Detailed information for compound 1438780

Basic information

Technical information
  • TDR Targets ID: 1438780
  • Name: N-(3,5-dimethylphenyl)-2-(4-pyrrol-1-ylphenyl )acetamide
  • MW: 304.386 | Formula: C20H20N2O
  • H donors: 1 H acceptors: 1 LogP: 3.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(C)cc(c1)C)Cc1ccc(cc1)n1cccc1
  • InChi: 1S/C20H20N2O/c1-15-11-16(2)13-18(12-15)21-20(23)14-17-5-7-19(8-6-17)22-9-3-4-10-22/h3-13H,14H2,1-2H3,(H,21,23)
  • InChiKey: YVMALNOEEGPGDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,5-dimethylphenyl)-2-[4-(1-pyrrolyl)phenyl]acetamide
  • N-(3,5-dimethylphenyl)-2-(4-pyrrol-1-ylphenyl)ethanamide
  • MLS000584874
  • N-(3,5-dimethylphenyl)-2-[4-(1H-pyrrol-1-yl)phenyl]acetamide
  • SMR000207259

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0116 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0116 0.0147
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0049 0.0008
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0116 0.0365
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0213 0.0213
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Echinococcus multilocularis cathepsin L cysteine protease 0.0074 0.1165 0.1165
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0734 0.0929
Giardia lamblia Cathepsin L precursor 0.0026 0.0116 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Echinococcus multilocularis histone deacetylase 7 0.0042 0.0467 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0026 0.0116 0.0147
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0116 0.0147
Brugia malayi glutathione reductase 0.0048 0.0579 0.0579
Echinococcus multilocularis cathepsin L 0.0026 0.0116 0.0116
Echinococcus granulosus geminin 0.0205 0.4008 0.4008
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0047 0.0557 0.0705
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0048
Onchocerca volvulus 0.0232 0.46 0.9551
Onchocerca volvulus 0.0074 0.1165 0.2418
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0049 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0734 0.0734
Giardia lamblia Cathepsin B precursor 0.0026 0.0116 0.0365
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0116 0.0116
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0026 0.0116 0.0607
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.004 0.0423 0.0423
Onchocerca volvulus 0.0074 0.1165 0.2418
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0589 0.0745
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.191 0.325
Schistosoma mansoni hypothetical protein 0.0205 0.4008 0.5076
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0048
Trypanosoma brucei cysteine peptidase C (CPC) 0.0107 0.1882 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0178 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Trypanosoma brucei histone deacetylase 4 0.0042 0.0467 0.2277
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0875 0.0875
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0049 0.0049
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0049 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0047 0.0557 0.0557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0116 0.0365
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0116 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0589 0.0589
Onchocerca volvulus 0.0031 0.0213 0.0441
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0875 0.1108
Mycobacterium tuberculosis Probable oxidoreductase 0.0286 0.5777 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2091 0.2091
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Echinococcus granulosus cathepsin l cysteine peptidase 0.0074 0.1165 0.1165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.4852 0.4852
Giardia lamblia Cathepsin L precursor 0.0026 0.0116 0.0365
Echinococcus granulosus caspase 2 0.0031 0.0213 0.0213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.2752 0.2752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Leishmania major histone deacetylase, putative 0.0042 0.0467 0.2281
Trichomonas vaginalis set domain proteins, putative 0.0232 0.46 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.2639 0.3342
Onchocerca volvulus Deterin homolog 0.004 0.0423 0.0879
Onchocerca volvulus 0.0074 0.1165 0.2418
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0074 0.1165 0.1165
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0213 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0026 0.0116 0.0147
Schistosoma mansoni hypothetical protein 0.0292 0.5912 0.7487
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0116 0.0607
Giardia lamblia Cathepsin B precursor 0.0026 0.0116 0.0365
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.1165 0.1931
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.4817 0.4817
Schistosoma mansoni DNA polymerase eta 0.0054 0.0721 0.0913
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0116 0.0607
Plasmodium falciparum thioredoxin reductase 0.0048 0.0579 0.4419
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0074 0.1165 1
Brugia malayi Histone deacetylase family protein 0.0042 0.0467 0.0467
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0875 0.1442
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Onchocerca volvulus 0.0074 0.1165 0.2418
