Detailed information for compound 1399101

Basic information

Technical information
  • TDR Targets ID: 1399101
  • Name: ethyl 2-[6-carbamoyl-2-(3-methylphenyl)-8-oxo -9-(oxolan-2-ylmethyl)purin-7-yl]acetate
  • MW: 439.464 | Formula: C22H25N5O5
  • H donors: 1 H acceptors: 5 LogP: 1.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cn1c(=O)n(c2c1c(nc(n2)c1cccc(c1)C)C(=O)N)CC1CCCO1
  • InChi: 1S/C22H25N5O5/c1-3-31-16(28)12-26-18-17(19(23)29)24-20(14-7-4-6-13(2)10-14)25-21(18)27(22(26)30)11-15-8-5-9-32-15/h4,6-7,10,15H,3,5,8-9,11-12H2,1-2H3,(H2,23,29)
  • InChiKey: OLEQHFQLARXIOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[6-carbamoyl-2-(3-methylphenyl)-8-oxo-9-(tetrahydrofuran-2-ylmethyl)purin-7-yl]acetate
  • 2-[6-carbamoyl-2-(3-methylphenyl)-8-oxo-9-(2-tetrahydrofuranylmethyl)-7-purinyl]acetic acid ethyl ester
  • 2-[6-carbamoyl-8-keto-2-(3-methylphenyl)-9-(tetrahydrofurfuryl)purin-7-yl]acetic acid ethyl ester
  • ethyl 2-[6-aminocarbonyl-2-(3-methylphenyl)-8-oxo-9-(oxolan-2-ylmethyl)purin-7-yl]ethanoate
  • G656-0467
  • NCGC00132724-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0103
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0128
Brugia malayi Doublecortin family protein 0.0021 0.0008 0.0002
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0759 0.19 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0058 0.0104 0.0119
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0075 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0522 0.2872
Brugia malayi follicle stimulating hormone receptor 0.0233 0.0551 0.0667
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0104 0.0116
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0131 0.0125
Brugia malayi Pre-SET motif family protein 0.0091 0.0188 0.0222
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0057 0.0498
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0008 0.0001
Treponema pallidum glutamate/aspartate transporter 0.0336 0.0817 0.2269
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0022 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Loa Loa (eye worm) hypothetical protein 0.0091 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0007
Echinococcus granulosus atrial natriuretic peptide receptor 0.0417 0.1023 0.1018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1098 0.2768 0.2763
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0012 0.0032
Brugia malayi Ets-domain containing protein 0.0075 0.0147 0.0172
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0108 1
Brugia malayi hypothetical protein 0.0235 0.0558 0.0675
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0041 0.0059 0.2879
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0024 0.0027
Echinococcus multilocularis glutamate receptor 4 0.0041 0.0061 0.0055
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0044 0.134
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0022 0.1639
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0104 0.0116
Brugia malayi intermediate filament protein 0.0082 0.0165 0.0195
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0075 0.0674
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0058 0.0104 0.0543
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0059 0.0296
Brugia malayi PXA domain containing protein 0.0058 0.0104 0.0119
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0104 0.0097
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0373 0.0911 0.2546
Brugia malayi metabotropic glutamate receptor type 2 0.1629 0.4129 0.5046
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0008 0.0007
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0024 0.1845
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0041 0.0059 0.0059
Brugia malayi hypothetical protein 0.0041 0.0059 0.0065
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0248 0.0591 0.0585
Schistosoma mansoni lipoxygenase 0.0021 0.0008 0.0009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0131 0.1226
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0633 0.1577 0.1576
Brugia malayi PXA domain containing protein 0.0058 0.0104 0.0119
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0187 0.0181
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0108 0.5203
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Brugia malayi von Willebrand Factor 0.0041 0.0059 0.0065
Onchocerca volvulus 0.0041 0.0059 0.0274
Brugia malayi Cytochrome P450 family protein 0.0068 0.013 0.0152
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0558 0.0552
Loa Loa (eye worm) excitatory amino acid transporter 0.0759 0.19 0.19
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Entamoeba histolytica hypothetical protein 0.0058 0.0104 0.0958
Echinococcus granulosus Excitatory amino acid transporter 0.0759 0.19 0.1895
Chlamydia trachomatis neutral amino acid transporter 0.0336 0.0817 0.4228
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0024 0.0018
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0336 0.0817 0.0811
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0024
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Echinococcus granulosus glutamate receptor 2 0.0666 0.1661 0.1655
Echinococcus granulosus glutamate receptor 1 0.0041 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0917 0.2305 0.2304
Loa Loa (eye worm) norepinephrine transporter 0.0076 0.0149 0.0149
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0108 0.0168
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0251
