Detailed information for compound 1446326

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 579.964 | Formula: C28H23ClFN5O6
  • H donors: 0 H acceptors: 4 LogP: 3.17 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCn1/c(=N\C(=O)c2c(C)onc2c2c(F)cccc2Cl)/c(cc2c1nc1ccccn1c2=O)C(=O)OCC
  • InChi: 1S/C28H23ClFN5O6/c1-4-40-28(38)17-14-16-24(31-20-10-5-6-11-34(20)27(16)37)35(12-13-39-3)25(17)32-26(36)21-15(2)41-33-23(21)22-18(29)8-7-9-19(22)30/h5-11,14H,4,12-13H2,1-3H3/b32-25-
  • InChiKey: LCNXGEUSJCOHAM-MKCFTUBBSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium vivax chitinase 0.0022 0.0048 0.0125
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0037 0.0233 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0026 0.004
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0031 0.0057
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0025 0.0091 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Schistosoma mansoni lamin 0.0033 0.0182 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.0001
Toxoplasma gondii hypothetical protein 0.0233 0.2639 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Entamoeba histolytica protein kinase domain containing protein 0.0179 0.1977 1
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0028
Brugia malayi hypothetical protein 0.0043 0.0316 0.0579
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0334
Schistosoma mansoni lamin 0.0033 0.0182 0.0167
Brugia malayi prolyl oligopeptidase family protein 0.0156 0.1691 0.3098
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.1977 1
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Echinococcus granulosus Dipeptidyl peptidase 9 0.0156 0.1691 0.1678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Plasmodium vivax vivapain-2 0.002 0.0031 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0009
Loa Loa (eye worm) haspin protein kinase 0.0135 0.1435 0.2629
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma brucei oligopeptidase b 0.0037 0.0233 0.1109
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Onchocerca volvulus 0.002 0.0031 0.0057
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0156 0.1691 0.6388
Echinococcus multilocularis lamin 0.0033 0.0182 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0728 0.3632
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0728 0.3632
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0233 0.2639 0.2627
Loa Loa (eye worm) cuticular endochitinase 0.0147 0.1582 0.2898
Plasmodium vivax vivapain-2 0.002 0.0031 0.006
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0091 0.0619
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0026 0.0053
Loa Loa (eye worm) cysteine protease 0.002 0.0031 0.0057
Loa Loa (eye worm) fibroinase 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0037 0.0233 0.0427
Brugia malayi prolyl oligopeptidase family protein 0.0037 0.0233 0.0427
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0017 0.0007
Brugia malayi Protein kinase domain containing protein 0.0025 0.0091 0.0167
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0037 0.0233 0.1401
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus 0.002 0.0031 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0007
Brugia malayi glutathione reductase 0.0057 0.0483 0.0885
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0463 0.5458 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0026 0.001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Onchocerca volvulus 0.002 0.0031 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0031 0.008
Brugia malayi jmjC domain containing protein 0.0071 0.0654 0.1198
Trypanosoma cruzi prolyl endopeptidase 0.0037 0.0233 0.1109
Schistosoma mansoni hypothetical protein 0.0023 0.0069 0.0053
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0233 0.2639 0.2627
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.006 0.0521 0.0955
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0017 0.0031
Plasmodium falciparum MO15-related protein kinase 0.0025 0.0091 0.0288
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0483 0.0885
Echinococcus multilocularis dual specificity 0.0106 0.1081 0.1067
Schistosoma mansoni hypothetical protein 0.0135 0.1435 0.1422
Entamoeba histolytica protein kinase, putative 0.0179 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.1954 0.3581
Echinococcus granulosus dual specificity 0.0106 0.1081 0.1067
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0037 0.0233 0.1037
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0654 0.064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0088
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0233 0.2639 0.4835
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0037 0.0233 0.1109
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0057
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0106 0.1081 0.5431
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0182 0.0334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.003
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0815 0.7479
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Schistosoma mansoni serine/threonine kinase 0.0025 0.0091 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Brugia malayi GSG2 0.0135 0.1435 0.2629
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0025 0.0091 0.0386
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0048 0.0087
Plasmodium vivax glutathione reductase, putative 0.0057 0.0483 0.1784
