Detailed information for compound 1469750

Basic information

Technical information
  • TDR Targets ID: 1469750
  • Name: N-[4-[(2-chlorophenyl)carbamoyl]phenyl]pyridi ne-3-carboxamide
  • MW: 351.786 | Formula: C19H14ClN3O2
  • H donors: 2 H acceptors: 3 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)NC(=O)c1cccnc1)Nc1ccccc1Cl
  • InChi: 1S/C19H14ClN3O2/c20-16-5-1-2-6-17(16)23-18(24)13-7-9-15(10-8-13)22-19(25)14-4-3-11-21-12-14/h1-12H,(H,22,25)(H,23,24)
  • InChiKey: CGHAHMYLDCLKIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[(2-chlorophenyl)amino]-oxomethyl]phenyl]-3-pyridinecarboxamide
  • N-[4-[(2-chlorophenyl)carbamoyl]phenyl]nicotinamide
  • ZINC04659794

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0063 0.0026 0.8391
Schistosoma mansoni hypothetical protein 0.0306 0.0315 0.2871
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0011 0.0008
Echinococcus granulosus discoidin domain containing receptor 2 0.0057 0.0019 0.0016
Schistosoma mansoni dock 0.0057 0.0019 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0027 0.043
Loa Loa (eye worm) cytochrome P450 0.0063 0.0026 0.0015
Plasmodium falciparum LCCL domain-containing protein 0.0057 0.0019 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0063 0.0026 0.0018
Schistosoma mansoni protein kinase 0.0048 0.0008 0.0048
Loa Loa (eye worm) CYP4Cod1 0.0089 0.0056 0.0046
Plasmodium vivax LCCL domain-containing protein 0.0057 0.0019 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0027 0.0226
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0011 0.0008
Echinococcus multilocularis discoidin domain containing receptor 2 0.0057 0.0019 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0059 0.0524
Echinococcus granulosus discoidin domain containing receptor 2 0.0057 0.0019 0.0016
Toxoplasma gondii hypothetical protein 0.5908 0.6973 1
Brugia malayi mbt repeat family protein 0.005 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0456 0.0493 0.0483
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0063 0.0026 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0063 0.0026 0.8391
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.8454 1 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0958 0.109 0.1088
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0063 0.0026 0.8391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0059 0.0057
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0048 0.0008 0.0005
Plasmodium vivax LCCL domain-containing protein 0.0057 0.0019 0.5
Schistosoma mansoni hypothetical protein 0.0057 0.0019 0.015
Leishmania major cytochrome p450-like protein 0.0063 0.0026 0.0018
Echinococcus granulosus tyrosine protein kinase ABL1 0.0422 0.0452 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Leishmania major cytochrome p450-like protein 0.0063 0.0026 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0059 0.0057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0027 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0059 0.0057
Brugia malayi Cytochrome P450 family protein 0.0233 0.0227 0.0225
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0027 0.0028
Toxoplasma gondii F5/8 type C domain-containing protein 0.0057 0.0019 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0063 0.0026 0.8391
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0019 0.0016
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0063 0.0026 0.8391
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0063 0.0026 0.8391
Echinococcus multilocularis activin receptor type 0.0048 0.0008 0.0005
Onchocerca volvulus 0.0057 0.0019 0.0367
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0057 0.0019 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Schistosoma mansoni discoidin domain receptor 0.0057 0.0019 0.015
Echinococcus multilocularis mitogen activated protein kinase 11 0.8454 1 1
Echinococcus multilocularis 0.0063 0.0026 0.0023
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0019 0.0016
Brugia malayi Cytochrome P450 family protein 0.0063 0.0026 0.0023
Brugia malayi Tyrosine-protein kinase abl-1 0.025 0.0247 0.0245
Toxoplasma gondii PA14 domain-containing protein 0.0057 0.0019 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0063 0.0026 0.8391
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Plasmodium falciparum LCCL domain-containing protein 0.0057 0.0019 1
Brugia malayi Protein kinase domain containing protein 0.0468 0.0507 0.0505
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0063 0.0026 0.8391
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0059 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0063 0.0026 0.8391
Echinococcus granulosus tyrosine protein kinase Lyn 0.0059 0.0021 0.0019
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.5908 0.6973 0.697
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0011 0.0075
Entamoeba histolytica hypothetical protein 0.0043 0.0002 0.2932
Schistosoma mansoni hypothetical protein 0.0063 0.0026 0.0213
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.0187 0.0184
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0011 0.0208
Loa Loa (eye worm) TK/ABL protein kinase 0.0422 0.0452 0.0442
Brugia malayi cytochrome P450 0.0063 0.0026 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0063 0.0026 0.8391
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.5908 0.6973 0.697
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0063 0.0026 0.8391
Schistosoma mansoni tyrosine kinase 0.0758 0.0852 0.7818
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0063 0.0026 0.8391
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0063 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.5908 0.6973 0.697
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0011 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0063 0.0026 0.8391
Brugia malayi Cytochrome P450 family protein 0.0089 0.0056 0.0054
Entamoeba histolytica hypothetical protein 0.0043 0.0002 0.2932
Toxoplasma gondii cytochrome p450 superfamily protein 0.0063 0.0026 0.0026
Toxoplasma gondii F5/8 type C domain-containing protein 0.0057 0.0019 0.0016
Schistosoma mansoni protein kinase 0.0048 0.0008 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0027 0.0226
