Detailed information for compound 1408166

Basic information

Technical information
  • TDR Targets ID: 1408166
  • Name: N-[2-(4,5-dimethoxy-2-nitrophenyl)-4-oxo-1,2- dihydroquinazolin-3-yl]methanesulfonamide
  • MW: 422.412 | Formula: C17H18N4O7S
  • H donors: 2 H acceptors: 5 LogP: 1.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C2Nc3ccccc3C(=O)N2NS(=O)(=O)C)c(cc1OC)[N+](=O)[O-]
  • InChi: 1S/C17H18N4O7S/c1-27-14-8-11(13(21(23)24)9-15(14)28-2)16-18-12-7-5-4-6-10(12)17(22)20(16)19-29(3,25)26/h4-9,16,18-19H,1-3H3
  • InChiKey: WZVHZSURVILIIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4,5-dimethoxy-2-nitro-phenyl)-4-oxo-1,2-dihydroquinazolin-3-yl]methanesulfonamide
  • N-[2-(4,5-dimethoxy-2-nitro-phenyl)-4-keto-1,2-dihydroquinazolin-3-yl]methanesulfonamide
  • A3427/0145369

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0245 0.0241
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.085 0.1579
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0126 0.0266
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0245 0.051
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0188 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0126 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0245 0.051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0005 0.001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0034 0.0431 0.0427
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0016 0.0126 0.0121
Trypanosoma brucei glucosidase, putative 0.0034 0.0432 0.0877
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0272 0.4564 0.9674
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0005 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.014 0.0242
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.014 0.025
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0281 0.4716 1
Echinococcus granulosus muscleblind protein 0.018 0.2974 0.3876
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0245 0.0241
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0069 0.1041 1
Brugia malayi PXA domain containing protein 0.0023 0.0245 0.051
Loa Loa (eye worm) hypothetical protein 0.018 0.2974 0.6307
Leishmania major cAMP-specific phosphodiesterase, putative 0.0016 0.0126 0.0225
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0062 0.0127
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0117 0.1881 0.3989
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0245 0.051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0443 0.0572
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0519
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Echinococcus multilocularis neutral alpha glucosidase AB 0.0034 0.0432 0.0427
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0027 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0153 0.2495 0.5287
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0245 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0392
Echinococcus multilocularis expressed protein 0.0451 0.7667 0.7666
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0245 0.051
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0126 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0188 0.0357
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Trichomonas vaginalis sucrase-isomaltase, putative 0.0034 0.0432 0.0794
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Echinococcus granulosus neutral alpha glucosidase AB 0.0034 0.0432 0.0558
Echinococcus multilocularis lamin dm0 0.0019 0.0181 0.0177
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0188 0.0269
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.085 0.1756
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0432 0.0794
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0272 0.4564 0.9674
Brugia malayi Cytochrome P450 family protein 0.0017 0.014 0.0288
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.085 0.1768
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0016 0.0126 0.0225
Schistosoma mansoni intermediate filament proteins 0.0019 0.0181 0.0375
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0245 0.0314
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0117 0.1881 0.1877
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Loa Loa (eye worm) RNA binding protein 0.0059 0.0874 0.1854
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0281 0.4716 1
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0281 0.4716 0.4713
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1138 0.2407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0005 0.001
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0245 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0874 0.1846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0519
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0027 0.0015
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0281 0.4716 0.6148
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.085 0.1579
Echinococcus multilocularis geminin 0.0249 0.4162 0.4159
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0034 0.0432 0.0915
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0188 0.0355
Schistosoma mansoni hypothetical protein 0.0219 0.3651 0.7741
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0245 0.051
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0016 0.0126 0.0257
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0245 0.0314
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0016 0.0126 0.0211
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0245 0.0314
Schistosoma mansoni hypothetical protein 0.0035 0.0443 0.093
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0027 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.0344
Brugia malayi Cytochrome P450 family protein 0.0039 0.0521 0.1097
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0245 0.0519
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0016 0.0126 0.0257
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0245 0.0519
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0519
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0281 0.4716 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0392
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0245 0.0314
