Detailed information for compound 1504106

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 269.204 | Formula: C11H9F2N3O3
  • H donors: 1 H acceptors: 4 LogP: 1.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)C(Cn1cnc(c1)[N+](=O)[O-])O
  • InChi: 1S/C11H9F2N3O3/c12-7-1-2-8(9(13)3-7)10(17)4-15-5-11(14-6-15)16(18)19/h1-3,5-6,10,17H,4H2
  • InChiKey: DLILHSWOKIAQMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0712 0.0733
Brugia malayi tubulin alpha chain - mouse 0.0185 0.3318 0.3799
Trypanosoma cruzi epsilon tubulin, putative 0.0133 0.2273 0.4734
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni tubulin subunit alpha 0.0185 0.3318 0.3258
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.3318 0.6179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.2685 0.3075
Schistosoma mansoni tubulin subunit alpha 0.0058 0.0781 0.0699
Loa Loa (eye worm) tubulin alpha 2 0.0128 0.2173 0.2488
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0643 0.0736
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0361 0.022
Loa Loa (eye worm) hypothetical protein 0.0185 0.3318 0.38
Echinococcus granulosus expressed conserved protein 0.0284 0.5292 0.5292
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0712 0.0629
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi beta-lactamase 0.0036 0.0361 0.0413
Echinococcus multilocularis protein patched 0.013 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.0414
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0645 0.1178
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0645 0.143
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0128 0.2173 0.3785
Leishmania major hypothetical protein, conserved 0.0051 0.0645 0.1178
Schistosoma mansoni tubulin subunit alpha 0.0185 0.3318 0.3258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Giardia lamblia Alpha-tubulin 0.0185 0.3318 0.6872
Brugia malayi hypothetical protein 0.0051 0.0645 0.0738
Brugia malayi alpha-tubulin 0.0185 0.3318 0.3799
Trichomonas vaginalis tubulin alpha chain, putative 0.0075 0.1128 0.1602
Schistosoma mansoni hypothetical protein 0.0105 0.172 0.1646
Plasmodium falciparum tubulin delta chain, putative 0.0058 0.0781 0.1732
Loa Loa (eye worm) hypothetical protein 0.0049 0.06 0.0688
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.06 0.06
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0361 0.0414
Brugia malayi Tubulin beta-1 chain 0.0245 0.4504 0.5158
Trypanosoma cruzi alpha tubulin, putative 0.0185 0.3318 0.72
Trypanosoma brucei beta tubulin 0.0133 0.2273 0.49
Echinococcus granulosus muscleblind protein 0.0159 0.2792 0.2792
Trichomonas vaginalis tubulin, putative 0.0075 0.1128 0.1602
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.0414
Leishmania major beta tubulin 0.0245 0.4504 1
Plasmodium falciparum alpha tubulin 1 0.0185 0.3318 0.7366
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0712 0.1048
Echinococcus multilocularis beta tubulin 0.0245 0.4504 0.4504
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0712 0.0712
Schistosoma mansoni hypothetical protein 0.0434 0.8277 0.8262
Echinococcus granulosus Tubulin alpha 1 chain 0.0185 0.3318 0.3318
Loa Loa (eye worm) tubulin beta-4 chain 0.0245 0.4504 0.5158
Trypanosoma cruzi epsilon tubulin, putative 0.0133 0.2273 0.4734
Plasmodium vivax delta tubulin, putative 0.0058 0.0781 0.1732
Schistosoma mansoni hypothetical protein 0.0049 0.06 0.0517
Echinococcus multilocularis tubulin alpha chain 0.0185 0.3318 0.3318
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0645 0.143
Trichomonas vaginalis tubulin gamma chain, putative 0.0133 0.2273 0.3996
Echinococcus granulosus cpg binding protein 0.0063 0.088 0.088
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Loa Loa (eye worm) BEN-1 protein 0.0245 0.4504 0.5158
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0307 0.5751 0.5713
Trypanosoma cruzi zeta tubulin, putative 0.0058 0.0781 0.121
Schistosoma mansoni glutaminase 0.0277 0.5146 0.5103
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.013 0.0286
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0361 0.0801
Loa Loa (eye worm) hypothetical protein 0.011 0.1825 0.2091
Echinococcus multilocularis Tubulin alpha 1 chain 0.0185 0.3318 0.3318
