Detailed information for compound 1488923

Basic information

Technical information
  • TDR Targets ID: 1488923
  • Name: (2R,3R,4S,5R)-2-(6-amino-2-ethylaminopurin-9- yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • MW: 310.309 | Formula: C12H18N6O4
  • H donors: 5 H acceptors: 6 LogP: -1.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
  • InChi: 1S/C12H18N6O4/c1-2-14-12-16-9(13)6-10(17-12)18(4-15-6)11-8(21)7(20)5(3-19)22-11/h4-5,7-8,11,19-21H,2-3H2,1H3,(H3,13,14,16,17)/t5-,7-,8-,11-/m1/s1
  • InChiKey: DSGZNQAGMVUXBZ-IOSLPCCCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5R)-2-(6-amino-2-ethylamino-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(6-amino-2-ethylamino-9-purinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(6-amino-2-ethylamino-purin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(6-amino-2-ethylamino-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0169 0.046
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0114 0.1296 1
Brugia malayi hypothetical protein 0.0413 0.4891 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0169 0.0144
Brugia malayi Animal haem peroxidase family protein 0.0413 0.4891 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1451
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0169 0.0144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0346
Loa Loa (eye worm) beta-lactamase 0.0073 0.0802 0.164
Treponema pallidum NADH oxidase 0.0022 0.0188 1
Loa Loa (eye worm) thioredoxin reductase 0.0064 0.0689 0.1409
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0157 0.2218
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0029 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0802 0.0802
Schistosoma mansoni peroxidasin 0.0413 0.4891 0.4891
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0114 0.1296 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0322
Trichomonas vaginalis abcb9, putative 0.0021 0.0169 0.2028
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0802 0.1408
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0229 0.1616
Brugia malayi hypothetical protein 0.0025 0.0229 0.0468
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0029 0.00000000039554
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0169 0.046
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0689 0.5316
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0064 0.0689 0.1203
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0043 0.0089
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0802 0.0779
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Trypanosoma brucei trypanothione reductase 0.0064 0.0689 0.5154
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0818 0.6308
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0045 0.0045
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0182 0.2185
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Loa Loa (eye worm) hypothetical protein 0.0073 0.0802 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Mycobacterium ulcerans lipase LipD 0.0073 0.0802 1
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0169 0.2028
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0188 0.0295
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0114 0.1296 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0157 0.0322
Echinococcus multilocularis microtubule associated protein 2 0.0715 0.8534 0.853
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0092
Leishmania major cysteine peptidase A (CPA) 0.002 0.0157 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0229 0.3264
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0138 0.0283
Loa Loa (eye worm) fibroinase 0.002 0.0157 0.0322
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Brugia malayi Animal haem peroxidase family protein 0.0413 0.4891 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0802 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.002
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2739 0.5601
Brugia malayi hypothetical protein 0.0302 0.3559 0.7276
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0802 0.1408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0092
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0117 0.024
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0725 0.5442
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Onchocerca volvulus Cathepsin L homolog 0.002 0.0157 0.0269
Mycobacterium ulcerans sulfatase 0.0009 0.0027 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0725 0.0702
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0045 0.0038
Brugia malayi beta-lactamase 0.0073 0.0802 0.164
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0045 0.0092
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0169 0.2028
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.008 0.0208
Brugia malayi hypothetical protein 0.0028 0.0256 0.0524
Schistosoma mansoni microtubule-associated protein tau 0.0715 0.8534 0.8534
Brugia malayi hypothetical protein 0.0016 0.012 0.0246
Plasmodium vivax vivapain-3 0.001 0.0043 0.0541
Echinococcus multilocularis geminin 0.0515 0.6124 0.6114
Onchocerca volvulus 0.0073 0.0802 0.1594
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0092
Onchocerca volvulus 0.002 0.0157 0.0269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0802 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0169 0.046
Echinococcus granulosus protein cereblon 0.0302 0.3559 0.3542
Schistosoma mansoni apoferritin-2 0.0009 0.0025 0.0025
Onchocerca volvulus 0.002 0.0157 0.0269
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0061 0.0663
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0029 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Loa Loa (eye worm) blistered cuticle protein 3 0.0413 0.4891 1
Plasmodium falciparum thioredoxin reductase 0.0064 0.0689 1
Brugia malayi Animal haem peroxidase family protein 0.0413 0.4891 1
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0027 0.0231