Onchocerca volvulus 0.0019 0.0181 0.0387
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0027 0.0015
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0245 0.051
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0245 0.0241
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0016 0.0126 0.0257
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0188 0.0269
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0181 0.0384
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0016 0.0126 0.0121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.0874 0.1854
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0432 0.0794
Echinococcus multilocularis musashi 0.0019 0.0181 0.0177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0134 0.2163 0.4557
Trypanosoma brucei RNA helicase, putative 0.0219 0.3651 0.7734
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0134 0.2163 0.2817
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0432 0.0794
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0281 0.4716 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0016 0.0126 0.0158
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0432 0.0864
Brugia malayi RNA binding protein 0.0059 0.0874 0.1846
Brugia malayi Muscleblind-like protein 0.018 0.2974 0.6304
Echinococcus granulosus intermediate filament protein 0.0019 0.0181 0.023
Brugia malayi hypothetical protein 0.0037 0.0493 0.1037
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.085 0.1756
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0281 0.4716 1
Trypanosoma brucei unspecified product 0.0017 0.0132 0.0239
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0245 0.051
Treponema pallidum fructose-bisphosphate aldolase 0.0141 0.2295 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0245 0.0314
Giardia lamblia hypothetical protein 0.0016 0.0126 0.0232
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0016 0.0126 0.0121
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Echinococcus granulosus nuclear factor of activated T cells 5 0.0034 0.0431 0.0557
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0443 0.093
Brugia malayi Cytochrome P450 family protein 0.0011 0.0027 0.0047
Brugia malayi hypothetical protein 0.0058 0.085 0.1795
Schistosoma mansoni alpha-glucosidase 0.0132 0.2126 0.4503
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0245 0.051
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0027 0.0015
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0245 0.051
Echinococcus multilocularis lysosomal alpha glucosidase 0.0153 0.2495 0.2492
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0126 0.0136
Echinococcus granulosus expressed protein 0.0451 0.7667 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0016 0.0126 0.0121
Schistosoma mansoni lamin 0.0019 0.0181 0.0375
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0134 0.2163 0.4717
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0027 0.0015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Entamoeba histolytica hypothetical protein 0.0023 0.0245 0.0392
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Entamoeba histolytica hypothetical protein 0.0023 0.0245 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0016 0.0126 0.0257
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0281 0.4716 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0281 0.4716 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0016 0.0126 0.0257
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0027 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Echinococcus granulosus tar DNA binding protein 0.0059 0.0874 0.1135
Brugia malayi cytochrome P450 0.0011 0.0027 0.0047
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0245 0.0241
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0134 0.2163 0.216
Onchocerca volvulus 0.0272 0.4564 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0027 0.0015
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0281 0.4716 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0016 0.0126 0.0211
Echinococcus multilocularis muscleblind protein 0.018 0.2974 0.2971
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0016 0.0126 0.0211
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0027 0.0015
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0432 0.0794
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0069 0.1041 0.2236
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.085 0.1579
Echinococcus multilocularis tar DNA binding protein 0.0059 0.0874 0.087
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0443 0.0438
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0126 0.0211
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0016 0.0126 0.0225
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0062 0.009
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0245 0.0241
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0874 0.1846
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0245 0.051
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0245 0.051
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0062 0.0076
Echinococcus multilocularis dna polymerase kappa 0.002 0.0188 0.0183
Brugia malayi TAR-binding protein 0.0059 0.0874 0.1846
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0874 0.1846
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0027 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0272 0.4564 0.9678
Echinococcus granulosus tm gpcr rhodopsin 0.0346 0.5842 0.7618
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0245 0.051
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0016 0.0126 0.0266
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Loa Loa (eye worm) CYP4Cod1 0.0017 0.014 0.0297
Echinococcus granulosus lysosomal alpha glucosidase 0.0153 0.2495 0.3251
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni hypothetical protein 0.0249 0.4162 0.8824
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0126 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0005 0.001
Brugia malayi hypothetical protein 0.0023 0.0245 0.051
Entamoeba histolytica hypothetical protein 0.0023 0.0245 0.0392
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0432 0.0864
