Detailed information for compound 1487986

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 148.16 | Formula: C5H12N2O3
  • H donors: 3 H acceptors: 2 LogP: -4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCOCCC(C(=O)O)N
  • InChi: 1S/C5H12N2O3/c6-3-10-2-1-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)
  • InChiKey: AKSIYNOQZYMJED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0107 0.0118
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.2755 0.4549
Loa Loa (eye worm) hypothetical protein 0.002 0.011 0.0123
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0536 0.0661
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0018 0.0082 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0173 0.0231
Toxoplasma gondii hypothetical protein 0.0082 0.1171 0.1854
Schistosoma mansoni nuclear hormone receptor 0.0021 0.013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0107 0.0038
Echinococcus multilocularis bloom syndrome protein 0.002 0.011 0.0123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0693 0.1109
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.013 0.0157
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.011 0.0044
Schistosoma mansoni nuclear receptor 0.0021 0.013 0.0123
Onchocerca volvulus 0.0021 0.013 0.0082
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0361 0.5955 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0548 0.0677
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0349 0.0528
Mycobacterium leprae Probable two component sensor kinase MprB 0.0018 0.0084 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0084 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0169 0.2667 0.3484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0349 0.0528
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0264 0.0383
Schistosoma mansoni protein farnesyltransferase subunit beta 0.002 0.0107 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0536 0.0843
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0057 0.0754 0.1211
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.2683 0.4472
Brugia malayi nuclear receptor RXR 0.0024 0.0173 0.0231
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.013 0.0157
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0176 0.0161
Echinococcus granulosus carbonic anhydrase 0.0082 0.1171 0.1916
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0107 0.0043
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0082 0.1171 0.1916
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0129 0.1984 0.3239
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.002 0.0107 0.0038
Brugia malayi nuclear receptor NHR-88 0.0045 0.0536 0.0843
Schistosoma mansoni DNA helicase recq1 0.002 0.011 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0548 0.0864
Brugia malayi hypothetical protein 0.0021 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0076
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.011 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0536 0.0843
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0536 0.0773
Schistosoma mansoni coup transcription factor 0.0045 0.0536 0.0661
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0084 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.06 0.0746
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0536 0.0661
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0536 0.0661
Entamoeba histolytica recQ family helicase, putative 0.002 0.011 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0618 0.0982
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Onchocerca volvulus 0.0021 0.013 0.0082
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.002 0.0107 0.0043
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0637 0.0941
Loa Loa (eye worm) hypothetical protein 0.0082 0.1171 0.1916
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0173 0.0181
Loa Loa (eye worm) hypothetical protein 0.003 0.0283 0.0416
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0637 0.1014
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0693 0.1109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0536 0.0843
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0066 0.0905 0.1402
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0084 0.0004
Echinococcus multilocularis carbonic anhydrase 0.0082 0.1171 0.1916
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1984 0.3236
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0121 0.0112
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0361 0.5955 1
Toxoplasma gondii DNA polymerase family B protein 0.0057 0.0754 0.1144
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0176 0.0161
Brugia malayi hypothetical protein 0.0018 0.0082 0.0076
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0637 0.0941
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.011 0.0048
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0084 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0107 0.0038
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0107 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0118
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0536 0.0843
Echinococcus granulosus intermediate filament protein 0.0054 0.0693 0.1109
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0536 0.0843
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.002 0.0107 0.0038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0198 0.0271
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0107 0.0043
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.385 0.6443
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0173 0.0181
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0159 0.2489 0.4098
Echinococcus granulosus carbonic anhydrase 0.0082 0.1171 0.1916