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0589 0.0589
Echinococcus multilocularis cathepsin b 0.0288 0.5826 0.5826
Echinococcus granulosus histone deacetylase 6 0.0042 0.0467 0.0467
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.3671 0.3671
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0116 0.0116
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0213 0.0269
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0049 0.0002
Plasmodium falciparum cysteine proteinase falcipain 3 0.0074 0.1165 1
Onchocerca volvulus 0.0074 0.1165 0.2418
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0116 0.0147
Brugia malayi Cathepsin L-like cysteine proteinase 0.0074 0.1165 0.1165
Giardia lamblia Cathepsin L precursor 0.0026 0.0116 0.0365
Echinococcus granulosus inhibitor of apoptosis protein 0.004 0.0423 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Schistosoma mansoni hypothetical protein 0.0047 0.0557 0.0705
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.1165 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0178 0.0225
Onchocerca volvulus Cathepsin L homolog 0.0074 0.1165 0.2418
Schistosoma mansoni hypothetical protein 0.0031 0.0213 0.0269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Loa Loa (eye worm) hypothetical protein 0.0074 0.1165 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0074 0.1165 0.2451
Giardia lamblia Cathepsin B precursor 0.0026 0.0116 0.0365
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.191 0.325
Onchocerca volvulus 0.0074 0.1165 0.2418
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0049 0.0062
Toxoplasma gondii histone deacetylase HDAC1 0.0042 0.0467 0.1985
Loa Loa (eye worm) hypothetical protein 0.0074 0.1165 0.1165
Brugia malayi Pre-SET motif family protein 0.0029 0.0178 0.0178
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.2639 0.2639
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0589 0.0745
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1165 0.1931
Echinococcus granulosus cathepsin b 0.0288 0.5826 0.5826
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0116 0.0607
Brugia malayi Papain family cysteine protease containing protein 0.0074 0.1165 0.1165
Echinococcus multilocularis caspase 2 0.0031 0.0213 0.0213
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0049 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0026 0.0116 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0116 0.0365
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0734 0.0734
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0049 0.0049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0875 0.1442
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0467 0.0591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0116 0.0147
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0074 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0467 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Echinococcus multilocularis dna polymerase eta 0.0054 0.0721 0.0721
Giardia lamblia Cathepsin B precursor 0.0107 0.1882 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Giardia lamblia Cathepsin L precursor 0.0026 0.0116 0.0365
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0116 0.0147
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Brugia malayi fibroinase precursor 0.0026 0.0116 0.0116
Loa Loa (eye worm) cysteine protease 0.0074 0.1165 0.1165
Brugia malayi cathepsin L-like cysteine proteinase 0.0026 0.0116 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0116 0.0116
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0074 0.1165 1
Loa Loa (eye worm) histone deacetylase 0.0042 0.0467 0.0467
Echinococcus granulosus cathepsin L 0.0026 0.0116 0.0116
Toxoplasma gondii thioredoxin reductase 0.0048 0.0579 0.2624
Giardia lamblia Hypothetical protein 0.0026 0.0116 0.0365
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0116 0.0365
Brugia malayi hypothetical protein 0.0242 0.4817 0.4817
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0178 0.0225
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0116 0.0147
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0116 0.0147
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.004 0.0423 0.0536
Loa Loa (eye worm) hypothetical protein 0.0142 0.2639 0.2639
Entamoeba histolytica cysteine protease, putative 0.0074 0.1165 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.2175 0.3712
Brugia malayi cathepsin L precursor 0.0026 0.0116 0.0116
Giardia lamblia Hypothetical protein 0.0026 0.0116 0.0365
Plasmodium vivax vivapain-2 0.0074 0.1165 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0288 0.5826 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0242 0.4817 0.4817
Echinococcus granulosus histone deacetylase 0.0042 0.0467 0.0467
Onchocerca volvulus Cathepsin F homolog 0.0074 0.1165 0.2418
Echinococcus multilocularis cathepsin L 0.0026 0.0116 0.0116
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.1165 0.1475
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0116 0.0147
Brugia malayi cathepsin Z-like cysteine proteinase 0.0026 0.0116 0.0116
Leishmania major cysteine peptidase A (CPA) 0.0074 0.1165 0.6088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Onchocerca volvulus 0.0026 0.0116 0.0241