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.1392 0.1392
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0712 0.0712
Trypanosoma cruzi tubulin gamma chain 0.0133 0.2273 0.4734
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0361 0.0462
Toxoplasma gondii ABC1 family protein 0.0036 0.0361 0.0801
Echinococcus granulosus tubulin alpha chain 0.0185 0.3318 0.3318
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0361 0.0559
Echinococcus multilocularis tubulin delta chain 0.0058 0.0781 0.0781
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.8277 0.8277
Loa Loa (eye worm) hypothetical protein 0.0457 0.8732 1
Brugia malayi Tubulin beta chain 0.0058 0.0781 0.0893
Schistosoma mansoni cpg binding protein 0.0063 0.088 0.0799
Schistosoma mansoni tyrosine kinase 0.0051 0.0643 0.0559
Giardia lamblia Delta tubulin 0.0058 0.0781 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0434 0.8277 0.8277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Plasmodium falciparum tubulin gamma chain 0.0133 0.2273 0.5046
Echinococcus multilocularis Tubulin beta 2C chain 0.0245 0.4504 0.4504
Loa Loa (eye worm) glutaminase 0.0277 0.5146 0.5894
Echinococcus granulosus tubulin delta chain 0.0058 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis Tubulin beta 2C chain 0.0245 0.4504 0.4504
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0268 0.0594
Echinococcus granulosus peroxisome assembly protein 26 0.0185 0.3318 0.3318
Mycobacterium ulcerans lipase LipD 0.0036 0.0361 0.0462
Brugia malayi Cell division protein ftsZ 0.0058 0.0781 0.0893
Trichomonas vaginalis tubulin, putative 0.0075 0.1128 0.1602
Trypanosoma brucei protein kinase, putative 0.0054 0.0712 0.1332
Echinococcus multilocularis Tubulin alpha 1 chain 0.0185 0.3318 0.3318
Echinococcus granulosus epidermal growth factor receptor 0.0085 0.1329 0.1329
Leishmania major beta tubulin 0.0245 0.4504 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0361 0.0559
Loa Loa (eye worm) tubulin gamma chain 0.0133 0.2273 0.2604
Echinococcus granulosus tubulin alpha chain 0.0185 0.3318 0.3318
Schistosoma mansoni hypothetical protein 0.0049 0.06 0.0517
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0268 0.0317
Trypanosoma brucei alpha tubulin 0.0185 0.3318 0.7288
Echinococcus multilocularis beta tubulin 0.0245 0.4504 0.4504
Echinococcus granulosus Tubulin alpha 1 chain 0.0185 0.3318 0.3318
Echinococcus granulosus Tubulin beta 2C chain 0.0245 0.4504 0.4504
Brugia malayi glutaminase DH11.1 0.0277 0.5146 0.5893
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0268 0.0594
Schistosoma mansoni hypothetical protein 0.0521 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0712 0.0712
Onchocerca volvulus 0.0457 0.8732 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0712 0.0712
Echinococcus granulosus epidermal growth factor receptor 0.0158 0.2787 0.2787
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0545 0.0545
Mycobacterium leprae cell division protein FtsZ 0.0058 0.0781 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0185 0.3318 0.6179
Toxoplasma gondii alpha tubulin TUBA1 0.0185 0.3318 0.7366
Mycobacterium tuberculosis Conserved protein 0.0036 0.0361 0.0559
Brugia malayi Tubulin alpha chain 0.0058 0.0781 0.0893
Brugia malayi Muscleblind-like protein 0.0159 0.2792 0.3197
Echinococcus multilocularis cpg binding protein 0.0063 0.088 0.088
Echinococcus granulosus Tubulin beta 2C chain 0.0245 0.4504 0.4504
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0361 0.0361
Echinococcus multilocularis tubulin alpha chain 0.0185 0.3318 0.3318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus beta tubulin 0.0245 0.4504 0.4504
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0712 0.0816
Echinococcus granulosus tubulin alpha chain 0.0185 0.3318 0.3318
Loa Loa (eye worm) hypothetical protein 0.0105 0.172 0.197
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0268 0.0307
Echinococcus granulosus Protein patched homolog 1 0.013 0.222 0.222
Schistosoma mansoni tyrosine kinase 0.0158 0.2787 0.2722
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0268 0.0317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0361 0.0276
Loa Loa (eye worm) alpha-tubulin 0.0185 0.3318 0.38