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.002
Loa Loa (eye worm) animal heme peroxidase 0.0413 0.4891 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0188 0.2344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0098 0.0098
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1576 0.1576
Trichomonas vaginalis abcb9, putative 0.0021 0.0169 0.2028
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0818 0.6308
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.006 0.0034
Entamoeba histolytica hypothetical protein, conserved 0.0302 0.3559 1
Schistosoma mansoni multidrug resistance protein 0.0021 0.0169 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0157 0.1877
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0045 0.0045
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0169 0.2028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0045 0.002
Brugia malayi Cathepsin L-like precursor 0.002 0.0157 0.0322
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0169 0.1134
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0169 0.2394
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0045 0.0045
Brugia malayi Peroxidasin 0.0413 0.4891 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Schistosoma mansoni hypothetical protein 0.0011 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0045 0.0092
Trichomonas vaginalis rotamase, putative 0.0034 0.0328 0.4032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0092
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0157 0.0426
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0027 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0802 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Onchocerca volvulus 0.001 0.0045 0.0038
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0188 0.1286
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0029 0.0346
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0188 0.1286
Brugia malayi Animal haem peroxidase family protein 0.0413 0.4891 1
Schistosoma mansoni hypothetical protein 0.0127 0.1453 0.1453
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0045 0.0045
Echinococcus multilocularis cysteine protease 0.002 0.0157 0.0132
Loa Loa (eye worm) hypothetical protein 0.0013 0.008 0.0163
Schistosoma mansoni ferritin light chain 0.0009 0.0025 0.0025
Loa Loa (eye worm) ctsf protein 0.002 0.0157 0.0322
Brugia malayi tumor suppressor. 0.0328 0.387 0.7914
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0188 0.1155
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0328 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0725 0.5594
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0114 0.1296 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0157 0.0426
Brugia malayi Cathepsin L-like precursor 0.0013 0.008 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0802 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0256 0.0524
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0043 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0484 0.046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0083 0.0936
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0169 0.0144
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0083 0.0936
Echinococcus multilocularis cysteine protease 0.002 0.0157 0.0132
Brugia malayi hypothetical protein 0.0123 0.1403 0.2868
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Schistosoma mansoni hypothetical protein 0.0837 1 1
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0188 0.1155
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0188 0.0384
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0169 0.046
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0027 0.0231
Leishmania major cathepsin L-like protease 0.002 0.0157 0.0892
Brugia malayi Animal haem peroxidase family protein 0.0413 0.4891 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0229 0.1765
Echinococcus multilocularis protein quaking 0.0028 0.0256 0.0231
Brugia malayi glutathione reductase 0.0064 0.0689 0.1409
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0169 0.2028
Mycobacterium ulcerans hydrolase 0.0009 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0055
Onchocerca volvulus Cathepsin L homolog 0.002 0.0157 0.0269
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0098 0.0073
Brugia malayi nuclear hormone receptor 0.001 0.0045 0.0092
Echinococcus multilocularis peroxidasin 0.0413 0.4891 0.4878
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0188 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Onchocerca volvulus Chorion peroxidase homolog 0.0413 0.4891 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0188 0.0295
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0169 0.0346
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0169 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0043 0.0441
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0341
Schistosoma mansoni multidrug resistance protein 0.0021 0.0169 0.0169
Brugia malayi beta-lactamase family protein 0.0073 0.0802 0.164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0043 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0182 0.0157
Echinococcus granulosus protein quaking 0.0028 0.0256 0.0231
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0043 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.002
Brugia malayi nuclear receptor NHR-88 0.001 0.0045 0.0092
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0046 0.1254
Trypanosoma cruzi cysteine protease, putative 0.001 0.0043 0.0335
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0046 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Brugia malayi multidrug resistance protein 3 0.0021 0.0169 0.0346
Schistosoma mansoni multidrug resistance protein 0.0021 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Plasmodium vivax vivapain-2 0.002 0.0157 0.1961
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0188 0.2344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0319 0.2184
