Detailed information for compound 1401901

Basic information

Technical information
  • TDR Targets ID: 1401901
  • Name: 6-(4-ethoxy-3-methoxyphenyl)-3-(phenylmethyls ulfanyl)-6,7-dihydro-[1,2,4]triazino[5,6-d][3 ,1]benzoxazepine
  • MW: 472.559 | Formula: C26H24N4O3S
  • H donors: 1 H acceptors: 3 LogP: 5.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)C1Oc2nc(SCc3ccccc3)nnc2c2c(N1)cccc2
  • InChi: 1S/C26H24N4O3S/c1-3-32-21-14-13-18(15-22(21)31-2)24-27-20-12-8-7-11-19(20)23-25(33-24)28-26(30-29-23)34-16-17-9-5-4-6-10-17/h4-15,24,27H,3,16H2,1-2H3
  • InChiKey: DTRGRMUYHVBCMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-ethoxy-3-methoxy-phenyl)-3-(phenylmethylsulfanyl)-6,7-dihydro-[1,2,4]triazino[5,6-d][3,1]benzoxazepine
  • 6-(4-ethoxy-3-methoxyphenyl)-3-(phenylmethylthio)-6,7-dihydro-[1,2,4]triazino[5,6-d][3,1]benzoxazepine
  • 3-(benzylthio)-6-(4-ethoxy-3-methoxy-phenyl)-6,7-dihydro-[1,2,4]triazino[5,6-d][3,1]benzoxazepine
  • NCGC00100690-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0307 0.4198 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.1836 0.3861
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.0613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0052 0.0052
Echinococcus multilocularis transferase 0.0022 0.0118 0.0118
Echinococcus granulosus ectonucleotide 0.012 0.1516 0.1516
Leishmania major hypothetical protein, conserved 0.0027 0.0191 0.0337
Brugia malayi neuropeptide F receptor 0.0018 0.0052 0.007
Brugia malayi G-protein coupled receptor 0.0018 0.0052 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.1272 0.2853
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Echinococcus granulosus neuropeptide receptor 0.0018 0.0052 0.0052
Trypanosoma cruzi peter pan protein, putative 0.0075 0.0869 0.1902
Schistosoma mansoni P2X receptor subunit 0.0427 0.5926 0.5907
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0052 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.026 0.3536 1
Trypanosoma brucei endonuclease G, putative 0.0085 0.1022 0.2264
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0309 0.1423
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0071
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0048 0.0061
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0309 0.0613
Schistosoma mansoni neuropeptide receptor 0.0018 0.0052 0.0004
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Onchocerca volvulus 0.0142 0.1836 0.4304
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0052 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0052 0.0004
Onchocerca volvulus Putative thymidylate kinase 0.007 0.0799 0.1803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0173 0.0361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Brugia malayi hypothetical protein 0.0022 0.0118 0.023
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0309 0.058
Echinococcus granulosus transferase 0.0022 0.0118 0.0118
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.0799 0.1804
Brugia malayi putative neuropeptide receptor 0.0018 0.0052 0.007
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0142 0.1836 0.1797
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0052 0.0004
Schistosoma mansoni opsin-like receptor 0.0018 0.0052 0.0004
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.007 0.0799 1
Echinococcus granulosus peter pan 0.0075 0.0869 0.0869
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0052 0.0052
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0052 0.0052
Echinococcus granulosus sex peptide receptor 0.0018 0.0052 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Echinococcus granulosus thymidylate kinase 0.007 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0052 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0309 0.2131
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0205 0.0205
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0052 0.0052
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0139 0.179 0.1751
Brugia malayi sulfakinin receptor protein 0.0018 0.0052 0.007
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.217 0.5767
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0309 0.0927
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0309 0.058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0309 0.0309
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0052 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0052 0.007
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0022 0.0118 0.0118
Treponema pallidum 5'-nucleotidase (ushA) 0.0139 0.179 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0264 0.0264
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0027 0.0191 0.0302
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0052 0.0052
Schistosoma mansoni peter pan-related 0.0075 0.0869 0.0825
Trypanosoma cruzi endonuclease G, putative 0.0085 0.1022 0.2264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi Dopamine receptor 0.0018 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0309 0.0613
Echinococcus multilocularis peter pan 0.0075 0.0869 0.0869
Onchocerca volvulus 0.0142 0.1836 0.4304
Echinococcus granulosus orexin receptor type 2 0.0018 0.0052 0.0052
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0022 0.0118 0.0118
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0052 0.0052
Toxoplasma gondii brix domain-containing protein 0.0075 0.0869 0.4667
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0063 0.0132
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0052 0.0052
