Detailed information for compound 1415642

Basic information

Technical information
  • TDR Targets ID: 1415642
  • Name: 4,6-bis(4-chlorophenyl)-2-methyl-4,5-dihydrop yridazin-3-one
  • MW: 333.212 | Formula: C17H14Cl2N2O
  • H donors: 0 H acceptors: 1 LogP: 4.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1=NN(C)C(=O)C(C1)c1ccc(cc1)Cl
  • InChi: 1S/C17H14Cl2N2O/c1-21-17(22)15(11-2-6-13(18)7-3-11)10-16(20-21)12-4-8-14(19)9-5-12/h2-9,15H,10H2,1H3
  • InChiKey: GTVYCMJNPZUHDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6K-675S
  • 4,6-bis(4-chlorophenyl)-2-methyl-4,5-dihydro-3(2H)-pyridazinone
  • MLS000721483
  • SMR000337123

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sodium and chloride dependent glycine 0.0366 0.1633 0.1624
Loa Loa (eye worm) hypothetical protein 0.0052 0.0163 0.0152
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0091 0.0349 0.0349
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0091 0.0349 0.0338
Loa Loa (eye worm) CYP4Cod1 0.002 0.0015 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0091 0.0349 0.0341
Schistosoma mansoni hypothetical protein 0.0091 0.0349 0.0341
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0003
Brugia malayi Bromodomain containing protein 0.0046 0.0138 0.0138
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0024 0.1175
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1256 0.1246
Onchocerca volvulus Neuropeptide F receptor homolog 0.0091 0.0349 0.0333
Loa Loa (eye worm) hypothetical protein 0.005 0.0158 0.0147
Brugia malayi Dopamine receptor protein 1 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0046 0.0139 0.0128
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0091 0.0349 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.0974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0161 0.0152
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0093 0.6588
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0125 0.0114
Brugia malayi RE15519p 0.0091 0.0349 0.0349
Schistosoma mansoni biogenic amine receptor 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Brugia malayi G-protein coupled receptor 0.0091 0.0349 0.0349
Echinococcus granulosus alpha 1A adrenergic receptor 0.0091 0.0349 0.0338
Schistosoma mansoni biogenic amine receptor 0.0091 0.0349 0.0341
Onchocerca volvulus 0.0091 0.0349 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.018 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0349 0.0338
Brugia malayi PHD-finger family protein 0.003 0.0063 0.0063
Echinococcus granulosus flap endonuclease 1 0.0027 0.0047 0.0035
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0349 0.0338
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.0484 0.0474
Schistosoma mansoni vesicular amine transporter 0.0186 0.079 0.0782
Echinococcus granulosus orexin receptor type 2 0.0091 0.0349 0.0338
Plasmodium vivax amine transporter, putative 0.0366 0.1633 1
Echinococcus granulosus neuropeptide receptor 0.0091 0.0349 0.0338
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0091 0.0349 0.0338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0059 0.0048
Trypanosoma brucei cytochrome P450, putative 0.002 0.0015 0.0476
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0015 0.5
Echinococcus granulosus sex peptide receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis zinc finger protein 0.0024 0.0033 0.0021
Echinococcus granulosus dro:myosuppressin receptor 0.0091 0.0349 0.0338
Schistosoma mansoni amine GPCR 0.0091 0.0349 0.0341
Onchocerca volvulus 0.0242 0.1051 0.1037
Onchocerca volvulus 0.0091 0.0349 0.0333
Brugia malayi hypothetical protein 0.0366 0.1633 0.1633
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.018 0.0169
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Brugia malayi Melatonin receptor type 1A 0.0091 0.0349 0.0349
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0366 0.1633 0.1633
Echinococcus granulosus 7tm_1 domain containing protein 0.0091 0.0349 0.0338
Echinococcus multilocularis serotonin receptor 0.0091 0.0349 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0093 0.0542
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1256 0.1246
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0047 0.2959
Schistosoma mansoni growth hormone secretagogue receptor 0.0091 0.0349 0.0341
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0016 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0091 0.0349 0.0349
Brugia malayi AKH receptor 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0349 0.0338
Schistosoma mansoni neuropeptide receptor 0.0091 0.0349 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Onchocerca volvulus 0.0091 0.0349 0.0333
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0349 0.0338
Plasmodium falciparum flap endonuclease 1 0.0027 0.0047 0.0186
Treponema pallidum sodium- and chloride- dependent transporter 0.2159 1 0.5
Brugia malayi Pre-SET motif family protein 0.0212 0.0914 0.0914
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0349 0.0338
Brugia malayi Dopamine receptor protein 2 0.0091 0.0349 0.0349
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0016 0.0005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0091 0.0349 0.0338
Plasmodium falciparum amino acid transporter, putative 0.0366 0.1633 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0016 0.0005
Loa Loa (eye worm) melatonin receptor type 1A 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Echinococcus granulosus tm gpcr rhodopsin 0.0601 0.273 0.2721
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0366 0.1633 0.5
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus zinc finger protein 0.0024 0.0033 0.0021
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0082 0.0246
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0137 1
Brugia malayi neuropeptide F receptor 0.0091 0.0349 0.0349
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0137 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0038 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0137 1
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0022 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0349 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0158 0.015
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0366 0.1633 0.1624
Brugia malayi hypothetical protein 0.0286 0.1256 0.1256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.018 0.018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Echinococcus multilocularis sex peptide receptor 0.0091 0.0349 0.0338