Schistosoma mansoni thyroid hormone receptor 0.017 0.2683 0.3505
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0536 0.0843
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3857 0.6428
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0389 0.0308
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0072 0.0998 0.156
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0107 0.0043
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0107 0.0043
Brugia malayi hypothetical protein 0.0021 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0123 0.1883 0.3119
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0361 0.5955 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0048
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0129 0.1984 0.3239
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0536 0.0661
Brugia malayi Nuclear hormone receptor E75 0.0021 0.013 0.0157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.013 0.0157
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1916 0.3174
Plasmodium vivax geranylgeranyltransferase, putative 0.002 0.0107 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.013 0.0157
Brugia malayi Nuclear hormone receptor E75 0.0021 0.013 0.0157
Echinococcus multilocularis lamin dm0 0.0054 0.0693 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0754 0.1144
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.002 0.0107 0.0118
Brugia malayi Bloom's syndrome protein homolog 0.002 0.011 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0536 0.0843
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0107 0.0118
Brugia malayi hypothetical protein 0.0238 0.385 0.6443
Schistosoma mansoni lamin 0.0054 0.0693 0.087
Onchocerca volvulus 0.003 0.0283 0.0343
Onchocerca volvulus 0.0049 0.06 0.0883
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0536 0.0843
Brugia malayi conserved hypotetical protein 0.0021 0.013 0.0157
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.008 0.1139 0.1139
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.011 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0548 0.0864
Brugia malayi DNA polymerase delta catalytic subunit 0.0361 0.5955 1
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0173 0.0231
Schistosoma mansoni DNA helicase recq5 0.002 0.011 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.1181 0.1934
Leishmania major geranylgeranyltransferase, putative 0.002 0.0107 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.385 0.6443
Loa Loa (eye worm) hypothetical protein 0.0025 0.0198 0.0271
Loa Loa (eye worm) hypothetical protein 0.0082 0.1171 0.1916
Loa Loa (eye worm) hypothetical protein 0.005 0.0618 0.0982
Trypanosoma brucei carbonic anhydrase-like protein 0.0174 0.2755 0.4549
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0169 0.2667 0.4444
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0389 0.0596
Brugia malayi bZIP transcription factor family protein 0.0082 0.1181 0.1934
Brugia malayi Pre-SET motif family protein 0.0209 0.3361 0.5616
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0361 0.5955 1
Brugia malayi hypothetical protein 0.0024 0.0173 0.0231
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0107 0.0043
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.002 0.0107 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0536 0.0843
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0361 0.5955 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0754 0.1211
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.002 0.0107 0.0043
Toxoplasma gondii exonuclease III APE 0.0018 0.0084 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Loa Loa (eye worm) hypothetical protein 0.008 0.1143 0.1868
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0173 0.0231
Onchocerca volvulus 0.0054 0.0693 0.1041
Schistosoma mansoni hypothetical protein 0.0125 0.1916 0.2488
Schistosoma mansoni cathepsin D (A01 family) 0.0018 0.0082 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0618 0.0982
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0138 0.2136 0.3494
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.06 0.0952
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0107 0.0093
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0169 0.2667 0.4444
Onchocerca volvulus 0.0036 0.0389 0.0524
Onchocerca volvulus Huntingtin homolog 0.0123 0.1883 0.3066
Brugia malayi nuclear hormone receptor 0.0021 0.013 0.0157
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0176 0.0161
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0637 0.1014
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0018 0.0084 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0548 0.0864
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.013 0.0157
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0174 0.2755 0.4592
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0637 0.0941
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0118
Onchocerca volvulus 0.0054 0.0693 0.1041
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.002 0.0107 0.0038
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1916 0.3174
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0018 0.0082 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0536 0.0843
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.011 0.0044
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0215 0.03
Loa Loa (eye worm) hypothetical protein 0.0082 0.1171 0.1916
Schistosoma mansoni cathepsin D (A01 family) 0.0018 0.0082 0.006
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.011 0.0123
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.013 0.0123
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.002 0.0107 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0283 0.0326
