Detailed information for compound 1420631

Basic information

Technical information
  • TDR Targets ID: 1420631
  • Name: 5-(4-acetylphenyl)-N-(6-methoxypyridin-3-yl)f uran-2-carboxamide
  • MW: 336.341 | Formula: C19H16N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)NC(=O)c1ccc(o1)c1ccc(cc1)C(=O)C
  • InChi: 1S/C19H16N2O4/c1-12(22)13-3-5-14(6-4-13)16-8-9-17(25-16)19(23)21-15-7-10-18(24-2)20-11-15/h3-11H,1-2H3,(H,21,23)
  • InChiKey: KRTJAUBGQCJGJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-acetylphenyl)-N-(6-methoxy-3-pyridyl)furan-2-carboxamide
  • 5-(4-acetylphenyl)-N-(6-methoxy-3-pyridyl)-2-furancarboxamide
  • 5-(4-acetylphenyl)-N-(6-methoxy-3-pyridyl)-2-furamide
  • 5-(4-ethanoylphenyl)-N-(6-methoxypyridin-3-yl)furan-2-carboxamide
  • ZINC03350772

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0274
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0172 0.1268
Loa Loa (eye worm) patched family protein 0.0007 0.0015 0.0037
Toxoplasma gondii patched family protein 0.0007 0.0015 0.0199
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0257 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0257 0.0654
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0146 0.1096
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.009 0.0228
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0255 0.1921
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0317 0.0768
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.009 0.0272
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Plasmodium falciparum importin beta, putative 0.0031 0.0255 0.6955
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.009 0.0272
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0257 0.0778
Echinococcus multilocularis protein patched 0.0051 0.0465 0.0465
Onchocerca volvulus 0.006 0.0554 0.1879
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0257 0.0654
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0687 0.2081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0731 0.1859
Loa Loa (eye worm) hypothetical protein 0.0051 0.0465 0.1182
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.009 0.009
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0731 0.1208
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0216 0.0549
Leishmania major DNA polymerase eta, putative 0.0006 0.0004 0.0031
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0257 0.0844
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0731 0.2532
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0146 0.0353
Plasmodium falciparum lipid/sterol:H+ symporter 0.0007 0.0015 0.0396
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.009 0.0228
Schistosoma mansoni nuclear receptor 0.0015 0.009 0.0272
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0257 0.0654
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0172 0.2356
Entamoeba histolytica Ran family GTPase 0.0023 0.0172 0.1482
Leishmania major hypothetical protein, conserved 0.0077 0.0731 0.5499
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0172 0.469
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Brugia malayi hypothetical protein 0.0015 0.009 0.0228
Loa Loa (eye worm) hypothetical protein 0.0077 0.0731 0.1859
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.009 0.009
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0136 0.0346
Onchocerca volvulus 0.0015 0.009 0.0262
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Schistosoma mansoni DNA polymerase eta 0.002 0.0146 0.0441
Echinococcus multilocularis protein quaking 0.0033 0.0278 0.0278
Schistosoma mansoni ran 0.0023 0.0172 0.0521
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0004 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0317 0.0962
Trypanosoma brucei unspecified product 0.0014 0.0082 0.0617
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0731 0.2532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0257 0.0654
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0371
Brugia malayi hypothetical protein 0.0015 0.009 0.0228
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0465 0.1124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0257 0.0622
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Giardia lamblia DINP protein human, muc B family 0.002 0.0146 0.39
Brugia malayi CXXC zinc finger family protein 0.003 0.0246 0.0626
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0559 0.1422
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.009 0.0228
Echinococcus granulosus dna polymerase eta 0.002 0.0146 0.0353
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.009 0.0217
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0317 0.0808
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0317 0.0317
Brugia malayi protein C24B5.3 0.0007 0.0015 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.009 0.0217
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0257 0.0778
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0146 0.1096
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0257 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0257 0.0654
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5912
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0406 0.1406
Echinococcus granulosus importin subunit beta 1 0.0031 0.0255 0.0618
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0257 0.0257
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1686 0.1686
Trypanosoma brucei hypothetical protein 0.0135 0.1329 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0146 0.1254
Trypanosoma brucei unspecified product 0.002 0.0146 0.1096
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0004 0.0031
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0146 0.1096
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0257 0.0778
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0257 0.0778
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0317 0.0962
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.009 0.0262
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.1068
