Detailed information for compound 1411236

Basic information

Technical information
  • TDR Targets ID: 1411236
  • Name: 4-(1H-perimidin-2-yl)aniline
  • MW: 259.305 | Formula: C17H13N3
  • H donors: 2 H acceptors: 0 LogP: 3.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)c1nc2cccc3c2c([nH]1)ccc3
  • InChi: 1S/C17H13N3/c18-13-9-7-12(8-10-13)17-19-14-5-1-3-11-4-2-6-15(20-17)16(11)14/h1-10H,18H2,(H,19,20)
  • InChiKey: BFSIRHIRXMIVBW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [4-(1H-perimidin-2-yl)phenyl]amine
  • ZINC00267420
  • BIM-0031794.P001
  • 4-(1H-Perimidin-2-yl)-phenylamine
  • BAS 00720753
  • CBMicro_031934
  • MLS000567502
  • SMR000175908

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens transmembrane protease, serine 15 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photuris pennsylvanica Luciferase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative Luciferase   552 aa 544 aa 21.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferase   552 aa 570 aa 21.8 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferase   552 aa 554 aa 21.3 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 446 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 546 aa 21.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferase   552 aa 478 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 546 aa 21.6 %
Plasmodium vivax long-chain fatty acid CoA ligase, putative Luciferase   552 aa 453 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 515 aa 21.9 %
Mycobacterium tuberculosis Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 483 aa 23.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferase   552 aa 476 aa 25.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferase   552 aa 541 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 530 aa 22.4 %
Toxoplasma gondii propionate-CoA ligase Luciferase   552 aa 503 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 516 aa 26.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferase   552 aa 470 aa 23.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferase   552 aa 536 aa 23.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 486 aa 25.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferase   552 aa 546 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 581 aa 21.3 %
Onchocerca volvulus Luciferase   552 aa 487 aa 24.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferase   552 aa 508 aa 22.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferase   552 aa 523 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 530 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferase   552 aa 525 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 537 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 470 aa 25.1 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 482 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferase   552 aa 445 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferase   552 aa 500 aa 23.2 %
Babesia bovis acetyl-CoA synthetase, putative Luciferase   552 aa 545 aa 21.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferase   552 aa 468 aa 20.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferase   552 aa 492 aa 25.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferase   552 aa 461 aa 26.0 %
Neospora caninum hypothetical protein Luciferase   552 aa 529 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 464 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferase   552 aa 605 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferase   552 aa 442 aa 21.7 %
Onchocerca volvulus Luciferase   552 aa 553 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferase   552 aa 514 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 483 aa 21.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferase   552 aa 473 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferase   552 aa 486 aa 25.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferase   552 aa 480 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferase   552 aa 445 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 478 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 540 aa 22.8 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 458 aa 22.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 510 aa 23.1 %
Onchocerca volvulus Matrilysin homolog Luciferase   552 aa 499 aa 22.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferase   552 aa 492 aa 25.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferase   552 aa 470 aa 24.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 467 aa 20.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferase   552 aa 531 aa 24.9 %
Giardia lamblia Long chain fatty acid CoA ligase 5 Luciferase   552 aa 491 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferase   552 aa 491 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 530 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 588 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferase   552 aa 476 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 557 aa 21.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Leishmania mexicana long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative Luciferase   552 aa 472 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 472 aa 24.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferase   552 aa 493 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferase   552 aa 476 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 518 aa 26.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferase   552 aa 473 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 531 aa 22.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferase   552 aa 476 aa 24.6 %