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0083 0.0936
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0169 0.2028
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Echinococcus granulosus peroxidasin 0.0413 0.4891 0.4878
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0157 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0114 0.1296 1
Mycobacterium ulcerans hypothetical protein 0.0073 0.0802 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0114 0.1296 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0802 0.164
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0043 0.0043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0092
Echinococcus granulosus cysteine protease 0.001 0.0043 0.0018
Toxoplasma gondii cathepsin CPL 0.002 0.0157 0.1037
Loa Loa (eye worm) hypothetical protein 0.0176 0.2043 0.4178
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0027 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0045 0.002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0157 0.0322
Onchocerca volvulus Peroxidase homolog 0.0413 0.4891 1
Echinococcus granulosus cpg binding protein 0.0062 0.067 0.0646
Onchocerca volvulus 0.002 0.0157 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.008 0.0163
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0043 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0837 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0229 0.148
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.0167 0.0142
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0802 0.1408
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Loa Loa (eye worm) animal heme peroxidase 0.0413 0.4891 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0045 0.0092
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0188 0.0163
Loa Loa (eye worm) hypothetical protein 0.0073 0.0802 0.164
Plasmodium falciparum thioredoxin reductase 0.0022 0.0188 0.2667
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0626 0.483
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0061 0.0121
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0188 0.2263
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0188 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0043 0.0335
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0319 0.246
Brugia malayi Sulfatase family protein 0.0009 0.0027 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0802 0.6189
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0095 0.1089
Brugia malayi steroid hormone receptor 0.001 0.0045 0.0092
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0169 0.2028
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0029 0.006
Schistosoma mansoni ferritin light chain 0.0009 0.0025 0.0025
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0045 0.0038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0188 0.2093
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0319 0.0881
Schistosoma mansoni hypothetical protein 0.0515 0.6124 0.6124
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0043 0.0106
Plasmodium falciparum glutathione reductase 0.0064 0.0689 1
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0802 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0083 0.0936
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0188 0.0295
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0725 0.0725
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0188 0.0163
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0328 0.0672
Onchocerca volvulus 0.0176 0.2043 0.4146
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0802 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.1423 0.1423
Onchocerca volvulus Peroxidase homolog 0.0413 0.4891 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0725 0.0702
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0046 0.0133
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Schistosoma mansoni hypothetical protein 0.0515 0.6124 0.6124
Trypanosoma brucei calpain, putative 0.0114 0.1296 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0098 0.0073
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0169 0.0144
Mycobacterium tuberculosis Conserved protein 0.0073 0.0802 0.1408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0188 0.0188
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0061 0.014
Brugia malayi Thioredoxin reductase 0.0064 0.0689 0.1409
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0169 0.2028
Loa Loa (eye worm) animal heme peroxidase 0.0413 0.4891 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0319 0.246
Loa Loa (eye worm) hypothetical protein 0.0025 0.0229 0.0468
Schistosoma mansoni myst-related protein 0.0007 0.0006 0.0006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0046 0.0353
Loa Loa (eye worm) hypothetical protein 0.0073 0.0802 0.164
Schistosoma mansoni hypothetical protein 0.0028 0.0256 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0802 1
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Plasmodium vivax vivapain-1 0.001 0.0043 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Loa Loa (eye worm) hypothetical protein 0.0073 0.0802 0.164
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.378 0.773
Mycobacterium leprae Probable lipase LipE 0.0073 0.0802 1
Onchocerca volvulus 0.002 0.0157 0.0269
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0027 0.0017
Brugia malayi Cathepsin L-like precursor 0.0013 0.008 0.0163
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0188 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0029 0.0004
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0114 0.1296 1
Loa Loa (eye worm) tumor suppressor 0.0328 0.387 0.7914
Brugia malayi cathepsin L-like precursor 0.0013 0.008 0.0163
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0043 0.0335
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1137
Trichomonas vaginalis taga, putative 0.0021 0.0169 0.2028