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0536 0.0843
Plasmodium falciparum protein farnesyltransferase subunit beta 0.002 0.0107 0.0043
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.013 0.0157
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.2755 0.36
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.3361 0.5616
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0072 0.0998 0.156
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0018 0.0084 0.0084
Schistosoma mansoni ap endonuclease 0.0018 0.0084 0.0063
Brugia malayi Pepsin A precursor 0.0018 0.0082 0.0076
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.013 0.0157
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0536 0.0843
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.013 0.0157
Leishmania major farnesyltransferase beta subunit 0.002 0.0107 0.0038
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0107 0.0118
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0173 0.0231
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0018 0.0084 0.0084
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.002 0.0107 0.0038
Schistosoma mansoni ap endonuclease 0.0018 0.0084 0.0063
Echinococcus multilocularis carbonic anhydrase 0.0082 0.1171 0.1916
Brugia malayi tailless protein 0.0021 0.013 0.0157
Schistosoma mansoni intermediate filament proteins 0.0054 0.0693 0.087
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.002 0.0107 0.0093
Schistosoma mansoni hypothetical protein 0.0067 0.0916 0.1165
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Brugia malayi PAS domain containing protein 0.0049 0.0608 0.0964
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0018 0.0084 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.013 0.0082
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0084 0.0084
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0637 0.1014
Onchocerca volvulus 0.0045 0.0536 0.0773
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.013 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0021 0.013 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0536 0.0843
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.036 0.5938 0.7815
Brugia malayi DNA polymerase alpha catalytic subunit 0.0159 0.2489 0.4143
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0536 0.0843
Schistosoma mansoni carbonic anhydrase 0.0082 0.1171 0.1502
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0173 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Plasmodium vivax farnesyltransferase beta subunit, putative 0.002 0.0107 0.0043
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0107 0.0043
Trypanosoma cruzi lanosterol synthase, putative 0.0144 0.2246 0.3681
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0637 0.1014
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0026 0.0219 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0536 0.0843
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0129 0.1984 0.3239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0084 0.008
Echinococcus granulosus carbonic anhydrase II 0.0174 0.2755 0.4592
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Brugia malayi hypothetical protein 0.0123 0.1883 0.3119
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.002 0.0107 0.0038
Schistosoma mansoni zinc finger protein 0.0021 0.013 0.0123
Trypanosoma brucei protein kinase, putative 0.0051 0.0637 0.0941
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0536 0.0661
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0361 0.5955 1
Echinococcus granulosus lamin dm0 0.0054 0.0693 0.1109
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0138 0.2136 0.3497
Brugia malayi hypothetical protein 0.0065 0.0878 0.1421
Loa Loa (eye worm) hypothetical protein 0.0238 0.385 0.6443
Loa Loa (eye worm) hypothetical protein 0.0057 0.0754 0.1211
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0536 0.0843
Brugia malayi DNA polymerase family B containing protein 0.0129 0.1984 0.329
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.013 0.0157
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0215 0.03
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.1171 0.1502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.013 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0548 0.0677
Brugia malayi nuclear receptor NHR-88 0.0021 0.013 0.0157
Schistosoma mansoni single-minded 0.0049 0.0608 0.0756
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0637 0.0795
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0536 0.0843
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.013 0.0157
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0361 0.5955 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0637 0.0941
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0536 0.0661
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0018 0.0084 0.0084
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0536 0.0773
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0138 0.2136 0.3494
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0231
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0283 0.0416
Loa Loa (eye worm) hypothetical protein 0.0053 0.0676 0.1081
Toxoplasma gondii DNA polymerase 0.0361 0.5955 1
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0057 0.0754 0.114
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0048
Echinococcus multilocularis carbonic anhydrase 0.0082 0.1171 0.1916
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0176 0.0161
Loa Loa (eye worm) RecQ helicase 0.002 0.011 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0637 0.0945
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Plasmodium vivax DNA polymerase alpha, putative 0.0159 0.2489 0.4098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0548 0.0864
