TDR Targets

Basic information

Technical information

TDR Targets ID: 1405753
Name: N-(1-furan-2-ylethyl)-4-methyl-N-pyridin-2-yl benzamide
MW: 306.358 | Formula: C19H18N2O2
H donors: 0 H acceptors: 2 LogP: 3.56 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)C(=O)N(C(c1ccco1)C)c1ccccn1
InChi: 1S/C19H18N2O2/c1-14-8-10-16(11-9-14)19(22)21(18-7-3-4-12-20-18)15(2)17-6-5-13-23-17/h3-13,15H,1-2H3
InChiKey: WLCCBPXXWAARAK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[1-(2-furyl)ethyl]-4-methyl-N-(2-pyridyl)benzamide
N-(1-furan-2-ylethyl)-4-methyl-N-pyridin-2-yl-benzamide
Enamine_003380
T0509-4497
MLS000082200
SMR000061537

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed), beta	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania donovani	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania infantum	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania braziliensis	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania mexicana	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania major	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	polymerase (DNA directed), beta	335 aa	303 aa	32.3 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.021	0.0778
Entamoeba histolytica	hypothetical protein	0.0023	0.021	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0284	0.0803
Brugia malayi	Smad1	0.0008	0.0036	0.0049
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0036	0.0049
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0048	0.0508	0.0695
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0006	0.0005	0.0012
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0532	0.0532
Brugia malayi	cytochrome P450	0.0007	0.0022	0.003
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0025	0.0234	0.0939
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.061	0.0835
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0184	0.0521
Schistosoma mansoni	hypothetical protein	0.0051	0.0549	0.1552
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0036	0.0101
Brugia malayi	Importin beta-1 subunit	0.0028	0.0274	0.0374
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0184	0.0184
Schistosoma mansoni	hypothetical protein	0.03	0.3537	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.2011	0.4655
Brugia malayi	cathepsin B-like cysteine proteinase	0.014	0.1618	0.2213
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0532	0.1187
Toxoplasma gondii	hypothetical protein	0.0059	0.0643	0.2815
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.061	0.26
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0532	0.1232
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0036	0.0101
Schistosoma mansoni	hypothetical protein	0.0165	0.1918	0.5424
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0051	0.0549	0.1552
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0687	0.1548
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.061	0.1413
Brugia malayi	peptidase family M13 containing protein	0.0048	0.0508	0.0695
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0195	0.2285	0.6459
Brugia malayi	MH1 domain containing protein	0.0008	0.0036	0.0049
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.06	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1713	0.2343
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.061	0.26
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0184	0.0342
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0532	0.1232
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.014	0.1618	0.4574
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0532	0.1232
Leishmania major	cytochrome p450-like protein	0.0007	0.0022	0.0051
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0234	0.0321
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0022	0.003
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0284	0.0803
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.06	0.06
Schistosoma mansoni	importin beta-1	0.0028	0.0274	0.0773
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0553	0.1235
Echinococcus multilocularis	cathepsin b	0.014	0.1618	0.1618
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0046	0.0491	0.1137
Echinococcus granulosus	cathepsin b	0.014	0.1618	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0284	0.0389
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0532	0.1505
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0184	0.6492
Schistosoma mansoni	hypothetical protein	0.0051	0.0549	0.1552
Mycobacterium leprae	probable zinc metalloprotease	0.0195	0.2285	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0284	0.0803
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0274	0.0773
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0274	0.9626
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0274	0.0374
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0274	0.0274
Echinococcus multilocularis	Smad4	0.0008	0.0036	0.0036
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.2245	0.9826
Trypanosoma brucei	protein kinase, putative	0.005	0.0532	0.1232
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0022	0.003
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0234	0.0494
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.061	0.1725
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.432	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0184	0.0378
Brugia malayi	MH2 domain containing protein	0.0008	0.0036	0.0049
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0172	0.0349
Loa Loa (eye worm)	POT family protein	0.0263	0.3092	0.423
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0046	0.0491	0.1137
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0553	0.1235
Mycobacterium ulcerans	zinc metalloprotease	0.0195	0.2285	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.1618	0.2213
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0007	0.0022	0.0051
Giardia lamblia	Cathepsin B precursor	0.0046	0.0491	0.8859