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0229 0.2852
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Onchocerca volvulus 0.0013 0.008 0.0109
Trypanosoma brucei calpain-like protein, putative 0.0114 0.1296 1
Onchocerca volvulus 0.0021 0.0169 0.0293
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0157 0.0322
Leishmania major cathepsin L-like protease 0.002 0.0157 0.0892
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0169 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0008 0.00000000055641
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0157 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0092
Leishmania major cathepsin L-like protease 0.002 0.0157 0.0892
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.008 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0141 0.0116
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0169 0.0144
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0188 0.1137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Schistosoma mansoni cpg binding protein 0.0062 0.067 0.067
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0095 0.007
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0725 0.1483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1451
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0484 0.046
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0167 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0188 0.1137
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0188 0.2667
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0157 0.1214
Mycobacterium ulcerans beta-lactamase 0.0073 0.0802 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0169 0.2111
Loa Loa (eye worm) glutathione reductase 0.0064 0.0689 0.1409
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0043 0.0335
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0043 0.0043
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0169 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Schistosoma mansoni cpg binding protein 0.0059 0.063 0.063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0725 0.2025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0725 0.5594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0083 0.0936
Onchocerca volvulus Peroxidasin homolog 0.0413 0.4891 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0157 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0169 0.2028
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0022 0.0188 0.2093
Entamoeba histolytica cysteine protease, putative 0.002 0.0157 0.0426
Schistosoma mansoni rotamase 0.0034 0.0328 0.0328
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0169 0.0144
Leishmania major cathepsin L-like protease 0.0074 0.0818 0.6173
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0157 0.0132
Trichomonas vaginalis ferritin, putative 0.0009 0.0025 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Schistosoma mansoni ferritin 0.0009 0.0025 0.0025
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0169 0.046
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Plasmodium vivax vivapain-2 0.002 0.0157 0.1961
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Onchocerca volvulus 0.0073 0.0802 0.1594
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0141 0.0116
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0092
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0725 0.5433
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0029 0.017
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0169 0.0144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Onchocerca volvulus 0.0073 0.0802 0.1594
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0027 0.0017
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0157 0.2218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0484 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0045 0.002
Brugia malayi Cathepsin L-like precursor 0.002 0.0157 0.0322
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0256 0.0524
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0346
Leishmania major p-glycoprotein 0.0021 0.0169 0.0988
Brugia malayi Cathepsin L-like precursor 0.002 0.0157 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0043 0.0441
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.5544 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0092
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0802 0.1408
Brugia malayi ABC transporter family protein 0.0021 0.0169 0.0346
Schistosoma mansoni smdr2 0.0021 0.0169 0.0169
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.015 0.2115
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0157 0.0132
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0027 0.0002
Brugia malayi beta-lactamase family protein 0.0073 0.0802 0.164
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0188 0.2093
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0098 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0043 0.0106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0802 0.0802
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Echinococcus granulosus expressed protein 0.0034 0.0328 0.0304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0328 0.4032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0092
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0043 0.0043
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0045 0.0092
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Schistosoma mansoni ferritin 0.0009 0.0025 0.0025
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0188 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0092
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0045 0.002
Onchocerca volvulus 0.0413 0.4891 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0169 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0157 0.1877
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0027 0.0017
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0188 0.2263
