Detailed information for compound 1396213

Basic information

Technical information
  • TDR Targets ID: 1396213
  • Name: 1-[4-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-y l]-2-nitrophenyl]-4-methylpiperazine
  • MW: 395.412 | Formula: C20H21N5O4
  • H donors: 0 H acceptors: 4 LogP: 3.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1noc(n1)c1ccc(c(c1)[N+](=O)[O-])N1CCN(CC1)C
  • InChi: 1S/C20H21N5O4/c1-23-9-11-24(12-10-23)17-8-5-15(13-18(17)25(26)27)20-21-19(22-29-20)14-3-6-16(28-2)7-4-14/h3-8,13H,9-12H2,1-2H3
  • InChiKey: MFXIDSPGVGOGOL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[4-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-nitro-phenyl]-4-methyl-piperazine
  • D349-2613
  • NCGC00119282-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0049 0.1182
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0045 0.0151
Echinococcus granulosus DNA polymerase subunit gamma 0.0009 0.0006 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.0859 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0049 0.0572
Onchocerca volvulus 0.002 0.0045 0.0041
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0113 0.1319
Toxoplasma gondii cathepsin CPL 0.002 0.0045 0.0151
Plasmodium vivax DNA polymerase 1, putative 0.0009 0.0006 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase I protein B, putative 0.0009 0.0006 0.0007
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0011 0.0026
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0049 0.4126
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0074 0.184
Plasmodium falciparum telomerase reverse transcriptase 0.079 0.2713 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0113 0.1319
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0049 0.0719
Giardia lamblia Telomerase catalytic subunit 0.079 0.2713 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0045 0.0655
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0025 0.0063 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0113 0.0403
Mycobacterium ulcerans hypothetical protein 0.0029 0.0074 0.184
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0084 0.0266 0.0968
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0074 0.184
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0045 0.0655
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0113 0.1319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0011 0.0026
Plasmodium falciparum plastid replication-repair enzyme 0.0034 0.0094 0.0331
Trypanosoma cruzi mitochondrial DNA polymerase I protein C 0.0009 0.0006 0.0007
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0045 0.0655
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0113 0.1319
Loa Loa (eye worm) hypothetical protein 0.0034 0.0094 0.8208
Trypanosoma cruzi mitochondrial DNA polymerase I protein C 0.0009 0.0006 0.0007
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0004 0.0047
Leishmania major telomerase reverse transcriptase, putative 0.079 0.2713 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0011 0.0026
Brugia malayi DNA polymerase I family protein 0.0009 0.0006 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0113 0.2865
Echinococcus granulosus DNA polymerase theta 0.0009 0.0006 0.0046
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0113 0.1721
Leishmania major mitochondrial DNA polymerase I protein C, putative 0.0009 0.0006 0.0007
Loa Loa (eye worm) ctsf protein 0.002 0.0045 0.3751
Echinococcus multilocularis twinkle protein, mitochondrial 0.0025 0.0063 0.093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.4124
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0185 0.0667
Echinococcus granulosus cathepsin l1 0.002 0.0045 0.0655
Toxoplasma gondii ABC1 family protein 0.004 0.0113 0.0403
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0113 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0045 0.3751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Chlamydia trachomatis DNA polymerase I 0.0118 0.0385 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.3751
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Brugia malayi beta-lactamase family protein 0.004 0.0113 0.015
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0074 0.0097
Brugia malayi Cathepsin L-like precursor 0.002 0.0045 0.0056
Brugia malayi Cathepsin L-like precursor 0.002 0.0045 0.0056
Loa Loa (eye worm) fibroinase 0.002 0.0045 0.3751
Mycobacterium tuberculosis Conserved protein 0.004 0.0113 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0011 0.0927
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0074 0.184
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0011 0.0026
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0034 0.0094 0.0331
Plasmodium vivax vivapain-2 0.002 0.0045 0.0151
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0049 0.0166
Schistosoma mansoni DNA polymerase I 0.0034 0.0094 0.1415
Echinococcus multilocularis hypothetical protein 0.0009 0.0006 0.0046
Mycobacterium leprae Probable lipase LipE 0.004 0.0113 0.2865
Brugia malayi Cathepsin L-like precursor 0.002 0.0045 0.0056
Onchocerca volvulus 0.002 0.0045 0.0041
Echinococcus multilocularis cathepsin L 0.001 0.0011 0.0124
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0084 0.0266 0.0968
Trichomonas vaginalis esterase, putative 0.004 0.0113 1
Echinococcus multilocularis cysteine protease 0.002 0.0045 0.0655
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 1
Schistosoma mansoni hypothetical protein 0.0193 0.0643 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0049 0.4307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.019 0.0685
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0049 0.0166
Schistosoma mansoni cpg binding protein 0.0035 0.0095 0.1431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0045 0.0524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0113 0.1721
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0049 0.0166
Mycobacterium ulcerans lipase LipD 0.004 0.0113 0.2865
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0176
Brugia malayi Cathepsin L-like precursor 0.0014 0.0022 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0215 0.3313
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0113 0.0403
Brugia malayi Cathepsin L-like precursor 0.0014 0.0022 0.0025
Trypanosoma brucei telomerase reverse transcriptase 0.079 0.2713 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0011 0.0124
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0242 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0045 0.0655
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0113 0.1721
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.6422
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0118 0.0385 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0049 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0049 0.5027
Trypanosoma cruzi cysteine protease, putative 0.001 0.0011 0.0026
