Detailed information for compound 1396445

Basic information

Technical information
  • TDR Targets ID: 1396445
  • Name: 3-(butylcarbamoylamino)-4-methyl-benzoic acid methyl ester
  • MW: 264.32 | Formula: C14H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)Nc1cc(ccc1C)C(=O)OC
  • InChi: 1S/C14H20N2O3/c1-4-5-8-15-14(18)16-12-9-11(13(17)19-3)7-6-10(12)2/h6-7,9H,4-5,8H2,1-3H3,(H2,15,16,18)
  • InChiKey: UXLYKMGWWSFVSA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(butylamino-oxomethyl)amino]-4-methylbenzoic acid methyl ester
  • methyl 3-(butylcarbamoylamino)-4-methylbenzoate
  • methyl 3-(butylcarbamoylamino)-4-methyl-benzoate
  • MLS000113410
  • SMR000109309
  • ZINC02812021

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0016 0.001
Echinococcus granulosus calpain 5 0.0021 0.0037 0.0053
Leishmania major farnesyltransferase beta subunit 0.0111 0.0607 1
Schistosoma mansoni hypothetical protein 0.0515 0.3176 0.4475
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0166 0.2279
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0267 0.5
Brugia malayi calpain family protein 1 0.0055 0.0257 0.0349
Brugia malayi RE15519p 0.0052 0.0236 0.0321
Mycobacterium tuberculosis Conserved protein 0.0073 0.037 0.0394
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.0166 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.1094 0.1094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0236 0.0236
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0009 0.0013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0037 0.0334
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0236 0.0321
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0166 0.0166
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.0166 0.1377
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.2279
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0236 0.0333
Echinococcus multilocularis musashi 0.0031 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.003 0.0095 0.0134
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0267 0.0364
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0212 0.0278
Schistosoma mansoni hypothetical protein 0.0036 0.0131 0.0172
Echinococcus granulosus geminin 0.0515 0.3176 0.4482
Schistosoma mansoni neuropeptide receptor 0.0052 0.0236 0.0321
Schistosoma mansoni myosin xvIII 0.0052 0.0236 0.0321
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0267 0.0267
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0257 0.0349
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0037 0.0334
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0016 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0236 0.0236
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0236 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0016 0.001
Schistosoma mansoni histamine h1 receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0016 0.0023
Trypanosoma cruzi protein farnesyltransferase, putative 0.0111 0.0607 0.8966
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0267 0.335
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0164 0.0231
Loa Loa (eye worm) hypothetical protein 0.0049 0.0217 0.0306
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0236 0.0333
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.003 0.0095 0.1211
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0016 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0236 0.0333
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0022
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.037 0.0522
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0041 0.0166 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0373
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0552 0.0767
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0236 0.0236
Mycobacterium leprae conserved hypothetical protein 0.0073 0.037 0.5
Schistosoma mansoni cpg binding protein 0.0032 0.0106 0.0137
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0028 0.0222
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0236 0.0321
Echinococcus granulosus hypothetical protein 0.0052 0.0236 0.0333
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0373
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Echinococcus granulosus thyrotropin releasing hormone receptor 0.029 0.1749 0.2468
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0334
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0272 0.0272
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0236 0.0333
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.003 0.0095 0.0095
Onchocerca volvulus 0.0073 0.037 0.0501
Plasmodium vivax hypothetical protein, conserved 0.0073 0.037 0.5985
Echinococcus granulosus neuropeptide receptor 0.0052 0.0236 0.0333
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0254 0.0346
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.0522
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.0166 0.0221
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0341 0.2073 0.2925
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.003 0.0095 0.0122
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0016 0.001
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0111 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0212 0.0286
Onchocerca volvulus 0.0052 0.0236 0.0313
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0016 0.0001
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0254 0.0359
Onchocerca volvulus 0.0087 0.0458 0.0626
Onchocerca volvulus 0.0052 0.0236 0.0313
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0037 0.0334
Echinococcus multilocularis cpg binding protein 0.0032 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0166 0.0234
Schistosoma mansoni opsin-like receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0189 0.1103 0.1556
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0028 0.0027
Onchocerca volvulus 0.0052 0.0236 0.0313
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.1131 0.7087 0.7087
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0236 0.0333
Echinococcus granulosus dnaJ subfamily B 0.0428 0.2624 0.3702
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Onchocerca volvulus 0.0052 0.0236 0.0313
Echinococcus multilocularis apoptotic protease activating factor 1 0.0341 0.2073 0.2073
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0236 0.0236
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.029 0.1749 0.2458
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0037 0.004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0236 0.0321