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0169 0.1134
Leishmania major hypothetical protein, conserved 0.0073 0.0802 0.605
Plasmodium vivax glutathione reductase, putative 0.0064 0.0689 0.859
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0802 0.1408
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.006 0.0034
Plasmodium falciparum glutathione reductase 0.0022 0.0188 0.2667
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Schistosoma mansoni ferritin 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0264
Echinococcus multilocularis cathepsin L 0.001 0.0043 0.0018
Toxoplasma gondii ABC1 family protein 0.0073 0.0802 0.6265
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0098 0.1219
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.1576 0.1555
Schistosoma mansoni peroxidasin 0.0413 0.4891 0.4891
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1137
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0188 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0157 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0537
Onchocerca volvulus Protein cereblon homolog 0.0302 0.3559 0.7262
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0188 0.1451
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0802 0.6189
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0043 0.0106
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0802 1
Loa Loa (eye worm) animal heme peroxidase 0.0413 0.4891 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0098 0.0073
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0169 0.2028
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0141 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0802 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0188 0.1155
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1451
Trichomonas vaginalis rotamase, putative 0.0033 0.0319 0.3912
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1576 0.1576
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0157 0.0157
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0029 0.006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0484 0.0989
Brugia malayi CXXC zinc finger family protein 0.0059 0.063 0.1288
Schistosoma mansoni apoferritin-2 0.0009 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0045 0.002
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1453 0.1432
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0045 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0092
Loa Loa (eye worm) RecQ helicase 0.0022 0.0182 0.0372
Echinococcus multilocularis thioredoxin glutathione reductase 0.0064 0.0689 0.0665
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0169 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.002
Echinococcus granulosus geminin 0.0515 0.6124 0.6114
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0169 0.0144
Brugia malayi hypothetical protein 0.0009 0.0027 0.0055
Leishmania major cathepsin L-like protease 0.002 0.0157 0.0892
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0043 0.0106
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1263 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0046 0.0353
Leishmania major hypothetical protein, conserved 0.0025 0.0229 0.1464
Loa Loa (eye worm) hypothetical protein 0.0073 0.0802 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Trichomonas vaginalis abcb9, putative 0.0021 0.0169 0.2028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0802 0.164
Onchocerca volvulus 0.0059 0.063 0.124
Echinococcus multilocularis protein cereblon 0.0302 0.3559 0.3542
Schistosoma mansoni myst-related protein 0.0007 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0302 0.3559 0.7276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2739 0.5601
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0725 0.1483
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0024 0.0024
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0061 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Schistosoma mansoni coup transcription factor 0.001 0.0045 0.0045
Mycobacterium tuberculosis Conserved protein 0.0073 0.0802 0.1408
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Onchocerca volvulus Cathepsin F homolog 0.002 0.0157 0.0269
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0169 0.0261
Echinococcus granulosus hypothetical protein 0.0028 0.0256 0.0231
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0114 0.1296 1
Onchocerca volvulus 0.002 0.0157 0.0269
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0818 0.6308
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0157 0.2218
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0045 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.008 0.0898
Onchocerca volvulus Peroxidasin homolog 0.0413 0.4891 1
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0387 0.0363
Echinococcus granulosus microtubule associated protein 2 0.0715 0.8534 0.853
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0188 0.2093
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0027 0.0002
Schistosoma mansoni hypothetical protein 0.0302 0.3559 0.3559
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Onchocerca volvulus 0.0413 0.4891 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0182 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1451
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0169 0.046
Schistosoma mansoni hypothetical protein 0.0028 0.0256 0.0256
Brugia malayi hypothetical protein 0.0176 0.2043 0.4178
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0169 0.2028
Onchocerca volvulus 0.002 0.0157 0.0269
Brugia malayi Blistered cuticle protein 3 0.0413 0.4891 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0802 0.1408
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0061 0.047
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0045 0.0092
Echinococcus granulosus cathepsin L 0.001 0.0043 0.0018
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0169 0.2028