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0272 0.4564 0.9674
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0134 0.2163 0.4582
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Loa Loa (eye worm) hypothetical protein 0.0058 0.085 0.1803
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0272 0.4564 0.9674
Leishmania major hypothetical protein, conserved 0.0058 0.085 0.1768
Brugia malayi PXA domain containing protein 0.0023 0.0245 0.051
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0281 0.4716 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0874 0.1846
Echinococcus granulosus lamin dm0 0.0019 0.0181 0.023
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni hypothetical protein 0.0249 0.4162 0.8824
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0027 0.0015
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0016 0.0126 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0016 0.0126 0.0158
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni hypothetical protein 0.0026 0.0295 0.0616
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0519
Onchocerca volvulus 0.0019 0.0181 0.0387
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0346 0.5842 0.584
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0005 0.001
Schistosoma mansoni cytochrome P450 0.0011 0.0027 0.0047
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0016 0.0126 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0016 0.0126 0.0211
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0281 0.4716 1
Echinococcus multilocularis 0.0011 0.0027 0.0022
Schistosoma mansoni hypothetical protein 0.0035 0.0443 0.093
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0281 0.4716 1
Schistosoma mansoni alpha glucosidase 0.0034 0.0432 0.0907
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0016 0.0126 0.0257
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0062 0.0076
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0295 0.0379
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0027 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0009 0.0006 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0443 0.093
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0126 0.0211
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0016 0.0126 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0027 0.0015
Loa Loa (eye worm) cytochrome P450 0.0011 0.0027 0.0056
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0272 0.4564 0.9674
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0027 0.0015
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0009 0.0006 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0104 0.0179
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.014 0.0297
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0034 0.0432 0.0864
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0153 0.2495 0.5292
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0016 0.0126 0.0211
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0175 0.0371
Loa Loa (eye worm) hypothetical protein 0.018 0.2974 0.6307
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0272 0.4564 0.9674
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0432 0.0794
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0245 0.0241
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0245 0.051
Leishmania major hypothetical protein, conserved 0.0016 0.0126 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0005 0.001
Trichomonas vaginalis maltase-glucoamylase, putative 0.0034 0.0432 0.0794
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0027 0.0015
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0069 0.1041 0.2247
Leishmania major alpha glucosidase II subunit, putative 0.0034 0.0432 0.0877
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0132 0.0239
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.0344
Brugia malayi hypothetical protein 0.0023 0.0245 0.051
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0245 0.0241
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0016 0.0126 0.0211
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0134 0.2163 0.2817
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.014 0.0242
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0281 0.4716 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0519
Loa Loa (eye worm) hypothetical protein 0.0019 0.0181 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0245 0.051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1738 0.368
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0432 0.0794
Brugia malayi Glycosyl hydrolases family 31 protein 0.0034 0.0432 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0062 0.0132
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0134 0.2163 0.216
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0126 0.0225
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0272 0.4564 1
Loa Loa (eye worm) PDE1B protein 0.0016 0.0126 0.0266
Loa Loa (eye worm) hypothetical protein 0.0134 0.2163 0.4588
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0181 0.0384
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0272 0.4564 0.9678
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Echinococcus granulosus dna polymerase kappa 0.002 0.0188 0.0239
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.0344
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0519
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0245 0.0314
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0016 0.0126 0.0121
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0245 0.0314
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0016 0.0126 0.0257
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0181 0.0375
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1738 0.3686
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0027 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0392
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.085 0.1756
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0245 0.0241
Leishmania major cytochrome p450-like protein 0.0011 0.0027 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0126 0.0211
Trypanosoma brucei cytochrome P450, putative 0.0017 0.014 0.0256