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0089 0.0056 1
Schistosoma mansoni protein kinase 0.0048 0.0008 0.0048
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0008 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0019 0.0152
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0063 0.0026 0.8391
Loa Loa (eye worm) hypothetical protein 0.0167 0.0149 0.0138
Loa Loa (eye worm) hypothetical protein 0.0411 0.0439 0.0429
Echinococcus multilocularis mitogen activated protein kinase 14 0.8454 1 1
Mycobacterium leprae putative cytochrome p450 0.0063 0.0026 1
Brugia malayi Cytochrome P450 family protein 0.0089 0.0056 0.0054
Entamoeba histolytica hypothetical protein 0.0043 0.0002 0.2932
Brugia malayi mbt repeat family protein 0.005 0.0011 0.0008
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0422 0.0452 0.045
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0063 0.0026 0.0018
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0057 0.0019 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0089 0.0056 0.0049
Echinococcus multilocularis tyrosine protein kinase Abl 0.0178 0.0163 0.016
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.8454 1 1
Echinococcus multilocularis protein tyrosine kinase 0.0758 0.0852 0.085
Loa Loa (eye worm) TK/DDR protein kinase 0.0411 0.0439 0.0429
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0063 0.0026 0.8391
Onchocerca volvulus 0.005 0.0011 0.0208
Leishmania major cytochrome p450-like protein 0.0089 0.0056 0.0049
Echinococcus granulosus mitogen activated protein kinase 11 0.8454 1 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.8454 1 1
Echinococcus granulosus mitogen activated protein kinase 14 0.8454 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0019 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Echinococcus multilocularis mitogen activated protein kinase 11 0.8454 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0063 0.0026 0.8391
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0019 0.0016
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0019 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.5908 0.6973 0.697
Echinococcus granulosus protein tyrosine kinase 0.0758 0.0852 0.085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0059 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0057 0.0019 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0063 0.0026 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0048 0.0008 0.0005
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0057 0.0019 0.0008
Echinococcus multilocularis discoidin domain receptor 0.0057 0.0019 0.0016
Echinococcus granulosus cytochrome P450 2K1 0.0063 0.0026 0.0023
Trichomonas vaginalis hypothetical protein 0.0057 0.0019 0.5
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0958 0.109 0.108
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0063 0.0026 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0059 0.0057
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0057 0.0019 0.0016
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.8454 1 1
Onchocerca volvulus 0.0468 0.0507 1
Schistosoma mansoni discoidin domain receptor 0.0057 0.0019 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0958 0.109 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0027 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0059 0.0524
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0011 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Brugia malayi Stress-activated protein kinase jnk-1 0.0958 0.109 0.1088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0059 0.0524
Loa Loa (eye worm) TK/FAK protein kinase 0.0767 0.0863 0.0853
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0027 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.8454 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0089 0.0056 0.0046
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.0187 0.0184
Brugia malayi Protein kinase domain containing protein 0.0767 0.0863 0.0861
Toxoplasma gondii F5/8 type C domain-containing protein 0.0057 0.0019 0.0016
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0958 0.109 0.1088
Loa Loa (eye worm) cytochrome P450 family protein 0.0233 0.0227 0.0217
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0027 0.043
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.8454 1 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0057 0.0019 0.0016
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0057 0.0019 0.5
Echinococcus granulosus activin receptor type 0.0048 0.0008 0.0005
Schistosoma mansoni septate junction protein 0.0057 0.0019 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0027 0.043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0019 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0089 0.0056 0.0046
Trypanosoma cruzi cytochrome P450, putative 0.0089 0.0056 0.0049
Trypanosoma brucei cytochrome P450, putative 0.0089 0.0056 0.0049
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0057 0.0019 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0019 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0027 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0063 0.0026 0.8391
Schistosoma mansoni btb and poz domain-containing protein 0.0057 0.0019 0.015
Loa Loa (eye worm) MBCTL1 0.0057 0.0019 0.0008
Schistosoma mansoni cytochrome P450 0.0063 0.0026 0.0213
Schistosoma mansoni tyrosine kinase 0.0416 0.0445 0.4074
Echinococcus multilocularis discoidin domain containing receptor 2 0.0057 0.0019 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0063 0.0026 0.8391
Echinococcus multilocularis discoidin domain containing receptor 2 0.0057 0.0019 0.0016
Echinococcus granulosus discoidin domain receptor 0.0456 0.0493 0.0491
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0011 0.0008
Brugia malayi Tyrosine-protein kinase abl-1 0.0178 0.0163 0.016
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0063 0.0026 0.8391
Entamoeba histolytica hypothetical protein 0.0043 0.0002 0.2932
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0063 0.0026 0.8391

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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