TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 325.147 | Formula: C14H10Cl2N2O3
H donors: 2 H acceptors: 3 LogP: 4.83 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c(O)c(Cl)c(c2c1c(N)c(o2)C(=O)C=C(C)C)Cl
InChi: 1S/C14H10Cl2N2O3/c1-5(2)3-7(19)13-11(18)8-6(4-17)12(20)9(15)10(16)14(8)21-13/h3,20H,18H2,1-2H3
InChiKey: NMURHDTUQLKRRC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 2, alpha 1 polypeptide		References
Homo sapiens	casein kinase 2, beta polypeptide	Starlite/ChEMBL	References
Homo sapiens	casein kinase 2, alpha prime polypeptide		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania major	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	ck2 beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania mexicana	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania mexicana	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei gambiense	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Theileria parva	casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania donovani	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania infantum	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma mansoni	casein kinase II beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Loa Loa (eye worm)	CMGC/CK2 protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Brugia malayi	Casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania major	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	casein kinase ii beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03097 casein kinase 2, alpha polypeptide, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	unspecified product	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma congolense	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma congolense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium hominis	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania donovani	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Toxoplasma gondii	casein kinase ii regulatory subunit protein	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	casein kinase II beta 4 subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium hominis	protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	YOR039Wp-like protein, related	Get druggable targets OG5_126846	All targets in OG5_126846
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative casein kinase II regulatory subunit; besthit Pf 23508244	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126901	All targets in OG5_126901
Toxoplasma gondii	CMGC kinase, CK2 family	Get druggable targets OG5_126901	All targets in OG5_126901
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	hypothetical protein	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania braziliensis	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania braziliensis	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	casein kinase II, alpha chain (CK II)	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Kinase, CMGC CK2	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	Protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania infantum	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Brugia malayi	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma brucei gambiense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	casein kinase II, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha 1 polypeptide	391 aa	316 aa	51.3 %
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha prime polypeptide	350 aa	319 aa	50.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0043	0.0056	0.0367
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0042	0.0048	0.0709
Echinococcus granulosus	plexin a4	0.0267	0.1119	0.1338
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Brugia malayi	plexin A	0.0267	0.1119	0.1118
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0032	0.0001	0.0001
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Onchocerca volvulus		0.0223	0.0914	1
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Schistosoma mansoni	regulator of G protein signaling	0.0346	0.1495	0.1494
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0043	0.0056	0.0367
Echinococcus granulosus	defective proboscis extension response	0.0082	0.0239	0.0285
Loa Loa (eye worm)	oxysterol binding protein	0.0032	0.0001	0.0001
Schistosoma mansoni	serine/threonine protein kinase	0.1636	0.7632	0.7631
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Echinococcus multilocularis	regulator of G protein signaling 3	0.0346	0.1495	0.1788
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0048	0.0315
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Brugia malayi	Sema domain containing protein	0.0099	0.032	0.0319
Echinococcus multilocularis	transcription factor collier	0.0043	0.0056	0.0066
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0165	0.0164
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0101	0.033	0.0329
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Entamoeba histolytica	casein kinase, putative	0.0171	0.0665	0.4442