Schistosoma mansoni chromobox protein 0.0084 0.0815 0.0801
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0037 0.0233 0.1037
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Plasmodium falciparum peptidase, putative 0.0037 0.0233 0.0829
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0192 0.1581
Echinococcus granulosus GPCR family 2 0.0019 0.0017 0.0001
Loa Loa (eye worm) haspin protein kinase 0.0137 0.1457 0.267
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0028
Brugia malayi endochitinase 0.0147 0.1582 0.2898
Onchocerca volvulus 0.002 0.0031 0.0057
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0037 0.0233 0.1109
Echinococcus granulosus serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Loa Loa (eye worm) prolyl oligopeptidase 0.0463 0.5458 1
Trichomonas vaginalis chitinase, putative 0.0022 0.0048 0.0212
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.138 0.8844
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0156 0.1691 0.8543
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0361 0.3182
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0025 0.0091 0.0167
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0031 0.0016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0026 0.004
Brugia malayi chromobox protein homolog 3 0.0047 0.0361 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0192 0.1581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus multilocularis dual specificity 0.0106 0.1081 0.1067
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.138 0.8844
Loa Loa (eye worm) hypothetical protein 0.0233 0.2639 0.4835
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis acylamino acid releasing enzyme 0.0037 0.0233 0.0218
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0037 0.0233 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi oligopeptidase b 0.0037 0.0233 0.1109
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0405 0.0742
Loa Loa (eye worm) hypothetical protein 0.0177 0.1954 0.3581
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0017 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0037 0.0233 0.1109
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0106 0.1081 0.198
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1081 0.1067
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.1977 0.1964
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0031 0.0016
Brugia malayi hypothetical protein 0.0022 0.0048 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0288 0.0527
Loa Loa (eye worm) glutathione reductase 0.0057 0.0483 0.0885
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0037 0.0233 0.1109
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0023 0.0069 0.0053
Schistosoma mansoni protein kinase 0.0025 0.0091 0.0076
Mycobacterium ulcerans PE-PGRS family protein 0.0022 0.0048 0.0173
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0233 0.0427
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0119 0.1241 0.2274
Entamoeba histolytica hypothetical protein 0.0023 0.0069 0.0193
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0179 0.1977 1
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0025 0.0091 0.0288
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0026 0.5
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0106 0.1081 0.4061
Mycobacterium tuberculosis Probable peptidase 0.0037 0.0233 0.1401
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0106 0.1081 0.5431
Brugia malayi Glycosyl hydrolases family 18 protein 0.0022 0.0048 0.0088
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0325 0.3763 0.3754
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0233 0.1109
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0022 0.0048 0.0033
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0026 0.0056
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0026 0.004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0483 0.0469
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0182 0.0334
Trypanosoma cruzi oligopeptidase b 0.0037 0.0233 0.1109
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0026 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0091 0.0619
Echinococcus granulosus cathepsin l1 0.002 0.0031 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0031 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0179 0.1977 1
Echinococcus multilocularis dual specificity 0.0106 0.1081 0.1067
Trichomonas vaginalis serine/threonine kinase, putative 0.0025 0.0091 0.0619
Entamoeba histolytica chitinase, putative 0.0147 0.1582 0.797
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.138 0.8844
Brugia malayi Endochitinase 0.0164 0.1799 0.3296
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0025 0.0091 0.0386
Onchocerca volvulus Putative endochitinase 0.0164 0.1799 0.3296
Entamoeba histolytica prolyl oligopeptidase family protein 0.0037 0.0233 0.1037
Schistosoma mansoni chitinase 0.0022 0.0048 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0031 0.005
Onchocerca volvulus Cathepsin F homolog 0.002 0.0031 0.0057
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0017 0.0009
Schistosoma mansoni hypothetical protein 0.0205 0.2292 0.228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Echinococcus granulosus chromobox protein 1 0.0084 0.0815 0.0801
Onchocerca volvulus 0.0033 0.0182 0.0334
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0483 0.3025
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0463 0.5458 0.5451