Leishmania major ethanolamine phosphotransferase, putative 0.0022 0.0118 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0052 0.0052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0309 0.058
Brugia malayi AKH receptor 0.0018 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0085 0.1022 0.2291
Brugia malayi Flap endonuclease-1 0.0028 0.0205 0.0437
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0022 0.0118 0.0161
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0052 0.0052
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0052 0.0052
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0052 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.058
Brugia malayi Dopamine receptor protein 1 0.0018 0.0052 0.007
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0052 0.0108
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0022 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0063 0.0097
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.3161 0.8837
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0052 0.0108
Brugia malayi RE15519p 0.0018 0.0052 0.007
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0052 0.0052
Brugia malayi Brix domain containing protein 0.0075 0.0869 0.2028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.058
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0052 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.058
Brugia malayi Thrombospondin type 1 domain containing protein 0.0307 0.4198 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0085 0.1022 0.2264
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0307 0.4198 0.8827
Schistosoma mansoni endonuclease related 0.0085 0.1022 0.0979
Schistosoma mansoni P2X receptor subunit 0.0427 0.5926 0.5907
Echinococcus granulosus hypothetical protein 0.0018 0.0052 0.0052
Echinococcus multilocularis thymidylate kinase 0.007 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0249
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.4301 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0052 0.0052
Brugia malayi thymidylate kinase 0.007 0.0799 0.1861
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0431 0.0869
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Leishmania major trypanothione reductase 0.0103 0.1272 0.2878
Plasmodium vivax SET domain protein, putative 0.0032 0.0264 0.1769
Schistosoma mansoni biogenic amine receptor 0.0018 0.0052 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0249
Trichomonas vaginalis ssf, putative 0.0075 0.0869 0.2016
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0309 0.0309
Echinococcus granulosus neuropeptide receptor 0.0018 0.0052 0.0052
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0085 0.1022 0.2264
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0309 0.0927
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus multilocularis Endonuclease G 0.0085 0.1022 0.1022
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0569 0.1196
Plasmodium falciparum BRIX domain, putative 0.0075 0.0869 0.6708
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0052 0.0052
Chlamydia trachomatis thymidylate kinase 0.007 0.0799 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0309 0.058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0249
Brugia malayi neuropeptide F receptor 0.0018 0.0052 0.007
Echinococcus granulosus allatostatin A receptor 0.0018 0.0052 0.0052
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.3161 0.8837
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0022 0.0118 0.0249
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0052 0.0052
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0309 0.1423
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0127 0.1625 0.3416
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0027 0.0191 0.0302
Echinococcus multilocularis lamin 0.0029 0.0217 0.0217
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0052 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0264 0.0264
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0264 0.0264
Echinococcus granulosus somatostatin receptor 0.0018 0.0052 0.0052
Brugia malayi AEL166Cp 0.0022 0.0118 0.023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0309 0.0686
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi GnHR receptor homolog 0.0018 0.0052 0.007
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Schistosoma mansoni myosin xvIII 0.0018 0.0052 0.0004
Brugia malayi Pre-SET motif family protein 0.0032 0.0264 0.0579
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0264 0.0218
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0004
Schistosoma mansoni peter pan-related 0.0075 0.0869 0.0825
Schistosoma mansoni amine GPCR 0.0018 0.0052 0.0004
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.007 0.0799 0.1992
Toxoplasma gondii hypothetical protein 0.0051 0.0524 0.2671
Brugia malayi intermediate filament protein 0.0029 0.0217 0.0466
Mycobacterium ulcerans hypothetical protein 0.0165 0.217 1
Leishmania major peter pan protein, putative 0.0075 0.0869 0.1931
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.0799 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.058
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0456
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0022 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Schistosoma mansoni opsin-like receptor 0.0018 0.0052 0.0004
Echinococcus granulosus g protein coupled receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Loa Loa (eye worm) thymidylate kinase 0.007 0.0799 0.168
