Detailed information for compound 1433461

Basic information

Technical information
  • TDR Targets ID: 1433461
  • Name: 2-amino-7-diethylamino-4-pyridin-3-yl-4H-chro mene-3-carbonitrile
  • MW: 320.388 | Formula: C19H20N4O
  • H donors: 1 H acceptors: 2 LogP: 3.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc2c(c1)OC(=C(C2c1cccnc1)C#N)N)CC
  • InChi: 1S/C19H20N4O/c1-3-23(4-2)14-7-8-15-17(10-14)24-19(21)16(11-20)18(15)13-6-5-9-22-12-13/h5-10,12,18H,3-4,21H2,1-2H3
  • InChiKey: WDOIQXLSUHZAMD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-amino-7-diethylamino-4-(3-pyridyl)-4H-chromene-3-carbonitrile
  • ST070467
  • MLS000039122
  • SMR000034925
  • Oprea1_856172

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.058 0.0905
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0326 0.0326
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.0606 0.0945
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0693 0.1819
Schistosoma mansoni retinoic acid receptor RXR 0.0124 0.1937 0.5631
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0592 0.0924
Schistosoma mansoni hypothetical protein 0.0049 0.0558 0.1622
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0076 0.022
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1851 0.2886
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0076 0.0076
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1885 0.5478
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0239 0.1355
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0076 0.0118
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0474 0.0474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0076 0.0118
Schistosoma mansoni alpha-glucosidase 0.0169 0.2786 0.8099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0076 0.0118
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.3294 0.3294
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1851 0.1851
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0592 0.0592
Brugia malayi PAS domain containing protein 0.0062 0.0795 0.1239
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0123
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0076 0.022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0474 0.0142
Echinococcus granulosus metabotropic glutamate receptor 2 0.005 0.0567 0.0567
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0042 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0076 0.0076
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0052 0.0606 0.0945
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0076 0.0118
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0063 0.0823 0.1283
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Schistosoma mansoni coup transcription factor 0.0023 0.0076 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0076 0.0118
Loa Loa (eye worm) glutamate receptor 0.0079 0.1119 0.1745
Loa Loa (eye worm) hypothetical protein 0.0365 0.6413 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0042 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.1037 0.1037
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1761 0.266
Echinococcus multilocularis expressed conserved protein 0.0112 0.1717 0.1717
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0042 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0076 0.022
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0474 0.0474
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0033 0.0254 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0076 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0042 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0042 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0474 0.2693
Brugia malayi metabotropic glutamate receptor type 2 0.0098 0.1471 0.2294
Schistosoma mansoni hypothetical protein 0.0049 0.0558 0.1622
Brugia malayi nuclear hormone receptor 0.0023 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.0052 0.0606 0.0945
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0042 1
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0592 0.0592
Echinococcus granulosus expressed conserved protein 0.0112 0.1717 0.1717
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0076 0.022
Mycobacterium leprae putative cytochrome p450 0.0021 0.0042 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0124 0.1937 0.1937
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1761 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0456 0.0456
Schistosoma mansoni kinase 0.0058 0.0721 0.2096
Echinococcus multilocularis muscleblind protein 1 0.018 0.2991 0.2991
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0076 0.0076
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1851 0.1851
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0592 0.0592
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.2797 0.2797
Schistosoma mansoni metabotropic glutamate receptor 0.0098 0.1471 0.4277
Brugia malayi Cytochrome P450 family protein 0.0032 0.0239 0.0372
Schistosoma mansoni cellular tumor antigen P53 0.005 0.058 0.1686
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0326 0.0946
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0076 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0076 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0409 0.0638
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0456 0.0456
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.3294 0.5137
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0474 0.1378
Brugia malayi hypothetical protein 0.0365 0.6413 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0474 0.1378
Echinococcus multilocularis protein patched 0.0051 0.0592 0.0592
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0 0.5
Echinococcus multilocularis GPCR, family 3, C terminal 0.0033 0.0254 0.0254
Echinococcus granulosus tumor protein p63 0.0344 0.6027 0.6027
Brugia malayi Cytochrome P450 family protein 0.0067 0.0897 0.1399
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0076 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0076 0.0118