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0095 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Leishmania major cathepsin L-like protease 0.002 0.0157 0.0892
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0083 0.0936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0083 0.0936
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0387 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Plasmodium vivax unspecified product 0.001 0.0043 0.0541
Entamoeba histolytica cysteine proteinase 2 0.001 0.0043 0.0106
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0319 0.2199
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0157 0.0132
Schistosoma mansoni DNA helicase recq5 0.0009 0.0029 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0802 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0157 0.0322
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.063 0.1288
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0802 0.164
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.074 0.5709
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0319 0.2347
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0484 0.0989
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0027 0.0017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0802 0.1408
Echinococcus granulosus cathepsin l1 0.0013 0.008 0.0054
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0188 0.0295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0188 0.1451
Brugia malayi ecdysteroid receptor 0.001 0.0045 0.0092
Echinococcus granulosus bloom syndrome protein 0.0022 0.0182 0.0157
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0802 0.6057
Leishmania major cathepsin L-like protease 0.0074 0.0818 0.6173
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0818 0.6308
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0188 0.1451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0484 0.046
Schistosoma mansoni ferritin 0.0009 0.0025 0.0025
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0169 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0013 0.008 0.0163
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0169 0.0144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.002
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0045 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0092
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0802 0.1408
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0169 0.046
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0029 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0188 0.1451
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0117 0.024
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0169 0.0988
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0043 0.055
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0029 0.0004
Trypanosoma brucei hypothetical protein 0.0114 0.1296 1
Loa Loa (eye worm) hypothetical protein 0.0413 0.4891 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0083 0.0936
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0229 0.3264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.008 0.0898
Trichomonas vaginalis helicase, putative 0.0013 0.0083 0.0936
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.002
Onchocerca volvulus 0.002 0.0157 0.0269
Toxoplasma gondii thioredoxin reductase 0.0064 0.0689 0.5348
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0092
Echinococcus multilocularis cpg binding protein 0.0062 0.067 0.0646
Brugia malayi Cathepsin L-like precursor 0.002 0.0157 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Onchocerca volvulus Dual oxidase homolog 0.0413 0.4891 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.008 0.0163
Echinococcus granulosus thioredoxin glutathione reductase 0.0064 0.0689 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0818 0.6181
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0169 0.2028
Echinococcus granulosus FTZ F1 alpha 0.001 0.0045 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0229 0.1765
Echinococcus multilocularis expressed protein 0.0034 0.0328 0.0304
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0182 0.2185
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0188 0.2667
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1453 0.1432
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0083 0.0936
Trichomonas vaginalis esterase, putative 0.0073 0.0802 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Loa Loa (eye worm) cysteine protease 0.002 0.0157 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0027 0.0231
Entamoeba histolytica cysteine protease, putative 0.001 0.0043 0.0106
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0127 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0484 0.046
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0092
Leishmania major trypanothione reductase 0.0064 0.0689 0.5145
Leishmania major cathepsin L-like protease 0.0074 0.0818 0.6173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0157 0.1877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0157 0.1877
Echinococcus granulosus cathepsin l1 0.002 0.0157 0.0132
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.002
Onchocerca volvulus 0.0413 0.4891 1
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0095 0.007
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0169 0.0144
Schistosoma mansoni DNA helicase recq1 0.0009 0.0029 0.0029
Schistosoma mansoni nuclear hormone receptor 0.001 0.0045 0.0045
Schistosoma mansoni cpg binding protein 0.0062 0.067 0.067
Plasmodium vivax thioredoxin reductase, putative 0.0064 0.0689 0.859

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) mM Inhibition of Trypanosoma brucei Phosphoglycerate kinase (PGK). ChEMBL. 11063610
Ki (binding) = 29.8 uM Inhibition of calf placental adenosine deaminase by Lineweaver-Burk plot analysis ChEMBL. 21138280

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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