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0111 0.0607 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0236 0.0333
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0236 0.0333
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.0166 0.2542
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.003 0.0095 0.135
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.0166 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0131 0.0184
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0029 0.0086 0.0121
Brugia malayi Serotonin receptor 0.0052 0.0236 0.0321
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0111 0.0607 0.0857
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.003 0.0095 0.0122
Toxoplasma gondii hypothetical protein 0.0041 0.0166 0.2542
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0236 0.0333
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0041 0.0166 0.1377
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0201 0.0272
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0111 0.0607 1
Echinococcus granulosus somatostatin receptor 0.0052 0.0236 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0016 0.001
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0166 0.2012
Schistosoma mansoni amine GPCR 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.1131 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0236 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1094 0.1533
Echinococcus granulosus cpg binding protein 0.0032 0.0106 0.015
Schistosoma mansoni calpain (C02 family) 0.0021 0.0037 0.004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.037 0.037
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0166 0.2012
Onchocerca volvulus 0.0052 0.0236 0.0313
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0267 0.5
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0037 0.004
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0037 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0016 0.0023
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.003 0.0095 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0095 0.1211
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0111 0.0607 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0236 0.0333
Brugia malayi CXXC zinc finger family protein 0.003 0.0095 0.0122
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0235 0.0319
Schistosoma mansoni neuropeptide receptor 0.0052 0.0236 0.0321
Echinococcus multilocularis inhibitor of apoptosis protein 0.1131 0.7087 0.7087
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0016 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0095 0.1211
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0236 0.0236
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0028 0.0222
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0016 0.001
Brugia malayi nuclear hormone receptor 0.0018 0.0016 0.001
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.1094 0.1533
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.2279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0016 0.0023
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0166 0.2279
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0016 0.001
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0086 0.0108
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0016 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0267 0.335
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0189 0.1103 0.1545
Brugia malayi Melatonin receptor type 1A 0.0052 0.0236 0.0321
Echinococcus granulosus lamin 0.0031 0.0102 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.037 0.5366
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0016 0.0016
Brugia malayi Kringle domain containing protein 0.0017 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0102 0.0552 0.0778
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0041 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.0522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.004
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0229 0.136 0.1919
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0016 0.001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.1189 0.1189
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0254 0.0254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.037 1
Echinococcus multilocularis hypothetical protein 0.0021 0.0037 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1094 0.1533
Brugia malayi mbt repeat family protein 0.0048 0.0212 0.0286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.037 0.0394
Onchocerca volvulus 0.0029 0.0086 0.01
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0212 0.0212
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0016 0.0016
Onchocerca volvulus 0.0052 0.0236 0.0313
Echinococcus multilocularis serotonin receptor 0.0052 0.0236 0.0236
Echinococcus multilocularis max protein X 0.0504 0.3107 0.3107
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0236 0.0236
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0309 0.0424
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0164 0.0164
Echinococcus multilocularis agrin 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0111 0.0607 1
Loa Loa (eye worm) beta-lactamase 0.0073 0.037 0.0522
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0037 0.0037
Brugia malayi putative neuropeptide receptor 0.0052 0.0236 0.0321
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0016 0.001
Schistosoma mansoni amine GPCR 0.0052 0.0236 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.1094 0.1544
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0236 0.0333
Onchocerca volvulus 0.0052 0.0236 0.0313
Onchocerca volvulus 0.0019 0.0028 0.0019
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0236 0.0236
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0016 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0016 0.0023
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0212 0.0286
Brugia malayi sulfakinin receptor protein 0.0052 0.0236 0.0321
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0212 0.0299
Echinococcus granulosus apoptotic protease activating factor 1 0.0341 0.2073 0.2925
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.037 0.0394
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.003 0.0095 0.0122
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.0522
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0236 0.0313
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.0048 0.0212 0.0299
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0028 0.0027