Onchocerca volvulus Luciferase   552 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 480 aa 21.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferase   552 aa 580 aa 21.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferase   552 aa 533 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 480 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 481 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 459 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 448 aa 23.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 496 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferase   552 aa 559 aa 21.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferase   552 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 481 aa 20.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferase   552 aa 485 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 473 aa 22.4 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 557 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferase   552 aa 501 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferase   552 aa 514 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 492 aa 24.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferase   552 aa 570 aa 21.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferase   552 aa 510 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferase   552 aa 525 aa 22.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferase   552 aa 460 aa 24.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 486 aa 24.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 491 aa 23.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferase   552 aa 503 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferase   552 aa 505 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferase   552 aa 474 aa 24.5 %
Schistosoma mansoni long-chain-fatty-acid--CoA ligase Luciferase   552 aa 526 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 529 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 467 aa 20.8 %
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) Luciferase   552 aa 512 aa 22.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferase   552 aa 509 aa 22.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferase   552 aa 460 aa 25.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 550 aa 24.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferase   552 aa 613 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 451 aa 22.4 %
Theileria parva acetyl-coenzyme A synthetase, putative Luciferase   552 aa 580 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 481 aa 23.7 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0077 0.0721 0.3286
Loa Loa (eye worm) hypothetical protein 0.0255 0.2699 0.2699
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Brugia malayi Pre-SET motif family protein 0.0036 0.0265 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Echinococcus granulosus MAM 0.0019 0.0081 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0183 0.0536
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0227 0.0227
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0183 0.0536
Leishmania major cathepsin L-like protease 0.002 0.0089 0.0236
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0202 0.2113 0.3367
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.022
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0089 0.0089
Mycobacterium tuberculosis Probable glucanase GlgE 0.0063 0.0562 0.1964
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0373 0.1602
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1153 0.4186
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0361 0.1547
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0379 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1024 0.3699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0227 0.0227
Plasmodium falciparum glutathione reductase 0.0046 0.0373 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0089 0.1471
Onchocerca volvulus 0.0033 0.0227 0.0396
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0183
Entamoeba histolytica alpha-amylase family protein 0.0574 0.6247 1
Leishmania major cathepsin L-like protease 0.0077 0.0721 0.3286
Entamoeba histolytica alpha-amylase, putative 0.0063 0.0562 0.0879
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0102 0.0233
Schistosoma mansoni hypothetical protein 0.01 0.0977 0.1137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0202 0.2113 0.7798
Onchocerca volvulus 0.0527 0.5726 1
Schistosoma mansoni alpha-glucosidase 0.0784 0.8589 1
Schistosoma mansoni lamin 0.0033 0.0227 0.0264
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0102 0.0233
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0089 0.0119
Mycobacterium ulcerans trehalose synthase TreS 0.0063 0.0562 0.1964
Schistosoma mansoni lipoxygenase 0.0067 0.0606 0.0706
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1024 0.3699
Schistosoma mansoni alpha glucosidase 0.0202 0.2113 0.2461
Brugia malayi Muscle positioning protein 4 0.0018 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0039
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0373 0.0373
Mycobacterium ulcerans trehalose synthase TreS 0.0063 0.0562 0.1964
Schistosoma mansoni loxhd1 0.0024 0.0129 0.015
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0255 0.2699 0.2699
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0089 0.0184
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0361 0.1547
Onchocerca volvulus 0.0018 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0265 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Onchocerca volvulus 0.002 0.0089 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Schistosoma mansoni intermediate filament proteins 0.0033 0.0227 0.0264
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0702 0.1102
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0721 0.3286
Schistosoma mansoni alpha-amylase 0.0063 0.0562 0.0655
Entamoeba histolytica alpha-amylase family protein 0.0063 0.0562 0.0879
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0702 0.1102
Loa Loa (eye worm) ctsf protein 0.002 0.0089 0.0089
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0076
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0361 0.0361
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0251 0.0251
Toxoplasma gondii thioredoxin reductase 0.0046 0.0373 0.125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0265 0.0309
Trichomonas vaginalis amylase, putative 0.0574 0.6247 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0058 0.0058
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0702 0.1102
Mycobacterium ulcerans glycogen branching protein 0.0255 0.2699 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.004 0.004
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0977 0.0977