Schistosoma mansoni hypothetical protein 0.0521 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.2792 0.3197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.06 0.0688
Loa Loa (eye worm) beta-tubulin 0.0245 0.4504 0.5158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0085 0.1329 0.1251
Trichomonas vaginalis tubulin alpha chain, putative 0.0075 0.1128 0.1602
Schistosoma mansoni tyrosine kinase 0.0085 0.1329 0.1251
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.06 0.06
Echinococcus multilocularis Tubulin beta 2C chain 0.0245 0.4504 0.4504
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Brugia malayi Niemann-Pick C1 protein precursor 0.0303 0.5657 0.6479
Trypanosoma cruzi beta tubulin, putative 0.0245 0.4504 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.2792 0.3197
Plasmodium vivax tubulin gamma chain, putative 0.0133 0.2273 0.5046
Leishmania major zeta tubulin, putative 0.0058 0.0781 0.1489
Entamoeba histolytica tubulin family protein 0.0245 0.4504 0.7914
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.1392 0.1316
Trichomonas vaginalis tubulin epsilon chain, putative 0.0245 0.4504 0.8658
Trichomonas vaginalis tubulin gamma chain, putative 0.0245 0.4504 0.8658
Trypanosoma brucei beta tubulin 0.0245 0.4504 1
Leishmania major beta tubulin 0.0245 0.4504 1
Brugia malayi CXXC zinc finger family protein 0.0059 0.0813 0.0931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0361 0.0276
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0361 0.0559
Echinococcus multilocularis hypothetical protein 0.0185 0.3318 0.3318
Echinococcus multilocularis tubulin epsilon chain 0.0133 0.2273 0.2273
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Trichomonas vaginalis tubulin alpha chain, putative 0.0075 0.1128 0.1602
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0361 0.0559
Schistosoma mansoni tubulin subunit beta 0.0245 0.4504 0.4455
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.013 0.222 0.2542
Leishmania major epsilon tubulin, putative 0.0133 0.2273 0.49
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Giardia lamblia Beta tubulin 0.0245 0.4504 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0158 0.2787 0.3191
Echinococcus multilocularis insulin receptor 0.0051 0.0643 0.0643
Echinococcus granulosus GPCR family 2 0.0049 0.06 0.06
Echinococcus multilocularis tubulin alpha chain 0.0185 0.3318 0.3318
Trichomonas vaginalis tubulin alpha chain, putative 0.0133 0.2273 0.3996
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0268 0.0268
Schistosoma mansoni alpha tubulin 0.0185 0.3318 0.3258
Echinococcus multilocularis tubulin beta 1 chain 0.0245 0.4504 0.4504
Toxoplasma gondii alpha-tubulin I, putative 0.0185 0.3318 0.7366
Loa Loa (eye worm) tubulin alpha chain 0.0185 0.3318 0.38
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0303 0.5657 1
Plasmodium vivax tubulin beta chain, putative 0.0245 0.4504 1
Schistosoma mansoni cpg binding protein 0.0059 0.0813 0.0731
Plasmodium vivax tubulin alpha chain, putative 0.0185 0.3318 0.7366
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0361 0.0413
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.013 0.0286
Echinococcus multilocularis tubulin gamma 1 chain 0.0133 0.2273 0.2273
Trypanosoma brucei zeta tubulin, putative 0.0058 0.0781 0.1489
Schistosoma mansoni tubulin subunit epsilon 0.0133 0.2273 0.2204
Echinococcus multilocularis tubulin alpha 3 chain 0.0185 0.3318 0.3318
Echinococcus granulosus tubulin subunit TubB 0.0185 0.3318 0.3318
Schistosoma mansoni tubulin subunit beta 0.0058 0.0781 0.0699
Schistosoma mansoni cpg binding protein 0.0063 0.088 0.0799
Echinococcus multilocularis epidermal growth factor receptor 0.0158 0.2787 0.2787
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1867 0.4144
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0712 0.1332
Schistosoma mansoni hypothetical protein 0.0125 0.2127 0.2057
Onchocerca volvulus 0.0075 0.1128 0.1291
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0128 0.2173 0.2488
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) alpha-tubulin 0.0185 0.3318 0.38
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trichomonas vaginalis tubulin alpha chain, putative 0.0245 0.4504 0.8658
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) beta-lactamase 0.0036 0.0361 0.0414