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0234	0.0494
Toxoplasma gondii	peptidase family M13 protein	0.0195	0.2285	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0172	0.0664
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0532	0.0728
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0532	0.0532
Echinococcus granulosus	endothelin converting enzyme 1	0.0195	0.2285	0.6459
Toxoplasma gondii	exonuclease III APE	0.002	0.0172	0.0754
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0099	0.1121	0.317
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0022	0.003
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0284	0.1244
Leishmania major	importin beta-1 subunit, putative	0.0023	0.021	0.0485
Echinococcus granulosus	geminin	0.0165	0.1918	0.5424
Echinococcus granulosus	snurportin 1	0.03	0.3537	1
Schistosoma mansoni	endothelin-converting enzyme-related	0.0048	0.0508	0.1437
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0048	0.0508	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0149	0.0203
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0466	0.5542	0.7581
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.432	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0036	0.0036
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.2011	0.4655
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0284	0.0803
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0532	0.1187
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.014	0.1618	0.4574
Echinococcus granulosus	cathepsin b	0.014	0.1618	0.4574
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0284	0.0284
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0144	0.1672	0.2287
Brugia malayi	Peptidase family M13 containing protein	0.0195	0.2285	0.3125
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0046	0.0491	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1713	0.2343
Loa Loa (eye worm)	cytochrome P450	0.0007	0.0022	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.0298	0.0643
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0036	0.0101
Leishmania major	GTP-binding protein, putative	0.0021	0.0184	0.0427
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0172	0.0399
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0099	0.1121	0.317
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0172	0.6294
Plasmodium falciparum	importin beta, putative	0.0028	0.0274	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.06	0.1697
Leishmania major	hypothetical protein, conserved	0.003	0.0298	0.0691
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.061	0.26
Onchocerca volvulus		0.023	0.2697	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0284	0.0803
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0007	0.0022	0.0051
Schistosoma mansoni	ap endonuclease	0.002	0.0172	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2285	0.3125
Brugia malayi	MH1 domain containing protein	0.0008	0.0036	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2285	0.3125
Loa Loa (eye worm)	hypothetical protein	0.0097	0.11	0.1504
Brugia malayi	Pre-SET motif family protein	0.0029	0.0284	0.0389
Loa Loa (eye worm)	cathepsin B	0.0046	0.0491	0.0672
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0099	0.1121	0.317
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0532	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2362	0.3231
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0532	0.1974
Entamoeba histolytica	Ran family GTPase	0.0021	0.0184	0.8795
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.014	0.1618	0.4574
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.014	0.1618	0.4574
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0046	0.0491	0.1092
Trichomonas vaginalis	set domain proteins, putative	0.023	0.2697	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0051	0.0553	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1672	0.2287
Echinococcus multilocularis		0.0007	0.0022	0.0022
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0532	0.1187
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0048	0.0508	0.1437
Schistosoma mansoni	hypothetical protein	0.0051	0.0549	0.1552
Echinococcus multilocularis	cathepsin b	0.014	0.1618	0.1618
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0274	0.0633
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0007	0.0022	0.0096
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0099	0.1121	0.317
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0184	0.0378
Schistosoma mansoni	ran	0.0021	0.0184	0.0521
Brugia malayi	RNA, U transporter 1	0.008	0.0895	0.1225
Brugia malayi	Angiotensin-converting enzyme family protein	0.0613	0.731	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1672	0.2287
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.432	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.06	0.1697
Echinococcus multilocularis	smad	0.0008	0.0036	0.0036
Brugia malayi	POT family protein	0.0263	0.3092	0.423
Schistosoma mansoni	Smad4	0.0008	0.0036	0.0101
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0234	0.0321
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0172	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0025	0.0234	0.0543
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.06	0.06
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0532	0.1974
Plasmodium vivax	SET domain protein, putative	0.0029	0.0284	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.06	0.0821
Brugia malayi	MAP kinase sur-1	0.005	0.0532	0.0728
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0172	0.0172
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1397	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1713	0.2343
Mycobacterium ulcerans	hypothetical protein	0.0192	0.2245	0.9826
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.3537	0.4839
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0172	0.0399
Schistosoma mansoni	hypothetical protein	0.0051	0.0549	0.1552