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	sema domain-containing protein	0.0099	0.032	0.032
Echinococcus multilocularis	regulator of G protein signaling 7	0.0346	0.1495	0.1788
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0048	0.0315
Entamoeba histolytica	protein kinase domain containing protein	0.0171	0.0665	0.4442
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.0061	0.0898
Trichomonas vaginalis	conserved hypothetical protein	0.0346	0.1495	1
Schistosoma mansoni	regulator of G protein signaling	0.0346	0.1495	0.1494
Echinococcus granulosus	beta-adrenergic receptor kinase	0.1636	0.7632	0.9134
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Schistosoma mansoni	regulator of G protein signaling	0.0346	0.1495	0.1494
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0171	0.0665	1
Loa Loa (eye worm)	AUR protein kinase	0.0066	0.0165	0.0165
Echinococcus granulosus	twitchin	0.0092	0.0286	0.0341
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0043	0.0056	0.0367
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.0061	0.0653
Echinococcus granulosus	Immunoglobulin	0.0082	0.0239	0.0285
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Echinococcus multilocularis	hypothetical protein	0.0099	0.032	0.0381
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1788	0.8355	0.8355
Entamoeba histolytica	hypothetical protein	0.0042	0.0048	0.0315
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0346	0.1495	0.1494
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Echinococcus granulosus	transcription factor collier	0.0043	0.0056	0.0066
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0171	0.0665	0.0665
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.0061	0.0898
Echinococcus granulosus	serine/threonine protein kinase	0.0042	0.0048	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Leishmania major	serine/threonine-protein kinase a, putative	0.0042	0.0048	0.0709
Echinococcus multilocularis	expressed protein	0.0346	0.1495	0.1788
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0042	0.0048	0.0709
Entamoeba histolytica	protein kinase , putative	0.0066	0.0165	0.11
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0165	0.11
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	plexin A	0.0267	0.1119	0.1119
Brugia malayi	hypothetical protein	0.0082	0.0239	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Echinococcus granulosus	regulator of G protein signaling 7	0.0346	0.1495	0.1788
Echinococcus multilocularis	axis inhibition protein axin	0.0346	0.1495	0.1788
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0042	0.0048	0.0709
Entamoeba histolytica	hypothetical protein	0.0043	0.0056	0.0367
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0165	0.11
Schistosoma mansoni	regulator of G protein signaling	0.0346	0.1495	0.1494
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Echinococcus granulosus	casein kinase ii subunit alpha	0.0171	0.0665	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0099	0.032	0.032
Echinococcus granulosus	casein kinase ii subunit beta	0.0044	0.0061	0.0071
Loa Loa (eye worm)	RGS-3 protein	0.0346	0.1495	0.1495
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Loa Loa (eye worm)	Plekhf2 protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1636	0.7632	0.7632
Trypanosoma cruzi	Protein kinase B	0.0042	0.0048	0.0709
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0165	0.11
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0171	0.0665	0.0794
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0042	0.0048	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0914	0.0914
Loa Loa (eye worm)	rho-GTPase-activating	0.0032	0.0001	0.0001
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0066	0.0165	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0444	0.0444
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Trichomonas vaginalis	conserved hypothetical protein	0.0346	0.1495	1
Entamoeba histolytica	p21-activated kinase	0.0042	0.0048	0.0315
Schistosoma mansoni	casein kinase II beta subunit	0.0044	0.0061	0.006
Entamoeba histolytica	protein kinase domain containing protein	0.0062	0.0146	0.0972
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1788	0.8355	1
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0346	0.1495	1
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Entamoeba histolytica	hypothetical protein	0.0043	0.0056	0.0367
Schistosoma mansoni	hypothetical protein	0.0043	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0346	0.1495	0.1494
Brugia malayi	Plexin repeat family protein	0.0223	0.0914	0.0913
Onchocerca volvulus		0.0099	0.032	0.3492
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0346	0.1495	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0023	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0044	0.0061	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1495	0.1495
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0042	0.0048	0.0709
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0042	0.0048	0.0709