Onchocerca volvulus Peter pan protein homolog 0.0075 0.0869 0.1971
Brugia malayi Thioredoxin reductase 0.0103 0.1272 0.2993
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0138 0.1784 0.1745
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0052 0.0108
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0071
Plasmodium falciparum thioredoxin reductase 0.0103 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0052 0.0004
Schistosoma mansoni biogenic amine receptor 0.0018 0.0052 0.0004
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0205 0.0335
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0052 0.0052
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.007 0.0799 0.152
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0052 0.0052
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.0613
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0264 0.0218
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.1272 0.2674
Loa Loa (eye worm) hypothetical protein 0.0345 0.4756 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.026 0.3536 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0052 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0309 0.0927
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0052 0.0052
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0052 0.0004
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0309 0.2535
Mycobacterium tuberculosis Probable reductase 0.0234 0.3161 0.8837
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0022 0.0118 0.0161
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0309 0.058
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Plasmodium falciparum glutathione reductase 0.0103 0.1272 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.058
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0309 0.2131
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0052 0.0004
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1929 0.4423
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0309 0.2131
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.026 0.3536 1
Schistosoma mansoni lamin 0.0029 0.0217 0.017
Schistosoma mansoni hypothetical protein 0.0307 0.4198 0.417
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Giardia lamblia Peter pan protein 0.0075 0.0869 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0052 0.007
Echinococcus multilocularis lamin dm0 0.0029 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0052 0.0052
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0052 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Trypanosoma brucei brix domain containing protein, putative 0.0075 0.0869 0.1902
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0052 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Echinococcus granulosus g protein coupled receptor 0.0018 0.0052 0.0052
Echinococcus granulosus Endonuclease G 0.0085 0.1022 0.1022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.01
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.012 0.1516 0.1516
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0139 0.179 1
Schistosoma mansoni neuropeptide receptor 0.0018 0.0052 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0052 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0431 0.0869
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0052 0.0052
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0309 0.0315
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0052 0.0052
Echinococcus granulosus lamin dm0 0.0029 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Plasmodium falciparum thioredoxin reductase 0.0036 0.0309 0.2131
Echinococcus multilocularis sex peptide receptor 0.0018 0.0052 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0309 0.2131
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0022 0.0118 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi Serotonin receptor 0.0018 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0209 0.044
Brugia malayi Variant SH3 domain containing protein 0.0127 0.1625 0.3837
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Brugia malayi hypothetical protein 0.0133 0.17 0.4018
Loa Loa (eye worm) hypothetical protein 0.012 0.1516 0.3187
Plasmodium vivax glutathione reductase, putative 0.0103 0.1272 1
Schistosoma mansoni flap endonuclease-1 0.0026 0.0166 0.0119
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0052 0.0052
Echinococcus multilocularis ectonucleotide 0.012 0.1516 0.1516
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0052 0.0052
Onchocerca volvulus 0.0018 0.0063 0.0027
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0063 0.0063
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.4301 1
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0004
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0052 0.0052
Plasmodium falciparum thymidylate kinase 0.007 0.0799 0.6139
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0052 0.0052
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0173 0.0361
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.4301 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.3161 0.8902
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0052 0.0052
Trypanosoma brucei endonuclease G, putative 0.0085 0.1022 0.2264
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0052 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1929 0.4403
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0247 0.0247
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0205 0.1151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0249