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0089 0.0089
Schistosoma mansoni starch branching enzyme II 0.0255 0.2699 0.3142
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0089 0.0104
Schistosoma mansoni hypothetical protein 0.0024 0.0129 0.015
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0265 0.0265
Onchocerca volvulus 0.002 0.0089 0.0156
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3047 0.4866
Plasmodium vivax SET domain protein, putative 0.0036 0.0265 0.6773
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0075 0.0702 0.3191
Schistosoma mansoni hypothetical protein 0.0019 0.0081 0.0094
Mycobacterium tuberculosis Probable reductase 0.0104 0.1024 0.3699
Onchocerca volvulus 0.0018 0.0065 0.0114
Entamoeba histolytica cysteine protease, putative 0.002 0.0089 0.0119
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0265 0.0846
Echinococcus multilocularis RUN 0.0024 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0255 0.2699 0.2699
Loa Loa (eye worm) alpha amylase 0.0063 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0183
Echinococcus multilocularis trehalose 6 phosphate hydrolase 0.0063 0.0562 0.0562
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0265 0.0309
Echinococcus granulosus cathepsin l1 0.002 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Entamoeba histolytica alpha-amylase family protein 0.0063 0.0562 0.0879
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0129
Trichomonas vaginalis alpha-amylase, putative 0.0574 0.6247 1
Brugia malayi cathepsin L-like precursor 0.0014 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1024 0.3699
Chlamydia trachomatis glycogen hydrolase 0.0063 0.0562 0.1964
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0075 0.0702 0.1226
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0183 0.027
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0721 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Mycobacterium ulcerans maltooligosyltrehalose synthase TreX 0.0063 0.0562 0.1964
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.004 0.0041
Trichomonas vaginalis alpha-amylase, putative 0.0574 0.6247 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0075 0.0702 0.0702
Leishmania major glycosyl hydrolase-like protein 0.0075 0.0702 0.3191
Plasmodium vivax glutathione reductase, putative 0.0046 0.0373 1
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Brugia malayi Protein kinase domain containing protein 0.0019 0.0081 0.0081
Brugia malayi Cathepsin L-like precursor 0.002 0.0089 0.0089
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0129 0.0129
Schistosoma mansoni apoptosis regulator bax 0.01 0.0977 0.1137
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0977 0.0977
Loa Loa (eye worm) cysteine protease 0.002 0.0089 0.0089
Echinococcus granulosus lysosomal alpha glucosidase 0.0911 1 1
Leishmania major cathepsin L-like protease 0.002 0.0089 0.0236
Onchocerca volvulus 0.0018 0.0065 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0183
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0255 0.2699 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0202 0.2113 0.3367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Mycobacterium tuberculosis 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) 0.0255 0.2699 1
Trichomonas vaginalis amylase, putative 0.0574 0.6247 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0977 0.0977
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0063 0.0562 0.3912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Schistosoma mansoni alpha-glucosidase 0.0784 0.8589 1
Schistosoma mansoni alpha-amylase 0.0063 0.0562 0.0655
Onchocerca volvulus 0.0036 0.0265 0.0463
Chlamydia trachomatis 1,4-alpha-glucan branching enzyme 0.0255 0.2699 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0089 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0089 0.1471
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0227 0.0227
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0183 0.027
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0089 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0202 0.2113 0.3367
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0089 0.0089
Plasmodium vivax vivapain-2 0.002 0.0089 0.1471
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0015 0.0017
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0089 0.0089
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0089 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Loa Loa (eye worm) fibroinase 0.002 0.0089 0.0089
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0075 0.0702 0.3191
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0265 0.0265
Trypanosoma brucei trypanothione reductase 0.0046 0.0373 0.1602
Giardia lamblia 1,4-alpha-glucan branching enzyme 0.0255 0.2699 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0089 0.0184
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0183 0.0536
Toxoplasma gondii glycosyltransferase 0.0255 0.2699 1
Trichomonas vaginalis alpha-amylase, putative 0.0574 0.6247 1
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0255 0.2699 0.4306
Leishmania major cathepsin L-like protease 0.0077 0.0721 0.3286
Echinococcus granulosus RUN 0.0024 0.0129 0.0129
Schistosoma mansoni alpha-amylase 0.0063 0.0562 0.0655
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0102 0.0233
Schistosoma mansoni lamin 0.0033 0.0227 0.0264
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0977 0.0977
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0361 0.0556
Leishmania major cathepsin L-like protease 0.002 0.0089 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.004 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1153 0.4186
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0089 0.0119
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0202 0.2113 0.3367
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0606 0.0606
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0089 0.1471
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0129 0.2673
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0129 0.0129
Brugia malayi Cathepsin L-like precursor 0.002 0.0089 0.0089
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0255 0.2699 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0019 0.0081 0.0081