Brugia malayi Fli-1 protein 0.0228 0.0538 0.0651
Brugia malayi Ets-domain containing protein 0.0075 0.0147 0.0172
Onchocerca volvulus Poor gastrulation protein homolog 0.05 0.1236 0.6494
Echinococcus granulosus bloom syndrome protein 0.0022 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Brugia malayi Zona pellucida-like domain containing protein 0.0041 0.0059 0.0065
Schistosoma mansoni axis inhibition protein axin 0.0058 0.0104 0.0116
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0076 0.0149 0.0175
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0102 0.0216 0.0216
Loa Loa (eye worm) serotonin transporter b 0.0076 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0103
Toxoplasma gondii microneme protein MIC2 0.0041 0.0059 0.2264
Brugia malayi 6-phosphofructokinase 0.0221 0.0522 0.0631
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0057 0.005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.0267 0.0299
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0131 0.1226
Echinococcus granulosus collagen alpha 1VII chain 0.0041 0.0059 0.0053
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0108 0.5203
Onchocerca volvulus 0.0048 0.0078 0.0372
Leishmania major hypothetical protein, conserved 0.0026 0.0022 0.0154
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.005 0.0434
Echinococcus multilocularis axis inhibition protein axin 0.0058 0.0104 0.0097
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0057 0.0498
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0759 0.19 1
Onchocerca volvulus 0.0076 0.0149 0.0747
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0024 0.0027
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0482 0.1191 0.1333
Echinococcus multilocularis Regulator of G protein signaling 20 0.0058 0.0104 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0057 0.0282
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0108 0.5584
Loa Loa (eye worm) hypothetical protein 0.008 0.0161 0.0161
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0108 0.0568
Onchocerca volvulus 0.0041 0.0059 0.0274
Loa Loa (eye worm) CUTiclin family member 0.0041 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0417 0.1023 1
Echinococcus granulosus Excitatory amino acid transporter 0.0759 0.19 0.1895
Brugia malayi hypothetical protein 0.0026 0.0022 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Brugia malayi Receptor family ligand binding region containing protein 0.0417 0.1023 0.1245
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0108 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0057 0.0282
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Onchocerca volvulus 0.0417 0.1023 0.5367
Echinococcus granulosus excitatory amino acid transporter 2 0.0759 0.19 0.1895
Echinococcus multilocularis neutral amino acid transporter A 0.0759 0.19 0.1895
Schistosoma mansoni hypothetical protein 0.05 0.1236 0.1384
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0914 0.2296 0.2291
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0006 0.0007
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0008 0.0251
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0221 0.0522 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0108 0.0568
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0041 0.0059 0.2879
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0024 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.0551 0.0551
Entamoeba histolytica hypothetical protein 0.0041 0.0059 0.0523
Echinococcus multilocularis tyrosine kinase 0.0417 0.1023 0.1018
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Brugia malayi hypothetical protein 0.0058 0.0104 0.0119
Onchocerca volvulus 0.0102 0.0216 0.1102
Brugia malayi Cache domain containing protein 0.0442 0.1087 0.1322
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0417 0.1023 0.1245
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0058 0.0104 0.0103
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Echinococcus granulosus axis inhibition protein axin 0.0058 0.0104 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0103
Treponema pallidum sodium- and chloride- dependent transporter 0.0076 0.0149 0.029
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0103
Onchocerca volvulus 0.0041 0.0059 0.0274
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0188 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0058 0.0104 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0024
Schistosoma mansoni 6-phosphofructokinase 0.0221 0.0522 0.0584
Echinococcus granulosus regulator of G protein signaling 3 0.0058 0.0104 0.0097
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0131 0.0131
Leishmania major extracellular receptor, putative 0.0417 0.1023 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0041 0.0059 0.0065
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0122 0.0267 0.0261
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0057 0.0051
Brugia malayi 6-phosphofructokinase 0.0221 0.0522 0.0631
Leishmania major ATP-dependent phosphofructokinase 0.0221 0.0522 0.5069
Treponema pallidum hypothetical protein 0.0041 0.0059 0.0024
Echinococcus granulosus glutamate receptor 2 0.0914 0.2296 0.2291
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.2428
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0104 0.0097
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0373 0.0911 0.4775
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0064 0.0119 0.0119