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trypanosoma cruzi	NIMA-related kinase, putative	0.0042	0.0048	0.0709
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0066	0.0165	0.11
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1495	0.1495
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0044	0.0061	0.0898
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0044	0.0061	0.0898
Echinococcus multilocularis	axis inhibition protein axin	0.0346	0.1495	0.1788
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Schistosoma mansoni	regulator of G protein signaling	0.0346	0.1495	0.1494
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0048	0.0315
Plasmodium vivax	unspecified product	0.0171	0.0665	1
Brugia malayi	hypothetical protein	0.0099	0.032	0.0319
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Entamoeba histolytica	protein kinase, putative	0.0066	0.0165	0.11
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0056	0.0056
Echinococcus multilocularis	roundabout 2	0.0082	0.0239	0.0285
Entamoeba histolytica	hypothetical protein	0.0346	0.1495	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0346	0.1495	0.1788
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0048	0.0047
Echinococcus granulosus	roundabout 2	0.0082	0.0239	0.0285
Echinococcus multilocularis	aurora kinase A	0.0066	0.0165	0.0197
Schistosoma mansoni	vesicular amine transporter	0.0084	0.0251	0.025
Entamoeba histolytica	hypothetical protein	0.0346	0.1495	1
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0165	0.11
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0042	0.0048	0.0709
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0042	0.0048	0.0709
Trichomonas vaginalis	conserved hypothetical protein	0.0346	0.1495	1
Trypanosoma brucei	Casein kinase II	0.0171	0.0665	1
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0061	0.0399
Brugia malayi	serine/threonine kinase 12	0.0066	0.0165	0.0164
Brugia malayi	Casein kinase II, alpha chain	0.0171	0.0665	0.0664
Schistosoma mansoni	protein kinase	0.0171	0.0665	0.0664
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0042	0.0048	0.0048
Brugia malayi	regulator of G-protein signaling rgs-7	0.0346	0.1495	0.1494
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0082	0.0239	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Leishmania major	folate/biopterin transporter, putative	0.0042	0.0048	0.0709
Entamoeba histolytica	hypothetical protein	0.0042	0.0048	0.0315
Loa Loa (eye worm)	AUR protein kinase	0.0066	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Brugia malayi	DNA-binding protein LAG-1	0.0043	0.0056	0.0055
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0061	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0099	0.032	0.032
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Toxoplasma gondii	protein kinase domain-containing protein	0.0042	0.0048	0.0709
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0048	0.0315
Entamoeba histolytica	hypothetical protein	0.0043	0.0056	0.0367
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0048	0.0315
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1495	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0056	0.0367
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0346	0.1495	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0056	0.0056
Giardia lamblia	Kinase, CMGC CK2	0.0171	0.0665	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Echinococcus multilocularis	rac serine:threonine kinase	0.0042	0.0048	0.0056
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0066	0.0165	0.2476
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.129	0.5987	0.7165
Schistosoma mansoni	axis inhibition protein axin	0.0346	0.1495	0.1494
Loa Loa (eye worm)	syntrophin-1	0.0032	0.0001	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Echinococcus granulosus	regulator of G protein signaling 3	0.0346	0.1495	0.1788
Trypanosoma cruzi	aurora B kinase, putative	0.0066	0.0165	0.2476
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.0061	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Echinococcus granulosus	neuroglian	0.0082	0.0239	0.0285
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1636	0.7632	0.9134
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Echinococcus granulosus	Regulator of G protein signaling 20	0.0346	0.1495	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0099	0.032	0.032
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0042	0.0048	0.0315
Echinococcus granulosus	axis inhibition protein axin	0.0346	0.1495	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1495	0.1495
Echinococcus granulosus	semaphorin 1A	0.0099	0.032	0.0381
Echinococcus granulosus	aurora kinase A	0.0066	0.0165	0.0197
Brugia malayi	Csnk2b protein	0.0044	0.0061	0.006
Schistosoma mansoni	cell adhesion molecule	0.0082	0.0239	0.0238
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0066	0.0165	0.11
Schistosoma mansoni	hypothetical protein	0.0099	0.032	0.0319
Trichomonas vaginalis	conserved hypothetical protein	0.0346	0.1495	1
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.0061	0.0898