Onchocerca volvulus 0.002 0.0031 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) chitinase I 0.0147 0.1582 0.2898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Giardia lamblia Alanyl dipeptidyl peptidase 0.0037 0.0233 0.1964
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0654 0.064
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0025 0.0091 0.0386
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0646 0.3214
Brugia malayi prolyl oligopeptidase family protein 0.0037 0.0233 0.0427
Loa Loa (eye worm) hypothetical protein 0.0037 0.0236 0.0433
Echinococcus granulosus serine:threonine protein kinase NLK 0.0025 0.0091 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0463 0.5458 0.5451
Onchocerca volvulus 0.0033 0.0182 0.0334
Onchocerca volvulus 0.002 0.0031 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0031 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0026 0.0053
Leishmania major serine/threonine kinase-like protein, putative 0.0025 0.0091 0.0386
Onchocerca volvulus Putative chitinase 0.0022 0.0048 0.0088
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0815 0.1493
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0025 0.0091 0.0076
Echinococcus granulosus prolyl endopeptidase 0.0037 0.0233 0.0218
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma brucei prolyl endopeptidase 0.0037 0.0233 0.1109
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0031 0.005
Entamoeba histolytica hypothetical protein 0.0179 0.1977 1
Schistosoma mansoni hypothetical protein 0.0233 0.2639 0.2627
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0026 0.0053
Brugia malayi hypothetical protein 0.0022 0.0048 0.0088
Brugia malayi jmjC domain containing protein 0.0019 0.0015 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0521 0.0955
Trypanosoma brucei prolyl oligopeptidase, putative 0.0037 0.0233 0.1109
Echinococcus multilocularis musashi 0.0033 0.0182 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus Cathepsin L homolog 0.002 0.0031 0.0057
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0361 0.0662
Loa Loa (eye worm) hypothetical protein 0.0047 0.0361 0.0662
Onchocerca volvulus 0.0233 0.2639 0.4835
Echinococcus granulosus dual specificity 0.0106 0.1081 0.1067
Entamoeba histolytica prolyl oligopeptidase family protein 0.0037 0.0233 0.1037
Trypanosoma brucei protein kinase, putative 0.0025 0.0091 0.0386
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0017 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus multilocularis lamin dm0 0.0033 0.0182 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0325 0.3763 0.3754
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0017 0.0001
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0025 0.0091 0.0619
Schistosoma mansoni chromobox protein 0.0084 0.0815 0.0801
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0521 0.0955
Echinococcus granulosus chromobox protein 1 0.0084 0.0815 0.0801
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0405 0.3598
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis cysteine protease 0.002 0.0031 0.0016
Echinococcus multilocularis hypothetical protein 0.0023 0.0069 0.0053
Echinococcus multilocularis prolyl endopeptidase 0.0037 0.0233 0.0218
Plasmodium falciparum conserved protein, unknown function 0.0233 0.2639 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0233 0.0829
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0026 0.0053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.138 0.8844
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0031 0.0016
Plasmodium falciparum chitinase 0.0022 0.0048 0.0125
Plasmodium falciparum glutathione reductase 0.0057 0.0483 0.1784
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0017 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Mycobacterium tuberculosis Possible chitinase 0.0125 0.1317 0.8434
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0028
Brugia malayi Thioredoxin reductase 0.0057 0.0483 0.0885
Plasmodium vivax hypothetical protein, conserved 0.0233 0.2639 1
Leishmania major cathepsin L-like protease 0.0077 0.0728 0.3632
Entamoeba histolytica cell division protein kinase 2, putative 0.0025 0.0091 0.0308
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0405 0.3598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0031 0.0016
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0037 0.0233 0.1109
Loa Loa (eye worm) hypothetical protein 0.0233 0.2639 0.4835
Trypanosoma brucei trypanothione reductase 0.0057 0.0483 0.2385
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0654 0.064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0017 0.003
Onchocerca volvulus Putative endochitinase 0.0147 0.1582 0.2898
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Brugia malayi jmjC domain containing protein 0.0071 0.0654 0.1198
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0031 0.006
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0025 0.0091 0.0386
Brugia malayi prolyl oligopeptidase family protein 0.0037 0.0233 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0025 0.0091 0.0076
Echinococcus multilocularis cyclin dependent kinase 9 0.0025 0.0091 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0026 0.0053
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0025 0.0091 0.0288
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0483 0.2385
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0037 0.0233 0.0829