Brugia malayi Cytochrome P450 family protein 0.002 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0366 0.1633 0.1633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.018 0.0172
Brugia malayi G protein-coupled receptor F59B2.13 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Brugia malayi Cytochrome P450 family protein 0.002 0.0015 0.0015
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0093 0.0542
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0349 0.0341
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0349 0.0341
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0366 0.1633 0.1626
Echinococcus multilocularis neuropeptide s receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0137 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0366 0.1633 0.1624
Echinococcus granulosus g protein coupled receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis serotonin receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.006 0.0204 0.0192
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0366 0.1633 0.1626
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni adenoreceptor 0.0091 0.0349 0.0341
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0043 0.2648
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Loa Loa (eye worm) TYRA-2 protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0005
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0349 0.0338
Brugia malayi Serotonin receptor 0.0091 0.0349 0.0349
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.005 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0085 0.0321 0.031
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0366 0.1633 0.1626
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0061 0.0233
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0065 0.0139
Echinococcus granulosus g protein coupled receptor 0.0091 0.0349 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Echinococcus granulosus peptide allatostatin:somatostatin 0.0091 0.0349 0.0338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0204 0.0192
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0091 0.0349 0.0338
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0349 0.0338
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0349 0.0338
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0366 0.1633 0.1633
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0093 0.6588
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0091 0.0349 0.0338
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0366 0.1633 0.1624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0038 0.0002
Echinococcus multilocularis allatostatin A receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0349 0.0341
Echinococcus multilocularis tumor protein p63 0.0345 0.1533 0.1523
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0349 0.0341
Echinococcus granulosus serotonin receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus sodium and chloride dependent glycine 0.0366 0.1633 0.1624
Schistosoma mansoni neuropeptide receptor 0.0091 0.0349 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni alpha-1 adrenergic receptor 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0161 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0349 0.0338
Brugia malayi Dopamine receptor 0.0091 0.0349 0.0349
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0065 0.0053
Echinococcus multilocularis serotonin transporter 0.2159 1 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0016 0.0005
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0366 0.1633 0.1624
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0137 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0091 0.0349 0.0338
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Onchocerca volvulus 0.0091 0.0349 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus allatostatin A receptor 0.0091 0.0349 0.0338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0049 0.0111
Plasmodium vivax hypothetical protein, conserved 0.0366 0.1633 1
Echinococcus granulosus hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0366 0.1633 0.1624
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0366 0.1633 0.1626
Brugia malayi sulfakinin receptor protein 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0091 0.0349 0.0338
Brugia malayi larval opioid receptor 0.0091 0.0349 0.0349
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0349 0.0338
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0349 0.0338
Schistosoma mansoni hypothetical protein 0.002 0.0016 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Schistosoma mansoni rab6-interacting 0.002 0.0016 0.0008
Brugia malayi Doublecortin family protein 0.002 0.0016 0.0016
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0349 0.0338
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0043 0.0162
Onchocerca volvulus 0.0366 0.1633 0.1619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.0484 0.0474
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0366 0.1633 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0125 0.0114
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0366 0.1633 0.1626
Onchocerca volvulus 0.0366 0.1633 0.1619
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0161 0.0152
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0091 0.0349 0.0349
Schistosoma mansoni bromodomain containing protein 0.0076 0.0279 0.0271
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0047 0.0186
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0137 0.0137
Brugia malayi Flap endonuclease-1 0.0027 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni amine GPCR 0.0091 0.0349 0.0341
Loa Loa (eye worm) norepinephrine transporter 0.2159 1 1
Brugia malayi Abnormal catecholamine distribution protein 1 0.0186 0.079 0.079
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0349 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Echinococcus multilocularis g-protein coupled receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0161 0.015
Echinococcus multilocularis synaptic vesicular amine transporter 0.0186 0.079 0.078
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0137 0.0125
Schistosoma mansoni myosin xvIII 0.0091 0.0349 0.0341
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0093 0.6588
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0366 0.1633 0.1626