Echinococcus multilocularis	regulator of G protein signaling 7	0.0346	0.1495	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Echinococcus multilocularis	Immunoglobulin	0.0082	0.0239	0.0285
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0043	0.0056	0.0367
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Toxoplasma gondii	ck2 beta subunit	0.0044	0.0061	0.0898
Entamoeba histolytica	protein kinase domain containing protein	0.0066	0.0165	0.11
Entamoeba histolytica	hypothetical protein	0.0346	0.1495	1
Echinococcus granulosus	G protein coupled receptor kinase 1	0.129	0.5987	0.7165
Echinococcus granulosus	exocyst complex component 2	0.0043	0.0056	0.0066
Leishmania major	protein kinase, putative	0.0042	0.0048	0.0709
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0042	0.0048	0.0709
Trypanosoma brucei	aurora B kinase	0.0066	0.0165	0.2476
Loa Loa (eye worm)	hypothetical protein	0.0099	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1495	0.1495
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0042	0.0048	0.0709
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1788	0.8355	1
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Schistosoma mansoni	protein kinase	0.0066	0.0165	0.0164
Toxoplasma gondii	aurora kinase	0.0066	0.0165	0.2476
Schistosoma mansoni	serine/threonine protein kinase	0.1636	0.7632	0.7631
Trypanosoma cruzi	NIMA-related kinase, putative	0.0042	0.0048	0.0709
Giardia lamblia	Aurora kinase	0.0066	0.0165	0.1734
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0082	0.0239	0.0238
Echinococcus multilocularis	regulator of G protein signaling 3	0.0346	0.1495	0.1788
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0082	0.0239	0.0285
Echinococcus multilocularis	neuroglian	0.0082	0.0239	0.0285
Leishmania major	protein kinase, putative	0.0066	0.0165	0.2476
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Trypanosoma brucei	protein kinase, putative	0.0042	0.0048	0.0709
Brugia malayi	PXA domain containing protein	0.0346	0.1495	0.1494
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0048	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Echinococcus multilocularis	semaphorin 5B	0.0099	0.032	0.0381
Schistosoma mansoni	serine/threonine-protein kinase	0.0042	0.0048	0.0047
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0023	0.0026
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0066	0.0165	0.11
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0043	0.0056	0.0367
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Brugia malayi	Probable exocyst complex component Sec5	0.0043	0.0056	0.0055
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0346	0.1495	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Leishmania major	protein kinase, putative	0.0042	0.0048	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0056	0.0056
Schistosoma mansoni	serine/threonine-protein kinase	0.0042	0.0048	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Brugia malayi	A-kinase anchor protein 10, precursor	0.0346	0.1495	0.1494
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0011	0.0069
Echinococcus multilocularis	regulator of G protein signaling	0.0346	0.1495	0.1788
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0066	0.0165	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Echinococcus multilocularis	casein kinase ii subunit beta	0.0044	0.0061	0.0071
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0061	0.0399
Entamoeba histolytica	tyrosin kinase, putative	0.0062	0.0146	0.0972
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0066	0.0165	0.2476
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0042	0.0048	0.0709
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0042	0.0048	0.0709
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Echinococcus multilocularis	exocyst complex component 2	0.0043	0.0056	0.0066
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0082	0.0239	0.0238
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0032	0.0001	0.0001
Entamoeba histolytica	cell surface protease gp63, putative	0.0043	0.0056	0.0367
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0346	0.1495	0.1494
Brugia malayi	hypothetical protein	0.0346	0.1495	0.1494
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0346	0.1495	0.1494
Schistosoma mansoni	axis inhibition protein axin	0.0346	0.1495	0.1494
Brugia malayi	Sema domain containing protein	0.0099	0.032	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Brugia malayi	regulator of G-protein signaling egl-10	0.0346	0.1495	0.1494
Echinococcus multilocularis	plexin a4	0.0267	0.1119	0.1338
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0042	0.0048	0.0315
Loa Loa (eye worm)	Csnk2b protein	0.0044	0.0061	0.0061
Brugia malayi	PXA domain containing protein	0.0346	0.1495	0.1494
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0039	0.0038
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0082	0.0239	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1495	0.1495
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0042	0.0048	0.0709