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0052 0.0052
Echinococcus granulosus fmrfamide receptor 0.0018 0.0052 0.0052
Plasmodium falciparum flap endonuclease 1 0.0028 0.0205 0.1283
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.1272 0.2985
Brugia malayi Pre-SET motif family protein 0.0227 0.3051 0.7252
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0052 0.0052
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0052 0.0004
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.0799 0.1738
Treponema pallidum thymidylate kinase (tmk) 0.007 0.0799 0.3312
Giardia lamblia CDC8 0.007 0.0799 0.9071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.012 0.1516 0.1516
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0052 0.007
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0057 0.0618 0.3214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.1929 0.4403
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Trypanosoma brucei endonuclease G, putative 0.0085 0.1022 0.2264
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0052 0.0108
Schistosoma mansoni thymidylate kinase 0.007 0.0799 0.0755
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0022 0.0118 0.0118
Plasmodium vivax thymidylate kinase, putative 0.007 0.0799 0.6139
Trypanosoma brucei thymidylate kinase, putative 0.007 0.0799 0.1738
Leishmania major thymidylate kinase-like protein 0.007 0.0799 0.1767
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0052 0.007
Echinococcus granulosus zinc finger protein 598 0.0074 0.0862 0.0862
Echinococcus granulosus lamin 0.0029 0.0217 0.0217
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0052 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0052 0.0004
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0022 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0142 0.1836 0.3861
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0142 0.1836 0.1797
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0052 0.0004
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0052 0.007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0264 0.1167
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0052 0.0004
Echinococcus multilocularis musashi 0.0029 0.0217 0.0217
Schistosoma mansoni adenoreceptor 0.0018 0.0052 0.0004
Brugia malayi glutathione reductase 0.0103 0.1272 0.2993
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Onchocerca volvulus 0.0029 0.0217 0.0399
Onchocerca volvulus 0.0258 0.35 0.8316
Trichomonas vaginalis set domain proteins, putative 0.0258 0.35 1
Entamoeba histolytica brix domain containing protein 0.0075 0.0869 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0052 0.0052
Echinococcus granulosus g protein coupled receptor 0.0018 0.0052 0.0052
Echinococcus multilocularis somatostatin receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi Serotonin receptor 0.0018 0.0052 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0052 0.0052
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0052 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0869 0.6708
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0205 0.0822
Toxoplasma gondii thioredoxin reductase 0.0103 0.1272 0.7
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0205 0.1151
Brugia malayi larval opioid receptor 0.0018 0.0052 0.007
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0048 0.01
Brugia malayi endonuclease G, mitochondrial precursor 0.0085 0.1022 0.2395
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi hypothetical protein 0.0022 0.0118 0.023
Schistosoma mansoni opsin-like receptor 0.0018 0.0052 0.0004
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0063 0.0063
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0052 0.0004
Trypanosoma brucei thymidylate kinase, putative 0.007 0.0799 0.1738
Brugia malayi G-protein coupled receptor 0.0018 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0132
Giardia lamblia Hypothetical protein 0.0057 0.0612 0.658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0052 0.0052
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0205 0.0369
Schistosoma mansoni hypothetical protein 0.007 0.0799 0.0755
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0052 0.0052
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0205 0.0335
Onchocerca volvulus 0.0018 0.0063 0.0027
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0052 0.0108
Brugia malayi Melatonin receptor type 1A 0.0018 0.0052 0.007
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0022 0.0118 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0052 0.0052
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0022 0.0118 0.0071
Schistosoma mansoni neuropeptide receptor 0.0018 0.0052 0.0004
Brugia malayi G protein-coupled receptor 0.0018 0.0052 0.007
Schistosoma mansoni lamin 0.0029 0.0217 0.017
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0022 0.0118 0.0131
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0052 0.0052
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0052 0.0052
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0052 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0264 0.0218
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.3161 0.8837
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0309 0.058
Plasmodium falciparum glutathione reductase 0.0036 0.0309 0.2131
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.3051 0.6414
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0052 0.0052
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0217 0.0456
