TDR Targets

Basic information

Technical information

TDR Targets ID: 1509123
Name: 3-cyclobutyl-1-(1H-indol-6-yl)imidazo[5,1-c]p yrazin-8-amine
MW: 303.361 | Formula: C18H17N5
H donors: 2 H acceptors: 2 LogP: 3.34 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nccn2c1c(nc2C1CCC1)c1ccc2c(c1)[nH]cc2
InChi: 1S/C18H17N5/c19-17-16-15(13-5-4-11-6-7-20-14(11)10-13)22-18(12-2-1-3-12)23(16)9-8-21-17/h4-10,12,20H,1-3H2,(H2,19,21)
InChiKey: AITKPBKDPLVETG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-cyclobutyl-1-(1H-indol-6-yl)-8-imidazo[5,1-c]pyrazinamine
[3-cyclobutyl-1-(1H-indol-6-yl)imidazo[5,1-c]pyrazin-8-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0717	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0116	0.1647	0.1647
Giardia lamblia	Kinesin-5	0.0054	0.0726	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0022	0.0263	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0022	0.0263	0.5
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0116	0.1647	0.1647
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0022	0.0263	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0022	0.0263	0.5
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	0.1647
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0395	0.0395
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0351	0.0351
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0395	0.0395
Echinococcus granulosus	activated cdc42 kinase 1	0.02	0.2884	0.2884
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0351	0.0351
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0395	0.0395
Brugia malayi	cytochrome P450	0.0022	0.0263	0.0263
Onchocerca volvulus		0.0031	0.0395	0.0395
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0022	0.0263	0.5
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0116	0.1647	0.1647
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0717	0.0717
Echinococcus multilocularis	transfer RNA-Thr	0.02	0.2884	0.2884
Schistosoma mansoni	lamin	0.0028	0.0351	0.0351
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0395	0.0395
Schistosoma mansoni	kinesin eg-5	0.0054	0.0726	0.0726
Toxoplasma gondii	hypothetical protein	0.0116	0.1647	1
Toxoplasma gondii	kinesin motor domain-containing protein	0.0054	0.0726	0.3347
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0073	0.0073
Brugia malayi	Protein kinase domain containing protein	0.02	0.2884	0.2884
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0717	1
Brugia malayi	MAP kinase sur-1	0.0053	0.0717	0.0717
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Echinococcus multilocularis	activated cdc42 kinase 1	0.02	0.2884	0.2884
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0717	1
Echinococcus granulosus	intermediate filament protein	0.0028	0.0351	0.0351
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0717	0.328
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Loa Loa (eye worm)	CYP4Cod1	0.0031	0.0396	0.0396
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0022	0.0263	0.5
Onchocerca volvulus		0.0116	0.1647	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1083	0.1083
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0022	0.0263	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0395	0.0395
Echinococcus multilocularis		0.0022	0.0263	0.0263
Leishmania major	cytochrome p450-like protein	0.0031	0.0396	0.2934
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1068	0.1068
Brugia malayi	Cytochrome P450 family protein	0.0081	0.1134	0.1134
Echinococcus granulosus	lamin dm0	0.0028	0.0351	0.0351
Schistosoma mansoni	lamin	0.0028	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0131	0.0131
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0022	0.0263	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0116	0.1647	0.1647
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0717	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0396	0.0396
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0351	0.0351
Echinococcus granulosus	activated cdc42 kinase 1	0.02	0.2884	0.2884
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0031	0.0396	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0138	0.0138
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0078	0.1083	0.1083
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0022	0.0263	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0116	0.1647	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Loa Loa (eye worm)	cytochrome P450 family protein	0.0081	0.1134	0.1134
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0116	0.1647	0.1647
Brugia malayi	Kinesin motor domain containing protein	0.0054	0.0726	0.0726
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0022	0.0263	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Trypanosoma brucei	cytochrome P450, putative	0.0031	0.0396	0.2934
Onchocerca volvulus		0.0028	0.0351	0.0351
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0022	0.0263	0.5
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0116	0.1647	0.1647
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0717	0.0717
Schistosoma mansoni	hypothetical protein	0.0176	0.2524	0.2524
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.3499	0.3499
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0717	0.0717
Plasmodium vivax	kinesin-5	0.0054	0.0726	0.2644
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0396	0.0396
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0022	0.0263	0.5
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0022	0.0263	0.5
