Detailed information for compound 1449093

Basic information

Technical information
  • TDR Targets ID: 1449093
  • Name: (4S,6S)-4-(1-benzothiophen-3-yl)-6-[[4-(hydro xymethyl)phenyl]methoxy]-5,6-dihydro-4H-pyran -2-carboxamide
  • MW: 395.471 | Formula: C22H21NO4S
  • H donors: 2 H acceptors: 2 LogP: 3.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1ccc(cc1)CO[C@H]1OC(=C[C@H](C1)c1csc2c1cccc2)C(=O)N
  • InChi: 1S/C22H21NO4S/c23-22(25)19-9-16(18-13-28-20-4-2-1-3-17(18)20)10-21(27-19)26-12-15-7-5-14(11-24)6-8-15/h1-9,13,16,21,24H,10-12H2,(H2,23,25)/t16-,21+/m1/s1
  • InChiKey: YQRMLLFDKVCVMQ-IERDGZPVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S,6S)-4-(benzothiophen-3-yl)-6-[[4-(hydroxymethyl)phenyl]methoxy]-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,6S)-4-(3-benzothiophenyl)-6-[[4-(hydroxymethyl)phenyl]methoxy]-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,6S)-4-(benzothiophen-3-yl)-6-(4-methylolbenzyl)oxy-5,6-dihydro-4H-pyran-2-carboxamide
  • MLS000830640
  • SMR000442223

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1031 0.2826 0.4465
Schistosoma mansoni hypothetical protein 0.0168 0.0377 0.0377
Onchocerca volvulus 0.0059 0.0068 0.0709
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0258 0.0633 0.0633
Echinococcus multilocularis two pore calcium channel protein 2 0.0043 0.0022 0.0035
Schistosoma mansoni voltage-dependent calcium channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Schistosoma mansoni zinc finger protein 0.004 0.0015 0.0015
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0309 0.0363
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2265 0.3579
Toxoplasma gondii transporter, cation channel family protein 0.0043 0.0022 0.003
Echinococcus multilocularis ryanodine receptor 44f 0.0043 0.0022 0.0035
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0168 0.0377 0.4784
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0165 0.0261
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.007 0.0079
Onchocerca volvulus 0.0168 0.0377 0.4784
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.015 0.0326 0.0515
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0168 0.0377 0.0595
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0168 0.0377 0.0595
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.0377 0.0377
Brugia malayi follicle stimulating hormone receptor 0.0168 0.0377 0.0449
Schistosoma mansoni biogenic amine receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0059 0.0068 0.0709
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1222 0.3367 0.401
Schistosoma mansoni amine GPCR 0.0168 0.0377 0.0377
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0111 0.0214 0.025
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0043 0.0022 0.0035
Brugia malayi Bromodomain containing protein 0.0091 0.0157 0.0187
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0258 0.0633 0.0755
Brugia malayi G-protein coupled receptor 0.0168 0.0377 0.0449
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2265 0.3579
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0022 0.0022
Brugia malayi ORL1-like opioid receptor 0.0168 0.0377 0.0449
Toxoplasma gondii transporter, cation channel family protein 0.015 0.0326 0.1245
Echinococcus multilocularis ring and YY1 binding protein 0.004 0.0015 0.0023
Echinococcus granulosus SWI:SNF matrix associated 0.0114 0.0222 0.0351
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Echinococcus multilocularis two pore calcium channel protein 1 0.0043 0.0022 0.0035
Leishmania major hypothetical protein, conserved 0.0043 0.0022 0.0064
Schistosoma mansoni opsin-like receptor 0.0168 0.0377 0.0377
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0022 0.0035
Brugia malayi Dopamine receptor protein 1 0.0168 0.0377 0.0449
Echinococcus granulosus adenylate cyclase 9 0.006 0.007 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0107 0.0204 0.0238
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0086 0.0136
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0168 0.0377 0.0449
Schistosoma mansoni hypothetical protein 0.0205 0.0481 0.0481
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.004 0.0015 0.0018
Schistosoma mansoni brg-1 associated factor 0.0114 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0012
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0043 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0258 0.0633 0.0633
Echinococcus granulosus neuropeptide Y receptor 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0168 0.0377 0.4784
Brugia malayi voltage-dependent calcium channel 0.0043 0.0022 0.0027
Onchocerca volvulus 0.0168 0.0377 0.4784
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0108 0.0171
Brugia malayi sulfakinin receptor protein 0.2992 0.839 1
Loa Loa (eye worm) neuropeptide F receptor 0.0168 0.0377 0.0444
Schistosoma mansoni neuropeptide receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis neuropeptide Y receptor 0.0168 0.0377 0.0595
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0043 0.0022 0.0022
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0043 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0114 0.0222 0.0222
