Detailed information for compound 1436682

Basic information

Technical information
  • TDR Targets ID: 1436682
  • Name: 3-(2,3-dimethylphenyl)-1-(phenylmethyl)-1-pro pylthiourea
  • MW: 312.472 | Formula: C19H24N2S
  • H donors: 0 H acceptors: 0 LogP: 5.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=Nc1cccc(c1C)C)S)Cc1ccccc1
  • InChi: 1S/C19H24N2S/c1-4-13-21(14-17-10-6-5-7-11-17)19(22)20-18-12-8-9-15(2)16(18)3/h5-12H,4,13-14H2,1-3H3,(H,20,22)
  • InChiKey: ROMRJAYEVSBOHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,3-dimethylphenyl)-1-(phenylmethyl)-1-propyl-thiourea
  • 1-(benzyl)-3-(2,3-dimethylphenyl)-1-propyl-thiourea
  • T5308718
  • ZINC03331106
  • SMR000343640
  • MLS000770105

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.1008 0.1347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.055 0.051
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0006 0.0042 0.0224
Loa Loa (eye worm) beta-lactamase 0.0038 0.1008 0.097
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0555 0.2803
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.1008 0.103
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0221 0.093
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0184 0.0195
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0555 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.055 0.0542
Brugia malayi steroid hormone receptor 0.0023 0.055 0.0542
Onchocerca volvulus 0.0038 0.1008 0.103
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Onchocerca volvulus 0.0035 0.0909 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.055 0.0542
Onchocerca volvulus 0.0038 0.1008 0.103
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.1008 1
Giardia lamblia Hypothetical protein 0.0009 0.0131 0.1735
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Plasmodium falciparum thioredoxin reductase 0.0066 0.1872 1
Schistosoma mansoni sulfide quinone reductase 0.0006 0.0042 0.0044
Onchocerca volvulus Protein cereblon homolog 0.0315 0.9417 1
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.055 0.0542
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.055 0.0584
Onchocerca volvulus Peroxidasin homolog 0.0244 0.7277 0.7717
Giardia lamblia Hypothetical protein 0.0009 0.0131 0.1735
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.055 0.051
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0131 0.0124
Mycobacterium ulcerans hydrolase 0.0009 0.0131 0.0922
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Echinococcus granulosus bloom syndrome protein 0.0022 0.0539 0.053
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0539 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.1872 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0182 0.015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.055 0.0584
Onchocerca volvulus 0.0244 0.7277 0.7717
Brugia malayi follicle stimulating hormone receptor 0.0244 0.7262 0.7702
Brugia malayi conserved hypotetical protein 0.0011 0.0184 0.0151
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.1008 0.1347
Brugia malayi Blistered cuticle protein 3 0.0244 0.7277 0.7717
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Schistosoma mansoni hypothetical protein 0.0006 0.0042 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0184 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.055 0.0542
Brugia malayi beta-lactamase 0.0038 0.1008 0.103
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0098 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0223 0.0193
Loa Loa (eye worm) hypothetical protein 0.0038 0.1008 0.097
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Brugia malayi ecdysone receptor 0.0011 0.0184 0.0151
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0555 0.5313
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0555 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.037 0.035
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.1967 0.1933
Schistosoma mansoni coup transcription factor 0.0023 0.055 0.0584
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.1967 0.2054
Echinococcus multilocularis cpg binding protein 0.0037 0.0969 0.0989
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0042 0.0224
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0555 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.055 0.0542
Brugia malayi MH2 domain containing protein 0.0008 0.0098 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0555 0.2665
Schistosoma mansoni peroxidasin 0.0244 0.7277 0.7728
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.3401 0.3373
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.055 0.0542
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0006 0.0042 0.0044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0118 0.0081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.055 0.0542
Trichomonas vaginalis esterase, putative 0.0038 0.1008 1
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0184 0.0142
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0555 0.2665
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.055 0.0542
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.055 0.051
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0184 0.0151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.055 0.0542
Echinococcus multilocularis Smad4 0.0008 0.0098 0.006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0138 0.0097
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0555 0.5313
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.055 0.0542
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0042 0.0224
Entamoeba histolytica thioredoxin reductase, putative 0.0006 0.0042 0.0044
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0555 0.2964
Treponema pallidum oxidoreductase 0.0006 0.0042 0.0754
Brugia malayi hypothetical protein 0.0009 0.0131 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.1008 0.103
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0223 0.0182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Schistosoma mansoni peroxidasin 0.0244 0.7277 0.7728
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.055 0.0542
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0555 0.2803
Brugia malayi hypothetical protein 0.0012 0.0223 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.055 0.051
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.1008 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0009 0.0131 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Mycobacterium ulcerans sulfatase 0.0009 0.0131 0.0922
Brugia malayi beta-lactamase family protein 0.0038 0.1008 0.103
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0098 0.0056
