Detailed information for compound 1404123

Basic information

Technical information
  • TDR Targets ID: 1404123
  • Name: T5555492
  • MW: 445.489 | Formula: C21H23N3O6S
  • H donors: 2 H acceptors: 4 LogP: 1.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)N1CCOCC1)/C=C/C(=O)Nc1ccccc1C(=O)N
  • InChi: 1S/C21H23N3O6S/c1-29-18-8-6-15(14-19(18)31(27,28)24-10-12-30-13-11-24)7-9-20(25)23-17-5-3-2-4-16(17)21(22)26/h2-9,14H,10-13H2,1H3,(H2,22,26)(H,23,25)/b9-7+
  • InChiKey: WVFMFLNOIRTDLL-VQHVLOKHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0145 0.0523
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0281 0.4599 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0968 0.3495
Loa Loa (eye worm) acetyltransferase 0.0178 0.2768 1
Mycobacterium ulcerans lipoprotein LpqF 0.0281 0.4599 0.4467
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.086
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0035 0.0238 0.5298
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0035 0.0238 0.2332
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.2768 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.086
Entamoeba histolytica type A flavoprotein, putative 0.0035 0.0238 0.5298
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1022 1
Brugia malayi PHD-finger family protein 0.0034 0.0222 0.0803
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0035 0.0238 0.2332
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.1022 0.0803
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0281 0.4599 0.4467
Loa Loa (eye worm) hypothetical protein 0.0079 0.1022 0.369
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0035 0.0238 0.2332
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0968 0.3678
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0001 0.0007
Echinococcus granulosus serine protein kinase ATM 0.003 0.0145 0.055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.1022 0.369
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0238 0.2332
Entamoeba histolytica alkyl sulfatase, putative 0.0035 0.0238 0.5298
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.1022 0.0803
Loa Loa (eye worm) hypothetical protein 0.0079 0.1022 0.369
Trypanosoma brucei beta lactamase 0.0281 0.4599 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.086
Mycobacterium tuberculosis Conserved protein 0.0079 0.1022 0.0803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.1022 0.369
Trypanosoma cruzi glyoxalase II 0.0035 0.0238 0.2332
Entamoeba histolytica metallo-beta-lactamase family protein 0.0035 0.0238 0.5298
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1022 1
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.1022 0.0803
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.045 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0035 0.0238 0.5298
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.2631 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.1022 0.369
Schistosoma mansoni zinc phosphodiesterase 0.0035 0.0238 0.086
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0145 0.0523
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.1022 1
Mycobacterium leprae conserved hypothetical protein 0.0079 0.1022 0.1797
Brugia malayi beta-lactamase 0.0079 0.1022 0.369
Trichomonas vaginalis apoptosis inducing factor, putative 0.0035 0.0238 0.2332
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0035 0.0238 0.2332
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0238 0.2332
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0254
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0035 0.0238 0.2332
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0145 0.1417
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0035 0.0238 0.0906
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.2768 1
Schistosoma mansoni zinc phosphodiesterase 0.0035 0.0238 0.086
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0035 0.0238 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0096 0.0363
Brugia malayi metallo-beta-lactamase superfamily protein 0.0035 0.0238 0.086
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0238 0.2332
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0681 0.2458
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0035 0.0238 0.0518
Mycobacterium tuberculosis Conserved protein 0.0079 0.1022 0.0803
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.1022 0.0803
Loa Loa (eye worm) hypothetical protein 0.006 0.0681 0.2458
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0681 0.2458
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0145 0.0523
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.1022 0.369
Toxoplasma gondii ABC1 family protein 0.0079 0.1022 1
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0238 0.2332
Loa Loa (eye worm) hypothetical protein 0.0056 0.0602 0.2176
Brugia malayi beta-lactamase family protein 0.0079 0.1022 0.369
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.1022 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0238 0.2332
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0507 0.8615 0.8581
Mycobacterium tuberculosis Conserved protein 0.0079 0.1022 0.0803
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.1022 0.3884
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.1022 0.369
Loa Loa (eye worm) hypothetical protein 0.0079 0.1022 0.369
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.086
Mycobacterium ulcerans lipase LipD 0.0079 0.1022 0.0803
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0681 0.2458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.086
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0343 0.1238
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0035 0.0238 0.2332
Echinococcus multilocularis zinc finger protein 0.0028 0.0108 0.039
Mycobacterium ulcerans hypothetical protein 0.0079 0.1022 0.0803
Loa Loa (eye worm) hypothetical protein 0.0079 0.1022 0.369
Loa Loa (eye worm) hypothetical protein 0.0053 0.0561 0.2028
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0001 0.0007
Trypanosoma cruzi glyoxalase II 0.0035 0.0238 0.2332
Leishmania major metallo-beta-lactamase family protein-like protein 0.0035 0.0238 0.2332
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0035 0.0238 0.5298
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0576 0.5642