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0129 0.1984 0.2579
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0129 0.1984 0.3239
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.011 0.0044
Brugia malayi steroid hormone receptor 0.0045 0.0536 0.0843
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0107 0.0038
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0608 0.0756
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0361 0.5955 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0536 0.0843
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0176 0.0161
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0129 0.1984 0.329
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0536 0.0843
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0057 0.0754 0.1144
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0084 0.5
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0129 0.1984 0.329
Plasmodium falciparum geranylgeranyltransferase, putative 0.002 0.0107 0.0043
Echinococcus granulosus carbonic anhydrase 0.0082 0.1171 0.1916
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0107 0.0043
Brugia malayi hypothetical protein 0.0024 0.0173 0.0231
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0107 0.0043
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0283 0.0416
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0361 0.5955 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0018 0.0082 0.0076
Loa Loa (eye worm) DR-78 0.0021 0.013 0.0157
Trypanosoma cruzi lanosterol synthase, putative 0.0144 0.2246 0.3681
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.1181 0.1934
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.013 0.0157
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0107 0.0043
Schistosoma mansoni nuclear receptor 0.0021 0.013 0.0123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0536 0.0843
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0123
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0693 0.1109
Loa Loa (eye worm) hypothetical protein 0.019 0.3021 0.5042
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0084 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0283 0.0343
Onchocerca volvulus 0.0238 0.3857 0.6428
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0536 0.0843
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0129 0.1984 0.3239
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0361 0.5955 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.1883 0.3066
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0637 0.0941
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Brugia malayi hypothetical protein 0.0164 0.2585 0.4306
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0637 0.0945
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0536 0.0843
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0107 0.0118
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1984 0.3236
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0264 0.0384
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.013 0.0082
Plasmodium vivax SET domain protein, putative 0.003 0.0283 0.0343
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0057 0.0754 0.114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0076
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.011 0.0048
Echinococcus granulosus jun protein 0.0082 0.1181 0.1934
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.002 0.0107 0.0043
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0536 0.0661
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.03
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0637 0.0945
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0176 0.0161
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0082 0.1171 0.1916
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0536 0.0661
Toxoplasma gondii DNA polymerase family B protein 0.0129 0.1984 0.3239
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0536 0.0843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0536 0.0843
Brugia malayi aspartic protease BmAsp-1, identical 0.0018 0.0082 0.0076
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.013 0.0157
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0138 0.2136 0.3494
Schistosoma mansoni jun-related protein 0.0067 0.0916 0.1165
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0361 0.5955 1
Echinococcus granulosus lamin 0.0054 0.0693 0.1109
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0693 0.1109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0548 0.0677
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0283 0.0326
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.1171 0.1502
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.1171 0.1502
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0084 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0536 0.0843
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0018 0.0084 0.0084
Trichomonas vaginalis DNA polymerase II, putative 0.0138 0.2136 0.3497
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0637 0.0945
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0536 0.0661
Plasmodium falciparum carbonic anhydrase 0.0082 0.1171 0.1854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0536 0.0843
Brugia malayi ecdysone receptor 0.0021 0.013 0.0157
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.011 0.0123
Loa Loa (eye worm) hypothetical protein 0.0164 0.2585 0.4306
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0129 0.1984 0.3236
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.011 0.0123
Echinococcus granulosus single minded 2 0.0036 0.0389 0.0596
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.011 0.0048