Mycobacterium ulcerans hypothetical protein 0.0073 0.037 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0236 0.0236
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0009 0.0009
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0086 0.0108
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0086 0.01
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0236 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0016 0.001
Brugia malayi ORL1-like opioid receptor 0.0052 0.0236 0.0321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0144
Schistosoma mansoni opsin-like receptor 0.0052 0.0236 0.0321
Brugia malayi Dopamine receptor protein 1 0.0052 0.0236 0.0321
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.003 0.0095 0.0907
Brugia malayi G protein-coupled receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.0522
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Schistosoma mansoni hypothetical protein 0.0052 0.0236 0.0321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0016 0.001
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1131 0.7087 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0334
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0236 0.0321
Brugia malayi Cell death protein 3 precursor 0.0341 0.2073 0.2915
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.003 0.0095 0.0122
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0016 0.0023
Echinococcus granulosus calpain A 0.0021 0.0037 0.0053
Schistosoma mansoni ap endonuclease 0.0057 0.0267 0.0364
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.037 0.0394
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0236 0.0321
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0236 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0016 0.0023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Echinococcus multilocularis lamin 0.0031 0.0102 0.0102
Brugia malayi calpain 7 0.0021 0.0037 0.004
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0236 0.0333
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.037 0.0394
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0236 0.0333
Schistosoma mansoni survival motor neuron protein 0.0047 0.0201 0.0272
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0037 0.004
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.0522
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Echinococcus granulosus neuropeptide s receptor 0.052 0.3208 0.4526
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0037 0.0334
Schistosoma mansoni organic anion transporter 0.0029 0.0086 0.0108
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0236 0.0333
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0236 0.0333
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0236 0.0236
Loa Loa (eye worm) MBCTL1 0.0055 0.0254 0.0359
Brugia malayi prostaglandin transporter 0.0029 0.0086 0.0108
Brugia malayi sodium-independent organic anion transporter family protein 0.0029 0.0086 0.0108
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0236 0.0333
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0267 0.335
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0236 0.0236
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0086 0.01
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.037 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0236 0.0236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0236 0.0321
Schistosoma mansoni hypothetical protein 0.0428 0.2624 0.3694
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0164 0.0231
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0272 0.0372
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0015 0.0022
Toxoplasma gondii exonuclease III APE 0.0057 0.0267 0.4248
Plasmodium vivax calpain, putative 0.0021 0.0037 0.0373
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0267 0.4248
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0334
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.037 0.0394
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.003 0.0095 0.0122
Echinococcus multilocularis somatostatin receptor 0.0052 0.0236 0.0236
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0016 0.001
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0504 0.3107 0.4377
Trypanosoma cruzi protein farnesyltransferase, putative 0.0111 0.0607 0.8966
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0236 0.0333
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Toxoplasma gondii ABC1 family protein 0.0073 0.037 0.5985
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0016 0.0023
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Onchocerca volvulus 0.0052 0.0236 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0016 0.001
Echinococcus granulosus agrin 0.0019 0.0028 0.004
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Brugia malayi Trypsin family protein 0.0102 0.0552 0.0767
Schistosoma mansoni hypothetical protein 0.0052 0.0236 0.0321
Echinococcus granulosus follistatin 0.0019 0.0028 0.004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0236 0.0333
Brugia malayi G-protein coupled receptor 0.0052 0.0236 0.0321
Schistosoma mansoni amine GPCR 0.0052 0.0236 0.0321
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0028 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0016 0.001
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0236 0.0236
Onchocerca volvulus 0.0029 0.0086 0.01
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0236 0.0236
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.1377
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.136 0.1919
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0016 0.0016
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0236 0.0321
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0236 0.0321
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.0166 0.0166
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0236 0.0333
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0111 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0235 0.0332
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.037 0.5358
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0552 0.0767
Schistosoma mansoni hypothetical protein 0.0341 0.2073 0.2915
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Echinococcus granulosus orexin receptor type 2 0.0052 0.0236 0.0333
Mycobacterium ulcerans beta-lactamase 0.0073 0.037 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0016 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0639 0.0902
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0016 0.0016