Brugia malayi ecdysteroid receptor 0.0023 0.0076 0.0118
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1761 0.2746
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0456 0.0853
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0076 0.0118
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0076 0.0076
Brugia malayi CHE-14 protein 0.0051 0.0592 0.0924
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0076 0.0118
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0239 0.0372
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0076 0.022
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0474 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0042 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Echinococcus multilocularis geminin 0.0205 0.344 0.344
Loa Loa (eye worm) hypothetical protein 0.0051 0.0592 0.0924
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0456 0.2587
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0042 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 1 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0474 0.2693
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0456 0.2587
Leishmania major cytochrome p450-like protein 0.0032 0.0239 0.1355
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1761 0.2746
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3294 0.3294
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0042 1
Brugia malayi steroid hormone receptor 0.0023 0.0076 0.0118
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0239 0.1355
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0592 0.1046
Loa Loa (eye worm) glutamate receptor 0.0082 0.1175 0.1832
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0762 0.1189
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0474 0.0975
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1761 0.5119
Schistosoma mansoni hypothetical protein 0.0205 0.344 1
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0474 0.0474
Brugia malayi Cytochrome P450 family protein 0.0032 0.0239 0.0372
Loa Loa (eye worm) hypothetical protein 0.0117 0.1818 0.2835
Schistosoma mansoni hypothetical protein 0.0033 0.0254 0.0738
Loa Loa (eye worm) hypothetical protein 0.0129 0.204 0.3181
Leishmania major cytochrome p450-like protein 0.0021 0.0042 0.0241
Leishmania major cytochrome p450-like protein 0.0021 0.0042 0.0241
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0762 0.1189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0076 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0076 0.022
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3294 0.3294
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0076 0.0076
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.2797 0.2797
Echinococcus granulosus geminin 0.0205 0.344 0.344
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0474 0.2693
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0326 0.0326
Onchocerca volvulus 0.0046 0.0506 0.0679
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0239 0.1355
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0042 0.0241
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0076 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0286 0.4946 1
Brugia malayi Muscleblind-like protein 0.018 0.2991 0.4664
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0042 0.0241
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0456 0.0711
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0076 0.022
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0076 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0042 1
Schistosoma mansoni hypothetical protein 0.0049 0.0558 0.1622
Brugia malayi nuclear receptor NHR-88 0.0023 0.0076 0.0118
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0456 0.0921
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0076 0.0076
Brugia malayi cytochrome P450 0.0021 0.0042 0.0066
Schistosoma mansoni aryl hydrocarbon receptor 0.018 0.2976 0.8651
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.006 0.0762 0.1189
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0076 0.0076
Schistosoma mansoni single-minded 0.0062 0.0795 0.2309
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0042 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0456 0.0711
Schistosoma mansoni cytochrome P450 0.0021 0.0042 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1761 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0076 0.022
Echinococcus multilocularis transfer RNA-Lys 0.0046 0.0496 0.0496
Schistosoma mansoni hypothetical protein 0.0037 0.0326 0.0946
Loa Loa (eye worm) hypothetical protein 0.018 0.2991 0.4664
Trypanosoma brucei polo-like protein kinase 0.0114 0.1761 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.3294 0.5137
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0474 0.0142
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0474 0.2693
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0129 0.204 0.204
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1761 0.9414
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0076 0.0118
Echinococcus multilocularis neuropeptide s receptor 0.0558 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0076 0.0076
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0042 1
Mycobacterium ulcerans putative regulatory protein 0.0046 0.0496 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0042 0.0241
Echinococcus multilocularis neuropeptide receptor A26 0.0558 1 1
Echinococcus multilocularis tumor protein p63 0.0344 0.6027 0.6027
Brugia malayi Cytochrome P450 family protein 0.0021 0.0042 0.0066
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0042 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1761 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0474 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0042 1
Onchocerca volvulus 0.0114 0.1756 0.2652
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0076 0.022
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0042 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0239 0.0372