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0047 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0038 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0025 0.0039 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0349 0.0338
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2159 1 1
Schistosoma mansoni neuropeptide receptor 0.0091 0.0349 0.0341
Plasmodium vivax SET domain protein, putative 0.003 0.0065 0.0299
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis sodium and chloride dependent glycine 0.0366 0.1633 0.1624
Echinococcus granulosus g-protein coupled receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni amine GPCR 0.0091 0.0349 0.0341
Onchocerca volvulus 0.0058 0.0194 0.0178
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0091 0.0349 0.0338
Toxoplasma gondii hypothetical protein 0.0366 0.1633 1
Echinococcus granulosus RUN 0.002 0.0016 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0043 0.2648
Brugia malayi ORL1-like opioid receptor 0.0091 0.0349 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0093 0.0542
Echinococcus granulosus 7TM GPCR rhodopsin 0.0091 0.0349 0.0338
Echinococcus granulosus neuropeptide receptor A26 0.0091 0.0349 0.0338
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0366 0.1633 0.1626
Loa Loa (eye worm) hypothetical protein 0.2159 1 1
Echinococcus multilocularis RUN 0.002 0.0016 0.0005
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0186 0.079 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.018 0.0172
Schistosoma mansoni neuropeptide receptor 0.0091 0.0349 0.0341
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0091 0.0349 0.0341
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0015 0.0003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0091 0.0349 0.0349
Schistosoma mansoni sodium/chloride dependent transporter 0.2159 1 1
Loa Loa (eye worm) hypothetical protein 0.2159 1 1
Echinococcus granulosus neuropeptide receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis somatostatin receptor 0.0091 0.0349 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0093 0.0542
Schistosoma mansoni histamine h1 receptor 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0041 0.0115 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0349 0.0338
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0019 0.001
Echinococcus granulosus neuropeptide FF receptor 2 0.0091 0.0349 0.0338
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0065 0.0056
Onchocerca volvulus 0.0366 0.1633 0.1619
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0091 0.0349 0.0338
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0016 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0015 0.0476
Schistosoma mansoni lipoxygenase 0.0084 0.0315 0.0307
Onchocerca volvulus 0.0091 0.0349 0.0333
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0349 0.0338
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0047 0.2959
Onchocerca volvulus 0.0091 0.0349 0.0333
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0137 0.0125
Brugia malayi putative neuropeptide receptor 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.2159 1 1
Onchocerca volvulus 0.0091 0.0349 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0049 0.0111
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0366 0.1633 0.1624
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0011 0.0211
Onchocerca volvulus 0.2159 1 1
Echinococcus granulosus somatostatin receptor 0.0091 0.0349 0.0338
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1051 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0091 0.0349 0.0338
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.005 0.0038
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0137 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0105 0.0665
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni neuropeptide f receptor 76f 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0091 0.0349 0.0338
Schistosoma mansoni hypothetical protein 0.0091 0.0349 0.0341
Echinococcus granulosus g protein coupled receptor 0.0091 0.0349 0.0338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Brugia malayi hypothetical protein 0.002 0.0016 0.0016
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.018 0.0169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Schistosoma mansoni opsin-like receptor 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0051 0.0161 0.015
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0003
Schistosoma mansoni survival motor neuron protein 0.0058 0.0194 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.018 0.0169
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0349 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0123
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0019 0.0007
Brugia malayi GnHR receptor homolog 0.0091 0.0349 0.0349
Schistosoma mansoni sodium/chloride dependent transporter 0.0366 0.1633 0.1626
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0349 0.0338
Schistosoma mansoni hypothetical protein 0.0058 0.0194 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0093 0.0542
Brugia malayi G-protein coupled receptor 0.0091 0.0349 0.0349
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0349 0.0341
Echinococcus multilocularis G-protein coupled receptor, putative 0.0091 0.0349 0.0338
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0091 0.0349 0.0341
Loa Loa (eye worm) serotonin transporter b 0.2159 1 1
Echinococcus multilocularis orexin receptor type 2 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Brugia malayi Serotonin receptor 0.0091 0.0349 0.0349
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0366 0.1633 0.1633
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0039 0.0027
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Echinococcus multilocularis dro:myosuppressin receptor 0.0091 0.0349 0.0338
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0091 0.0349 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.0974
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.018 0.0169
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0091 0.0349 0.0338
Schistosoma mansoni sodium-dependent amino acid transporter 0.0366 0.1633 0.1626
Brugia malayi Tachykinin-like peptides receptor 99D 0.0091 0.0349 0.0349
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0091 0.0349 0.0338
Loa Loa (eye worm) solute carrier family 6 member 4 0.2159 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0259 0.0248
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Schistosoma mansoni amine GPCR 0.0091 0.0349 0.0341