Onchocerca volvulus 0.0059 0.0068 0.0709
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0168 0.0377 0.0595
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Brugia malayi jmjC domain containing protein 0.0093 0.0165 0.0197
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni neuropeptide receptor 0.0168 0.0377 0.0377
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.006 0.007 0.0735
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0214 0.0214
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0043 0.0022 0.0035
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0168 0.0377 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Echinococcus granulosus short transient receptor potential channel 6 0.0043 0.0022 0.0035
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0168 0.0377 0.0595
Loa Loa (eye worm) adenylyl cyclase 3 0.0142 0.0302 0.0355
Schistosoma mansoni hypothetical protein 0.035 0.0894 0.0894
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0064 0.01
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0043 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0409 0.1061 0.126
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0043 0.0022 0.0035
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0111 0.0214 0.025
Chlamydia trachomatis DNA topoisomerase I 0.0114 0.0222 0.5
Schistosoma mansoni TRABID protein (C64 family) 0.004 0.0015 0.0015
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.015 0.0326 0.0515
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0109 0.021 0.0245
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0043 0.0022 0.0022
Brugia malayi putative neuropeptide receptor 0.0168 0.0377 0.0449
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0105 0.0165
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0068 0.0214
Echinococcus granulosus shaker cognate 0.0043 0.0022 0.0035
Brugia malayi phosphoinositide-dependent protein kinase I 0.0111 0.0214 0.0255
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.004 0.0015 0.0023
Entamoeba histolytica protein kinase, putative 0.0111 0.0214 0.2376
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0043 0.0022 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0043 0.0022 0.0035
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0114 0.0222 0.0351
Echinococcus granulosus neuropeptide receptor 0.0168 0.0377 0.0595
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0022 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0168 0.0377 0.0377
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0022 0.0035
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2265 0.6329 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0902 1
Echinococcus multilocularis neuropeptide Y receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0164 0.0365 0.043
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0544 0.086
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0043 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0085 0.0142 0.0164
Echinococcus multilocularis conserved hypothetical protein 0.0043 0.0022 0.0035
Echinococcus granulosus voltage gated hydrogen channel 1 0.0043 0.0022 0.0035
Schistosoma mansoni two-pore calcium channel 0.0043 0.0022 0.0022
Echinococcus granulosus zinc finger protein Ran binding 0.004 0.0015 0.0023
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0114 0.0222 0.0831
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis sodium channel protein 0.0453 0.1186 0.1873
Schistosoma mansoni hypothetical protein 0.0409 0.1061 0.1061
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0022 0.0022
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0188 0.0435 0.0513
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0168 0.0377 0.0595
Echinococcus granulosus jun protein 0.0086 0.0145 0.0229
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Toxoplasma gondii microneme protein MIC4 0.0059 0.0068 0.0214
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0022 0.0035
Schistosoma mansoni biogenic amine receptor 0.0168 0.0377 0.0377
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0043 0.0022 0.0035
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.004 0.0015 0.0018
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0389 1
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0512 0.5569
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Loa Loa (eye worm) brahma associated protein 0.0114 0.0222 0.026
Echinococcus granulosus neuropeptide FF receptor 2 0.0394 0.1019 0.1609
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0168 0.0377 0.0449
Schistosoma mansoni hypothetical protein 0.0205 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0307 0.0771 1
Toxoplasma gondii hypothetical protein 0.0043 0.0022 0.003
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0369 0.0946 1
Brugia malayi Transient-receptor-potential like protein 0.0043 0.0022 0.0027
Schistosoma mansoni RNA binding protein 0.004 0.0015 0.0015
Loa Loa (eye worm) voltage-dependent calcium channel 0.015 0.0326 0.0383
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0043 0.0022 0.0035