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0172 0.1268
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0257 0.0257
Echinococcus granulosus GPCR family 2 0.0019 0.0136 0.0329
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0108 0.0261
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Brugia malayi Nuclear hormone receptor E75 0.0015 0.009 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0015 0.009 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0136 0.0346
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0406 0.0982
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2886 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0082 0.0617
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.003 0.003
Schistosoma mansoni lamin 0.0027 0.0216 0.0654
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0363 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Brugia malayi Myosin head containing protein 0.0007 0.0015 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0403 0.0975
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1162 0.2956
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0146 0.0505
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.003 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0731 1
Schistosoma mansoni hypothetical protein 0.0041 0.0363 0.11
Echinococcus multilocularis musashi 0.0027 0.0216 0.0216
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0406 0.5554
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0073 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0216 0.0549
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0731 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0136 0.0329
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0255 0.3494
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0246 0.0626
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0257 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0317 0.0962
Onchocerca volvulus 0.0077 0.0731 0.2494
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0731 0.1859
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0047 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0403 0.122
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0257 0.0778
Echinococcus granulosus lamin 0.0027 0.0216 0.0522
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Schistosoma mansoni hypothetical protein 0.0073 0.0687 0.2081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0403 0.0975
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.1068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0731 0.2532
Mycobacterium ulcerans beta-lactamase 0.0077 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0255 0.0649
Brugia malayi hypothetical protein 0.0016 0.0108 0.0274
Loa Loa (eye worm) hypothetical protein 0.006 0.0559 0.1422
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Mycobacterium ulcerans hypothetical protein 0.0077 0.0731 1
Onchocerca volvulus 0.0037 0.0317 0.1055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0406 0.5554
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0257 0.0778
Brugia malayi beta-lactamase family protein 0.0077 0.0731 0.1859
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Leishmania major GTP-binding protein, putative 0.0023 0.0172 0.1296
Echinococcus granulosus hypothetical protein 0.0033 0.0278 0.0673
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0196 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Schistosoma mansoni zinc finger protein 0.0015 0.009 0.0272
Loa Loa (eye worm) beta-lactamase 0.0077 0.0731 0.1859
Brugia malayi steroid hormone receptor 0.0031 0.0257 0.0654
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0004 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Echinococcus multilocularis dna polymerase eta 0.002 0.0146 0.0146
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0004 0.0113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0136 0.0136
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.3301 0.8399
Echinococcus granulosus dna polymerase kappa 0.002 0.0146 0.0353
Brugia malayi ecdysone receptor 0.0015 0.009 0.0228
Onchocerca volvulus 0.0287 0.2886 1
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0367 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Brugia malayi nuclear hormone receptor 0.0015 0.009 0.0228
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0146 0.0371
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Onchocerca volvulus 0.0077 0.0731 0.2494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Onchocerca volvulus 0.0015 0.009 0.0262
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Mycobacterium tuberculosis Conserved protein 0.0077 0.0731 0.1208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.009 0.0217
Leishmania major DNA polymerase eta, putative 0.002 0.0146 0.1096
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0257 0.0257
Echinococcus multilocularis GPCR, family 2 0.0019 0.0136 0.0136
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0004 0.0057
Brugia malayi hypothetical protein 0.0007 0.0015 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Toxoplasma gondii hypothetical protein 0.0007 0.0015 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.009 0.0228
Brugia malayi beta-lactamase 0.0077 0.0731 0.1859
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0731 0.1208
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0257 0.0654
Echinococcus granulosus tumor protein p63 0.0408 0.4132 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1329 1
Echinococcus multilocularis lamin dm0 0.0027 0.0216 0.0216
Schistosoma mansoni ran 0.0023 0.0172 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0257 0.0654
Schistosoma mansoni intermediate filament proteins 0.0027 0.0216 0.0654
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1329 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.1088 0.1088
Brugia malayi intermediate filament protein 0.0027 0.0216 0.0549
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0146 0.1096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0257 0.0622