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1397	0.1911
Schistosoma mansoni	hypothetical protein	0.0051	0.0549	0.1552
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0172	0.6059
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0172	0.0236
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.06	0.1697
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0172	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1672	0.2287
Schistosoma mansoni	hypothetical protein	0.0165	0.1918	0.5424
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0036	0.0036
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.2011	0.4628
Brugia malayi	follicle stimulating hormone receptor	0.0466	0.5542	0.7581
Schistosoma mansoni	ap endonuclease	0.002	0.0172	0.0487
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.014	0.1618	0.3714
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0172	0.0638
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0048	0.0508	0.1437
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0184	0.0252
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0532	0.1505
Schistosoma mansoni	smad	0.0008	0.0036	0.0101
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0184	0.0427
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0172	0.0236
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.06	0.1697
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.432	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1713	0.2343
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0195	0.2285	1
Giardia lamblia	Cathepsin B precursor	0.0046	0.0491	0.8859
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.021	0.0437
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0532	0.233
Schistosoma mansoni	ran	0.0021	0.0184	0.0521
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0048	0.0508	0.1437
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.061	0.1725
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0172	0.0638
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0274	0.0633
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0613	0.731	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1672	0.2287
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0172	0.0487
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0144	0.1672	0.2287
Schistosoma mansoni	hypothetical protein	0.0007	0.0022	0.0062
Echinococcus multilocularis	endothelin converting enzyme 1	0.0195	0.2285	0.2285
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0048	0.0508	0.1437
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0553	0.1235
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0532	0.1974
Schistosoma mansoni	cytochrome P450	0.0007	0.0022	0.0062
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0184	0.6744
Giardia lamblia	Cathepsin B precursor	0.0046	0.0491	0.8859
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0036	0.0101
Leishmania major	cytochrome p450-like protein	0.0007	0.0022	0.0051
Brugia malayi	MH2 domain containing protein	0.0008	0.0036	0.0049
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.0298	0.0643
Echinococcus multilocularis	snurportin 1	0.03	0.3537	0.3537
Brugia malayi	Pre-SET motif family protein	0.0202	0.2362	0.3231
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.06	0.1697
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0565	0.0773
Trichomonas vaginalis	ran, putative	0.0021	0.0184	0.0684
Schistosoma mansoni	neprilysin	0.0051	0.0549	0.1552
Leishmania major	cytochrome p450-like protein	0.0025	0.0234	0.0543
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0274	0.1197
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.061	0.061
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.021	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1713	0.2343
Loa Loa (eye worm)	Smad1	0.0008	0.0036	0.0049
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0172	0.0664
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0184	0.0807
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.021	0.0778
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0532	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0046	0.0491	0.1821
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2285	0.3125
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0532	0.1505
Echinococcus multilocularis	geminin	0.0165	0.1918	0.1918
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0234	0.0321
Echinococcus granulosus	Smad4	0.0008	0.0036	0.0101
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0271	0.0767
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0036	0.0101
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0234	0.0321
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0532	0.1974
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0036	0.0101
Onchocerca volvulus		0.0097	0.11	0.338
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1713	0.2343
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0099	0.1121	0.317
Toxoplasma gondii	cathepsin B	0.0046	0.0491	0.215
Echinococcus granulosus	cytochrome P450 2K1	0.0007	0.0022	0.0062
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0184	0.0252
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0172	0.5
Loa Loa (eye worm)	CYP4Cod1	0.0025	0.0234	0.0321
Brugia malayi	MH2 domain containing protein	0.0122	0.1397	0.1911
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0195	0.2285	0.3125
Schistosoma mansoni	hypothetical protein	0.0051	0.0549	0.1552
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0284	0.0284
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0036	0.0049
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0172	0.8209
Echinococcus granulosus	smad	0.0008	0.0036	0.0101

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1122 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.7783 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1543864

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1405753