Echinococcus granulosus serotonin receptor 0.0018 0.0052 0.0052
Trypanosoma brucei trypanothione reductase 0.0103 0.1272 0.2853
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0022 0.0118 0.0118
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0217 0.0456
Mycobacterium tuberculosis Probable oxidoreductase 0.026 0.3536 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.1272 0.1272
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Echinococcus granulosus flap endonuclease 1 0.0028 0.0205 0.0205
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0052 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0309 0.058
Echinococcus multilocularis serotonin receptor 0.0018 0.0052 0.0052
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0032 0.0252 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Schistosoma mansoni biogenic amine receptor 0.0018 0.0052 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0309 0.058
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0264 0.0556
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0052 0.007
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0052 0.0004
Schistosoma mansoni histamine h1 receptor 0.0018 0.0052 0.0004
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0022 0.0118 0.0161
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0052 0.007
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0142 0.1836 0.4344
Schistosoma mansoni amine GPCR 0.0018 0.0052 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0052 0.0108
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0052 0.0052
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0052 0.0108
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0085 0.1022 0.5555
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.0799 0.1804
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0052 0.0052
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0205 0.1283
Loa Loa (eye worm) brix domain-containing protein 0.0075 0.0869 0.1827
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0022 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0052 0.007
Trypanosoma cruzi peter pan protein, putative 0.0075 0.0869 0.1902
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0022 0.0118 0.0577
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0071
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0052 0.0052
Toxoplasma gondii thymidylate kinase 0.007 0.0799 0.4264
Loa Loa (eye worm) glutathione reductase 0.0103 0.1272 0.2674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.3161 0.8837
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0052 0.0052
Trypanosoma cruzi endonuclease G, putative 0.0085 0.1022 0.2264
Leishmania major phospholipase c-like protein 0.0018 0.0063 0.0035
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0309 0.0262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0132
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0217 0.0466
Schistosoma mansoni intermediate filament proteins 0.0029 0.0217 0.017
Entamoeba histolytica Thymidylate kinase, putative 0.007 0.0799 0.9071
Schistosoma mansoni thymidylate kinase 0.007 0.0799 0.0755
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0052 0.0052
Leishmania major endonuclease G, putative 0.0085 0.1022 0.2291
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.1272 0.1272
Schistosoma mansoni amine GPCR 0.0018 0.0052 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Mycobacterium ulcerans thymidylate kinase 0.007 0.0799 0.3319
Onchocerca volvulus 0.0029 0.0217 0.0399
Schistosoma mansoni amine GPCR 0.0018 0.0052 0.0004
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0142 0.1836 0.1836
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Echinococcus multilocularis zinc finger protein 598 0.0074 0.0862 0.0862
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0309 0.0315
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.3161 0.8837
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0052 0.0052
Echinococcus multilocularis serotonin receptor 0.0018 0.0052 0.0052
Brugia malayi hypothetical protein 0.0018 0.0052 0.007
Schistosoma mansoni neuropeptide receptor 0.0018 0.0052 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0052 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0052 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Schistosoma mansoni amine GPCR 0.0018 0.0052 0.0004
Loa Loa (eye worm) hypothetical protein 0.0142 0.1836 0.3861
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0142 0.1836 0.1797
Brugia malayi ORL1-like opioid receptor 0.0018 0.0052 0.007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0431 0.0869
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0048 0.0061
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0052 0.0004
Brugia malayi Dopamine receptor protein 2 0.0018 0.0052 0.007
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.4301 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0205 0.043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0052 0.0004
Echinococcus granulosus intermediate filament protein 0.0029 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0108
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0431 0.0869
Onchocerca volvulus 0.0032 0.0264 0.0513
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0264 0.0218
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0142 0.1836 0.1797
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0052 0.0052

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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