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0759 0.19 0.1895
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0473 0.1168 0.1162
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0024 0.0018
Brugia malayi A-kinase anchor protein 10, precursor 0.0058 0.0104 0.0119
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0108 0.5584
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Entamoeba histolytica hypothetical protein 0.0058 0.0104 0.0958
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.0267 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0104 0.0116
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0051 0.0238
Brugia malayi hypothetical protein 0.0021 0.0008 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.005 0.0246
Brugia malayi hypothetical protein 0.0021 0.0008 0.0002
Brugia malayi hypothetical protein 0.0102 0.0216 0.0257
Echinococcus multilocularis serotonin transporter 0.0076 0.0149 0.0143
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0147 0.0141
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0336 0.0817 0.0915
Toxoplasma gondii exonuclease III APE 0.0038 0.0051 0.1773
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0373 0.0911 0.4726
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0131 0.2441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.005 0.0246
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0187 0.0209
Echinococcus multilocularis RUN 0.0021 0.0008 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0024 0.0027
Trypanosoma brucei unspecified product 0.002 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Chlamydia trachomatis glutamine binding protein 0.0373 0.0911 0.4726
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0024
Echinococcus granulosus receptor type guanylyl cyclase 0.0417 0.1023 0.1018
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.0267 0.0299
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Echinococcus granulosus neutral amino acid transporter A 0.0759 0.19 0.1895
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0012 0.0032
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0221 0.0522 0.5069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0179 0.0173
Onchocerca volvulus 0.0041 0.0059 0.0274
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0057 0.0064
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1098 0.2768 0.2763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.005 0.0246
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0075 0.0084
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0075 0.1354
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0012 0.0133
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0058 0.0104 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0522 0.2872
Schistosoma mansoni hypothetical protein 0.0176 0.0407 0.0455
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0068 0.0067
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0221 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.0442 0.1087 0.1086
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0057
Onchocerca volvulus 0.0102 0.0217 0.1107
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0024 0.0018
Loa Loa (eye worm) 6-phosphofructokinase 0.0221 0.0522 0.0521
Echinococcus granulosus axis inhibition protein axin 0.0058 0.0104 0.0097
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0056
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1098 0.2768 0.2763
Loa Loa (eye worm) hypothetical protein 0.0122 0.0267 0.0267
Onchocerca volvulus 0.0041 0.0059 0.0274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0188 0.021
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0076 0.0149 0.0167
Loa Loa (eye worm) hypothetical protein 0.0076 0.0149 0.0149
Brugia malayi hypothetical protein 0.0058 0.0104 0.0119
Schistosoma mansoni glutamate receptor kainate 0.0455 0.1122 0.1256
Loa Loa (eye worm) solute carrier family 6 member 4 0.0076 0.0149 0.0149
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0336 0.0817 0.0811
Echinococcus multilocularis nmda type glutamate receptor 0.0621 0.1546 0.1541
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0057 0.0498
Schistosoma mansoni rab6-interacting 0.0021 0.0008 0.0009
Loa Loa (eye worm) CUTiclin-Like family member 0.0041 0.0059 0.0059
Echinococcus granulosus transcription factor Dp 1 0.004 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.09
Schistosoma mansoni lamin 0.0082 0.0165 0.0185
Onchocerca volvulus 0.0027 0.0024 0.0087
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0522 0.2872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0035 0.0162
Brugia malayi phosphofructokinase 0.0221 0.0522 0.0631
Onchocerca volvulus 0.072 0.1801 0.9475
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0022 0.0331
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0052
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0373 0.0911 0.2546
Onchocerca volvulus 0.0041 0.0059 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0026 0.011
Echinococcus multilocularis regulator of G protein signaling 0.0058 0.0104 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.0443
Treponema pallidum glutamate transporter 0.0336 0.0817 0.2269
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Trypanosoma cruzi extracellular receptor, putative 0.0417 0.1023 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.1023 0.1023
Schistosoma mansoni polycystin 1-related 0.0021 0.0008 0.0009