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0207 0.0487 0.0487
Schistosoma mansoni 60S ribosomal protein L21 0.0043 0.0022 0.0022
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0114 0.0222 1
Echinococcus granulosus TRP transient receptor potential channel 0.0043 0.0022 0.0035
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0064 0.0645
Toxoplasma gondii microneme protein MIC17C 0.0059 0.0068 0.0214
Echinococcus granulosus short transient receptor potential channel 6 0.0043 0.0022 0.0035
Echinococcus granulosus orexin receptor type 2 0.0168 0.0377 0.0595
Schistosoma mansoni biogenic amine receptor 0.0168 0.0377 0.0377
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0043 0.0022 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0022 0.0035
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0043 0.0022 0.0035
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0086 0.0136
Echinococcus multilocularis neuropeptide receptor A26 0.0635 0.1702 0.2689
Schistosoma mansoni opsin-like receptor 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0068 0.0076
Schistosoma mansoni protein kinase 0.0125 0.0256 0.0256
Onchocerca volvulus 0.0168 0.0377 0.4784
Brugia malayi Bromodomain containing protein 0.0046 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0012
Echinococcus granulosus sodium channel protein 0.0453 0.1186 0.1873
Echinococcus granulosus alpha 1A adrenergic receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis fmrfamide receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Echinococcus multilocularis transient receptor potential gamma protein 0.0043 0.0022 0.0035
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0785 0.8674
Loa Loa (eye worm) ion channel NompC 0.0043 0.0022 0.0021
Echinococcus multilocularis hyperpolarization activated cyclic 0.0043 0.0022 0.0035
Brugia malayi YY1-associated factor 2 0.004 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.0114 0.0222 0.0222
Brugia malayi SWIB/MDM2 domain containing protein 0.0114 0.0222 0.0265
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0067 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.0377 0.0595
Brugia malayi Dopamine receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.1222 0.3367 0.4013
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0043 0.0022 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Onchocerca volvulus 0.0059 0.0068 0.0709
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0389 1
Echinococcus granulosus neuropeptide Y receptor 0.0168 0.0377 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0785 0.8674
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0785 0.8674
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Brugia malayi cation channel family protein 0.0043 0.0022 0.0027
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0064 0.01
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0544 0.086
Brugia malayi Latrophilin receptor protein 2 0.0409 0.1061 0.1265
Echinococcus granulosus 7TM GPCR rhodopsin 0.0168 0.0377 0.0595
Schistosoma mansoni hypothetical protein 0.0409 0.1061 0.1061
Onchocerca volvulus 0.0168 0.0377 0.4784
Schistosoma mansoni bromodomain containing protein 0.0076 0.0117 0.0117
Schistosoma mansoni ryanodine receptor related 0.0043 0.0022 0.0022
Schistosoma mansoni neuropeptide F-like receptor 0.0168 0.0377 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0377 0.0377
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0258 0.0633 0.075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus granulosus G protein coupled receptor 139 0.0168 0.0377 0.0595
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0168 0.0377 0.0595
Brugia malayi Cyclic-nucleotide gated cation channel 0.0043 0.0022 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0307 0.0771 0.0771
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0043 0.0022 0.0035
Echinococcus granulosus sodium leak channel non selective protein 0.0043 0.0022 0.0035
Echinococcus granulosus g protein coupled receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis neuropeptide s receptor 0.0635 0.1702 0.2689
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0168 0.0377 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0086 0.0145 0.0229
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0068 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0168 0.0377 0.0377
Loa Loa (eye worm) voltage-gated potassium channel 0.0043 0.0022 0.0021
Echinococcus multilocularis sodium leak channel non selective protein 0.0043 0.0022 0.0035
Echinococcus granulosus ryanodine receptor 44f 0.0043 0.0022 0.0035
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0168 0.0377 0.0444
Echinococcus multilocularis calcium activated potassium channel 0.0044 0.0026 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0222 0.2276
Trypanosoma brucei RNA helicase, putative 0.0207 0.0487 0.5072
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.015 0.0326 0.0389
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0022 0.0035
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0043 0.0022 0.0035
Brugia malayi brahma associated protein 60 kDa 0.0114 0.0222 0.0265
