.234 0.2522
Entamoeba histolytica protein kinase, putative 0.008 0.0389 0.0225
Brugia malayi serine/threonine protein kinase 6 0.0982 0.8929 0.9624
Onchocerca volvulus 0.0067 0.027 0.0484
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0102 0.0601 0.0601
Brugia malayi Hr1 repeat family protein 0.0148 0.1029 0.1109
Onchocerca volvulus 0.0055 0.0156 0.0261
Echinococcus granulosus c-Jun N-terminal kinases 0.0279 0.2278 0.2278
Trypanosoma brucei casein kinase I, isoform 2 0.0068 0.0279 0.0244
Giardia lamblia Kinase, CMGC CK2 0.01 0.0582 0.035
Loa Loa (eye worm) RhoGAP domain-containing protein 0.007 0.0289 0.0312
Entamoeba histolytica protein kinase, putative 0.0069 0.028 0.0099
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0157 0.1122 0.1122
Brugia malayi Pleckstrin Homology Domain 0.0043 0.0041 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0302 0.0215
Echinococcus granulosus cyclin dependent kinase 19 0.017 0.1243 0.1243
Schistosoma mansoni protein kinase 0.0085 0.0436 0.0489
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0096 0.0541 0.0606
Entamoeba histolytica casein kinase 1, putative 0.0068 0.0279 0.0098
Leishmania major protein kinase, putative 0.0063 0.0223 0.018
Echinococcus multilocularis serine:threonine protein kinase 3 0.0271 0.2201 0.2465
Echinococcus multilocularis ephrin type A receptor 4 A 0.0105 0.0626 0.0701
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.014 0.0954 0.1052
Loa Loa (eye worm) hypothetical protein 0.0097 0.0553 0.0596
Schistosoma mansoni nck2/grb4 0.0058 0.0182 0.0204
Brugia malayi Protein kinase domain containing protein 0.0067 0.027 0.0291
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0182 0.1358 0.1358
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0083 0.0413 0.0394
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0054 0.0138 0.0154
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Schistosoma mansoni tyrosine kinase 0.007 0.0289 0.0324
Loa Loa (eye worm) TK/INSR protein kinase 0.0474 0.4122 0.4443
Echinococcus granulosus tyrosine protein kinase Src42A 0.0157 0.1122 0.1122
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0077 0.0356 0.0383
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.021 0.1621 0.1816
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.008 0.0389 0.0436
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0077 0.0356 0.0383
Loa Loa (eye worm) hypothetical protein 0.0067 0.0262 0.0282
Entamoeba histolytica protein kinase, putative 0.0125 0.0811 0.0707
Trichomonas vaginalis AGC family protein kinase 0.0154 0.1086 0.1104
Entamoeba histolytica protein kinase, putative 0.0132 0.0877 0.0783
Loa Loa (eye worm) TK/ABL protein kinase 0.0294 0.2412 0.26
Trypanosoma brucei rac serine-threonine kinase, putative 0.0288 0.2363 0.2594
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0132 0.0877 0.0945
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0182 0.1358 0.1358
Brugia malayi Furin-like cysteine rich region family protein 0.0651 0.5802 0.6253
Loa Loa (eye worm) hypothetical protein 0.0043 0.0041 0.0044
Echinococcus multilocularis serine:threonine protein kinase 0.0116 0.0727 0.0814
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0071 0.0302 0.032
Echinococcus granulosus tyrosine kinase 0.0067 0.027 0.027
Loa Loa (eye worm) variant SH3 domain-containing protein 0.004 0.0005 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0982 0.8929 1
Trichomonas vaginalis CAMK family protein kinase 0.0129 0.0853 0.084
Brugia malayi Cam kinase protein 1 0.0077 0.0356 0.0383
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0077 0.0356 0.033
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0084 0.0422 0.0405
Loa Loa (eye worm) hypothetical protein 0.0043 0.004 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0728 1
Entamoeba histolytica protein kinase, putative 0.0061 0.0212 0.0022
Toxoplasma gondii AGC kinase 0.0071 0.0302 0.0269
Echinococcus granulosus TGF-beta receptor type-1 0.0132 0.0877 0.0877
Entamoeba histolytica hypothetical protein 0.0125 0.0811 0.0707
Schistosoma mansoni protein kinase 0.0085 0.0436 0.0489
Entamoeba histolytica protein kinase, putative 0.0067 0.0269 0.0087
Plasmodium falciparum calcium-dependent protein kinase 1 0.0077 0.0356 0.033
Trypanosoma cruzi casein kinase, putative 0.0068 0.0279 0.0289
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0125 0.0811 0.0874
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0341 0.2862 0.3085
Echinococcus multilocularis roundabout 2 0.0123 0.0799 0.0894
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0083 0.0413 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0811 0.0908
Echinococcus multilocularis calcium activated potassium channel 0.0094 0.052 0.0582
Toxoplasma gondii casein kinase I 0.0068 0.0279 0.0244