Onchocerca volvulus 0.0244 0.7277 0.7717
Loa Loa (eye worm) hypothetical protein 0.0038 0.1008 0.097
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.1872 0.1953
Brugia malayi Animal haem peroxidase family protein 0.0244 0.7277 0.7717
Echinococcus granulosus peroxidasin 0.0244 0.7277 0.7717
Echinococcus granulosus transcription factor Dp 1 0.004 0.1078 0.1105
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.055 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.1008 1
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0555 0.5313
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.055 0.0542
Schistosoma mansoni DNA helicase recq1 0.0009 0.0138 0.0147
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0118 0.0081
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.1872 0.2553
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0184 0.0195
Echinococcus multilocularis protein cereblon 0.0315 0.9417 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0184 0.0151
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0131 0.0124
Echinococcus multilocularis transcription factor Dp 1 0.004 0.1078 0.1105
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0555 0.2803
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0138 0.0103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0223 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0555 0.2964
Brugia malayi Animal haem peroxidase family protein 0.0244 0.7277 0.7717
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0555 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0555 0.0547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0223 0.0182
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.055 0.0542
Brugia malayi nuclear receptor RXR 0.0012 0.0223 0.0193
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.055 0.0542
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0318 0.1507
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.1967 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0555 0.2665
Entamoeba histolytica disulphide oxidoreductase, putative 0.0006 0.0042 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.055 0.0542
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1967 1
Entamoeba histolytica hypothetical protein, conserved 0.0315 0.9417 1
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0131 0.0922
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.7211 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.1008 0.1347
Mycobacterium tuberculosis Conserved protein 0.0038 0.1008 0.1347
Loa Loa (eye worm) hypothetical protein 0.0038 0.1008 0.097
Schistosoma mansoni smad1 5 8 and 0.0008 0.0098 0.0104
Brugia malayi hypothetical protein 0.0128 0.3749 0.3954
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0223 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0184 0.0151
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.055 0.051
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0131 0.0124
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0184 0.0151
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.7277 0.7265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.1008 0.107
Mycobacterium ulcerans beta-lactamase 0.0038 0.1008 1
Schistosoma mansoni glutamate synthase 0.0006 0.0042 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.4575 0.4836
Echinococcus granulosus geminin 0.0179 0.5275 0.5582
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0131 0.0922
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0539 0.5145
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.1008 0.5016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Onchocerca volvulus Dual oxidase homolog 0.0244 0.7277 0.7717
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0095 0.055
Loa Loa (eye worm) blistered cuticle protein 3 0.0244 0.7277 0.7265
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.055 0.0584
Loa Loa (eye worm) hypothetical protein 0.0038 0.1008 0.097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0223 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0456 0.2262
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Schistosoma mansoni nuclear hormone receptor 0.0023 0.055 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.055 0.0542
Echinococcus granulosus protein cereblon 0.0315 0.9417 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Onchocerca volvulus Peroxidasin homolog 0.0244 0.7277 0.7717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0223 0.0182
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0182 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.3882 0.4096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0312 0.1668
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0221 0.093
Brugia malayi MH1 domain containing protein 0.0008 0.0098 0.006
Toxoplasma gondii ABC1 family protein 0.0038 0.1008 0.5382
Schistosoma mansoni disulfide oxidoreductase 0.0006 0.0042 0.0044
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0006 0.0042 0.0224
Brugia malayi nuclear receptor NHR-67 0.0011 0.0184 0.0151
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0555 0.5313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.055 0.051
Loa Loa (eye worm) DR-78 0.0011 0.0184 0.0142
Leishmania major trypanothione reductase 0.0066 0.1872 0.9507
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0223 0.0237
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.055 0.0584
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0138 0.0103
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0131 0.0922
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0138 0.0526
Schistosoma mansoni glutamate synthase 0.0006 0.0042 0.0044
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0009 0.0131 0.0095
Loa Loa (eye worm) hypothetical protein 0.0038 0.1008 0.097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Treponema pallidum thioredoxin reductase (trxB) 0.0006 0.0042 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0138 0.1875
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0184 0.0195
Toxoplasma gondii selenide, water dikinase 0.0006 0.0042 0.0224
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.3401 0.3373
Plasmodium falciparum glutathione reductase 0.0066 0.1872 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.1008 0.1347
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.1872 0.1838
Schistosoma mansoni cpg binding protein 0.0035 0.0909 0.0965
Mycobacterium leprae conserved hypothetical protein 0.0038 0.1008 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.2089 0.2219
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0184 0.0151
Echinococcus granulosus Smad4 0.0008 0.0098 0.006