Schistosoma mansoni survival motor neuron protein 0.0048 0.0078 0.0087
Echinococcus multilocularis excitatory amino acid transporter 3 0.0759 0.19 0.1895
Echinococcus multilocularis neutral amino acid transporter A 0.0759 0.19 0.1895
Brugia malayi hypothetical protein 0.0122 0.0269 0.0322
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0024 0.0018
Entamoeba histolytica phosphofructokinase, putative 0.0221 0.0522 0.5069
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0108 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0008 0.0001
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0058 0.0104 0.0116
Echinococcus granulosus metabotropic glutamate receptor 2 0.2708 0.6894 0.6892
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0024
Loa Loa (eye worm) PXA domain-containing protein 0.0058 0.0104 0.0103
Onchocerca volvulus 0.0027 0.0024 0.0087
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0165 0.0195
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0455 0.1122 0.1117
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0024 0.0913
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0041 0.0059 0.5277
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0122 0.0267 0.0261
Onchocerca volvulus 0.0102 0.0216 0.1102
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0006 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0051 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.011 0.0123
Echinococcus granulosus nmda type glutamate receptor 0.0621 0.1546 0.1541
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0057 0.0051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0057 0.005
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0057 0.4969
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0059 0.0523
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0104 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0057 0.0284
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0075 0.0674
Schistosoma mansoni glutamate receptor AMPA 0.0455 0.1122 0.1256
Plasmodium vivax SET domain protein, putative 0.0091 0.0188 1
Echinococcus multilocularis glutamate receptor 2 0.0666 0.1661 0.1655
Schistosoma mansoni metabotropic glutamate receptor 0.1629 0.4129 0.4623
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Schistosoma mansoni z-protein (S1r protein) 0.0058 0.0104 0.0116
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0251
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0248 0.0591 0.0585
Echinococcus granulosus RUN 0.0021 0.0008 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.005 0.0246
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0006 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.1145
Loa Loa (eye worm) glutamate receptor 0.3208 0.8176 0.8176
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0188 0.0182
Schistosoma mansoni glutamate receptor NMDA 0.0872 0.219 0.2452
Echinococcus multilocularis excitatory amino acid transporter 2 0.0759 0.19 0.1895
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0108 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0759 0.19 0.1895
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0108 0.1002
Echinococcus granulosus excitatory amino acid transporter 3 0.0759 0.19 0.1895
Onchocerca volvulus 0.0082 0.0165 0.0833
Echinococcus multilocularis regulator of G protein signaling 3 0.0058 0.0104 0.0097
Echinococcus multilocularis musashi 0.0082 0.0165 0.0159
Schistosoma mansoni axis inhibition protein axin 0.0058 0.0104 0.0116
Echinococcus multilocularis regulator of G protein signaling 3 0.0058 0.0104 0.0097
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0008 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.0059 0.0067
Schistosoma mansoni ATP-binding cassette transporter 0.0455 0.1122 0.1256
Onchocerca volvulus 0.0041 0.0059 0.0274
Schistosoma mansoni glutamate receptor NMDA 0.0455 0.1122 0.1256
Toxoplasma gondii hypothetical protein 0.0027 0.0024 0.0128
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0057 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0051 0.0055
Brugia malayi hypothetical protein 0.0027 0.0024 0.0022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0057 0.1008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0024 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0041 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0026 0.011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0103
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0104 0.0097
Brugia malayi regulator of G-protein signaling rgs-7 0.0058 0.0104 0.0119
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0008 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0917 0.2305 0.2304
Echinococcus granulosus 6 phosphofructokinase 0.0221 0.0522 0.0516
Brugia malayi Pre-SET motif family protein 0.0633 0.1577 0.1922
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0041 0.0059 0.5277
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0998 0.2511 0.2507
Echinococcus granulosus nmda type glutamate receptor 0.0417 0.1023 0.1018
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0108 0.5203
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0108 0.0448
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0075 0.0674
Echinococcus granulosus neutral amino acid transporter 0.0759 0.19 0.1895
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0104 0.0116