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0721 0.3286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0183 0.0687
Trichomonas vaginalis amylase, putative 0.0255 0.2699 0.4306
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0202 0.2113 0.2113
Onchocerca volvulus 0.002 0.0089 0.0156
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0361 0.042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0265 0.0309
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0183 0.0536
Onchocerca volvulus 0.0024 0.0129 0.0226
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0361 0.042
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0063 0.0562 0.1964
Trichomonas vaginalis alpha-amylase, putative 0.0574 0.6247 1
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Toxoplasma gondii cathepsin CPL 0.002 0.0089 0.0184
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0265 0.0265
Leishmania major alpha glucosidase II subunit, putative 0.0202 0.2113 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1024 0.3699
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0361 0.0361
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0606 0.0606
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0202 0.2113 0.3367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0977 0.0977
Brugia malayi Cathepsin L-like precursor 0.002 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0265 0.0309
Brugia malayi Cathepsin L-like precursor 0.002 0.0089 0.0089
Onchocerca volvulus 0.0014 0.0015 0.0026
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0089 0.0089
Mycobacterium tuberculosis Maltooligosyltrehalose trehalohydrolase TreZ 0.0063 0.0562 0.1964
Brugia malayi Cathepsin L-like precursor 0.002 0.0089 0.0089
Loa Loa (eye worm) DOMON domain-containing protein 0.0018 0.0065 0.0065
Echinococcus multilocularis alpha glucosidase 0.0063 0.0562 0.0562
Trichomonas vaginalis sucrase-isomaltase, putative 0.0202 0.2113 0.3367
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0089 0.0104
Echinococcus granulosus alpha glucosidase 0.0063 0.0562 0.0562
Loa Loa (eye worm) glutathione reductase 0.0046 0.0373 0.0373
Brugia malayi Cathepsin L-like precursor 0.0014 0.0015 0.0015
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0015 0.0015
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0361 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Onchocerca volvulus 0.0286 0.3047 0.5321
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1024 0.8667
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Trichomonas vaginalis starch branching enzyme II, putative 0.0255 0.2699 0.4306
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0183 0.0687
Schistosoma mansoni alpha-amylase 0.0063 0.0562 0.0655
Treponema pallidum NADH oxidase 0.0016 0.004 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Echinococcus multilocularis MAM 0.0019 0.0081 0.0081
Brugia malayi intermediate filament protein 0.0033 0.0227 0.0227
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1153 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0202 0.2113 0.3367
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0081
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0647 0.2927
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0702 0.1102
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0361 0.0361
Onchocerca volvulus 0.0019 0.0081 0.0141
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0361 0.1547
Echinococcus multilocularis musashi 0.0033 0.0227 0.0227
Entamoeba histolytica hypothetical protein 0.0063 0.0562 0.0879
Schistosoma mansoni rab6-interacting 0.0024 0.0129 0.015
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0129 0.0129
Mycobacterium tuberculosis Trehalose synthase TreS 0.0063 0.0562 0.1964
Brugia malayi SEA domain containing protein 0.0018 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0129 0.0129
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.004 0.0041
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Brugia malayi glutathione reductase 0.0046 0.0373 0.0373
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0977 0.1137
Trichomonas vaginalis alpha-glucosidase, putative 0.0202 0.2113 0.3367
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0361 0.0556
Schistosoma mansoni rab6-interacting 0.0024 0.0129 0.015
Mycobacterium ulcerans hypothetical protein 0.0029 0.0183 0.0536
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1153 0.4186
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0183 0.0536
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0089 0.0089
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0255 0.2699 0.4306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Mycobacterium ulcerans maltooligosyltrehalose trehalohydrolase, TreZ 0.0063 0.0562 0.1964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Echinococcus granulosus cathepsin l1 0.0014 0.0015 0.0015
Mycobacterium ulcerans maltooligosyltrehalose synthase TreY 0.0063 0.0562 0.1964
Entamoeba histolytica beta/alpha-amylase precursor, putative 0.0063 0.0562 0.0879
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0361 0.0556
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0702 0.1102
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0361 0.0361
Trypanosoma brucei glucosidase, putative 0.0202 0.2113 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0183 0.027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0129 0.0129
Onchocerca volvulus Cathepsin F homolog 0.002 0.0089 0.0156
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0562 0.0879
Trichomonas vaginalis amylase, putative 0.0063 0.0562 0.0879
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0183 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0183 0.0183
Onchocerca volvulus 0.002 0.0089 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0089 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0063 0.0562 0.0879
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Brugia malayi Thioredoxin reductase 0.0046 0.0373 0.0373
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0361 0.1547
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0721 0.3286
Onchocerca volvulus 0.002 0.0089 0.0156
Onchocerca volvulus 0.0024 0.0129 0.0226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0183 0.0536