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0037 0.0233 0.1605
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0031 0.0057
Echinococcus granulosus dual specificity 0.0106 0.1081 0.1067
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0026 0.0053
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0654 0.064
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0025 0.0091 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1558 1
Schistosoma mansoni hypothetical protein 0.0043 0.0316 0.0301
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0288 0.0527
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.138 0.8844
Loa Loa (eye worm) hypothetical protein 0.0037 0.0233 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Giardia lamblia Kinase, CMGC DYRK 0.0106 0.1081 1
Leishmania major cathepsin L-like protease 0.0077 0.0728 0.3632
Leishmania major chitinase 0.0147 0.1582 0.7986
Brugia malayi prolyl oligopeptidase family protein 0.0463 0.5458 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0525 0.2601
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Onchocerca volvulus Cathepsin L homolog 0.002 0.0031 0.0057
Leishmania major cathepsin L-like protease 0.002 0.0031 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0031 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0091 0.0076
Mycobacterium ulcerans chitinase/cellulase 0.0125 0.1317 1
Brugia malayi cyclin-dependent kinase 7 homolog 0.0025 0.0091 0.0167
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0031 0.006
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.1977 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0022 0.0048 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1558 1
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0091 0.0619
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus granulosus acylamino acid releasing enzyme 0.0037 0.0233 0.0218
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0031 0.0016
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0017 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Onchocerca volvulus 0.002 0.0031 0.0057
Brugia malayi Endochitinase 0.0022 0.0048 0.0088
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0026 0.004
Brugia malayi Glycosyl hydrolases family 18 protein 0.0022 0.0048 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0156 0.1691 0.8543
Loa Loa (eye worm) haspin protein kinase 0.0135 0.1435 0.2629
Echinococcus granulosus intermediate filament protein 0.0033 0.0182 0.0167
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0037 0.0233 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus cyclin dependent kinase 9 0.0025 0.0091 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0316 0.0301
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0028
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0026 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0017 0.0001
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0037 0.0233 0.0218
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0037 0.0233 0.1964
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Brugia malayi Cathepsin L-like precursor 0.002 0.0031 0.0057
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.1081 0.5394
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0728 0.3632
Brugia malayi endochitinase 0.0164 0.1799 0.3296
Entamoeba histolytica protein kinase, putative 0.0179 0.1977 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0017 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0233 0.1037
Onchocerca volvulus Putative endochitinase 0.0164 0.1799 0.3296
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0026 0.0053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0521 0.0955
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1081 1
Entamoeba histolytica protein kinase, putative 0.0106 0.1081 0.5394
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0025 0.0091 0.0386
Brugia malayi hypothetical protein 0.0119 0.1241 0.2274
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0009
Brugia malayi Cell division protein kinase 2 0.0025 0.0091 0.0167
Loa Loa (eye worm) microfilarial chitinase 0.0143 0.1534 0.281
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.0091 0.0308
Echinococcus granulosus serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0316 0.0301
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0106 0.1081 0.5431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Plasmodium falciparum thioredoxin reductase 0.002 0.0026 0.004
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0325 0.3763 0.3754
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0026 0.5
Entamoeba histolytica prolyl oligopeptidase family protein 0.0037 0.0233 0.1037
Echinococcus multilocularis dual specificity 0.0179 0.1977 0.1964
Toxoplasma gondii hypothetical protein 0.0037 0.0233 0.0829
Echinococcus granulosus dual specificity 0.0179 0.1977 0.1964
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0321
Onchocerca volvulus Prolyl endopeptidase homolog 0.0037 0.0233 0.0427
Brugia malayi Protein kinase domain containing protein 0.0179 0.1977 0.3622
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0316 0.0301
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0026 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0654 0.1198
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0017 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0654 0.064
Echinococcus granulosus geminin 0.0205 0.2292 0.228