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Schistosoma mansoni rab6-interacting 0.0021 0.0008 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Echinococcus granulosus sodium:dicarboxylate symporter 0.0759 0.19 0.1895
Echinococcus granulosus beta-adrenergic receptor kinase 0.0058 0.0104 0.0097
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.1023 0.1023
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0058 0.0104 0.0116
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0059 0.0523
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0846 0.2123 0.2119
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0051 0.4422
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Echinococcus multilocularis lamin dm0 0.0082 0.0165 0.0159
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.2791 0.7108 0.8693
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0022
Echinococcus multilocularis metabotropic glutamate receptor 2 0.2708 0.6894 0.6892
Loa Loa (eye worm) RGC/RGC protein kinase 0.0417 0.1023 0.1023
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0075 0.0074
Loa Loa (eye worm) phosphofructokinase 0.0221 0.0522 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0188 0.021
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0473 0.1168 0.1162
Loa Loa (eye worm) hypothetical protein 0.0082 0.0165 0.0165
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0289 0.0697 0.0691
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0008 0.0001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0058 0.0104 0.0119
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0051 0.0443
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0216 0.0257
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0057 0.0051
Echinococcus granulosus glutamate receptor 4 0.0041 0.0061 0.0055
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0024 0.0018
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0006 0.0028
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0759 0.19 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0078 0.0088
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0131 0.0125
Echinococcus multilocularis glutamate receptor 2 0.0914 0.2296 0.2291
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0022 0.0154
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0235 0.0558 0.0557
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.005 0.0882
Plasmodium falciparum thrombospondin-related anonymous protein 0.0041 0.0059 0.5277
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0108 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.011 0.0104
Schistosoma mansoni serine-rich repeat protein 0.0515 0.1275 0.1428
Brugia malayi Receptor family ligand binding region containing protein 0.0917 0.2305 0.2813
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1098 0.2768 0.2763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0188 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0052
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0024 0.0027
Mycobacterium ulcerans 6-phosphofructokinase 0.0221 0.0522 0.57
Brugia malayi Glutamate receptor 2 precursor 0.0497 0.1228 0.1496
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0131 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Loa Loa (eye worm) RecQ helicase 0.0022 0.0012 0.0012
Brugia malayi hypothetical protein 0.0417 0.1023 0.1245
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0024 0.0018
Loa Loa (eye worm) RGS-3 protein 0.0058 0.0104 0.0103
Schistosoma mansoni tyrosine kinase 0.0417 0.1023 0.1146
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0543
Echinococcus multilocularis receptor type guanylyl cyclase 0.0417 0.1023 0.1018
Echinococcus granulosus lamin 0.0082 0.0165 0.0159
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0165 0.0165
Schistosoma mansoni ets-related 0.0228 0.0538 0.0603
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0024
Echinococcus granulosus geminin 0.0176 0.0407 0.0401
Entamoeba histolytica phosphofructokinase, putative 0.0221 0.0522 0.5069
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0058 0.0104 0.0103
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Echinococcus multilocularis axis inhibition protein axin 0.0058 0.0104 0.0097
Echinococcus multilocularis NMDA receptor 0.0473 0.1168 0.1162
Schistosoma mansoni hypothetical protein 0.0248 0.0591 0.0661
Echinococcus multilocularis 6 phosphofructokinase 0.0221 0.0522 0.0516
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Chlamydia trachomatis glutamate symporter 0.0759 0.19 1
Loa Loa (eye worm) glutamate receptor 1 0.0497 0.1228 0.1228
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0417 0.1023 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0543
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0102 0.0096
Loa Loa (eye worm) hypothetical protein 0.0102 0.0216 0.0216
Echinococcus granulosus GPCR family 3 C terminal 0.05 0.1236 0.1231
Loa Loa (eye worm) hypothetical protein 0.0058 0.0104 0.0103
Echinococcus granulosus voltage dependent calcium channel subunit 0.0998 0.2511 0.2507
Brugia malayi Glutamate receptor 1 precursor 0.0497 0.1228 0.1496
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.011 0.5302
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0058 0.0104 0.0097
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1355 0.3427 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0104 0.0097
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.05 0.1236 0.6494
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0102 0.0096