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0349 0.0338
Onchocerca volvulus 0.003 0.0065 0.0048
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0137 0.0125
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0137 0.0128
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0065 0.0056
Loa Loa (eye worm) hypothetical protein 0.0366 0.1633 0.1624
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0259 0.0248
Brugia malayi hypothetical protein 0.0091 0.0349 0.0349
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0091 0.0349 0.0341
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Brugia malayi putative neuropeptide receptor NPR1 0.0091 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0349 0.0341
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0091 0.0349 0.0349
Schistosoma mansoni zinc finger protein 0.0024 0.0033 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0066 0.0278
Echinococcus multilocularis neuropeptide FF receptor 2 0.0091 0.0349 0.0338
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Echinococcus granulosus fmrfamide receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0349 0.0338
Plasmodium falciparum transporter, putative 0.0366 0.1633 1
Echinococcus granulosus neuropeptide s receptor 0.0091 0.0349 0.0338
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0828 0.3787 0.3779
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis G protein coupled receptor 139 0.0091 0.0349 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Echinococcus granulosus G protein coupled receptor 139 0.0091 0.0349 0.0338
Onchocerca volvulus 0.0091 0.0349 0.0333
Brugia malayi Bromodomain containing protein 0.0091 0.0345 0.0345
Giardia lamblia GTOR 0.0046 0.0137 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0137 1
Brugia malayi Pre-SET motif family protein 0.003 0.0065 0.0065
Schistosoma mansoni biogenic amine receptor 0.0091 0.0349 0.0341
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0366 0.1633 0.1624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0038 0.0002
Echinococcus granulosus synaptic vesicular amine transporter 0.0186 0.079 0.078
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0043 0.2648
Schistosoma mansoni amine GPCR 0.0091 0.0349 0.0341
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0366 0.1633 0.1624
Brugia malayi G protein-coupled receptor 0.0091 0.0349 0.0349
Brugia malayi hypothetical protein 0.0026 0.0043 0.0043
Schistosoma mansoni polycystin 1-related 0.002 0.0016 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0123
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0137 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.005 0.0041
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0091 0.0349 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0349 0.0338
Toxoplasma gondii hypothetical protein 0.0366 0.1633 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0091 0.0349 0.0338
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Leishmania major hypothetical protein, conserved 0.0026 0.0043 0.2648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0082 0.0432
Loa Loa (eye worm) hypothetical protein 0.0286 0.1256 0.1246
Leishmania major cytochrome p450-like protein 0.002 0.0015 0.0476
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0047 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0349 0.0341
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0016 0.0005
Onchocerca volvulus 0.0091 0.0349 0.0333
Schistosoma mansoni flap endonuclease-1 0.0024 0.0035 0.0026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0019 0.001
Schistosoma mansoni loxhd1 0.002 0.0016 0.0008
Brugia malayi hypothetical protein 0.002 0.0016 0.0016
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0015 0.0476
Loa Loa (eye worm) hypothetical protein 0.0049 0.0152 0.0141
Schistosoma mansoni lipoxygenase 0.012 0.0484 0.0476
Schistosoma mansoni hypothetical protein 0.0091 0.0349 0.0341
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0091 0.0349 0.0341
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0091 0.0349 0.0341
Schistosoma mansoni sodium/chloride dependent transporter 0.0366 0.1633 0.1626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0123
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0047 0.0025
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus serotonin transporter 0.2159 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0091 0.0349 0.0338
Schistosoma mansoni opsin-like receptor 0.0091 0.0349 0.0341
Schistosoma mansoni opsin-like receptor 0.0091 0.0349 0.0341
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0043 0.0162
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0349 0.0338
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.018 0.0172
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0366 0.1633 0.1624
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0043 0.0162
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis neuropeptide receptor A26 0.0091 0.0349 0.0338
Onchocerca volvulus 0.005 0.0158 0.0142
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0047 0.0035
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0019 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0091 0.0349 0.0341
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus tumor protein p63 0.0345 0.1533 0.1523
Schistosoma mansoni rab6-interacting 0.002 0.0016 0.0008
Onchocerca volvulus 0.0091 0.0349 0.0333
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0349 0.0338
Brugia malayi neuropeptide F receptor 0.0091 0.0349 0.0349
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0914 0.0904
Schistosoma mansoni hypothetical protein 0.0041 0.0115 0.0106
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0047 0.2959
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0366 0.1633 1
Schistosoma mansoni hypothetical protein 0.0091 0.0349 0.0341
Echinococcus granulosus sodium and chloride dependent glycine 0.0366 0.1633 0.1624
Loa Loa (eye worm) hypothetical protein 0.0091 0.0349 0.0338
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0601 0.273 0.2721
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0366 0.1633 0.1626
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0349 0.0338
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0366 0.1633 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0349 0.0341

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0117 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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