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0184 0.0151
Onchocerca volvulus Chorion peroxidase homolog 0.0244 0.7277 0.7717
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Onchocerca volvulus Peroxidase homolog 0.0244 0.7277 0.7717
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Brugia malayi Animal haem peroxidase family protein 0.0244 0.7277 0.7717
Brugia malayi MH1 domain containing protein 0.0008 0.0098 0.006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0098 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.055 0.0542
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0221 0.1854
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0138 0.0097
Brugia malayi hypothetical protein 0.0011 0.0184 0.0151
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.1008 1
Schistosoma mansoni hypothetical protein 0.0133 0.3882 0.4122
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0184 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.1008 0.5016
Schistosoma mansoni nuclear receptor 0.0011 0.0184 0.0195
Onchocerca volvulus 0.0244 0.7277 0.7717
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.1008 0.1347
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0098 0.006
Brugia malayi Sulfatase family protein 0.0009 0.0131 0.0095
Schistosoma mansoni sulfide quinone reductase 0.0006 0.0042 0.0044
Schistosoma mansoni smad1 5 8 and 0.0008 0.0098 0.0104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0095 0.055
Loa Loa (eye worm) hypothetical protein 0.0315 0.9417 0.9414
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.055 0.0584
Schistosoma mansoni hypothetical protein 0.0315 0.9417 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0555 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0184 0.0151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.055 0.0542
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0555 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0555 0.2665
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Brugia malayi MH2 domain containing protein 0.0008 0.0098 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.1008 0.097
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0223 0.0193
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.3882 0.4096
Brugia malayi nuclear receptor NHR-88 0.0011 0.0184 0.0151
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.055 0.0584
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0118 0.0125
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0555 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.1008 0.5016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0555 0.2665
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0098 0.006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0555 0.5313
Brugia malayi Peroxidasin 0.0244 0.7277 0.7717
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0223 0.0193
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.1008 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.1008 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1967 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0095 0.055
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0221 0.093
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0221 0.0235
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.055 0.0584
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0395 0.042
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.1967 0.2054
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0095 0.055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.1008 0.103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.055 0.0542
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.1967 0.2089
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Loa Loa (eye worm) glutathione reductase 0.0066 0.1872 0.1838
Brugia malayi hypothetical protein 0.0244 0.7277 0.7717
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.055 0.0542
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0555 0.0716
Echinococcus granulosus cpg binding protein 0.0037 0.0969 0.0989
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.055 0.0542
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0539 0.5145
Onchocerca volvulus 0.0011 0.0184 0.0151
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.1967 0.2089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0131 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.055 0.0584
Trichomonas vaginalis helicase, putative 0.0008 0.0095 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Brugia malayi nuclear receptor NHR-88 0.0023 0.055 0.0542
Brugia malayi ecdysteroid receptor 0.0023 0.055 0.0542
Plasmodium vivax glutathione reductase, putative 0.0066 0.1872 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0095 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0909 0.0871
Schistosoma mansoni thyroid hormone receptor 0.0155 0.4575 0.4859
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0131 0.0922
Schistosoma mansoni hypothetical protein 0.0179 0.5275 0.5601
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.055 0.0542
Loa Loa (eye worm) RecQ helicase 0.0022 0.0539 0.0499
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.7277 0.7265
Schistosoma mansoni cpg binding protein 0.0037 0.0969 0.1029
Brugia malayi nuclear receptor RXR 0.0011 0.0184 0.0151
Brugia malayi Animal haem peroxidase family protein 0.0244 0.7277 0.7717
Echinococcus granulosus FTZ F1 alpha 0.0023 0.055 0.0542
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0095 0.055
Schistosoma mansoni smad 0.0008 0.0098 0.0104
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0006 0.0042 0.0044
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0131 0.0922
Loa Loa (eye worm) Smad1 0.0008 0.0098 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0223 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.055 0.0542
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0223 0.0193
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.1872 0.9507
Echinococcus multilocularis peroxidasin 0.0244 0.7277 0.7717
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.1872 0.1953
Schistosoma mansoni glutamate synthase 0.0006 0.0042 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0184 0.0151
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0138 0.0103
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0138 0.0738
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.055 0.051
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0138 0.0103
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.1008 1
Schistosoma mansoni hypothetical protein 0.0179 0.5275 0.5601