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0034 0.0094 0.0331
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0049 0.0572
Schistosoma mansoni hypothetical protein 0.0025 0.0063 0.093
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0045 0.0655
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0011 0.0026
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0011 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0074 0.184
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0074 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0074 0.7824
Trypanosoma cruzi mitochondrial DNA polymerase I protein D, putative 0.0009 0.0006 0.0007
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.079 0.2713 1
Schistosoma mansoni DNA polymerase gamma 0.0009 0.0006 0.0046
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Leishmania major hypothetical protein, conserved 0.004 0.0113 0.0403
Brugia malayi Telomerase reverse transcriptase 0.2102 0.7262 1
Brugia malayi beta-lactamase family protein 0.004 0.0113 0.015
Leishmania major cathepsin L-like protease 0.002 0.0045 0.0151
Schistosoma mansoni ap endonuclease 0.0021 0.0049 0.0719
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0049 0.0166
Entamoeba histolytica cysteine protease, putative 0.002 0.0045 0.457
Leishmania major DNA polymerase theta (polymerase domain only), putative 0.0009 0.0006 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0084 0.0266 0.0968
Onchocerca volvulus 0.002 0.0045 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0113 0.1721
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0113 1
Mycobacterium ulcerans DNA polymerase I 0.0118 0.0385 1
Onchocerca volvulus 0.002 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.6422
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0074 0.0259
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0074 0.184
Onchocerca volvulus Cathepsin L homolog 0.002 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Echinococcus granulosus cathepsin l1 0.0014 0.0022 0.0293
Leishmania major cathepsin L-like protease 0.0077 0.0242 0.0878
Mycobacterium ulcerans hypothetical protein 0.004 0.0113 0.2865
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0242 0.0878
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0113 1
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0113 0.1319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Schistosoma mansoni cpg binding protein 0.0035 0.0095 0.1431
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0113 0.1319
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0045 0.0655
Plasmodium vivax unspecified product 0.001 0.0011 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0113 0.015
Onchocerca volvulus Cathepsin F homolog 0.002 0.0045 0.0041
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0074 0.0864
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0011 0.001
Schistosoma mansoni cpg binding protein 0.0033 0.0088 0.133
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0113 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0045 0.0056
Plasmodium vivax vivapain-2 0.002 0.0045 0.0151
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0004 0.0047
Echinococcus granulosus cpg binding protein 0.0035 0.0095 0.1431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0011 0.0927
Brugia malayi Cathepsin L-like precursor 0.002 0.0045 0.0056
Mycobacterium leprae conserved hypothetical protein 0.004 0.0113 0.2865
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0011 0.0124
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.1629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0045 0.0524
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0074 0.184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0074 0.0864
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Loa Loa (eye worm) cysteine protease 0.002 0.0045 0.3751
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0242 0.0878
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0034 0.0094 0.0331
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.1629
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0045 0.0151
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0034 0.0094 1
Brugia malayi beta-lactamase 0.004 0.0113 0.015
Echinococcus multilocularis geminin 0.0193 0.0643 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Mycobacterium ulcerans beta-lactamase 0.004 0.0113 0.2865
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0049 0.0166
Schistosoma mansoni ap endonuclease 0.0021 0.0049 0.0719
Trypanosoma brucei mitochondrial DNA polymerase I protein D, putative 0.0009 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.004 0.0113 0.1319
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0047
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0022 0.0025
Onchocerca volvulus 0.002 0.0045 0.0041
Leishmania major cathepsin L-like protease 0.002 0.0045 0.0151
Echinococcus multilocularis cpg binding protein 0.0035 0.0095 0.1431
Leishmania major mitochondrial DNA polymerase I protein D, putative 0.0009 0.0006 0.0007
Trypanosoma cruzi DNA polymerase theta 0.0009 0.0006 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0049 0.4307
Trypanosoma brucei mitochondrial DNA polymerase I protein C 0.0009 0.0006 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0004 0.0047
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.079 0.2713 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Leishmania major cathepsin L-like protease 0.002 0.0045 0.0151
Entamoeba histolytica cysteine proteinase 2 0.001 0.0011 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Onchocerca volvulus 0.002 0.0045 0.0041
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0022 0.1887
Onchocerca volvulus 0.002 0.0045 0.0041
Brugia malayi Cathepsin L-like precursor 0.002 0.0045 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Echinococcus granulosus cysteine protease 0.001 0.0011 0.0124
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0219 0.0793
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0011 0.0124
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.0541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0074 0.7824
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Leishmania major mitochondrial DNA polymerase I protein B, putative 0.0009 0.0006 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0011 0.0778
Plasmodium vivax plastid replication-repair enzyme, putative 0.0034 0.0094 0.0331
Toxoplasma gondii helicase, putative 0.0034 0.0094 0.0331
Onchocerca volvulus 0.004 0.0113 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0045 0.0524
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0074 0.184
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0034 0.0094 0.0331
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0113 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0004 0.0047