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0268 0.0317
Entamoeba histolytica tubulin alpha-1 chain 0.0185 0.3318 0.5768
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Brugia malayi beta-tubulin, identical 0.0245 0.4504 0.5158
Brugia malayi Furin-like cysteine rich region family protein 0.0158 0.2787 0.3191
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0268 0.0268
Echinococcus multilocularis peroxisome assembly protein 26 0.0185 0.3318 0.3318
Onchocerca volvulus 0.0036 0.0361 0.0413
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.06 0.0517
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0268 0.0594
Trichomonas vaginalis tubulin, putative 0.0245 0.4504 0.8658
Brugia malayi Tubulin gamma chain 0.0133 0.2273 0.2603
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0268 0.0306
Trypanosoma brucei beta tubulin 0.0245 0.4504 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0268 0.0268
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.2134 0.2064
Giardia lamblia Beta tubulin 0.0245 0.4504 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.013 0.0286
Echinococcus multilocularis tubulin alpha 1C chain 0.0185 0.3318 0.3318
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0361 0.022
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0085 0.1329 0.1329
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.06 0.06
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0058 0.0781 0.0877
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0545 0.0624
Leishmania major beta tubulin 0.0245 0.4504 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0245 0.4504 0.5158
Echinococcus multilocularis tubulin alpha chain 0.0185 0.3318 0.3318
Loa Loa (eye worm) hypothetical protein 0.0303 0.5657 0.6479
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0545 0.0545
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0361 0.0559
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0088 0.0088
Brugia malayi Tubulin alpha-2 chain 0.0185 0.3318 0.3799
Brugia malayi Tubulin alpha-2 chain 0.0185 0.3318 0.3799
Schistosoma mansoni tubulin subunit delta 0.0058 0.0781 0.0699
Trichomonas vaginalis tubulin epsilon chain, putative 0.0245 0.4504 0.8658
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0058 0.0781 0.1732
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Trypanosoma brucei beta tubulin 0.0245 0.4504 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.0414
Echinococcus granulosus Niemann Pick C1 protein 0.0433 0.8242 0.8242
Leishmania major beta tubulin 0.0245 0.4504 1
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.3318 0.6179
Schistosoma mansoni tyrosine kinase 0.0084 0.1311 0.1233
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.1392 0.1594
Plasmodium vivax tubulin epsilon chain, putative 0.0133 0.2273 0.5046
Trypanosoma brucei alpha tubulin 0.0185 0.3318 0.7288
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Schistosoma mansoni patched 1 0.013 0.222 0.2151
Toxoplasma gondii beta-1 tubulin, putative 0.0245 0.4504 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0185 0.3318 0.38
Trypanosoma brucei tubulin gamma chain 0.0133 0.2273 0.49
Loa Loa (eye worm) tubulin alpha 2 0.0128 0.2173 0.2488
Mycobacterium ulcerans beta-lactamase 0.0036 0.0361 0.0462
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0245 0.4504 0.4504
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) glutaminase 2 0.0277 0.5146 0.5894
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0645 0.143
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0712 0.1048
Trypanosoma brucei alpha tubulin, putative 0.0075 0.1128 0.2282
Giardia lamblia Beta tubulin 0.0245 0.4504 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0645 0.143
Echinococcus granulosus Tubulin alpha 1 chain 0.0185 0.3318 0.3318
Echinococcus granulosus tubulin alpha 1C chain 0.0185 0.3318 0.3318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis tubulin subunit beta 0.0245 0.4504 0.4504
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0643 0.0643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis tubulin alpha chain 0.0185 0.3318 0.3318
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.3318 0.6179
Brugia malayi Tubulin alpha chain 0.0185 0.3318 0.3799