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0196 0.0678
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5912
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Echinococcus multilocularis dna polymerase kappa 0.002 0.0146 0.0146
Brugia malayi Patched related family protein 4 0.0007 0.0015 0.0037
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0172 0.0172
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0406 0.5554
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0731 0.1208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Echinococcus multilocularis lamin 0.0027 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0174
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.009 0.0228
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0004 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0257 0.0654
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0257 0.0257
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0317 0.4345
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1162 0.1162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0033
Schistosoma mansoni hypothetical protein 0.0049 0.0446 0.135
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.009 0.0228
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0465 0.1124
Brugia malayi nuclear hormone receptor 0.0031 0.0257 0.0654
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0403 0.122
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0257 0.0654
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0257 0.0778
Schistosoma mansoni hypothetical protein 0.0049 0.0446 0.135
Onchocerca volvulus 0.0031 0.0257 0.0844
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5912
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.009 0.0262
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0731 0.2532
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0257 0.0654
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0187
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0108 0.0274
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0108 0.0326
Toxoplasma gondii patched family protein 0.0007 0.0015 0.0199
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1523 0.4613
Schistosoma mansoni nuclear hormone receptor 0.0015 0.009 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0257 0.0654
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Brugia malayi Patched related family protein 10 0.0007 0.0015 0.0037
Brugia malayi hypothetical protein 0.0007 0.0015 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0257 0.0257
Brugia malayi Patched related family protein 12 0.0007 0.0015 0.0037
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.009 0.0228
Loa Loa (eye worm) patched family protein 0.0007 0.0015 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0257 0.0622
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0077 0.0731 0.1859
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0257 0.0654
Schistosoma mansoni cpg binding protein 0.0031 0.0263 0.0798
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0257 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Schistosoma mansoni importin beta-1 0.0031 0.0255 0.0773
Trypanosoma brucei unspecified product 0.0014 0.0082 0.0617
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0274
Brugia malayi Patched protein homolog 1 0.0007 0.0015 0.0037
Loa Loa (eye worm) acetyltransferase 0.0154 0.1523 0.3875
Schistosoma mansoni hypothetical protein 0.0033 0.0278 0.0842
Mycobacterium leprae Probable lipase LipE 0.0077 0.0731 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0403 0.0403
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0257 0.0778
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0257 0.0654
Schistosoma mansoni coup transcription factor 0.0031 0.0257 0.0778
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0172 0.2356
Plasmodium vivax SET domain protein, putative 0.0037 0.0317 0.4345
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0004 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0257 0.0778
Schistosoma mansoni cpg binding protein 0.003 0.0246 0.0745
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0687 0.1662
Loa Loa (eye worm) hypothetical protein 0.0077 0.0731 0.1859
Brugia malayi hypothetical protein 0.0033 0.0278 0.0708
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.1068
Brugia malayi CHE-14 protein 0.0051 0.0465 0.1182
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0559 0.1422
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0146 0.0441
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0033
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1523 0.3875
Loa Loa (eye worm) hypothetical protein 0.0077 0.0731 0.1859
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0172 0.0438
Toxoplasma gondii ABC1 family protein 0.0077 0.0731 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0731 0.2532
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0412
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0216 0.0549
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2529 0.6435
Loa Loa (eye worm) hypothetical protein 0.0033 0.0278 0.0708
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0088 0.0224
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0367 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0731 0.1208
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0172 0.0417
Brugia malayi nuclear receptor NHR-88 0.0031 0.0257 0.0654
Echinococcus multilocularis protein dispatched 1 0.0058 0.0539 0.0539
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0146 0.1096
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0257 0.0778
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0274
Schistosoma mansoni patched 1 0.0051 0.0465 0.1407
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1181 0.3577
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0731 0.1208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0403 0.0403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0731 0.2213
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0731 0.1208