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0361 0.5955 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0283 0.0326
Echinococcus multilocularis carbonic anhydrase II 0.0174 0.2755 0.4592
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0174 0.2755 0.4592
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.011 0.0044
Schistosoma mansoni memapsin-2 (A01 family) 0.0456 0.7587 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0264 0.0383
Mycobacterium ulcerans short chain dehydrogenase 0.0596 1 1
Leishmania major lanosterol synthase, putative 0.0125 0.1906 0.3104
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0129 0.1984 0.329
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0536 0.0843
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0637 0.0941
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0637 0.0945
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0018 0.0084 0.0084
Giardia lamblia Prenyltransferase 0.002 0.0107 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0536 0.0843
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0107 0.0093
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0637 0.1014
Echinococcus multilocularis lamin 0.0054 0.0693 0.1109
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0031 0.0302 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0536 0.0843
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0283 0.0416
Trypanosoma brucei protein farnesyltransferase beta subunit 0.002 0.0107 0.0038
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.011 0.0123
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0066 0.0905 0.1398
Brugia malayi intermediate filament protein 0.0054 0.0693 0.1109
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0084 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0536 0.0843
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0107 0.0038
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0057 0.0754 0.114
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.013 0.0157
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0289 0.4725 0.7904
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0536 0.0843
Echinococcus multilocularis musashi 0.0054 0.0693 0.1109
Schistosoma mansoni lamin 0.0054 0.0693 0.087
Loa Loa (eye worm) hypothetical protein 0.0072 0.0998 0.1624
Echinococcus granulosus bloom syndrome protein 0.002 0.011 0.0123
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0018 0.0082 0.0076
Brugia malayi Eukaryotic aspartyl protease family protein 0.0018 0.0082 0.0076
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.013 0.0123
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0536 0.0661
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0076
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0176 0.0161
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.019 0.3021 0.5004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0536 0.0843
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0123
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0107 0.0038
Trypanosoma brucei lanosterol synthase 0.0144 0.2246 0.3681
Onchocerca volvulus DNA polymerase homolog 0.0129 0.1984 0.3239
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0536 0.0843
Echinococcus granulosus protein farnesyltransferase subunit beta 0.002 0.0107 0.0118
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.002 0.0107 0.0118
Brugia malayi Pre-SET motif family protein 0.003 0.0283 0.0416
Loa Loa (eye worm) hypothetical protein 0.0072 0.0998 0.1624
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.1171 0.1916
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0018 0.0084 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0536 0.0773
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1984 0.3236
Brugia malayi nuclear receptor RXR 0.0021 0.013 0.0157
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.1171 0.1916
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0536 0.0843
Loa Loa (eye worm) hypothetical protein 0.0026 0.0219 0.0307
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0536 0.0843
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0129 0.1984 0.2579
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0637 0.0941
Loa Loa (eye worm) carbonic anhydrase 3 0.0174 0.2755 0.4592
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0389 0.0596
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0176 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0018 0.0084 0.0084
Brugia malayi nuclear receptor NHR-67 0.0021 0.013 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0548 0.0864
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0536 0.0843
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.0843
Loa Loa (eye worm) hypothetical protein 0.0123 0.1883 0.3119
Schistosoma mansoni survival motor neuron protein 0.0049 0.06 0.0746
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.2755 0.36
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0536 0.0843
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.2367 0.3937
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.2755 0.4592
Schistosoma mansoni thyroid hormone receptor 0.017 0.2683 0.3505
Echinococcus multilocularis jun protein 0.0082 0.1181 0.1934
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1984 0.3236
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0129 0.1984 0.3236
Schistosoma mansoni hypothetical protein 0.0082 0.1171 0.1502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0536 0.0843
Schistosoma mansoni hypothetical protein 0.0034 0.0349 0.0414
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0129 0.1984 0.329
Brugia malayi MAP kinase sur-1 0.0051 0.0637 0.1014
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0637 0.0941