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0268 0.0334
Mycobacterium ulcerans cell division protein FtsZ 0.0058 0.0781 0.1298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.06 0.06
Echinococcus multilocularis 0.0049 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0128 0.2173 0.2488
Schistosoma mansoni tubulin subunit beta 0.0245 0.4504 0.4455
Brugia malayi Latrophilin receptor protein 2 0.0049 0.06 0.0687
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0712 0.0733
Leishmania major beta tubulin 0.0245 0.4504 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0781 0.0877
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.013 0.222 0.2542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus tubulin alpha chain 0.0185 0.3318 0.3318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trichomonas vaginalis tubulin gamma chain, putative 0.0058 0.0781 0.0877
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.3318 0.6179
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.3318 0.6179
Mycobacterium ulcerans glutaminase 0.0277 0.5146 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0645 0.0889
Echinococcus multilocularis tubulin alpha 1C chain 0.0185 0.3318 0.3318
Echinococcus multilocularis muscleblind protein 0.0159 0.2792 0.2792
Toxoplasma gondii beta tubulin 0.0245 0.4504 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0712 0.1048
Brugia malayi CHE-14 protein 0.013 0.222 0.2542
Schistosoma mansoni hypothetical protein 0.0125 0.2127 0.2057
Trypanosoma brucei alpha tubulin 0.0185 0.3318 0.7288
Schistosoma mansoni hypothetical protein 0.0125 0.2127 0.2057
Brugia malayi Protein kinase domain containing protein 0.0051 0.0643 0.0735
Plasmodium vivax tubulin alpha chain, putative 0.0185 0.3318 0.7366
Onchocerca volvulus 0.0036 0.0361 0.0413
Schistosoma mansoni tubulin subunit beta 0.0245 0.4504 0.4455
Mycobacterium ulcerans hypothetical protein 0.0036 0.0361 0.0462
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Treponema pallidum cell division protein FtsZ 0.0058 0.0781 1
Echinococcus granulosus beta tubulin 0.0245 0.4504 0.4504
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trichomonas vaginalis tubulin epsilon chain, putative 0.0058 0.0781 0.0877
Brugia malayi beta-lactamase family protein 0.0036 0.0361 0.0413
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0001
Trichomonas vaginalis glutaminase, putative 0.0277 0.5146 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0185 0.3318 0.3318
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0088 0.0088
Loa Loa (eye worm) tubulin alpha-3 chain 0.011 0.1825 0.2091
Echinococcus multilocularis Tubulin beta 2C chain 0.0245 0.4504 0.4504
Giardia lamblia Alpha-tubulin 0.0185 0.3318 0.6872
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Leishmania major delta tubulin, putative 0.0058 0.0781 0.1489
Trypanosoma brucei beta tubulin 0.0245 0.4504 1
Leishmania major beta tubulin 0.0245 0.4504 1
Schistosoma mansoni tubulin subunit beta 0.0245 0.4504 0.4455
Leishmania major beta tubulin 0.0245 0.4504 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0185 0.3318 0.3318
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0361 0.0462
Trypanosoma brucei epsilon tubulin 0.0133 0.2273 0.49
Mycobacterium tuberculosis Conserved protein 0.0036 0.0361 0.0559
Schistosoma mansoni tyrosine kinase 0.0051 0.0643 0.0559
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0075 0.1128 0.1602
Leishmania major beta tubulin 0.0245 0.4504 1
Echinococcus multilocularis tubulin subunit TubB 0.0185 0.3318 0.3318
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0813 0.0931
Trypanosoma cruzi tubulin delta chain 0.0058 0.0781 0.121
Trichomonas vaginalis tubulin beta chain, putative 0.0075 0.1128 0.1602
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.4272 1
Giardia lamblia Epsilon tubulin 0.0058 0.0781 0.0181
Echinococcus granulosus Tubulin beta 2C chain 0.0245 0.4504 0.4504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0545 0.0461
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.0414
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0645 0.0889
Echinococcus granulosus tubulin alpha 1C chain 0.0185 0.3318 0.3318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0545 0.0461