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0297 0.0719
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0049 0.0118
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0278 0.0708
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) patched family protein 0.0007 0.0015 0.0037
Brugia malayi nuclear receptor RXR 0.0015 0.009 0.0228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0108 0.0326
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.1068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0317 0.0317
Loa Loa (eye worm) patched family protein 0.0007 0.0015 0.0037
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0257 0.0654
Loa Loa (eye worm) tumor suppressor 0.0388 0.393 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0082 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0731 0.5484
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0082 0.0617
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0108 0.0108
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Brugia malayi Pre-SET motif family protein 0.0252 0.2529 0.6435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0403 0.122
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Leishmania major DNA damage repair protein, putative 0.0006 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0062 0.0583 0.1482
Entamoeba histolytica hypothetical protein 0.0025 0.0196 0.1685
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1523 0.1523
Brugia malayi beta-lactamase family protein 0.0077 0.0731 0.1859
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0049 0.0049
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1329 1
Echinococcus granulosus protein quaking 0.0033 0.0278 0.0673
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0136 0.0136
Mycobacterium tuberculosis Conserved protein 0.0077 0.0731 0.1208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0033
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.009 0.009
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0172 0.1296
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.5912
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0146 0.1948
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0088 0.0224
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0136 0.0329
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0146 0.0146
Echinococcus granulosus snurportin 1 0.0327 0.3301 0.7988
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0049 0.0124
Plasmodium vivax importin-beta 2, putative 0.0031 0.0255 0.3494
Brugia malayi tumor suppressor. 0.0388 0.393 1
Schistosoma mansoni hypothetical protein 0.0049 0.0446 0.135
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0554 0.141
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0146 0.0371
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0731 0.2213
Brugia malayi nuclear receptor NHR-67 0.0015 0.009 0.0228
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Trypanosoma brucei calpain, putative 0.0135 0.1329 1
Brugia malayi nuclear receptor NHR-88 0.0015 0.009 0.0228
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.009 0.0217
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0257 0.0654
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0274
Brugia malayi RNA, U transporter 1 0.0087 0.0836 0.2126
Onchocerca volvulus 0.0077 0.0731 0.2494
Schistosoma mansoni nuclear receptor 0.0015 0.009 0.0272
Plasmodium vivax patched family protein, putative 0.0007 0.0015 0.0199
Brugia malayi hypothetical protein 0.0016 0.0108 0.0274
Brugia malayi Pre-SET motif family protein 0.0037 0.0317 0.0808
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0257 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0257 0.0622
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0406 0.1406
Brugia malayi Importin beta-1 subunit 0.0031 0.0255 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0257 0.0622
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0033
Echinococcus granulosus geminin 0.0205 0.2043 0.4943
Brugia malayi tailless protein 0.0015 0.009 0.0228
Loa Loa (eye worm) patched family protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0367 0.3159
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1329 1
Mycobacterium ulcerans lipase LipD 0.0077 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0536
Leishmania major importin beta-1 subunit, putative 0.0025 0.0196 0.1473
Loa Loa (eye worm) hypothetical protein 0.0119 0.1162 0.2956
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0257 0.0654
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0072
Schistosoma mansoni hypothetical protein 0.0205 0.2043 0.6188
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Onchocerca volvulus 0.003 0.0246 0.0806
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1686 0.408
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0602 0.1823
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0108 0.0274
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0146 0.1948
Trichomonas vaginalis ran, putative 0.0023 0.0172 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Brugia malayi hypothetical protein 0.0073 0.0687 0.1748
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0004 0.0057
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0465 0.0465
Echinococcus multilocularis tumor protein p63 0.0408 0.4132 0.4132
Brugia malayi nuclear receptor RXR 0.0016 0.0108 0.0274
Echinococcus granulosus expressed conserved protein 0.0112 0.1088 0.2632
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.009 0.0217
Brugia malayi hypothetical protein 0.0007 0.0015 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0731 0.0731
Schistosoma mansoni lamin 0.0027 0.0216 0.0654
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0257 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0257 0.0654
Echinococcus multilocularis geminin 0.0205 0.2043 0.2043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0257 0.0257
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0257 0.0622
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0136 0.0346