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0184 0.0142
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.055 0.0542
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0184 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.1008 0.107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0095 0.055
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0555 0.2665
Schistosoma mansoni smad1 5 8 and 0.0008 0.0098 0.0104
Brugia malayi glutathione reductase 0.0066 0.1872 0.1953
Brugia malayi CXXC zinc finger family protein 0.0035 0.0909 0.0925
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0555 0.0589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0401 0.036
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.1008 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Brugia malayi Animal haem peroxidase family protein 0.0244 0.7277 0.7717
Onchocerca volvulus Peroxidase homolog 0.0244 0.7277 0.7717
Echinococcus multilocularis geminin 0.0179 0.5275 0.5582
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.037 0.035
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0006 0.0042 0.0044
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1967 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1851 0.9885
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0184 0.0151
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0555 0.0716
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.1008 0.1347
Onchocerca volvulus 0.0011 0.0184 0.0151
Onchocerca volvulus 0.0038 0.1008 0.103
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.1967 0.2054
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.7262 0.7251
Mycobacterium tuberculosis Conserved protein 0.0038 0.1008 0.1347
Brugia malayi Thioredoxin reductase 0.0066 0.1872 0.1953
Brugia malayi hypothetical protein 0.0011 0.0184 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.1008 0.1347
Mycobacterium ulcerans hypothetical protein 0.0038 0.1008 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0184 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.055 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0006 0.0042 0.0044
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0098 0.0104
Brugia malayi nuclear hormone receptor 0.0023 0.055 0.0542
Toxoplasma gondii thioredoxin reductase 0.0066 0.1872 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0184 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.055 0.0542
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0095 0.055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0023 0.0555 0.5313
Brugia malayi nuclear hormone receptor 0.0011 0.0184 0.0151
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Brugia malayi Smad1 0.0008 0.0098 0.006
Treponema pallidum NADH oxidase 0.0023 0.0555 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.055 0.0584
Loa Loa (eye worm) hypothetical protein 0.0038 0.1008 0.097
Loa Loa (eye worm) hypothetical protein 0.0023 0.055 0.051
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0182 0.0141
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0555 1
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0555 0.2665
Loa Loa (eye worm) hypothetical protein 0.0011 0.0184 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.055 0.0542
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0131 0.0922
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.055 0.0542
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.055 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.055 0.051
Brugia malayi tailless protein 0.0011 0.0184 0.0151
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.7277 0.7265
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0184 0.0151
Brugia malayi beta-lactamase family protein 0.0038 0.1008 0.103
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0555 0.2665
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.055 0.0542
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0138 0.0738
Onchocerca volvulus 0.0023 0.055 0.0542
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0006 0.0042 0.0044
Echinococcus multilocularis smad 0.0008 0.0098 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.7277 0.7265
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0138 0.0103
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0184 0.0151
Plasmodium falciparum glutathione reductase 0.0023 0.0555 0.2803
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0539 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Mycobacterium tuberculosis Conserved protein 0.0038 0.1008 0.1347
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0555 0.0716
Brugia malayi hypothetical protein 0.0315 0.9417 1
Schistosoma mansoni Smad4 0.0008 0.0098 0.0104
Trypanosoma brucei trypanothione reductase 0.0066 0.1872 0.9507
Schistosoma mansoni nuclear receptor 0.0011 0.0184 0.0195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0555 0.2665
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0042 0.0224
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0098 0.006
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0555 0.2665
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0178 0.0145
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0131 0.0124
Leishmania major hypothetical protein, conserved 0.0038 0.1008 0.5016
Mycobacterium ulcerans lipase LipD 0.0038 0.1008 1
Plasmodium falciparum thioredoxin reductase 0.0023 0.0555 0.2803
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0184 0.0195
Loa Loa (eye worm) hypothetical protein 0.0244 0.7277 0.7265
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.055 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.055 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0131 0.0922
Brugia malayi hypothetical protein 0.0012 0.0223 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.055 0.0542
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0184 0.0151
Schistosoma mansoni zinc finger protein 0.0011 0.0184 0.0195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0081
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0138 0.0103
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.055 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0095 0.055
Schistosoma mansoni DNA helicase recq5 0.0009 0.0138 0.0147
Brugia malayi MH2 domain containing protein 0.0117 0.3401 0.3583
Plasmodium vivax hypothetical protein, conserved 0.0038 0.1008 0.5276
Schistosoma mansoni cpg binding protein 0.0037 0.0969 0.1029
Echinococcus granulosus smad 0.0008 0.0098 0.006
Schistosoma mansoni thyroid hormone receptor 0.0155 0.4575 0.4859

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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