Schistosoma mansoni amine GPCR 0.0383 0.7897 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Echinococcus multilocularis GPCR, family 2 0.0047 0.0557 0.0557
Brugia malayi Pre-SET motif family protein 0.0204 0.3986 0.3986
Giardia lamblia Cysteine protease 0.0026 0.0116 0.0365
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0178 0.0178
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0557 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0026 0.0116 0.0147
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0734 0.0734
Leishmania major histone deacetylase, putative 0.0042 0.0467 0.2281
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0213 0.0441
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0875 0.1442
Loa Loa (eye worm) histone deacetylase 7A 0.0042 0.0467 0.0467
Trypanosoma brucei histone deacetylase 3 0.0042 0.0467 0.2277
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0055 0.0734 0.0734
Schistosoma mansoni hypothetical protein 0.0047 0.0557 0.0705
Echinococcus multilocularis inhibitor of apoptosis protein 0.004 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0142 0.2639 0.2639
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0467 0.0722
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Schistosoma mansoni inhibitor of apoptosis protein 0.004 0.0423 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0178 0.0225
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1165 0.1931
Echinococcus multilocularis serotonin receptor 0.0142 0.2639 0.2639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Giardia lamblia Cathepsin L-like protease 0.0026 0.0116 0.0365
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.1882 0.2383
Giardia lamblia Cysteine protease 0.0026 0.0116 0.0365
Loa Loa (eye worm) MBCTL1 0.0055 0.0734 0.0734
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.037 0.0555
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0116 0.0116
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.1165 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0734 0.0734
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.1165 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.2752 0.2752
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0875 0.4506
Trypanosoma brucei histone deacetylase, putative 0.0042 0.0467 0.2277
Loa Loa (eye worm) hypothetical protein 0.0147 0.2752 0.2752
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2091 0.2091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Loa Loa (eye worm) hypothetical protein 0.0101 0.1736 0.1736
Echinococcus multilocularis serotonin receptor 0.0142 0.2639 0.2639
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0721 0.0721
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0467 0.0722
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0107 0.1882 1
Onchocerca volvulus 0.0098 0.1674 0.3475
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.1165 0.1475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Onchocerca volvulus 0.0074 0.1165 0.2418
Schistosoma mansoni cathepsin C 0.0026 0.0116 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.004 0.0423 0.0423
Brugia malayi Thioredoxin reductase 0.0048 0.0579 0.0579
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0116 0.0607
Loa Loa (eye worm) hypothetical protein 0.0048 0.0589 0.0589
Echinococcus granulosus cysteine protease 0.0026 0.0116 0.0116
Echinococcus multilocularis cysteine protease 0.0074 0.1165 0.1165
Echinococcus granulosus dna polymerase kappa 0.0023 0.0049 0.0049
Schistosoma mansoni survival motor neuron protein 0.0098 0.1674 0.212
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0589 0.0589
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Loa Loa (eye worm) hypothetical protein 0.004 0.0423 0.0423
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0557 0.0557
Giardia lamblia Cathepsin B precursor 0.0107 0.1882 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0049 0.0062
Echinococcus multilocularis histone deacetylase 0.0042 0.0467 0.0467
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0579 0.0579
Echinococcus granulosus cathepsin L 0.0026 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Echinococcus multilocularis geminin 0.0205 0.4008 0.4008
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0467 0.0722
Brugia malayi Cell death protein 3 precursor 0.0031 0.0213 0.0213
Giardia lamblia Encystation-specific protease 0.0026 0.0116 0.0365
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Loa Loa (eye worm) glutathione reductase 0.0048 0.0579 0.0579
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0467 0.0467
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0734 0.0734
Plasmodium vivax histone deacetylase 2, putative 0.0042 0.0467 0.3342
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0116 0.0147
Echinococcus multilocularis cathepsin L cysteine protease 0.0074 0.1165 0.1165
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.2752 0.2752
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Giardia lamblia Cathepsin L precursor 0.0026 0.0116 0.0365
Echinococcus multilocularis cysteine protease 0.0074 0.1165 0.1165
Leishmania major DNA polymerase kappa, putative 0.0023 0.0049 0.0005