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0157
Giardia lamblia DNA polymerase alpha subunit A 0.0097 0.1437 0.2304
Loa Loa (eye worm) aspartyl protease 6 0.0018 0.0082 0.0076
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.013 0.0157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0548 0.0864
Brugia malayi hypothetical protein 0.0018 0.0082 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0536 0.0843
Brugia malayi nuclear hormone receptor 0.0045 0.0536 0.0843
Onchocerca volvulus 0.0065 0.0878 0.1355
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0072 0.0998 0.1624
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0283 0.0326
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0618 0.0982
Brugia malayi ecdysteroid receptor 0.0045 0.0536 0.0843
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0107 0.0043
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0018 0.0082 0.0076
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.013 0.0157
Leishmania major carbonic anhydrase-like protein 0.0174 0.2755 0.4549
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.1171 0.1916
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0536 0.0843
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0536 0.0843
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.002 0.0107 0.0118
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.011 0.0048
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0082 0.1171 0.1916
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0129 0.1984 0.329
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0084 0.008
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0361 0.5955 0.7839
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.2755 0.4549
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0082 0.006
Brugia malayi hypoxia-induced factor 1 0.0152 0.2367 0.3937
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0084 0.008

Activities

Activity type Activity value Assay description Source Reference
Drug uptake (ADMET) = 32 % Drug accumulation in Saccharomyces cerevisiae AD12345678 reenergized with glucose at pH 6.0 assessed as intracellular accumulation after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 32 % Drug accumulation in Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump reenergized with glucose at pH 6.0 assessed as intracellular accumulation after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 32 % Drug accumulation in Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump reenergized with glucose at pH 6.0 after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 1.36 nmol/min Drug uptake in Saccharomyces cerevisiae ADMDR1 expressing Candida albicans MDR1 efflux pump at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 1.44 nmol/min Drug uptake in Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 1.48 nmol/min Drug uptake in Saccharomyces cerevisiae AD12345678 at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
Drug uptake (ADMET) = 1.81 nmol/min Drug uptake in Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump at 200 uM pretreated for 10 mins measured after 60 mins by fluorescamine staining ChEMBL. 18794383
MIC (functional) = 2 ug ml-1 Antifungal activity against Saccharomyces cerevisiae ADCDR1 expressing Candida albicans CDR1 efflux pump in YNPG medium containing 1 mg/ml 1-glutamate after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 4 ug ml-1 Antifungal activity against fluconazole resistant Candida albicans isolate Gu5 overexpressing CDR1 and CDR2 in RPMI-1640 buffered medium after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 4 ug ml-1 Antifungal activity against Saccharomyces cerevisiae ADCDR2 expressing Candida albicans CDR2 efflux pump in YNPG medium containing 1 mg/ml 1-glutamate after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 8 ug ml-1 Antifungal activity against Saccharomyces cerevisiae AD12345678 in YNPG medium containing 1 mg/ml 1-glutamate after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 8 ug ml-1 Antifungal activity against wild type Saccharomyces cerevisiae ATCC 9763 in YNPG medium containing 1 mg/ml 1-glutamate after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 16 ug ml-1 Antifungal activity against fluconazole sensitive Candida albicans isolate B3 in RPMI-1640 buffered medium after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 16 ug ml-1 Antifungal activity against fluconazole sensitive Candida albicans isolate Gu4 in RPMI-1640 buffered medium after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 16 ug ml-1 Antifungal activity against wild type Candida albicans 10261 in RPMI-1640 buffered medium after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 16 ug ml-1 Antifungal activity against Saccharomyces cerevisiae ADMDR1 expressing Candida albicans MDR1 efflux pump in YNPG medium containing 1 mg/ml 1-glutamate after 24 hrs by microdilution method ChEMBL. 18794383
MIC (functional) = 31 ug ml-1 Compound was tested for its lowest concentration at which growth of H-317 strain of C. albicans was clearly inhibited. ChEMBL. 1992114
MIC (functional) = 31 ug ml-1 Compound was tested for its lowest concentration at which growth of 124 strain of C. albicans was clearly inhibited. ChEMBL. 1992114
MIC (functional) = 31 ug ml-1 Compound was tested for its lowest concentration at which growth of 124N5 strain of C. albicans was clearly inhibited. ChEMBL. 1992114
MIC (functional) = 32 ug ml-1 Antifungal activity against fluconazole resistant Candida albicans isolate B4 overexpressing MDR1 in RPMI-1640 buffered medium after 24 hrs by microdilution method ChEMBL. 18794383

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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