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0255 0.2699 0.2699
Trichomonas vaginalis alpha-amylase, putative 0.0511 0.5549 0.888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0089 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0183 0.0536
Onchocerca volvulus 0.0033 0.0227 0.0396
Schistosoma mansoni hypothetical protein 0.01 0.0977 0.1137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0202 0.2113 0.3367
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Leishmania major cathepsin L-like protease 0.002 0.0089 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.004 0.004
Echinococcus multilocularis neutral alpha glucosidase AB 0.0202 0.2113 0.2113
Onchocerca volvulus Cathepsin L homolog 0.002 0.0089 0.0156
Echinococcus granulosus neutral alpha glucosidase AB 0.0202 0.2113 0.2113
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0102 0.1864
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0129 0.0129
Loa Loa (eye worm) alpha amylase 0.0063 0.0562 0.0562
Onchocerca volvulus 0.0019 0.0081 0.0141
Echinococcus multilocularis lysosomal alpha glucosidase 0.0911 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0702 0.1102
Echinococcus granulosus lamin 0.0033 0.0227 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0202 0.2113 1
Brugia malayi hypothetical protein 0.0024 0.0129 0.0129
Brugia malayi hypothetical protein 0.0019 0.0081 0.0081
Leishmania major cathepsin L-like protease 0.002 0.0089 0.0236
Echinococcus multilocularis lysosomal alpha glucosidase 0.0911 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0089 0.0119
Echinococcus multilocularis lamin dm0 0.0033 0.0227 0.0227
Mycobacterium ulcerans glycosidase 0.0063 0.0562 0.1964
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1024 0.3699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0089 0.0119
Schistosoma mansoni hypothetical protein 0.0019 0.0081 0.0094
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0373 0.125
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0702 0.1102
Schistosoma mansoni hypothetical protein 0.0063 0.0562 0.0655
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0089 0.0184
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0373 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0361 0.0556
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0039 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0202 0.2113 0.3367
Trichomonas vaginalis maltase-glucoamylase, putative 0.0202 0.2113 0.3367
Plasmodium falciparum thioredoxin reductase 0.0046 0.0373 1
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0227
Onchocerca volvulus 0.0018 0.0065 0.0114
Brugia malayi Cathepsin L-like precursor 0.002 0.0089 0.0089
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0361 0.0361
Echinococcus granulosus lamin dm0 0.0033 0.0227 0.0227
Leishmania major trypanothione reductase 0.0046 0.0373 0.1602
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0379 0.0379
Entamoeba histolytica alpha-amylase, putative 0.0063 0.0562 0.0879
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0102 0.1864
Onchocerca volvulus Cathepsin L homolog 0.002 0.0089 0.0156
Brugia malayi Doublecortin family protein 0.0024 0.0129 0.0129
Brugia malayi hypothetical protein 0.0024 0.0129 0.0129
Brugia malayi Pre-SET motif family protein 0.0251 0.2661 0.2661
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0202 0.2113 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0702 0.1102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0089 0.0119
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0538 0.2401
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.004 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0089 0.0184
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0183 0.0536
Onchocerca volvulus 0.0029 0.0183 0.0319
Onchocerca volvulus 0.002 0.0089 0.0156
Echinococcus granulosus intermediate filament protein 0.0033 0.0227 0.0227
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0063 0.0562 0.0562
Echinococcus granulosus trehalose 6 phosphate hydrolase 0.0063 0.0562 0.0562
Toxoplasma gondii Alpha-amylase AMY3, putative 0.0063 0.0562 0.1964
Mycobacterium tuberculosis Maltooligosyltrehalose synthase TreY 0.0063 0.0562 0.1964
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0089
Schistosoma mansoni alpha-amylase 0.0063 0.0562 0.0655
Trichomonas vaginalis alpha-amylase, putative 0.0063 0.0562 0.0879
Leishmania major cysteine peptidase A (CPA) 0.002 0.0089 0.0236
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0129 0.2673
Schistosoma mansoni polycystin 1-related 0.0024 0.0129 0.015
Entamoeba histolytica alpha-amylase family protein 0.0574 0.6247 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0702 0.1102
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0361 0.1207
Onchocerca volvulus 0.0018 0.0065 0.0114
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0129 0.0129
Echinococcus multilocularis cysteine protease 0.002 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.01 0.0977 0.1137
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0183 0.0687
Plasmodium vivax vivapain-2 0.002 0.0089 0.1471
Trypanosoma brucei glycosyl hydrolase-like protein 0.0075 0.0702 0.3191
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0063 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.004 0.0047
Echinococcus multilocularis lamin 0.0033 0.0227 0.0227
Brugia malayi Glycosyl hydrolases family 31 protein 0.0202 0.2113 0.2113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2661 0.2661
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0183 0.0536
Echinococcus multilocularis cysteine protease 0.002 0.0089 0.0089
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0361 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0721 0.3286
Brugia malayi Cathepsin L-like precursor 0.0014 0.0015 0.0015
Schistosoma mansoni lipoxygenase 0.0024 0.0129 0.015
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0977 0.0977
Onchocerca volvulus 0.002 0.0089 0.0156
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0911 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.856219369 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: Counterscreen for Luciferase (Kinase-Glo TM) Inhibition. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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