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0483 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus lamin dm0 0.0033 0.0182 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0233 0.1964
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0031 0.0057
Echinococcus granulosus lamin 0.0033 0.0182 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0037 0.0233 0.1964
Leishmania major oligopeptidase b 0.0037 0.0233 0.1109
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0026 0.004
Loa Loa (eye worm) ctsf protein 0.002 0.0031 0.0057
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1558 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0015 0.0028
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0026 0.5
Echinococcus multilocularis chromobox protein 1 0.0084 0.0815 0.0801
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0026 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0106 0.1081 0.198
Onchocerca volvulus Putative endochitinase 0.0022 0.0048 0.0088
Leishmania major cysteine peptidase A (CPA) 0.002 0.0031 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0182 0.0334
Plasmodium falciparum thioredoxin reductase 0.0057 0.0483 0.1784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0031 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Echinococcus granulosus serine:threonine protein kinase haspin 0.0135 0.1435 0.1422
Toxoplasma gondii prolyl endopeptidase 0.0037 0.0233 0.0829
Brugia malayi Heterochromatin protein 1 0.0084 0.0815 0.1493
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0037 0.0233 0.0218
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0815 0.7479
Loa Loa (eye worm) hypothetical protein 0.0125 0.1317 0.2413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0026 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Toxoplasma gondii cathepsin CPL 0.002 0.0031 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0361 0.3182
Echinococcus multilocularis geminin 0.0205 0.2292 0.228
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.1463
Plasmodium falciparum glutathione reductase 0.002 0.0026 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0156 0.1691 0.8543
Schistosoma mansoni intermediate filament proteins 0.0033 0.0182 0.0167
Brugia malayi hypothetical protein 0.0135 0.1435 0.2629
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0483 0.1784
Leishmania major cathepsin L-like protease 0.0077 0.0728 0.3632
Leishmania major trypanothione reductase 0.0057 0.0483 0.2385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Giardia lamblia Alanyl dipeptidyl peptidase 0.0037 0.0233 0.1964
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.138 0.8655
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Onchocerca volvulus Putative endochitinase 0.0164 0.1799 0.3296
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0026 0.0047
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0017 0.0007
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0179 0.1977 0.3622
Toxoplasma gondii thioredoxin reductase 0.0057 0.0483 0.1784
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Onchocerca volvulus Putative endochitinase 0.0147 0.1582 0.2898
Brugia malayi intermediate filament protein 0.0033 0.0182 0.0334
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0156 0.1691 0.1678
Treponema pallidum NADH oxidase 0.002 0.0026 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Echinococcus granulosus mitogen activated protein kinase 15 0.0025 0.0091 0.0076
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0463 0.5458 0.5451
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0022 0.0048 0.0088
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0026 0.0053
Echinococcus multilocularis cysteine protease 0.002 0.0031 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0156 0.1691 0.8543
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0001
Loa Loa (eye worm) prolyl oligopeptidase 0.0037 0.0233 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0031 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0031 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0728 0.3632
Schistosoma mansoni hypothetical protein 0.0205 0.2292 0.228
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0017 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1558 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0156 0.1691 0.1678
Echinococcus multilocularis chromobox protein 1 0.0084 0.0815 0.0801
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0654 0.064
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0007
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0156 0.1691 0.8543
Mycobacterium tuberculosis Probable reductase 0.013 0.138 0.8844
Mycobacterium ulcerans chitinase/cellulase 0.0125 0.1317 1
Onchocerca volvulus 0.0037 0.0236 0.0433
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0091 0.0619
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0233 0.1109
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0728 0.3632
Schistosoma mansoni hypothetical protein 0.0041 0.0288 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0091 0.0619
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0654 0.064
Onchocerca volvulus 0.0233 0.2639 0.4835
Brugia malayi isocitrate dehydrogenase 0.0019 0.0017 0.0031
Trichomonas vaginalis protein kinase atmrk1, putative 0.0025 0.0091 0.0619

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.0251 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.