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0982 0.8929 1
Schistosoma mansoni protein kinase 0.0077 0.0356 0.0398
Brugia malayi Variant SH3 domain containing protein 0.007 0.0289 0.0312
Loa Loa (eye worm) CAMK protein kinase 0.0048 0.0086 0.0093
Entamoeba histolytica protein kinase, putative 0.0069 0.028 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Echinococcus granulosus Immunoglobulin 0.0082 0.0412 0.0412
Echinococcus granulosus roundabout 2 0.0041 0.0017 0.0017
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0239 0.1894 0.2122
Loa Loa (eye worm) hypothetical protein 0.007 0.0292 0.0315
Leishmania major protein kinase, putative 0.0077 0.0356 0.033
Loa Loa (eye worm) TK protein kinase 0.0099 0.0571 0.0615
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0044 0.0044 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0982 0.8929 1
Trypanosoma cruzi cdc2-related kinase 1 0.0121 0.0775 0.0846
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0775 0.0752
Echinococcus multilocularis roundabout 2 0.0041 0.0017 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.1898 0.2126
Echinococcus multilocularis tyrosine protein kinase Srms 0.0131 0.0876 0.0981
Echinococcus granulosus tyrosine protein kinase Src42A 0.0096 0.0541 0.0541
Trichomonas vaginalis AGC family protein kinase 0.008 0.0389 0.0314
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0125 0.0811 0.0843
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0051 0.0112 0.0102
Onchocerca volvulus 0.0346 0.2906 0.5619
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1029 0.1153
Echinococcus multilocularis casein kinase ii subunit alpha 0.01 0.0582 0.0652
Loa Loa (eye worm) hypothetical protein 0.0082 0.0412 0.0444
Trichomonas vaginalis STE family protein kinase 0.0061 0.0212 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1029 0.104
Schistosoma mansoni tyrosine kinase 0.0094 0.0517 0.0579
Loa Loa (eye worm) hypothetical protein 0.0067 0.027 0.0291
Echinococcus multilocularis serine:threonine protein kinase 0.0116 0.0727 0.0814
Echinococcus multilocularis cyclin dependent kinase 0.0121 0.0775 0.0868
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0077 0.0356 0.033
Echinococcus multilocularis tyrosine kinase 0.0067 0.027 0.0302
Echinococcus multilocularis mitogen activated protein kinase 14 0.0165 0.1192 0.1334
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0413 0.0341
Entamoeba histolytica protein kinase domain containing protein 0.0132 0.0877 0.0783
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0157 0.1122 0.1257
Echinococcus multilocularis cyclin dependent kinase 5 0.0121 0.0775 0.0868
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0162 0.1166 0.1243
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0044 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0067 0.027 0.0291
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0376 0.319 0.3438
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1029 0.1153
Echinococcus granulosus protein kinase c epsilon type 0.0186 0.1396 0.1396
Echinococcus granulosus aurora kinase A 0.0982 0.8929 0.8929
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0068 0.0279 0.0301
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0302 0.0338
Brugia malayi ephrin receptor 1 precursor 0.0068 0.0277 0.0298
Loa Loa (eye worm) hypothetical protein 0.0157 0.1114 0.12
Loa Loa (eye worm) hypothetical protein 0.0058 0.0182 0.0196
Echinococcus granulosus serine:threonine protein kinase 0.0116 0.0727 0.0727
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Entamoeba histolytica cell division protein kinase 2, putative 0.0121 0.0775 0.0666
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0148 0.1029 0.1029
Onchocerca volvulus 0.0151 0.1064 0.2031
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1805 0.2022
Brugia malayi Variant SH3 domain containing protein 0.004 0.0005 0.0006
Schistosoma mansoni tyrosine kinase 0.0424 0.3651 0.4089
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0286 0.234 0.234
Trichomonas vaginalis CAMK family protein kinase 0.0129 0.0853 0.084
Trypanosoma cruzi casein kinase, putative 0.0068 0.0279 0.0289
Schistosoma mansoni tyrosine kinase 0.0474 0.4122 0.4617
Trypanosoma cruzi aurora B kinase, putative 0.0982 0.8929 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0165 0.1192 0.1272
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0063 0.0223 0.0226
Brugia malayi Protein kinase domain containing protein 0.0288 0.2363 0.2547
Echinococcus multilocularis RNA directed DNA polymerase 0.0043 0.004 0.0045
Trichomonas vaginalis STE family protein kinase 0.014 0.0954 0.0955
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Entamoeba histolytica protein kinase, putative 0.0148 0.1029 0.0957