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.045 1
Treponema pallidum ribonuclease Z 0.0035 0.0238 0.5
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0035 0.0238 0.086
Echinococcus multilocularis zinc phosphodiesterase 0.0035 0.0238 0.086
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.1022 0.0803
Mycobacterium ulcerans beta-lactamase 0.0079 0.1022 0.0803
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0035 0.0238 0.5298
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0576 0.5642
Entamoeba histolytica hypothetical protein 0.003 0.0145 0.3219
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0035 0.0238 0.2332
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.1022 1
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1022 1
Brugia malayi ethe1-prov protein 0.0035 0.0238 0.086
Loa Loa (eye worm) beta-lactamase 0.0079 0.1022 0.369
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0145 0.1417
Echinococcus multilocularis ETHE1 protein 0.0035 0.0238 0.086
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0238 0.2332
Onchocerca volvulus 0.0079 0.1022 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0145 0.0315
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0035 0.0238 0.086
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0035 0.0238 0.086
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0035 0.0238 0.0906
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0576 0.5642
Brugia malayi Bromodomain containing protein 0.0051 0.0509 0.1839
Schistosoma mansoni hypothetical protein 0.0025 0.0055 0.0197
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0035 0.0238 0.2332
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0035 0.0238 0.086
Loa Loa (eye worm) hypothetical protein 0.0079 0.1022 0.369
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0576 0.2191
Brugia malayi metallo-beta-lactamase superfamily protein 0.0035 0.0238 0.086
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0238 0.2332
Entamoeba histolytica type A flavoprotein, putative 0.0035 0.0238 0.5298
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0238 0.2332
Loa Loa (eye worm) hypothetical protein 0.0046 0.0435 0.157
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0035 0.0238 0.086
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0238 0.2332
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.2768 1
Trichomonas vaginalis esterase, putative 0.0079 0.1022 1
Trypanosoma cruzi glyoxalase II 0.0035 0.0238 0.2332
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0096 0.0345
Brugia malayi beta-lactamase family protein 0.0079 0.1022 0.369
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.086
Brugia malayi hypothetical protein 0.0035 0.0238 0.086
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0035 0.0238 0.0518
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0035 0.0238 0.5298
Onchocerca volvulus 0.0079 0.1022 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0382 0.1453
Leishmania major hypothetical protein, conserved 0.0079 0.1022 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0576 0.4317
Onchocerca volvulus 0.0079 0.1022 1
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.1238
Leishmania major hypothetical protein, conserved 0.0035 0.0238 0.2332
Echinococcus granulosus zinc phosphodiesterase 0.0035 0.0238 0.0906
Schistosoma mansoni bromodomain containing protein 0.0081 0.1044 0.3772
Echinococcus granulosus zinc finger protein 0.0028 0.0108 0.0411
Loa Loa (eye worm) hypothetical protein 0.0079 0.1022 0.369
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0035 0.0238 0.2332
Toxoplasma gondii FATC domain-containing protein 0.003 0.0145 0.1417
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0055 0.0197
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0035 0.0238 0.086
Trichomonas vaginalis A-type flavoprotein 0.0035 0.0238 0.2332
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0035 0.0238 0.086
Brugia malayi Bromodomain containing protein 0.0095 0.1295 0.4679
Entamoeba histolytica alkyl sulfatase, putative 0.0035 0.0238 0.5298
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0035 0.0238 0.086
Echinococcus granulosus ETHE1 protein 0.0035 0.0238 0.0906
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.1022 0.0803
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.086
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0035 0.0238 0.0518
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0238 0.2332
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.045 1
Plasmodium vivax hypothetical protein, conserved 0.0079 0.1022 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0035 0.0238 0.5298
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0035 0.0238 0.5298
Loa Loa (eye worm) hypothetical protein 0.0041 0.0343 0.1238
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.1022 1
Trypanosoma brucei glyoxalase II 0.0035 0.0238 0.0518
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0035 0.0238 0.2332
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0067 0.0242
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0576 0.5642
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.1022 0.2222
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.007 0.0687
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0096 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0238 0.2332
Leishmania major metallo-beta-lactamase family-like protein 0.0035 0.0238 0.2332
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.1022 0.0803
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0238 0.5298
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0035 0.0238 0.0906
Trichomonas vaginalis beta lactamase domain, putative 0.0035 0.0238 0.2332
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.1022 1
Mycobacterium leprae Probable lipase LipE 0.0079 0.1022 0.1797
Chlamydia trachomatis ribonuclease Z 0.0035 0.0238 0.5
Loa Loa (eye worm) hypothetical protein 0.0085 0.1128 0.4073
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0238 0.2332
Schistosoma mansoni zinc finger protein 0.0028 0.0108 0.039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0382 0.1381
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.1022 0.0803

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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