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0168 0.0377 0.0595
Toxoplasma gondii hypothetical protein 0.0043 0.0022 0.003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0108 0.0171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0023 0.0037
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0043 0.0022 0.0027
Echinococcus granulosus adenylate cyclase type IX 0.0084 0.0139 0.022
Toxoplasma gondii PAN/Apple domain-containing protein 0.0059 0.0068 0.0214
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0043 0.0022 0.0035
Echinococcus multilocularis serotonin receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0046 0.0032 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Onchocerca volvulus 0.0059 0.0068 0.0709
Brugia malayi Serotonin receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0168 0.0377 0.0444
Schistosoma mansoni hypothetical protein 0.0409 0.1061 0.1061
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0068 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0005 0.0005
Toxoplasma gondii microneme protein MIC17B 0.0059 0.0068 0.0214
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0214 0.2183
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0125 0.0256 0.0404
Brugia malayi hypothetical protein 0.2992 0.839 1
Echinococcus granulosus Zinc finger RanBP2 type 0.004 0.0015 0.0023
Loa Loa (eye worm) calcium channel 0.015 0.0326 0.0383
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0013 0.002
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0043 0.0022 0.0027
Echinococcus multilocularis dro:myosuppressin receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis short transient receptor potential channel 6 0.0043 0.0022 0.0035
Schistosoma mansoni fusion 0.004 0.0015 0.0015
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0043 0.0022 0.0035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0902 1
Toxoplasma gondii microneme protein, putative 0.0059 0.0068 0.0214
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0377 0.0595
Schistosoma mansoni neuropeptide receptor 0.0168 0.0377 0.0377
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0394 0.1019 0.1609
Brugia malayi putative neuropeptide receptor NPR1 0.0168 0.0377 0.0449
Echinococcus multilocularis shaker cognate 0.0043 0.0022 0.0035
Brugia malayi bZIP transcription factor family protein 0.0086 0.0145 0.0173
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0409 0.1061 0.1677
Echinococcus multilocularis somatostatin receptor 0.0168 0.0377 0.0595
Schistosoma mansoni apoptosis regulator bax 0.0258 0.0633 0.0633
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0005 0.0005
Onchocerca volvulus 0.0168 0.0377 0.4784
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0168 0.0377 0.0449
Onchocerca volvulus 0.0168 0.0377 0.4784
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis neuropeptides capa receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0307 0.0771 0.0914
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0168 0.0377 0.0444
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Brugia malayi Melatonin receptor type 1A 0.0168 0.0377 0.0449
Onchocerca volvulus 0.0168 0.0377 0.4784
Leishmania major hypothetical protein, unknown function 0.0043 0.0022 0.0064
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0043 0.0022 0.0022
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0258 0.0633 0.1001
Schistosoma mansoni hypothetical protein 0.0258 0.0633 0.0633
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.015 0.0326 0.0515
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Onchocerca volvulus 0.0059 0.0068 0.0709
Schistosoma mansoni hypothetical protein 0.0813 0.2206 0.2206
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0168 0.0377 0.0595
Echinococcus multilocularis neuropeptides capa receptor 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0043 0.0022 0.0099
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0168 0.0377 0.4784
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0105 0.0165
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus multilocularis SWI:SNF matrix associated 0.0114 0.0222 0.0351
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0043 0.0022 0.0035
Onchocerca volvulus 0.0168 0.0377 0.4784
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.015 0.0326 0.0383
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0022 0.0035
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0902 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0111 0.0214 0.0338
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0022 0.0022
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0043 0.0022 0.0035
Echinococcus multilocularis short transient receptor potential channel 6 0.0043 0.0022 0.0035
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0369 0.0946 0.1127
Loa Loa (eye worm) hypothetical protein 0.0058 0.0064 0.007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0369 0.0946 0.1123
Echinococcus multilocularis g-protein coupled receptor 0.0168 0.0377 0.0595
Schistosoma mansoni transient receptor potential channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Brugia malayi olfactory channel protein osm-9 0.0043 0.0022 0.0027