Loa Loa (eye worm) hypothetical protein 0.0041 0.0409 0.0638
Echinococcus granulosus metabotropic glutamate receptor 5 0.0129 0.204 0.204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0076 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0456 0.2587
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1851 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0474 0.0474
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0897 0.1399
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0076 0.0076
Giardia lamblia Kinase, PLK 0.0114 0.1761 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0042 0.0241
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0456 0.0853
Loa Loa (eye worm) hypothetical protein 0.0033 0.0254 0.0396
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0474 0.0474
Onchocerca volvulus 0.0365 0.6413 1
Brugia malayi hypothetical protein 0.0037 0.0326 0.0508
Brugia malayi Metabotropic glutamate receptor precursor. 0.0082 0.1175 0.1832
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0239 0.4324
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0042 0.0086
Brugia malayi bHLH-PAS transcription factor 0.0046 0.0496 0.0774
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0042 1
Loa Loa (eye worm) hypothetical protein 0.018 0.2991 0.4664
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0117 0.1818 0.2835
Trypanosoma brucei glucosidase, putative 0.0044 0.0456 0.2587
Echinococcus multilocularis 0.0021 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0076 0.0118
Echinococcus granulosus muscleblind protein 0.018 0.2991 0.2991
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.0119 0.1851 0.2886
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.0118 0.1828 0.285
Loa Loa (eye worm) hypothetical protein 0.0062 0.0805 0.1255
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1761 0.1761
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0474 0.074
Schistosoma mansoni patched 1 0.0051 0.0592 0.1721
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0762 0.1189
Schistosoma mansoni alpha-glucosidase 0.0169 0.2786 0.8099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0474 0.074
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0042 1
Echinococcus granulosus single minded 2 0.0046 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.1037 0.1037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0076 0.0118
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0042 1
Onchocerca volvulus Poor gastrulation protein homolog 0.0033 0.0254 0.0281
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0042 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0042 1
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0033 0.0254 0.0281
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0111 0.171 0.171
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0052 0.0606 0.0945
Schistosoma mansoni hypothetical protein 0.0049 0.0558 0.1622
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0076 0.0076
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1761 1
Schistosoma mansoni hypothetical protein 0.0205 0.344 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0076 0.0076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0076 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0076 0.022
Onchocerca volvulus 0.005 0.058 0.0796
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0042 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.005 0.0567 0.0567
Loa Loa (eye worm) cytochrome P450 0.0021 0.0042 0.0066
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0076 0.0076
Echinococcus multilocularis muscleblind protein 0.018 0.2991 0.2991
Echinococcus granulosus GPCR family 3 C terminal 0.0033 0.0254 0.0254
Schistosoma mansoni hypothetical protein 0.0041 0.0409 0.119
Schistosoma mansoni alpha glucosidase 0.0044 0.0456 0.1325
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0076 0.022
Echinococcus multilocularis aryl hydrocarbon receptor 0.0134 0.2126 0.2126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0076 0.0118
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0076 0.0076
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0042 0.0241
Echinococcus granulosus aryl hydrocarbon receptor 0.0134 0.2126 0.2126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Onchocerca volvulus 0.0133 0.2116 0.322
Loa Loa (eye worm) hypothetical protein 0.0133 0.2116 0.33
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0076 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0693 0.1819
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0076 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0286 0.4946 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0076 0.0118
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.011 0.1688 0.4906
Schistosoma mansoni metabotropic glutamate receptor 0.005 0.0567 0.1648
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0239 0.0372
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0076 0.0118
Echinococcus multilocularis protein dispatched 1 0.0058 0.0726 0.0726
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1761 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.891250938 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.891250938 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
EC50 (functional) = 0.341 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 0.368 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 0.396 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.1836 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2239 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.5805 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.0441 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) 15.7578 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.6805 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.6805 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Hemoglobin Beta Chain Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 33.8078 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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