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0172 0.0438
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.009 0.0217
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.009 0.0272
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0004 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1162 0.2812
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0146 0.0371
Schistosoma mansoni nuclear hormone receptor 0.0015 0.009 0.0272
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.1329 1
Brugia malayi Patched family protein 0.0007 0.0015 0.0037
Brugia malayi protein C24B5.3 0.0007 0.0015 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0257 0.0257
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0465 0.1182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0571 0.7821
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0731 0.5499
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0731 0.1208
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0731 0.1768
Toxoplasma gondii patched family protein 0.0007 0.0015 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0274
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0196 0.1446
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0257 0.0654
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0257 0.0622
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0004 0.0013
Leishmania major DNA polymerase kappa, putative 0.0006 0.0004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Onchocerca volvulus 0.0027 0.0216 0.0701
Onchocerca volvulus 0.0027 0.0216 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.1096
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0412
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Loa Loa (eye worm) DR-78 0.0015 0.009 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0257 0.0654
Echinococcus granulosus intermediate filament protein 0.0027 0.0216 0.0522
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0654
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Schistosoma mansoni hypothetical protein 0.0049 0.0446 0.135
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0257 0.0257
Leishmania major DNA polymerase kappa, putative 0.002 0.0146 0.1096
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1329 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Echinococcus multilocularis cpg binding protein 0.0031 0.0263 0.0263
Schistosoma mansoni hypothetical protein 0.0327 0.3301 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0216 0.0549
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1162 1
Schistosoma mansoni hypothetical protein 0.0019 0.0136 0.0412
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0004 0.0031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0491 0.4989 1
Brugia malayi polk-prov protein 0.0006 0.0004 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.009 0.009
Brugia malayi conserved hypotetical protein 0.0015 0.009 0.0228
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0257 0.0778
Toxoplasma gondii patched family protein 0.0007 0.0015 0.0199
Loa Loa (eye worm) hypothetical protein 0.0077 0.0731 0.1859
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0257 0.0654
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0108 0.0274
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0403 0.1025
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0228
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0146 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0257 0.0654
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0559 0.1422
Echinococcus granulosus lamin dm0 0.0027 0.0216 0.0522
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.1478 0.3578
Brugia malayi hypothetical protein 0.0007 0.0015 0.0037
Trichomonas vaginalis esterase, putative 0.0077 0.0731 0.2532
Schistosoma mansoni hypothetical protein 0.0033 0.0278 0.0842
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.003 0.0072
Mycobacterium tuberculosis Conserved protein 0.0077 0.0731 0.1208
Schistosoma mansoni hypothetical protein 0.0205 0.2043 0.6188
Echinococcus multilocularis snurportin 1 0.0327 0.3301 0.3301
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0731 0.5484
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.009 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0403 0.1025
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1329 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0687 0.0687
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0146 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0465 0.161
Schistosoma mansoni cpg binding protein 0.0031 0.0263 0.0798
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0196 0.0678
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0257 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0257 0.0654
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1329 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0172 0.463
Trichomonas vaginalis helicase, putative 0.0007 0.001 0.0033
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0255 0.1921
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0554 0.1678
Brugia malayi ecdysteroid receptor 0.0031 0.0257 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0317 0.0962
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0346
Loa Loa (eye worm) hypothetical protein 0.0041 0.0363 0.0924
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0146 0.1068
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0257 0.0622
Echinococcus granulosus cpg binding protein 0.0031 0.0263 0.0637
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0731 0.1859
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1329 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0731 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.102 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 16.416 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1699 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a: Hit Confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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