Schistosoma mansoni hypothetical protein 0.0041 0.0059 0.0067
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0024 0.0018
Loa Loa (eye worm) 6-phosphofructokinase 0.0221 0.0522 0.0521
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0075 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Loa Loa (eye worm) fli-1 protein 0.0228 0.0538 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Trichomonas vaginalis set domain proteins, putative 0.072 0.1801 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.0773 0.0773
Echinococcus multilocularis excitatory amino acid transporter 2 0.0759 0.19 0.1895
Toxoplasma gondii hypothetical protein 0.0027 0.0024 0.0128
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0221 0.0522 0.2722
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0022 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.005 0.0246
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0336 0.0817 0.0915
Loa Loa (eye worm) glutamate receptor 0.1212 0.3061 0.3061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0027 0.0113
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0024 0.0018
Schistosoma mansoni metabotropic glutamate receptor 0.2708 0.6894 0.7719
Echinococcus multilocularis glutamate receptor 2 0.0497 0.1228 0.1223
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0131 0.1226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0057 0.0498
Onchocerca volvulus 0.0082 0.0165 0.0833
Brugia malayi Zona pellucida-like domain containing protein 0.0041 0.0059 0.0065
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0012 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0075 0.0674
Plasmodium vivax thrombospondin-related anonymous protein 0.0041 0.0059 0.2879
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.005 0.0434
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0917 0.2305 0.2304
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0543
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.013 0.013
Plasmodium vivax amine transporter, putative 0.0027 0.0024 0.0913
Echinococcus granulosus voltage dependent calcium channel subunit 0.2193 0.5575 0.5572
Echinococcus granulosus lamin dm0 0.0082 0.0165 0.0159
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0051 0.0443
Loa Loa (eye worm) hypothetical protein 0.0122 0.0267 0.0267
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.011 0.0547
Loa Loa (eye worm) hypothetical protein 0.0076 0.0149 0.0149
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0187 0.0181
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0022
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0059 0.0065
Echinococcus multilocularis nmda type glutamate receptor 0.0417 0.1023 0.1018
Entamoeba histolytica hypothetical protein 0.0058 0.0104 0.0958
Echinococcus granulosus glutamate receptor subunit protein glur 0.0289 0.0697 0.0691
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0075 0.1354
Schistosoma mansoni lamin 0.0082 0.0165 0.0185
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0075 0.0674
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0012 0.0007
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0957 0.2407 0.2695
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0051 0.0498
Schistosoma mansoni gabp alpha 0.0075 0.0147 0.0165
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.011 0.1018
Onchocerca volvulus 0.0417 0.1023 0.5367
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0024 0.0027
Schistosoma mansoni DNA polymerase eta 0.002 0.0006 0.0007
Echinococcus granulosus regulator of G protein signaling 3 0.0058 0.0104 0.0097
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0759 0.19 0.1895
Loa Loa (eye worm) hypothetical protein 0.05 0.1236 0.1236
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Echinococcus multilocularis geminin 0.0176 0.0407 0.0401
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.3503 0.8932 1
Plasmodium falciparum transporter, putative 0.0027 0.0024 0.1845
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0104 0.0116
Echinococcus granulosus neutral amino acid transporter A 0.0759 0.19 0.1895
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0075 0.0382
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0373 0.0911 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0188 0.0182
Echinococcus granulosus excitatory amino acid transporter 2 0.0759 0.19 0.1895
Echinococcus granulosus serotonin transporter 0.0076 0.0149 0.0143
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0108 0.0568
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0108 0.0568
Schistosoma mansoni hypothetical protein 0.0176 0.0407 0.0455
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0057
Brugia malayi Guanylyl cyclase protein 23 0.0417 0.1023 0.1245
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.0221 0.0522 0.5069
Echinococcus multilocularis GPCR, family 3, C terminal 0.05 0.1236 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Schistosoma mansoni glutamate receptor AMPA 0.0455 0.1122 0.1256
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0473 0.1168 0.1162
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1098 0.2768 0.2763
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2193 0.5575 0.5572
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0059 0.2879
Schistosoma mansoni glutamate receptor kainate 0.0681 0.17 0.1903
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0188 0.0182
Loa Loa (eye worm) hypothetical protein 0.0076 0.0149 0.0149