Onchocerca volvulus 0.0059 0.0068 0.0709
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0043 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Echinococcus granulosus neuropeptide receptor A26 0.0635 0.1702 0.2689
Onchocerca volvulus 0.006 0.007 0.0735
Echinococcus multilocularis neuropeptide receptor 0.0168 0.0377 0.0595
Leishmania major C-8 sterol isomerase-like protein 0.0369 0.0946 0.7952
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Schistosoma mansoni vesicular amine transporter 0.0043 0.0022 0.0022
Schistosoma mansoni myosin xvIII 0.0168 0.0377 0.0377
Brugia malayi ion channel NompC 0.0043 0.0022 0.0027
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0023 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0409 0.1061 0.1677
Brugia malayi hypothetical protein 0.0043 0.0022 0.0027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0394 0.1019 0.1214
Brugia malayi brahma associated protein 60 kDa 0.0114 0.0222 0.0265
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0064 0.007
Echinococcus multilocularis allatostatin A receptor 0.0307 0.0771 0.1218
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0059 0.0068 0.0214
Loa Loa (eye worm) MBCTL1 0.0066 0.0086 0.0097
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1031 0.2826 0.4465
Onchocerca volvulus 0.0059 0.0068 0.0709
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0168 0.0377 0.0377
Schistosoma mansoni jun-related protein 0.007 0.0099 0.0099
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0086 0.0086
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Schistosoma mansoni hypothetical protein 0.007 0.0099 0.0099
Toxoplasma gondii hypothetical protein 0.0059 0.0068 0.0214
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0123 0.0249 0.0394
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0166 0.0372 0.4723
Echinococcus granulosus voltage dependent calcium channel 0.015 0.0326 0.0515
Echinococcus granulosus fmrfamide receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.004 0.0015 0.0018
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0022 0.0035
Schistosoma mansoni amine GPCR 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus neuropeptides capa receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Brugia malayi Protein kinase domain containing protein 0.0111 0.0214 0.0255
Echinococcus granulosus transient receptor potential gamma protein 0.0043 0.0022 0.0035
Echinococcus granulosus tachykinin peptides receptor 99D 0.0468 0.1227 0.1939
Brugia malayi jmjC domain containing protein 0.0037 0.0005 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus multilocularis adenylate cyclase type IX 0.0084 0.0139 0.022
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0043 0.0022 0.0099
Onchocerca volvulus 0.0168 0.0377 0.4784
Loa Loa (eye worm) G-protein coupled receptor 0.0168 0.0377 0.0444
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Echinococcus granulosus hyperpolarization activated cyclic 0.0043 0.0022 0.0035
Onchocerca volvulus 0.0168 0.0377 0.4784
Echinococcus granulosus dro:myosuppressin receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis voltage dependent calcium channel 0.015 0.0326 0.0515
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0022 0.0022
Chlamydia trachomatis SWIB complex protein 0.0114 0.0222 0.5
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0114 0.0222 0.0831
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0043 0.0022 0.0027
Brugia malayi Dopamine receptor protein 2 0.0168 0.0377 0.0449
Echinococcus granulosus voltage dependent calcium channel 0.015 0.0326 0.0515
Loa Loa (eye worm) hypothetical protein 0.0066 0.0086 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1844 0.5132 0.6117
Brugia malayi G protein-coupled receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0022 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0114 0.0222 0.5
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.004 0.0015 0.0015
Brugia malayi Adenylyl cyclase protein 0.006 0.007 0.0084
Echinococcus granulosus hyperpolarization activated cyclic 0.0043 0.0022 0.0035
Brugia malayi neuropeptide F receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0084 0.0138 0.0159
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Trypanosoma brucei C-8 sterol isomerase, putative 0.0369 0.0946 1
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0022 0.0035
Toxoplasma gondii subtilisin SUB12 0.0059 0.0068 0.0214
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0214 0.2183
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0043 0.0022 0.0022
Schistosoma mansoni neuropeptide f receptor 76f 0.0168 0.0377 0.0377
Schistosoma mansoni protein kinase 0.0125 0.0256 0.0256
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0022 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Echinococcus granulosus tm gpcr rhodopsin 0.1204 0.3317 0.524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Brugia malayi G protein-coupled receptor F59B2.13 0.0168 0.0377 0.0449
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Loa Loa (eye worm) TYRA-2 protein 0.0168 0.0377 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0785 0.8674