Trypanosoma brucei	protein kinase, putative	0.0053	0.0717	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0022	0.0263	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0078	0.1083	0.1083
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0116	0.1647	0.1647
Plasmodium falciparum	transporter, putative	0.0116	0.1647	1
Onchocerca volvulus		0.0116	0.1647	0.1647
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Schistosoma mansoni	sodium/chloride dependent transporter	0.0117	0.1654	0.1654
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0022	0.0263	0.5
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0116	0.1647	0.1647
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	1
Echinococcus multilocularis	kinesin family 1	0.0412	0.5994	0.5994
Schistosoma mansoni	cytochrome P450	0.0022	0.0263	0.0263
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	1
Plasmodium vivax	hypothetical protein, conserved	0.0116	0.1647	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0022	0.0263	0.5
Schistosoma mansoni	hypothetical protein	0.0176	0.2524	0.2524
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	0.1647
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.016	0.016
Brugia malayi	hypothetical protein	0.0116	0.1647	0.1647
Toxoplasma gondii	hypothetical protein	0.0116	0.1647	1
Plasmodium falciparum	amino acid transporter, putative	0.0116	0.1647	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	0.1647
Echinococcus multilocularis	lamin	0.0028	0.0351	0.0351
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0116	0.1647	0.1647
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.0263	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0343	0.0343
Echinococcus granulosus	lamin	0.0028	0.0351	0.0351
Brugia malayi	intermediate filament protein	0.0028	0.0351	0.0351
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.3499	0.3499
Schistosoma mansoni	sodium/chloride dependent transporter	0.0116	0.1647	0.1647
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0396	0.0396
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0395	0.0955
Echinococcus multilocularis	musashi	0.0028	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1068	0.1068
Loa Loa (eye worm)	cytochrome P450	0.0022	0.0263	0.0263
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0378	0.0378
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0717	0.0717
Schistosoma mansoni	tyrosine kinase	0.0078	0.1083	0.1083
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0116	0.1647	0.1647
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0131	0.0131
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0395	0.0395
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0054	0.0726	0.0726
Trypanosoma cruzi	cytochrome P450, putative	0.0031	0.0396	0.2934
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0717	0.0717
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0116	0.1647	0.1647
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0116	0.1647	0.1647
Schistosoma mansoni	hypothetical protein	0.0359	0.5207	0.5207
Onchocerca volvulus		0.0116	0.1647	0.1647
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	0.1647
Mycobacterium leprae	putative cytochrome p450	0.0022	0.0263	0.5
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0717	0.0717
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.016	0.016
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	0.1647
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0395	0.0395
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.3553	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0717	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0022	0.0263	0.5
Loa Loa (eye worm)	hypothetical protein	0.0199	0.2869	0.2869
Onchocerca volvulus		0.0028	0.0351	0.0351
Trypanosoma cruzi	cytochrome P450, putative	0.0031	0.0396	0.2934
Brugia malayi	Pre-SET motif family protein	0.0031	0.0395	0.0395
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.3114	0.3114
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0396	0.0396
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0022	0.0263	0.5
Echinococcus granulosus	kinesin family 1	0.0412	0.5994	0.5994
Brugia malayi	Pre-SET motif family protein	0.0216	0.3114	0.3114
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0116	0.1647	1
Echinococcus granulosus	cytochrome P450 2K1	0.0022	0.0263	0.0263
Onchocerca volvulus		0.0246	0.3553	0.3553
Echinococcus multilocularis	lamin dm0	0.0028	0.0351	0.0351
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0395	0.0395
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0138	0.0138
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0717	1
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0263	0.0263
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0022	0.0263	0.5
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0116	0.1647	0.5
Plasmodium vivax	amine transporter, putative	0.0116	0.1647	1
Echinococcus granulosus	geminin	0.0176	0.2524	0.2524
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0022	0.0263	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.02	0.2884	0.2884
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0116	0.1647	0.1647
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0351	0.0351
Entamoeba histolytica	kinesin, putative	0.0054	0.0726	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1647	0.1647
Echinococcus multilocularis	geminin	0.0176	0.2524	0.2524
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0717	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0263	0.0263

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1762096

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1509123