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0712 0.1048
Brugia malayi tubulin alpha-2 chain 0.0185 0.3318 0.3799
Trichomonas vaginalis tubulin, putative 0.0058 0.0781 0.0877
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0153 0.2685 0.3075
Echinococcus granulosus alpha tubulin 0.0185 0.3318 0.3318
Trypanosoma cruzi zeta tubulin, putative 0.0058 0.0781 0.121
Trypanosoma brucei zeta tubulin 0.0058 0.0781 0.1489
Leishmania major beta tubulin 0.0245 0.4504 1
Trichomonas vaginalis tubulin beta chain, putative 0.0245 0.4504 0.8658
Schistosoma mansoni alpha tubulin 0.0185 0.3318 0.3258
Echinococcus granulosus Tubulin beta 2C chain 0.0245 0.4504 0.4504
Entamoeba histolytica tubulin family protein 0.0245 0.4504 0.7914
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0268 0.0594
Echinococcus multilocularis sterol regulatory element binding protein 0.013 0.222 0.222
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Schistosoma mansoni alpha tubulin 0.0185 0.3318 0.3258
Schistosoma mansoni tubulin subunit alpha 0.0185 0.3318 0.3258
Echinococcus granulosus tubulin alpha 3 chain 0.0185 0.3318 0.3318
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0781 0.0877
Loa Loa (eye worm) tubulin beta-1 chain 0.0245 0.4504 0.5158
Mycobacterium leprae Probable lipase LipE 0.0036 0.0361 0.3558
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.06 0.0687
Echinococcus granulosus tubulin beta 4A class IVa 0.0245 0.4504 0.4504
Schistosoma mansoni hypothetical protein 0.0125 0.2127 0.2057
Giardia lamblia Gamma tubulin 0.0133 0.2273 0.4117
Brugia malayi hypothetical protein 0.0457 0.8732 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.1392 0.1595
Onchocerca volvulus 0.0036 0.0361 0.0413
Schistosoma mansoni hypothetical protein 0.0055 0.0728 0.0646
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0361 0.3558
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.013 0.0286
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0268 0.0268
Trypanosoma brucei epsilon tubulin 0.0133 0.2273 0.49
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.2685 0.3074
Loa Loa (eye worm) tubulin beta chain 0.0058 0.0781 0.0894
Loa Loa (eye worm) tubulin beta chain 0.0245 0.4504 0.5158
Echinococcus multilocularis muscleblind protein 1 0.0159 0.2792 0.2792
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0545 0.0461
Schistosoma mansoni tyrosine kinase 0.0084 0.1311 0.1233
Trypanosoma brucei tubulin delta chain 0.0058 0.0781 0.1489
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.0414
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0361 0.0559
Echinococcus multilocularis Tubulin beta 2C chain 0.0245 0.4504 0.4504
Mycobacterium tuberculosis Cell division protein FtsZ 0.0058 0.0781 0.1572
Trypanosoma brucei alpha tubulin 0.0185 0.3318 0.7288
Loa Loa (eye worm) hypothetical protein 0.0051 0.0645 0.0738
Leishmania major beta tubulin 0.0245 0.4504 1
Leishmania major beta tubulin 0.0245 0.4504 1
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.3318 0.6179
Schistosoma mansoni hypothetical protein 0.0049 0.06 0.0517
Brugia malayi isocitrate dehydrogenase 0.0032 0.0268 0.0306
Echinococcus granulosus sterol regulatory element binding protein 0.013 0.222 0.222
Echinococcus multilocularis Niemann Pick C1 protein 0.0433 0.8242 0.8242
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.2685 0.3074
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0643 0.0643
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0185 0.3318 0.6179
Echinococcus granulosus tubulin subunit beta 0.0245 0.4504 0.4504
Loa Loa (eye worm) BEN-1 protein 0.0245 0.4504 0.5158
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0712 0.0733
Brugia malayi hypothetical protein 0.0033 0.0287 0.0328
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0058 0.0781 0.1732
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.172 0.1969
Leishmania major beta tubulin 0.0245 0.4504 1
Schistosoma mansoni tubulin subunit beta 0.0245 0.4504 0.4455
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0545 0.0623
Loa Loa (eye worm) tubulin alpha 2 0.0053 0.068 0.0779
Leishmania major beta tubulin 0.0245 0.4504 1
Leishmania major beta tubulin 0.0245 0.4504 1