Onchocerca volvulus 0.0052 0.0236 0.0313
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.2542
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0016 0.0023
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0236 0.0333
Leishmania major hypothetical protein, conserved 0.0073 0.037 0.5985
Echinococcus granulosus caspase 2 0.0341 0.2073 0.2925
Brugia malayi hypothetical protein 0.0229 0.136 0.1909
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0236 0.0236
Schistosoma mansoni amine GPCR 0.0052 0.0236 0.0321
Echinococcus multilocularis calpain A 0.0058 0.0272 0.0272
Onchocerca volvulus 0.0047 0.0201 0.0263
Brugia malayi calpain family protein 1 0.0055 0.0257 0.0349
Brugia malayi Serotonin receptor 0.0052 0.0236 0.0321
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0373
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0236 0.0236
Brugia malayi G-protein coupled receptor 0.0052 0.0236 0.0321
Schistosoma mansoni hypothetical protein 0.0051 0.0227 0.0308
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0041 0.0166 0.2542
Brugia malayi GnHR receptor homolog 0.0052 0.0236 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0236 0.0321
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0016 0.001
Onchocerca volvulus 0.0029 0.0086 0.01
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0236 0.0333
Onchocerca volvulus 0.0035 0.0124 0.0153
Mycobacterium tuberculosis Conserved protein 0.0073 0.037 0.0394
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi nuclear receptor NHR-88 0.0018 0.0016 0.001
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0236 0.0236
Onchocerca volvulus 0.0341 0.2073 0.2909
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0121 0.0676 0.1567
Mycobacterium leprae Probable lipase LipE 0.0073 0.037 0.5
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0102 0.0144
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0267 0.0376
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0267 0.3595
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0236 0.0236
Schistosoma mansoni adenoreceptor 0.0052 0.0236 0.0321
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0166 0.0221
Brugia malayi hypothetical protein 0.0341 0.2073 0.2915
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0081 0.0417 0.678
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0236 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.037 0.0509
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.037 0.5358
Onchocerca volvulus 0.0029 0.0086 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0236 0.0333
Echinococcus multilocularis caspase 2 0.0341 0.2073 0.2073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0254 0.0359
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0236 0.0313
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.2012
Brugia malayi MH2 domain containing protein 0.0116 0.0639 0.0891
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0086 0.1193
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0267 0.0376
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0212 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0111 0.0607 0.893
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0111 0.0607 1
Echinococcus granulosus inhibitor of apoptosis protein 0.1131 0.7087 1
Echinococcus granulosus neuropeptide receptor A26 0.052 0.3208 0.4526
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.037 0.0394
Schistosoma mansoni biogenic amine receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0236 0.0333
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Onchocerca volvulus 0.0073 0.037 0.0501
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0236 0.0236
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0029 0.0086 0.0086
Echinococcus granulosus max protein X 0.0504 0.3107 0.4384
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.029 0.1749 0.1749
Loa Loa (eye worm) hypothetical protein 0.003 0.0095 0.0134
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0028 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.1131 0.7087 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0029 0.0086 0.0086
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0639 0.0902
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.1377
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0236 0.0333
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0016 0.0023
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0254 0.0346
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0028 0.004
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0504 0.3107 0.4377
Echinococcus multilocularis expressed protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Schistosoma mansoni cpg binding protein 0.0032 0.0106 0.0137
Loa Loa (eye worm) hypothetical protein 0.1131 0.7087 1
Echinococcus granulosus g protein coupled receptor 0.0052 0.0236 0.0333
Onchocerca volvulus 0.0052 0.0236 0.0313
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0011 0.0002
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.003 0.0095 0.0134
Echinococcus multilocularis GPCR, family 2 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0052 0.0236 0.0313
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0236 0.0236
Onchocerca volvulus 0.0041 0.0166 0.0213
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0362
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0212 0.0286
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0016 0.001
Onchocerca volvulus 0.0073 0.037 0.0501
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Onchocerca volvulus 0.0052 0.0236 0.0313
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0015 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0016 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0236 0.0321
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0236 0.0321
Echinococcus granulosus serotonin receptor 0.0052 0.0236 0.0333
Leishmania major geranylgeranyltransferase, putative 0.003 0.0095 0.135
Onchocerca volvulus 0.0031 0.0102 0.0123
Onchocerca volvulus 0.0052 0.0236 0.0313
Onchocerca volvulus Putative organic anion transporter 0.0029 0.0086 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0016 0.0023
Onchocerca volvulus 0.003 0.0095 0.0113
Schistosoma mansoni cpg binding protein 0.003 0.0095 0.0122
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.003 0.0095 0.135
Echinococcus granulosus GPCR family 2 0.0016 0.0009 0.0013
Schistosoma mansoni lamin 0.0031 0.0102 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0009 0.0013