Schistosoma mansoni	plexin	0.0125	0.0444	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0346	0.1495	1
Loa Loa (eye worm)	sema domain-containing protein	0.0099	0.032	0.032
Echinococcus granulosus	axis inhibition protein axin	0.0346	0.1495	0.1788
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Entamoeba histolytica	protein kinase, putative	0.0066	0.0165	0.11
Loa Loa (eye worm)	hypothetical protein	0.0099	0.032	0.032
Loa Loa (eye worm)	AUR protein kinase	0.0066	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0042	0.0048	0.0709
Entamoeba histolytica	hypothetical protein	0.0043	0.0056	0.0367
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0032	0.0001	0.0001
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Brugia malayi	serine/threonine protein kinase 6	0.0066	0.0165	0.0164
Schistosoma mansoni	hypothetical protein	0.0099	0.032	0.0319
Schistosoma mansoni	plexin	0.0223	0.0914	0.0913
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0039	0.0038
Loa Loa (eye worm)	uncoordinated protein 104	0.0032	0.0001	0.0001
Loa Loa (eye worm)	cytohesin 3	0.0032	0.0001	0.0001
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.0061	0.0898
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0346	0.1495	0.1495
Entamoeba histolytica	protein kinase, putative	0.0042	0.0048	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Trypanosoma cruzi	casein kinase II, putative	0.0171	0.0665	1
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.0061	0.0653
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0011	0.0069
Loa Loa (eye worm)	PXA domain-containing protein	0.0346	0.1495	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0239	0.0239
Brugia malayi	Fibronectin type III domain containing protein	0.0082	0.0239	0.0238
Echinococcus multilocularis	Immunoglobulin	0.0082	0.0239	0.0285
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.0061	0.0898
Schistosoma mansoni	fibrocystin l	0.0043	0.0056	0.0055
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0346	0.1495	0.1494
Schistosoma mansoni	hypothetical protein	0.0043	0.0056	0.0055
Loa Loa (eye worm)	PH domain-containing protein	0.0032	0.0001	0.0001
Echinococcus granulosus	semaphorin 5B	0.0099	0.032	0.0381
Schistosoma mansoni	nephrin	0.0082	0.0239	0.0238
Echinococcus granulosus	expressed protein	0.0346	0.1495	0.1788
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0346	0.1495	0.1788
Brugia malayi	serine/threonine-protein kinase 6	0.0066	0.0165	0.0164
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0023	0.0022
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0042	0.0048	0.0709
Schistosoma mansoni	hypothetical protein	0.0125	0.0444	0.0443
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0101	0.033	0.033
Toxoplasma gondii	CMGC kinase, CK2 family	0.0171	0.0665	1
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0171	0.0665	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1788	0.8355	0.8355
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0042	0.0048	0.0709
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.0665	0.4442
Schistosoma mansoni	semaphorin 5-related	0.0099	0.032	0.0319
Brugia malayi	IPT/TIG domain containing protein	0.0043	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0099	0.032	0.032
Leishmania major	casein kinase II, putative	0.0171	0.0665	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0042	0.0048	0.0709
Schistosoma mansoni	z-protein (S1r protein)	0.0346	0.1495	0.1494
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0042	0.0048	0.0709
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0346	0.1495	0.1494
Echinococcus granulosus	regulator of G protein signaling 3	0.0346	0.1495	0.1788
Brugia malayi	hypothetical protein	0.0099	0.032	0.0319
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1788	0.8355	0.8355
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0061	0.0399
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0048	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0001	0.0001
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0042	0.0048	0.0709

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	< 4 %	Inhibition of CK2 (unknown origin) assessed as residual activity using E-peptide as substrate at 10 uM incubated for 10 mins prior to testing by capillary electrophoretic analysis	PATENT.	No reference
IC50 (binding)	= 200 nM	Capillary Electrophoresis	BINDINGDB.	No reference
IC50 (binding)	= 0.2 uM	Inhibition of human recombinant CK2 using RRRDDDSDDD-EDANS peptide substrate by capillary electrophoresis analysis	ChEMBL.	21459578
IC50 (binding)	= 0.2 uM	Inhibition of CK2 (unknown origin) using E-peptide as substrate incubated for 10 mins prior to testing by capillary electrophoretic analysis	PATENT.	No reference
Inhibition (binding)	> 96 %	Inhibition of human recombinant CK2 using RRRDDDSDDD-EDANS peptide substrate at 10 mM by capillary electrophoresis analysis	ChEMBL.	21459578

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1765541

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1510202