Plasmodium vivax glycogen synthase kinase 3, putative 0.0132 0.0877 0.0965
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0421 0.362 0.4054
Echinococcus granulosus tyrosine protein kinase Blk 0.0131 0.0876 0.0876
Schistosoma mansoni protein kinase C mu 0.0154 0.1085 0.1215
Schistosoma mansoni serine/threonine protein kinase 0.0982 0.8929 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0132 0.0877 0.0918
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0077 0.0356 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1243 0.1392
Brugia malayi hypothetical protein 0.0067 0.027 0.0291
Schistosoma mansoni ephrin receptor 0.0105 0.0626 0.0701
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0084 0.0422 0.0262
Giardia lamblia Aurora kinase 0.0982 0.8929 1
Plasmodium vivax protein kinase Crk2 0.0121 0.0775 0.0851
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0058 0.0182 0.0196
Trichomonas vaginalis STE family protein kinase 0.0085 0.0436 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0775 0.0752
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.2906 0.3255
Giardia lamblia Kinase, CMGC GSK 0.0132 0.0877 0.0691
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0148 0.1029 0.1109
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.012 0.0771 0.0748
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.052 0.0582
Trypanosoma cruzi casein kinase, putative 0.0068 0.0279 0.0289
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0132 0.0877 0.0982
Leishmania major casein kinase II, putative 0.01 0.0582 0.0585
Trichomonas vaginalis AGC family protein kinase 0.0288 0.2363 0.2553
Echinococcus multilocularis Glutaredoxin protein 5 0.0135 0.0914 0.1023
Echinococcus multilocularis epidermal growth factor receptor 0.0424 0.3651 0.4089
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0132 0.0877 0.0945
Brugia malayi casein kinase 1, delta 0.0068 0.0279 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.234 0.2526
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.0319 0.0357
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1358 0.1521
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0157 0.1122 0.1257
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0157 0.1122 0.1257
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.027 0.0291
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0084 0.0422 0.045
Echinococcus multilocularis roundabout 2 0.0041 0.0017 0.0019
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0125 0.0814 0.0847
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0232 0.1829 0.2048
Schistosoma mansoni tyrosine kinase 0.0389 0.3317 0.3715
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0112 0.0126
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.008 0.0389 0.042
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0083 0.0413 0.0394
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0125 0.0811 0.0886
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0251 0.2013 0.2254
Onchocerca volvulus 0.0068 0.0279 0.0502
Trichomonas vaginalis AGC family protein kinase 0.008 0.0389 0.0314
Loa Loa (eye worm) SRC-1 0.0157 0.1122 0.121
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0067 0.027 0.0088
Schistosoma mansoni cell adhesion molecule 0.0041 0.0017 0.0019
Brugia malayi Casein kinase II, alpha chain 0.01 0.0582 0.0627
Giardia lamblia Kinase, NEK 0.014 0.0954 0.078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0667 0.5953 0.6416
Trypanosoma brucei aurora B kinase 0.0982 0.8929 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0553 0.0596
Brugia malayi Immunoglobulin I-set domain containing protein 0.027 0.2186 0.2356
Schistosoma mansoni serine/threonine kinase 0.0094 0.052 0.0582
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0162 0.1166 0.1306
Entamoeba histolytica casein kinase, putative 0.0068 0.0279 0.0098
Plasmodium vivax unspecified product 0.01 0.0582 0.0634
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0054 0.0138 0.0138
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.0359 0.0189
Schistosoma mansoni protein kinase 0.01 0.0582 0.0652
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0157 0.1122 0.1122
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1622 0.1816
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0083 0.0413 0.0439
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0165 0.1192 0.1272
Schistosoma mansoni tyrosine kinase 0.0424 0.3651 0.4089
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0149 0.1044 0.1169
Echinococcus granulosus protein kinase shaggy 0.0132 0.0877 0.0877
Schistosoma mansoni vav2 0.0076 0.0346 0.0387
Echinococcus multilocularis casein kinase i 0.0068 0.0279 0.0313
Echinococcus multilocularis mitogen activated protein kinase 11 0.0165 0.1192 0.1334