Brugia malayi hypothetical protein 0.0029 0.0086 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1094 0.1533
Schistosoma mansoni hypothetical protein 0.0052 0.0236 0.0321
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0037 0.0334
Onchocerca volvulus 0.0031 0.0102 0.0123
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0037 0.0334
Schistosoma mansoni biogenic amine receptor 0.0052 0.0236 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0016 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Brugia malayi SPARC precursor 0.0019 0.0028 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.2624 0.2624
Echinococcus granulosus Solute carrier organic anion transporter family 0.0029 0.0086 0.0121
Onchocerca volvulus Cell death protein 3 homolog 0.0341 0.2073 0.2909
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0166 0.2279
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0028 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0041 0.0166 0.2542
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.037 0.5358
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0111 0.0607 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0111 0.0607 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.037 0.0509
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0266 0.4238
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0236 0.0321
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Echinococcus granulosus tm gpcr rhodopsin 0.0582 0.3603 0.5084
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0235 0.0319
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi intermediate filament protein 0.0031 0.0102 0.0132
Echinococcus granulosus fmrfamide receptor 0.0052 0.0236 0.0333
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0016 0.0023
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0016 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.1648 0.2325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Schistosoma mansoni inhibitor of apoptosis protein 0.1131 0.7087 1
Trypanosoma cruzi lanosterol synthase, putative 0.0121 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.004
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0166 0.1377
Echinococcus granulosus sex peptide receptor 0.0052 0.0236 0.0333
Onchocerca volvulus 0.0052 0.0236 0.0313
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0236 0.0236
Schistosoma mansoni amine GPCR 0.0052 0.0236 0.0321
Schistosoma mansoni neuropeptide receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0236 0.0333
Echinococcus multilocularis calpain 5 0.0021 0.0037 0.0037
Echinococcus multilocularis serotonin receptor 0.0052 0.0236 0.0236
Brugia malayi Protein kinase domain containing protein 0.0017 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Loa Loa (eye worm) hypothetical protein 0.0102 0.0552 0.0778
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.0522
Schistosoma mansoni hypothetical protein 0.0306 0.1846 0.2595
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0236 0.0236
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0582 0.3603 0.3603
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0212 0.0212
Schistosoma mansoni lamin 0.0031 0.0102 0.0132
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0015 0.0015
Echinococcus multilocularis sex peptide receptor 0.0052 0.0236 0.0236
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0166 0.1377
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.3208 0.3208
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.037 0.0522
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0095 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.037 0.5206
Schistosoma mansoni agrin 0.0019 0.0028 0.0027
Schistosoma mansoni follistatin 0.0019 0.0028 0.0027
Echinococcus granulosus g protein coupled receptor 0.0052 0.0236 0.0333
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0131 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.1094 0.1544
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0504 0.3107 0.4377
Onchocerca volvulus 0.0052 0.0236 0.0313
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0028 0.0222
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0236 0.0236
Echinococcus granulosus lamin dm0 0.0031 0.0102 0.0144
Echinococcus granulosus neuropeptide receptor 0.0052 0.0236 0.0333
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.0166 0.2542
Plasmodium falciparum geranylgeranyltransferase, putative 0.003 0.0095 0.135
Echinococcus multilocularis neuropeptide s receptor 0.052 0.3208 0.3208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0016 0.001
Onchocerca volvulus 0.0018 0.0016 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0013
Schistosoma mansoni hypothetical protein 0.0047 0.0201 0.0272
Echinococcus granulosus g protein coupled receptor 0.0052 0.0236 0.0333
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0111 0.0607 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0272 0.0384
Schistosoma mansoni neuropeptide receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0166 0.2012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi beta-lactamase family protein 0.0073 0.037 0.0509
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0016 0.0016
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0037 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0236 0.0333
Echinococcus multilocularis follistatin 0.0019 0.0028 0.0028
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0166 0.1377
Brugia malayi ecdysteroid receptor 0.0018 0.0016 0.001
Brugia malayi AKH receptor 0.0052 0.0236 0.0321
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0029 0.0086 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Brugia malayi hypothetical protein 0.0029 0.0086 0.0108
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.2876 1
Brugia malayi follicle stimulating hormone receptor 0.0274 0.1648 0.2315
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0236 0.0321
Echinococcus multilocularis allatostatin A receptor 0.0189 0.1103 0.1103
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0236 0.0321
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0236 0.0333
Mycobacterium ulcerans lipase LipD 0.0073 0.037 1
Schistosoma mansoni hypothetical protein 0.0052 0.0236 0.0321
Echinococcus granulosus calpain 0.0021 0.0037 0.0053
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0028 0.004
Brugia malayi neuropeptide F receptor 0.0052 0.0236 0.0321
Schistosoma mansoni caspase-7 (C14 family) 0.0341 0.2073 0.2915
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0016 0.0023