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0043 0.0022 0.0027
Echinococcus multilocularis adenylate cyclase 9 0.006 0.007 0.0111
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0168 0.0377 0.0595
Echinococcus granulosus g protein coupled receptor 0.0168 0.0377 0.0595
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.015 0.0326 0.0515
Schistosoma mansoni neuropeptide receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0168 0.0377 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0785 0.8674
Loa Loa (eye worm) hypothetical protein 0.0043 0.0022 0.0021
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Loa Loa (eye worm) neuropeptide F receptor 0.0168 0.0377 0.0444
Echinococcus granulosus two pore calcium channel protein 1 0.0043 0.0022 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0222 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0168 0.0377 0.0449
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0022 0.0035
Schistosoma mansoni adenoreceptor 0.0168 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0168 0.0377 0.0377
Onchocerca volvulus 0.0059 0.0068 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus granulosus Nuclear pore complex protein Nup153 0.004 0.0015 0.0023
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2265 0.2265
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Echinococcus granulosus neuropeptide receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.015 0.0326 0.0515
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni transient receptor potential channel 0.0043 0.0022 0.0022
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Brugia malayi RE15519p 0.0168 0.0377 0.0449
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0114 0.0222 1
Onchocerca volvulus 0.0058 0.0064 0.0645
Brugia malayi latrophilin 2 splice variant baaae 0.0813 0.2206 0.2629
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0309 0.0363
Onchocerca volvulus 0.0168 0.0377 0.4784
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0468 0.1227 0.1939
Echinococcus multilocularis GPCR, family 2 0.0409 0.1061 0.1677
Echinococcus multilocularis geminin 0.0205 0.0481 0.076
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0022 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0785 0.8674
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0022 0.0022
Schistosoma mansoni alpha-1 adrenergic receptor 0.0168 0.0377 0.0377
Brugia malayi G-protein coupled receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Toxoplasma gondii PAN domain-containing protein 0.0921 0.2515 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0258 0.0633 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0109 0.021 0.025
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0022 0.0035
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0086 0.0136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0168 0.0377 0.0377
Brugia malayi MH2 domain containing protein 0.0144 0.0309 0.0369
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0409 0.1061 0.1265
Schistosoma mansoni protein kinase 0.0125 0.0256 0.0256
Echinococcus granulosus geminin 0.0205 0.0481 0.076
Schistosoma mansoni histamine h1 receptor 0.0168 0.0377 0.0377
Brugia malayi hypothetical protein 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0168 0.0377 0.0595
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0064 0.0064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0022 0.003
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0043 0.0022 0.0035
Schistosoma mansoni hypothetical protein 0.0409 0.1061 0.1061
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus multilocularis SWI:SNF matrix associated 0.0114 0.0222 0.0351
Loa Loa (eye worm) G-protein coupled receptor 0.0168 0.0377 0.0444
Echinococcus granulosus calcium activated potassium channel 0.0044 0.0026 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Echinococcus granulosus ring and YY1 binding protein 0.004 0.0015 0.0023
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0064 0.0064
Loa Loa (eye worm) bone morphogenic protein 6 0.0123 0.0249 0.0292
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus potassium large conductance calcium activated 0.0043 0.0022 0.0035
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0785 0.0936
Loa Loa (eye worm) hypothetical protein 0.0059 0.0068 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.0168 0.0377 0.0377
Schistosoma mansoni amine GPCR 0.0168 0.0377 0.0377
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Schistosoma mansoni calcium-activated potassium channel 0.0043 0.0022 0.0022
Brugia malayi Serotonin receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus 7tm_1 domain containing protein 0.0168 0.0377 0.0595
Schistosoma mansoni transient receptor potential channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0123 0.0249 0.0394
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus granulosus hypothetical protein 0.0168 0.0377 0.0595
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0902 0.5
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0258 0.0633 0.1001