Leishmania major beta tubulin 0.0245 0.4504 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Plasmodium falciparum tubulin beta chain 0.0245 0.4504 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0268 0.0182
Echinococcus multilocularis tubulin alpha 0.0133 0.2273 0.2273
Entamoeba histolytica tubulin gamma chain 0.0133 0.2273 0.3878
Trypanosoma brucei epsilon tubulin 0.0133 0.2273 0.49
Echinococcus granulosus Niemann Pick C1 protein 0.0303 0.5657 0.5657
Plasmodium falciparum alpha tubulin 2 0.0185 0.3318 0.7366
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0058 0.0781 1
Leishmania major alpha tubulin 0.0185 0.3318 0.7288
Mycobacterium tuberculosis Conserved protein 0.0036 0.0361 0.0559
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.0414
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0712 0.1332
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0712 0.0733
Echinococcus multilocularis expressed conserved protein 0.0284 0.5292 0.5292
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0361 0.0559
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.011 0.1825 0.306
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0712 0.158
Onchocerca volvulus 0.0059 0.0813 0.0931
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0268 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.013 0.222 0.3884
Leishmania major gamma-tubulin 0.0133 0.2273 0.49
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0159 0.2801 0.3208
Echinococcus granulosus tubulin alpha 0.0133 0.2273 0.2273
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0712 0.1332
Toxoplasma gondii beta-tubulin, putative 0.0245 0.4504 1
Schistosoma mansoni tubulin subunit gamma 0.0133 0.2273 0.2204
Schistosoma mansoni tubulin subunit beta 0.0245 0.4504 0.4455
Trichomonas vaginalis tubulin epsilon chain, putative 0.0185 0.3318 0.6179
Trichomonas vaginalis tubulin gamma chain, putative 0.0133 0.2273 0.3996
Trypanosoma cruzi tubulin delta chain 0.0058 0.0781 0.121
Leishmania major beta tubulin 0.0245 0.4504 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis GPCR, family 2 0.0049 0.06 0.06
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0361 0.0361
Brugia malayi MAP kinase sur-1 0.0054 0.0712 0.0815
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis geminin 0.0521 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0133 0.2273 0.5046
Brugia malayi Tubulin beta chain 0.0075 0.1128 0.1291
Echinococcus multilocularis protein dispatched 1 0.0148 0.2585 0.2585
Onchocerca volvulus 0.0088 0.1392 0.1594
Brugia malayi beta-lactamase family protein 0.0036 0.0361 0.0413
Echinococcus granulosus insulin receptor 0.0051 0.0643 0.0643
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0268 0.0268
Echinococcus granulosus tubulin alpha chain 0.0185 0.3318 0.3318
Echinococcus granulosus Tubulin beta 2C chain 0.0245 0.4504 0.4504
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0361 0.053
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.1392 0.1392
Entamoeba histolytica tubulin alpha chain, putative 0.0185 0.3318 0.5768
Plasmodium falciparum tubulin epsilon chain, putative 0.0133 0.2273 0.5046
Echinococcus multilocularis epidermal growth factor receptor 0.0085 0.1329 0.1329
Loa Loa (eye worm) tubulin alpha chain 0.0185 0.3318 0.38
Echinococcus granulosus tubulin beta 1 chain 0.0245 0.4504 0.4504
Schistosoma mansoni tyrosine kinase 0.0084 0.1311 0.1233
Leishmania major beta tubulin 0.0245 0.4504 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.013 0.5
Echinococcus granulosus tubulin epsilon chain 0.0133 0.2273 0.2273
Echinococcus granulosus tubulin gamma 1 chain 0.0133 0.2273 0.2273
Leishmania major hypothetical protein, conserved 0.0036 0.0361 0.053
Echinococcus multilocularis Niemann Pick C1 protein 0.0303 0.5657 0.5657
Echinococcus granulosus tubulin alpha 3 chain 0.0185 0.3318 0.3318

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 256 ug ml-1 Antifungal activity against Candida albicans ATCC 90027 after 48 hrs by broth microdilution method ChEMBL. 21277200
MIC (functional) = 256 ug ml-1 Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis H37Rv after 7 days by alamar blue assay ChEMBL. 21277200

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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