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.0166 0.0234
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0011 0.0015
Brugia malayi Dopamine receptor protein 2 0.0052 0.0236 0.0321
Schistosoma mansoni coup transcription factor 0.0018 0.0016 0.001
Schistosoma mansoni organic anion transporter 0.0029 0.0086 0.0108
Onchocerca volvulus 0.1131 0.7087 1
Onchocerca volvulus 0.0048 0.0212 0.0278
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0236 0.0333
Onchocerca volvulus Deterin homolog 0.1131 0.7087 1
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0041 0.0166 0.0221
Brugia malayi steroid hormone receptor 0.0018 0.0016 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.037 0.5358
Brugia malayi hypothetical protein 0.0052 0.0236 0.0321
Schistosoma mansoni intermediate filament proteins 0.0031 0.0102 0.0132
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0121
Brugia malayi larval opioid receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) calpain 0.0021 0.0037 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.1094 0.1544
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0212 0.0299
Schistosoma mansoni hypothetical protein 0.0515 0.3176 0.4475
Mycobacterium tuberculosis Conserved protein 0.0073 0.037 0.0394
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0236 0.0236
Trypanosoma cruzi MFS transporter, putative 0.0029 0.0086 0.107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0016 0.001
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0504 0.3107 0.4384
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0267 0.3809
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Onchocerca volvulus 0.0189 0.1103 0.1537
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.0166 0.0234
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Onchocerca volvulus 0.0102 0.0552 0.0759
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.037 0.0509
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0016 0.001
Echinococcus granulosus baculoviral IAP repeat containing protein 0.1131 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0124 0.0175
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0009 0.0009
Plasmodium vivax geranylgeranyltransferase, putative 0.003 0.0095 0.135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0016 0.001
Echinococcus multilocularis lamin dm0 0.0031 0.0102 0.0102
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0102 0.0132
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0166 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0016 0.0016
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1131 0.7087 1
Giardia lamblia Prenyltransferase 0.0111 0.0607 1
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0236 0.0333
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0236 0.0236
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0037 0.0334
Schistosoma mansoni biogenic amine receptor 0.0052 0.0236 0.0321
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0236 0.0333
Brugia malayi Dopamine receptor 0.0052 0.0236 0.0321
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0102 0.0144
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0267 0.4248
Echinococcus granulosus intermediate filament protein 0.0031 0.0102 0.0144
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0236 0.0321
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0016 0.0023
Brugia malayi neuropeptide F receptor 0.0052 0.0236 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0139
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0272 0.0372
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.1189 0.1677
Brugia malayi beta-lactamase 0.0073 0.037 0.0509
Echinococcus granulosus allatostatin A receptor 0.0189 0.1103 0.1556
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0267 0.335
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.003 0.0095 0.135
Brugia malayi mbt repeat family protein 0.0048 0.0212 0.0286
Onchocerca volvulus 0.0029 0.0086 0.01
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.037 0.0394
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0111 0.0607 0.0845
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0016 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0267 0.3809
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0236 0.0333
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0236 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.037 0.5366
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Brugia malayi beta-lactamase family protein 0.0073 0.037 0.0509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Schistosoma mansoni opsin-like receptor 0.0052 0.0236 0.0321
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0254 0.0359
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0111 0.0607 0.0857
Loa Loa (eye worm) hypothetical protein 0.0341 0.2073 0.2925
Echinococcus multilocularis geminin 0.0515 0.3176 0.3176
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0111 0.0607 0.0845
Trypanosoma cruzi lanosterol synthase, putative 0.0121 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0236 0.0321
Trypanosoma brucei lanosterol synthase 0.0121 0.0676 1
Onchocerca volvulus 0.0052 0.0236 0.0313
Schistosoma mansoni hypothetical protein 0.1131 0.7087 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0236 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0236 0.0236
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0028 0.0222
Leishmania major lanosterol synthase, putative 0.0091 0.0485 0.7933
Echinococcus multilocularis calpain 0.0021 0.0037 0.0037
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0111 0.0607 1
Schistosoma mansoni ap endonuclease 0.0057 0.0267 0.0364
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0016 0.001
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0236 0.0236
Trichomonas vaginalis esterase, putative 0.0073 0.037 0.5358
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.037 0.5358
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.003 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.0332
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0016 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0236 0.0333
Echinococcus granulosus calpain A 0.0058 0.0272 0.0384
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0257 0.0362
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.003 0.0095 0.135
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0267 0.4248
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0333

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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