Schistosoma mansoni hypothetical protein 0.0193 0.0643 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0074 0.0259
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0049 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0045 0.3944
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0022 0.1887
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0045 0.3944
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.4124
Brugia malayi CXXC zinc finger family protein 0.0033 0.0088 0.0116
Plasmodium falciparum DNA polymerase 1, putative 0.0009 0.0006 0.0007
Plasmodium vivax vivapain-3 0.001 0.0011 0.0026
Loa Loa (eye worm) twinkle helicase 0.0025 0.0063 0.5362
Toxoplasma gondii exonuclease III APE 0.0021 0.0049 0.0166
Onchocerca volvulus 0.004 0.0113 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Trypanosoma brucei mitochondrial DNA polymerase I protein B 0.0009 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0004 0.0047
Schistosoma mansoni hypothetical protein 0.0025 0.0063 0.093
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0074 0.0097
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0045 0.0655
Echinococcus granulosus twinkle protein mitochondrial 0.0025 0.0063 0.093
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0004 0.0016
Onchocerca volvulus 0.0014 0.0022 0.0018
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0004 0.0308
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0084 0.0266 0.3102
Trypanosoma cruzi mitochondrial DNA polymerase I protein D, putative 0.0009 0.0006 0.0007
Brugia malayi DNA polymerase I family protein 0.0034 0.0094 0.0123
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0041 0.0118 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0084 0.0266 0.0968
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0045 0.0655
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0022 0.1984
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0074 0.7824
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 1
Echinococcus granulosus geminin 0.0193 0.0643 1
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0011 0.0778
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0034 0.0094 0.0331
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0118 0.0385 0.4485
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0011 0.0778
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0034 0.0094 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Leishmania major cathepsin L-like protease 0.0077 0.0242 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0084 0.0266 0.0968
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0113 0.2865
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0011 0.0026
Toxoplasma gondii RNA-directed DNA polymerase 0.079 0.2713 1
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0011 0.0124
Plasmodium vivax telomerase reverse transcriptase, putative 0.079 0.2713 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0074 0.0259
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0045 0.3751
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0084 0.0266 0.0968
Onchocerca volvulus 0.0029 0.0074 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.001 0.0008
Leishmania major cathepsin L-like protease 0.002 0.0045 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0045 0.0524
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0074 0.184
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0047
Echinococcus multilocularis cysteine protease 0.002 0.0045 0.0655
Treponema pallidum DNA polymerase I (polA) 0.0118 0.0385 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.4124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.1629
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0004 0.0047
Leishmania major cathepsin L-like protease 0.0077 0.0242 0.0878
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0049 0.0719
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0049 0.1182
Loa Loa (eye worm) beta-lactamase 0.004 0.0113 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0045 0.457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0011 0.0026
Trichomonas vaginalis DNA polymerase I, putative 0.0034 0.0094 0.8263
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0011 0.0778
Trypanosoma cruzi mitochondrial DNA polymerase I protein B, putative 0.0009 0.0006 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0088 0.7708
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0049 0.0166
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0045 0.0151
Onchocerca volvulus Cathepsin L homolog 0.002 0.0045 0.0041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0113 0.1319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0113 1
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0022 0.0293
Echinococcus multilocularis DNA polymerase theta 0.0009 0.0006 0.0046
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0004 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0011 0.0778
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0113 0.1319
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.4124
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0074 0.184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0045 0.0151
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0004 0.0047
Plasmodium vivax vivapain-1 0.001 0.0011 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0045 0.457
Trypanosoma brucei DNA polymerase theta 0.0009 0.0006 0.0007
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0242 0.0878
Mycobacterium ulcerans 5'-3' exonuclease 0.0084 0.0266 0.6883
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.6422
Echinococcus granulosus cathepsin L 0.001 0.0011 0.0124
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0045 0.0151
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0004 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0113 0.0403
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0049 0.0166
Leishmania major cathepsin L-like protease 0.002 0.0045 0.0151
Onchocerca volvulus 0.004 0.0113 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0242 0.0878
Brugia malayi cathepsin L-like precursor 0.0014 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 1
Trypanosoma brucei DNA polymerase theta, putative 0.0009 0.0006 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.4124
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0045 0.0056
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0004 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0045 0.3944
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0118 0.0385 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0113 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0045 0.3944
Onchocerca volvulus 0.0033 0.0088 0.0084
Entamoeba histolytica cysteine protease, putative 0.001 0.0011 0.0778

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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