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0558 0.0552
Echinococcus multilocularis beta adrenergic receptor kinase 0.0058 0.0104 0.0097
Schistosoma mansoni hypothetical protein 0.0515 0.1275 0.1428
Echinococcus multilocularis neutral amino acid transporter A 0.0759 0.19 0.1895
Loa Loa (eye worm) hypothetical protein 0.0417 0.1023 0.1023
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0221 0.0522 0.1394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0027 0.0113
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0104 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0057 0.0282
Schistosoma mansoni 6-phosphofructokinase 0.0221 0.0522 0.0584
Schistosoma mansoni sodium/chloride dependent transporter 0.0076 0.0149 0.0167
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0008 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.011 0.0123
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0058 0.0104 0.0097
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0104 0.0116
Schistosoma mansoni lipoxygenase 0.0057 0.0102 0.0114
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0417 0.1023 0.1018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0022
Echinococcus granulosus tyrosine kinase 0.0417 0.1023 0.1018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Echinococcus multilocularis expressed protein 0.1129 0.2849 0.2844
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0041 0.0059 0.2264
Brugia malayi Excitatory amino acid transporter 0.0759 0.19 0.2318
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0131 0.0153
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1098 0.2768 0.2763
Schistosoma mansoni tyrosine kinase 0.0417 0.1023 0.1146
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0131 0.1226
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0057 0.0064
Treponema pallidum 76K protein 0.0041 0.0059 0.0024
Onchocerca volvulus 0.0027 0.0024 0.0087
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0108 0.0448
Echinococcus granulosus intermediate filament protein 0.0082 0.0165 0.0159
Brugia malayi regulator of G-protein signaling egl-10 0.0058 0.0104 0.0119
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0522 0.2872
Schistosoma mansoni intermediate filament proteins 0.0082 0.0165 0.0185
Echinococcus granulosus expressed protein 0.1129 0.2849 0.2844
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0041 0.0059 0.2879
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Brugia malayi metabotropic GABA-B receptor subtype 2 0.05 0.1236 0.1506
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.4489
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0059 0.0065
Schistosoma mansoni hypothetical protein 0.0048 0.0078 0.0087
Echinococcus multilocularis Excitatory amino acid transporter 0.0759 0.19 0.1895
Brugia malayi Metabotropic glutamate receptor precursor. 0.3208 0.8176 1
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0147 0.0141
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.1145
Schistosoma mansoni loxhd1 0.0021 0.0008 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0033 0.0148
Schistosoma mansoni hypothetical protein 0.0021 0.0008 0.0009
Schistosoma mansoni glutamate receptor kainate 0.0681 0.17 0.1903
Entamoeba histolytica elongation factor-2 kinase, putative 0.0041 0.0059 0.0523
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0075 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0075 0.0382
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0051 0.0443
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0187 0.0209
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0051 0.0045
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0041 0.0059 0.0053
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0914 0.2296 0.2291
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0024 0.0018
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0759 0.19 0.2127
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0104 0.0543
Loa Loa (eye worm) glutamate receptor 2 0.0455 0.1122 0.1122
Echinococcus granulosus glutamate NMDA receptor subunit 0.0455 0.1122 0.1117
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0417 0.1023 0.5367
Schistosoma mansoni protein kinase 0.0417 0.1023 0.1146
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0058 0.0104 0.0116
Echinococcus granulosus Regulator of G protein signaling 20 0.0058 0.0104 0.0097
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.011 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0075 0.0382
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0075 0.0674
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0022 0.1639
Giardia lamblia GTOR 0.0047 0.0075 0.6729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.002 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0102 0.0217 0.0243
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0128
Echinococcus multilocularis lamin 0.0082 0.0165 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0027 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0108 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0044 0.0211
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0024 0.0027
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0128
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0024 0.0022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0024 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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