Loa Loa (eye worm) cathepsin B 0.0107 0.1882 0.1882
Brugia malayi MH2 domain containing protein 0.0117 0.2091 0.2091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0048
Brugia malayi cathepsin B-like cysteine proteinase 0.0288 0.5826 0.5826
Schistosoma mansoni hypothetical protein 0.0205 0.4008 0.5076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Plasmodium vivax vivapain-2 0.0074 0.1165 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0116 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0049 0.0002
Schistosoma mansoni histone deacetylase hda2 0.0042 0.0467 0.0591
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0589 0.0745
Brugia malayi mbt repeat family protein 0.0048 0.0589 0.0589
Brugia malayi Histone deacetylase family protein 0.0042 0.0467 0.0467
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0557 0.0557
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0074 0.1165 0.1931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0467 0.0467
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0026 0.0116 0.0147
Giardia lamblia Cysteine protease 0.0026 0.0116 0.0365
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0116 0.0607
Onchocerca volvulus Cathepsin L homolog 0.0074 0.1165 0.2418
Plasmodium falciparum histone deacetylase, putative 0.0042 0.0467 0.3342
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0026 0.0116 0.0116
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0116 0.0241
Echinococcus multilocularis survival motor neuron protein 1 0.0479 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0026 0.0116 0.0116
Onchocerca volvulus 0.004 0.0423 0.0879
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0579 0.0918
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Echinococcus granulosus survival motor neuron protein 1 0.0479 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1674 0.1674
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0049 0.0049
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0116 0.0147
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Brugia malayi mbt repeat family protein 0.0048 0.0589 0.0589
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0721 0.3665
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Echinococcus granulosus neuropeptides capa receptor 0.0224 0.4428 0.4428
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0116 0.0116
Onchocerca volvulus 0.0048 0.0589 0.1222
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.191 0.325
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0116 0.0147
Brugia malayi follicle stimulating hormone receptor 0.0243 0.4852 0.4852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0875 0.4295
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0116 0.0365
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Onchocerca volvulus 0.0023 0.0048 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0116 0.0607
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1736 0.1736
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0026 0.0116 0.0365
Echinococcus granulosus dna polymerase eta 0.0054 0.0721 0.0721
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.004 0.0423 0.0423
Giardia lamblia Cysteine protease 0.0026 0.0116 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0116 0.0147
Plasmodium falciparum histone deacetylase 2 0.0042 0.0467 0.3342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Echinococcus granulosus baculoviral IAP repeat containing protein 0.004 0.0423 0.0423
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0579 0.0579
Leishmania major trypanothione reductase 0.0048 0.0579 0.2896
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.1882 0.4027
Trypanosoma brucei trypanothione reductase 0.0048 0.0579 0.2893
Onchocerca volvulus 0.0074 0.1165 0.2418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0178 0.0225
Schistosoma mansoni cathepsin B (C01 family) 0.0026 0.0116 0.0147
Onchocerca volvulus Huntingtin homolog 0.0242 0.4817 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0074 0.1165 0.1165
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0604 0.0604
Giardia lamblia Cathepsin L precursor 0.0026 0.0116 0.0365
Echinococcus granulosus histone deacetylase 6 0.0042 0.0467 0.0467
Toxoplasma gondii cathepsin CPL 0.0074 0.1165 0.5938
Loa Loa (eye worm) fibroinase 0.0074 0.1165 0.1165
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 0.5826 0.7378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Loa Loa (eye worm) hypothetical protein 0.0042 0.0467 0.0467
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.2175 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0721 0.0721
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0074 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0048
Echinococcus granulosus cathepsin L cysteine proteinase 0.0074 0.1165 0.1165
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0467 0.0591
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.191 0.325
Brugia malayi Cathepsin L-like precursor 0.0074 0.1165 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0579 0.4419
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0116 0.0147
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.2175 0.3712