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0077 0.0356 0.033
Echinococcus granulosus defective proboscis extension response 0.0082 0.0412 0.0412
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0279 0.0313
Brugia malayi SRC-1 0.0157 0.1122 0.121
Plasmodium falciparum glycogen synthase kinase 3 0.0132 0.0877 0.0918
Schistosoma mansoni ste20-related kinase 0.0215 0.1667 0.1867
Entamoeba histolytica PH domain containing protein kinase, putative 0.0168 0.1223 0.1178
Loa Loa (eye worm) hypothetical protein 0.0126 0.0827 0.0892
Plasmodium vivax glutathione reductase, putative 0.0046 0.0063 0.0052
Echinococcus granulosus nervana 2 0.0135 0.0908 0.0908
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0982 0.8929 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0294 0.2412 0.2412
Echinococcus granulosus NDR protein kinase 0.0148 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0121 0.0774 0.0834
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0017 0.0019
Echinococcus multilocularis insulin receptor 0.0474 0.4122 0.4617
Plasmodium vivax calcium-dependent protein kinase, putative 0.0077 0.0356 0.038
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0068 0.0279 0.0301
Echinococcus multilocularis cyclin dependent kinase 1 0.0121 0.0775 0.0868
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0121 0.0775 0.0775
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0294 0.2412 0.2702
Loa Loa (eye worm) hypothetical protein 0.0151 0.1064 0.1147
Schistosoma mansoni protein kinase 0.0077 0.0356 0.0398
Brugia malayi protein-tyrosine kinase 0.0131 0.0876 0.0944
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0376 0.319 0.6171
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0068 0.0279 0.0313
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0165 0.1192 0.1313
Brugia malayi Protein kinase c protein 2 0.0109 0.0664 0.0716
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0239 0.1898 0.2046
Brugia malayi protein kinase C II. 0.0186 0.1396 0.1504
Onchocerca volvulus 0.0067 0.027 0.0484
Echinococcus multilocularis death associated protein kinase 1 0.0916 0.8311 0.9308
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0077 0.0356 0.038
Schistosoma mansoni protein kinase 0.0063 0.0223 0.0249
Giardia lamblia Kinase, AGC AKT 0.0119 0.0757 0.0552
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0319 0.0357
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0068 0.0279 0.0279
Echinococcus multilocularis rho associated protein kinase 0.0346 0.2906 0.3255
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0376 0.319 0.319
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0286 0.234 0.2567
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0094 0.052 0.056
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0582 0.0533
Echinococcus granulosus tyrosine protein kinase Src64B 0.0157 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0122 0.0784 0.0845
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0162 0.1161 0.1251
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0338
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0071 0.0302 0.0338
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.014 0.0954 0.1005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0157 0.1122 0.1122
Entamoeba histolytica protein kinase, putative 0.0982 0.8929 1
Leishmania major protein kinase, putative 0.0084 0.0422 0.0405
Echinococcus granulosus RNA directed DNA polymerase 0.0043 0.004 0.004
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1018 0.9278 1
Leishmania major protein kinase A catalytic subunit 0.0071 0.0302 0.0269
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0077 0.0356 0.038
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0223 0.0034
Brugia malayi serine/threonine kinase 12 0.0982 0.8929 0.9624
Loa Loa (eye worm) hypothetical protein 0.0189 0.1418 0.1528
Entamoeba histolytica protein kinase, putative 0.0099 0.0571 0.0432
Echinococcus granulosus activin receptor type 0.0167 0.1211 0.1211
Entamoeba histolytica protein kinase , putative 0.0982 0.8929 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0601 0.0648
Echinococcus granulosus serine:threonine protein kinase 3 0.0271 0.2201 0.2201
Echinococcus multilocularis hypothetical protein 0.0067 0.0262 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0536 0.06
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0389 0.0436
Loa Loa (eye worm) hypothetical protein 0.013 0.0859 0.0926
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0618 0.8342
Leishmania major protein kinase A catalytic subunit isoform 2 0.0071 0.0302 0.0269
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0121 0.0775 0.0835

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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