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.2992 0.839 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.015 0.0326 0.3343
Echinococcus granulosus allatostatin A receptor 0.0307 0.0771 0.1218
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0022 0.0035
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0043 0.0022 0.008
Echinococcus multilocularis G-protein coupled receptor, putative 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Brugia malayi mbt repeat family protein 0.0058 0.0064 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0068 0.0214
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0064 0.01
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0453 0.1186 0.1873
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1204 0.3317 0.524
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0022 0.0035
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.015 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0043 0.0022 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0043 0.0022 0.0035
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0389 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0043 0.0022 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0481 0.6161
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0111 0.0111
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.015 0.0326 0.0515
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0064 0.01
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0043 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.015 0.0326 0.0383
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0168 0.0377 0.0595
Echinococcus multilocularis Zinc finger, RanBP2 type 0.004 0.0015 0.0023
Loa Loa (eye worm) voltage-gated potassium channel 0.0043 0.0022 0.0021
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0043 0.0022 0.0035
Onchocerca volvulus Neuropeptide F receptor homolog 0.0168 0.0377 0.4784
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0086 0.0103
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0043 0.0022 0.0035
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.015 0.0326 0.0515
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0512 0.5569
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Echinococcus multilocularis SWI:SNF matrix associated 0.0114 0.0222 0.0351
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0068 0.0092 0.1024
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Toxoplasma gondii hypothetical protein 0.0059 0.0068 0.0214
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0125 0.0256 0.0404
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0043 0.0022 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0481 0.5214
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0043 0.0022 0.0035
Echinococcus granulosus jumonji domain containing protein 0.004 0.0013 0.002
Echinococcus multilocularis zinc finger protein Ran binding 0.004 0.0015 0.0023
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0453 0.1186 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0108 0.0374
Brugia malayi Transforming growth factor beta like domain containing protein 0.0123 0.0249 0.0297
Loa Loa (eye worm) hypothetical protein 0.0107 0.0204 0.0238
Schistosoma mansoni voltage-gated ion channel 0.0043 0.0022 0.0022
Onchocerca volvulus 0.0168 0.0377 0.4784
Echinococcus granulosus GPCR family 2 0.0409 0.1061 0.1677
Echinococcus granulosus somatostatin receptor 0.0168 0.0377 0.0595
Brugia malayi neuropeptide F receptor 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0394 0.1019 0.1209
Loa Loa (eye worm) apoptosis regulator protein 0.0258 0.0633 0.075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Echinococcus multilocularis transfer RNA-Gly 0.0043 0.0022 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0377 0.0377
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0022 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.0168 0.0377 0.0377
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0022 0.0035
Brugia malayi PAN domain containing protein 0.0059 0.0068 0.0082
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0022 0.0022
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0785 0.0931
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0111 0.0214 0.0338
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0043 0.0022 0.0022
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.015 0.0326 0.0326
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0168 0.0377 0.0449
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0022 0.0022
Brugia malayi hypothetical protein 0.0068 0.0092 0.011
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0068 0.0076
Brugia malayi AKH receptor 0.0168 0.0377 0.0449
Echinococcus multilocularis serotonin receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis potassium large conductance calcium activated 0.0043 0.0022 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0043 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0168 0.0377 0.0377
Toxoplasma gondii microneme protein MIC17A 0.0059 0.0068 0.0214
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0377 0.0595