Echinococcus multilocularis lamin 0.0019 0.0181 0.0177
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0245 0.0519
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0245 0.0519
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Leishmania major cytochrome p450-like protein 0.0017 0.014 0.0256
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0521 0.1105
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0016 0.0126 0.0158
Schistosoma mansoni hypothetical protein 0.0035 0.0443 0.093
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0027 0.0015
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0016 0.0126 0.0158
Echinococcus granulosus geminin 0.0249 0.4162 0.5425
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.0874 0.1846
Schistosoma mansoni alpha-glucosidase 0.0132 0.2126 0.4503
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0016 0.0126 0.0225
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.0344
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0443 0.0438
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1738 0.368
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0272 0.4564 0.9674
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0443 0.0939
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0016 0.0126 0.0121
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0272 0.4564 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0281 0.4716 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0443 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0104 0.0179
Brugia malayi Cytochrome P450 family protein 0.0017 0.014 0.0288
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0016 0.0126 0.0257
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0117 0.1881 0.2449
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0117 0.1881 0.3983
Echinococcus multilocularis GPCR, family 2 0.0035 0.0443 0.0438
Giardia lamblia Hypothetical protein 0.0016 0.0126 0.0232
Echinococcus granulosus lamin 0.0019 0.0181 0.023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0126 0.0266
Echinococcus multilocularis lysosomal alpha glucosidase 0.0153 0.2495 0.2492
Brugia malayi intermediate filament protein 0.0019 0.0181 0.0375
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0432 0.0794
Loa Loa (eye worm) hypothetical protein 0.0075 0.1138 0.2414
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.0047
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0245 0.0519
Schistosoma mansoni hypothetical protein 0.0075 0.1138 0.2407
Loa Loa (eye worm) hypothetical protein 0.0016 0.0126 0.0266
Onchocerca volvulus 0.0088 0.1377 0.3011
Echinococcus multilocularis muscleblind protein 1 0.018 0.2974 0.2971
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0188 0.0357
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0016 0.0126 0.0225
Echinococcus granulosus GPCR family 2 0.0035 0.0443 0.0572
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0245 0.051
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0016 0.0126 0.0158
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0062 0.0123
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0874 0.1846
Giardia lamblia Fructose-bisphosphate aldolase 0.0141 0.2295 0.5008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.2295 0.4799
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0027 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0432 0.0794
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0016 0.0126 0.0257
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0016 0.0126 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.001
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0245 0.0314
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0016 0.0126 0.0136
Leishmania major cytochrome p450-like protein 0.0011 0.0027 0.0014
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0272 0.4564 0.9674
Leishmania major hypothetical protein, conserved 0.0016 0.0126 0.0225
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0016 0.0126 0.0225
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0295 0.029
Brugia malayi cytoplasmic intermediate filament protein 0.001 0.0024 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0392
Schistosoma mansoni hypothetical protein 0.0035 0.0443 0.093
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0027 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0245 0.051
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0027 0.0015
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0016 0.0126 0.0211
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0245 0.051
Loa Loa (eye worm) TAR-binding protein 0.0059 0.0874 0.1854
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0027 0.0015
Loa Loa (eye worm) hypothetical protein 0.0109 0.1738 0.3686
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0281 0.4716 1
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0062 0.009
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.014 0.0297
Loa Loa (eye worm) hypothetical protein 0.0035 0.0443 0.0939
Schistosoma mansoni lamin 0.0019 0.0181 0.0375
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0126 0.0211
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0245 0.0314
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0245 0.0241
Brugia malayi polk-prov protein 0.0015 0.0104 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0245 0.051
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0245 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0126 0.0136
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0272 0.4564 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.001 0.0024 0.0051
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0027 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0432 0.0794
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0016 0.0126 0.0136
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0281 0.4716 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.0357
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0126 0.0211
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0245 0.051
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0027 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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