Echinococcus granulosus cathepsin b 0.0288 0.5826 0.5826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0116 0.0147
Plasmodium vivax histone deacetylase, putative 0.0042 0.0467 0.3342
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.3986 0.3986
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0467 0.0467
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.3671 0.3671
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0721 0.1163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 0.5826 0.7378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0026 0.0116 0.0116
Giardia lamblia Cathepsin B precursor 0.0107 0.1882 1
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Echinococcus granulosus histone deacetylase 7 0.0042 0.0467 0.0467
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Schistosoma mansoni hypothetical protein 0.0047 0.0557 0.0705
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.1165 0.1475
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0288 0.5826 0.7378
Brugia malayi cathepsin L-like precursor 0.0074 0.1165 0.1165
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0579 0.0927
Entamoeba histolytica hypothetical protein 0.0026 0.0116 0.0607
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0155 0.0155
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0074 0.1165 0.2451
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0875 0.1108
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.191 0.8756
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0579 0.0579
Echinococcus granulosus histone deacetylase 6 0.0042 0.0467 0.0467
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.037 0.1438
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0178 0.0351
Brugia malayi hypothetical protein 0.0031 0.0213 0.0213
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1165 0.1931
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 0.5826 0.7378
Echinococcus granulosus cathepsin l1 0.0074 0.1165 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0116 0.0147
Plasmodium falciparum glutathione reductase 0.0048 0.0579 0.4419
Echinococcus multilocularis cathepsin b 0.0288 0.5826 0.5826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.1165 0.2451
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.191 0.325
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1165 0.1931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Echinococcus granulosus GPCR family 2 0.0047 0.0557 0.0557
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0116 0.0116
Toxoplasma gondii cathepsin B 0.0107 0.1882 1
Onchocerca volvulus Huntingtin homolog 0.0242 0.4817 1
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.004 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0074 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.004 0.0423 0.0536
Loa Loa (eye worm) hypothetical protein 0.0288 0.5826 0.5826
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0116 0.0147
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0074 0.1165 0.1165
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0098 0.1674 0.212
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Loa Loa (eye worm) hypothetical protein 0.0029 0.0178 0.0178
Entamoeba histolytica cysteine protease, putative 0.0026 0.0116 0.0607
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0178 0.0178
Mycobacterium tuberculosis Probable reductase 0.0109 0.191 0.325
Brugia malayi Cytochrome P450 family protein 0.0049 0.0604 0.0604
Echinococcus granulosus cathepsin l1 0.0074 0.1165 0.1165
Onchocerca volvulus 0.0029 0.0178 0.037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Giardia lamblia Cathepsin B precursor 0.0026 0.0116 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.1165 0.6086
Echinococcus multilocularis neuropeptides capa receptor 0.0224 0.4428 0.4428
Giardia lamblia Cathepsin L-like protease 0.0026 0.0116 0.0365
Giardia lamblia Cathepsin B precursor 0.0026 0.0116 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.1165 0.2451
Schistosoma mansoni cathepsin S (C01 family) 0.0026 0.0116 0.0147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.2175 0.3712
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0026 0.0116 0.0147
Loa Loa (eye worm) ctsf protein 0.0074 0.1165 0.1165
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0557 0.0557
Schistosoma mansoni hypothetical protein 0.0101 0.1736 0.2198
Mycobacterium ulcerans short chain dehydrogenase 0.0286 0.5777 1
Leishmania major DNA polymerase eta, putative 0.0054 0.0721 0.3668
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0589 0.1222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0116 0.0147
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0875 0.1442
Leishmania major cathepsin L-like protease 0.0074 0.1165 0.6088
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0557 0.0557
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0026 0.0116 0.0607
Plasmodium vivax glutathione reductase, putative 0.0048 0.0579 0.4419
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0107 0.1882 0.3173
Leishmania major DNA polymerase eta, putative 0.0038 0.037 0.1754

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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