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0377 0.0595
Onchocerca volvulus 0.0168 0.0377 0.4784
Schistosoma mansoni opsin-like receptor 0.0168 0.0377 0.0377
Echinococcus multilocularis hyperpolarization activated cyclic 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0022 0.0035
Loa Loa (eye worm) voltage-gated calcium channel 0.0043 0.0022 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0108 0.0108
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0114 0.0222 0.026
Loa Loa (eye worm) melatonin receptor type 1A 0.0168 0.0377 0.0444
Schistosoma mansoni transient receptor potential channel 4 0.0043 0.0022 0.0022
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0068 0.0076
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0043 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0114 0.0222 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0214 0.2183
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.1844 0.5132 0.6115
Loa Loa (eye worm) ryanodine receptor 0.0043 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0168 0.0377 0.0377
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0108 0.0798
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0168 0.0377 0.0595
Schistosoma mansoni amine GPCR 0.0168 0.0377 0.0377
Echinococcus granulosus neuropeptide s receptor 0.0635 0.1702 0.2689
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0114 0.0222 0.0351
Onchocerca volvulus 0.0059 0.0068 0.0709
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0022 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0043 0.0022 0.0035
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0022 0.0035
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0068 0.0076
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0086 0.0136
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.015 0.0326 0.3343
Echinococcus granulosus g-protein coupled receptor 0.0168 0.0377 0.0595
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0902 1
Onchocerca volvulus 0.0057 0.0063 0.064
Echinococcus multilocularis fmrfamide receptor 0.0168 0.0377 0.0595
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0165 0.0261
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.2265 0.6329 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0022 0.0035
Echinococcus granulosus peptide allatostatin:somatostatin 0.0168 0.0377 0.0595
Echinococcus multilocularis orexin receptor type 2 0.0168 0.0377 0.0595
Toxoplasma gondii transporter, cation channel family protein 0.0043 0.0022 0.003
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0043 0.0022 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0813 0.2206 0.2625
Echinococcus granulosus tm gpcr rhodopsin 0.0168 0.0377 0.0595
Echinococcus granulosus serotonin receptor 0.0168 0.0377 0.0595
Echinococcus multilocularis G protein coupled receptor 139 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0086 0.0145 0.0229
Onchocerca volvulus 0.0059 0.0068 0.0709
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus sex peptide receptor 0.0168 0.0377 0.0595
Brugia malayi cation channel family protein 0.0043 0.0022 0.0027
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0068 0.0214
Toxoplasma gondii hypothetical protein 0.0107 0.0204 0.0757
Echinococcus multilocularis voltage dependent calcium channel 0.015 0.0326 0.0515
Toxoplasma gondii PAN domain-containing protein 0.0921 0.2515 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0039 0.0041
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0022 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0409 0.1061 0.126
Echinococcus granulosus hypothetical protein 0.0043 0.0022 0.0035
Echinococcus multilocularis jun protein 0.0086 0.0145 0.0229
Brugia malayi GnHR receptor homolog 0.0168 0.0377 0.0449
Brugia malayi mbt repeat family protein 0.0058 0.0064 0.0076
Echinococcus granulosus two pore calcium channel protein 2 0.0043 0.0022 0.0035
Schistosoma mansoni serine-type protease inhibitor 0.3559 1 1
Onchocerca volvulus 0.0168 0.0377 0.4784
Brugia malayi larval opioid receptor 0.0168 0.0377 0.0449
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0022 0.0035
Echinococcus multilocularis sex peptide receptor 0.0168 0.0377 0.0595
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0022 0.0035
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0168 0.0377 0.0377
Schistosoma mansoni voltage-gated cation channel 0.015 0.0326 0.0326
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.004 0.0015 0.0018
Onchocerca volvulus 0.0114 0.0222 0.2746
Echinococcus multilocularis neuropeptide receptor 0.0168 0.0377 0.0595
Loa Loa (eye worm) hypothetical protein 0.0049 0.004 0.0042
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Schistosoma mansoni growth hormone secretagogue receptor 0.0168 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0444
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0005 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0022 0.0035

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 12.5594 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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